Hind S AboShabaan, Osama Alghannam, Faisal Ismail, Islam M El-Garawani, Mohamed El-Shahat, Roba M Talaat, Eman A El-Maadawy, Nasser Hussein, Zeinab A Kasemy, Eman Abdelsameea, Soghra Haq, Heba M Hathout
AIM OF THE STUDY: Bone morphogenic proteins (BMPs) have both inhibitory and stimulatory effects on growth of a tumor that depend on the type of cells, the dosage and the tumor microenvironment. We aimed to investigate the impact of the bone morphogenic protein-7 (BMP-7) single nucleotide polymorphism (SNP) rs230205 [A/G] on susceptibility to hepatocellular carcinoma (HCC) progression from liver cirrhosis after viral hepatitis infection in Egyptian patients. MATERIAL AND METHODS: The amplification-refractory mutation system (ARMS)-polymerase chain reaction (PCR) method was used to genotype the rs230205 [A/G] SNP in 150 subjects (50 patients with post-hepatitis C or B cirrhosis, 50 HCC patients, and 50 controls)...
June 2023: Clinical and Experimental Hepatology