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Clinical and Experimental Hepatology

Hamza Arif, Kristen Suchniak-Mussari, Moeezullah Beg, Suzanne Morrissey
A 75-year-old woman with a 50-pack-year history of tobacco abuse presented with abdominal pain, encephalopathy and elevated liver enzymes. Serologic evaluation for viral hepatitis, drug levels and chronic liver disease panel was negative. Computed tomography (CT) scan of the abdomen showed hepatomegaly and a large area of decreased attenuation in the lateral segment of the left lobe of the liver which was also demonstrated on the magnetic resonance cholangiopancreatography. CT of the chest was significant for a 1...
December 2018: Clinical and experimental hepatology
Joanna Małgorzata Krzowska-Firych, Robert Ściślak, Agnieszka Wójtowicz, Krzysztof Tomasiewicz, Georgia Lucas, Christiana Lucas
The aim of our study was to analyze medical records of all adult patients with acute hepatitis A virus (HAV) infection who were hospitalized at the Department of Infectious Diseases, Medical University of Lublin, Poland in 2017. During the studied period acute HAV infection was confirmed in 33 patients. In the study group there were 30 men and 3 women. The mean time of hospitalization was 12 days. All patients recovered with no clinical sequelae.
December 2018: Clinical and Experimental Hepatology
Lubomir Skladany, Daniela Janceková, Juraj Svac
Aim of the study: To determine the seroprevalence of hepatitis C virus (HCV) in outpatients with chronic kidney disease (CKD) attending a nephrology clinic. Material and methods: Prospective observational study on consecutive outpatients attending a nephrology clinic. Inclusion criteria were age > 18 years, CKD, informed consent. There were no exclusion criterias. Recorded variables were age, gender, CKD grade and etiology, anti-HCV antibodies (Ab). Patients with positive HCV Abs were tracked for HCV RNA detection...
December 2018: Clinical and Experimental Hepatology
Jan Heil, Daniel Schultze, Peter Schemmer, Helge Bruns
Aim of the study: Hepatocyte transplantation has been discussed as an alternative to liver transplantation in selected cases of acute and chronic liver failure and metabolic diseases. Immediately after infusion of hepatocytes, hypoxia-related cell injury is inevitable. N-acetylcysteine (NAC) has been suggested to attenuate hypoxic damage. This study's objective was to evaluate NAC's protective effect in a model of hypoxia-related hepatocyte injury. Material and methods: HepG2 cells were used as a model for hepatocytes and were cultured under standardized hypoxia or normoxia for 24 hours with or without NAC...
December 2018: Clinical and experimental hepatology
Mohammad Akbari, Suleyman Utku Celik, Akin Firat Kocaay, Omer Arda Cetinkaya, Seher Demirer
Aim of the study: In the initiation of liver regeneration, multiple stimulatory and inhibitory factors participate. In this study, we aimed to evaluate the effects of omega-3 fatty acids on liver regeneration after 30% partial hepatectomy in rats. Material and methods: A total of 14 male Wistar Albino rats were included in this study. The animals were randomly allocated to two groups: the control group ( n = 7) and the omega-3 group ( n = 7). Rats in the control group were fed a standard rat chow and rats in the omega-3 group received 10 mg/kg/day omega-3 supplementation in addition to normal rat chow in the perioperative period...
December 2018: Clinical and Experimental Hepatology
Alif Abd El-Hakim Allam, Sara Mohammed Eltaras, Mohsen Hassan Hussin, El-Sayed Ibrahem Salama, Olfat Mohamed Hendy, Maha Moawad Allam, Haidy Mohammed Zakaria
Aim of the study: We aimed to assess the utility and rapidity of granulocyte elastase (GE) latex immunoassay and leukocyte esterase (LE) reagent strips for the diagnosis of spontaneous bacterial peritonitis (SBP) in hepatic children with ascites. Material and methods: This study included 80 ascitic fluid (AF) samples from 45 patients with chronic liver diseases. They were divided into 2 groups (SBP and non-SBP groups). White blood cells > 500 cell/mm3 or polymorphonuclear leukocytes > 250 cell/mm3 were considered as a positive result for the diagnosis of SBP...
December 2018: Clinical and Experimental Hepatology
Damian Piotrowski, Anna Sączewska-Piotrowska, Jerzy Jaroszewicz, Anna Boroń-Kaczmarska
Aim of the study: To assess the performance of Child-Turcotte-Pugh (CTP) and Model for End-Stage Liver Disease (MELD) scores' kinetics during hospitalization in predicting in-hospital mortality in patients with liver cirrhosis. Material and methods: One hundred and seventy-four cases of hospitalized liver cirrhosis patients were selected. The diagnosis of cirrhosis was made based on clinical, biochemical, ultrasonic, histological, and endoscopic findings and results...
December 2018: Clinical and Experimental Hepatology
K Janani, Mayank Jain, Joy Vargese, Vijaya Srinivasan, Kavya Harika, Tom Michael, Jayanthi Venkataraman
Aim of the study: To determine the factors that are likely to influence the domains of health-related quality of life (HRQOL) using SF-36 and CLDQ questionnaires in patients with liver cirrhosis. Material and methods: Patients with liver cirrhosis were compared with age- and gender-matched healthy controls for physical and mental components of the SF-36 score. Effects of age, co-morbidity, namely diabetes, severity of liver disease and complications of liver cirrhosis on HRQOL using self-administered or by direct interview SF-36 and CLDQ questionnaires were studied...
December 2018: Clinical and Experimental Hepatology
Karolina Anna Rostkowska, Anna Szymanek-Pasternak, Krzysztof Adam Simon
Spontaneous bacterial peritonitis (SBP) is one of the most common bacterial infections in patients with liver cirrhosis and it significantly contributes to the deterioration of the prognosis and increased risk of mortality. Previous data suggested that the most common pathogens causing SBP are G-negative aerobic bacteria and treatment recommended by the international guidelines (EASL, AASLD) is highly effective. In recent years, due to the widespread use of antibiotic prophylaxis and the increased frequency of hospitalization along with the use of invasive procedures in patients with cirrhosis, the involvement of Gram-positive cocci and multi-drug resistant bacteria in the etiology of SBP is increasing...
December 2018: Clinical and experimental hepatology
Tomasz Menżyk, Martyna Bator, Aleksandra Derra, Rafał Kierach, Michał Kukla
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder which typically commences in the late second or third trimester and resolves within 48 hours after delivery. It is characterized by mild to severe pruritus, without any specific dermatologic features, elevated liver enzymes and increased serum bile acids (BA). The etiology of ICP is still not completely explicit. Pathogenesis includes a combination of hormonal and environmental factors superimposing on a genetic predisposition...
December 2018: Clinical and Experimental Hepatology
Monika Pazgan-Simon, Krzysztof A Simon, Ewa Jarowicz, Katarzyna Rotter, Anna Szymanek-Pasternak, Jolanta Zuwała-Jagiełło
Chronic hepatitis B virus (HBV) infection and HBV-related liver disease are estimated to affect about 240 million people worldwide. Now that a vaccine is available, the number of new HBV infection cases has plummeted. Yet, there are still regions with very high incidence of HBV. Hepatocellular carcinoma (HCC) is the fourth to six most common malignancy in men and the ninth most common malignancy in women worldwide. 54% of all HCC cases are HBV-associated, making it the most common cause of cancer worldwide...
September 2018: Clinical and Experimental Hepatology
Jingqiao Zhang, Xiaozhong Guo, Hongyu Li, Xiaodong Shao, Jiao Deng, Zhendong Liang, Xia Zhang, Ji Feng, Hao Lin, Xingshun Qi
IgG4-related sclerosing cholangitis is a rare autoimmune liver disease. Biliary tract imaging, serum IgG4 concentration, and histopathological examination are the major diagnostic criteria for IgG4-related sclerosing cholangitis. In this paper, we report a male patient with yellowish skin, in whom classical liver-protection drugs were initially given, but the efficacy was poor. After that, IgG4-related sclerosing cholangitis was diagnosed, and he achieved a good response to steroid therapy.
September 2018: Clinical and Experimental Hepatology
Uday Sanglodkar, Mayank Jain, Dinesh Jothimoni, Subhashree Parida, Balajee G, Jayanthi Venkataraman
Introduction: Cirrhosis of the liver predisposes patients to serious bacterial infections including cellulitis. The aim of the study was to determine the clinical and bacteriological profile of cellulitis in patients with liver cirrhosis. Material and methods: In this prospective study, consecutive cirrhotic patients hospitalized between February and September 2017 were enrolled. Data retrieved included demographics, aetiology, co-morbidity, cirrhosis-related complications, site of cellulitis, baseline investigations, and wound and blood culture...
September 2018: Clinical and Experimental Hepatology
Adriano Pellicelli, Valerio Giannelli, Valerio Zoli, Valeria Pellicelli, Anna Linda Zignego
Introduction: Hepatitis C infection (HCV) is highly prevalent worldwide and has a well-known association with B-cell lymphoid malignancies. While several studies have demonstrated that antiviral therapy (AT) is effective to induce a complete hematological response in HCV-related low-grade B cell lymphoma, in HCV-related high-grade B cell non-Hodgkin lymphomas such as diffuse large B cell lymphoma (DLBCL) chemotherapy is the only possible choice. However, the role of AT to reduce relapse of DLBCL after an effective chemotherapy containing rituximab (CT-R) has not been analyzed in previous studies...
September 2018: Clinical and Experimental Hepatology
Adel Abdel-Moneim, Alaa Abood, Mohamed Abdel-Gabaar, Mohamed I Zanaty, Mohamed Ramadan
Introduction: New regimens involving direct-acting antiviral agents (DAAs) have recently been approved for the treatment of hepatitis C virus (HCV) genotype 4 (GT4). The current study aims to assess the efficacy and safety of sofosbuvir (SOF) with pegylated interferon (PegINF)/ribavirin (RBV) for chronic HCV GT4 patients at the beginning of the interferon-free era. Material and methods: Between March 2015 and November 2015, 99 patients (59 naïve and 40 experienced) infected with HCV GT4 were enrolled in the study...
September 2018: Clinical and Experimental Hepatology
Ebrahim Shakiba, Mazaher Ramezani, Masoud Sadeghi
Aim of the study: This meta-analysis evaluated serum interleukin-6 (IL-6) levels in hepatocellular carcinoma (HCC) patients compared with healthy controls and hepatitis and cirrhotic patients. Material and methods: The three databases PubMed, Scopus, and Web of Science were searched for assessment of IL-6 levels in HCC patients (without cirrhosis and hepatitis) compared with healthy controls (without HCC, cirrhosis and hepatitis) and the studies were selected based on inclusion and exclusion criteria...
September 2018: Clinical and Experimental Hepatology
Mohamed A Ibrahim, Asmaa Abdel-Aziz, Azza El-Sheikh, Maha Kamel, Al-Zahraa Khalil, Hisham Abdelhaleem
Introduction: The study aimed at investigating the hepatic effect of direct acting anti-hepatitis C virus drugs (DAAs), sofosbuvir (Sof) and daclatasvir (Dac), in thioacetamide (TAA)-induced liver injury in rats. Material and methods: Animals were allocated to 7 groups: a normal control group, a TAA group (receiving TAA 50 mg/kg, i.p. twice weekly), two TAA groups receiving either a low or a high dose of Sof (Sof-L and Sof-H; 41.1 mg/kg and 82.2 mg/kg, respectively), two TAA groups receiving either a low or a high dose of Dac (Dac-L and Dac-H; 6...
September 2018: Clinical and Experimental Hepatology
Christiana Lucas, Georgia Lucas, Nicholas Lucas, Joanna Krzowska-Firych, Krzysztof Tomasiewicz
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the Western world. Ongoing research has furthered our understanding of NAFLD, the nature of progression of this disease, and its impact on morbidity and mortality. An active form of NAFLD is non-alcoholic steatohepatitis (NASH); it is the most severe subtype, without any current recommended therapies, according to the European Medicines Agency. The development of new therapies presents challenges, notably due to the slow progression of NASH and the clinically relevant endpoints...
September 2018: Clinical and Experimental Hepatology
Ewelina Tuchendler, Paweł K Tuchendler, Grzegorz Madej
The syndrome of decreased immunity caused by cirrhosis is a combination of different immunological mechanisms and reactions which result from an advanced stage of the liver disease. The synthesis of proteins of the acute phase becomes impaired, there develop different deficiencies of the complement system, and there ensues a decrease of receptors that are meant to recognize antigens. The negative changes become apparent in the field of cell responses, e.g. there are changes in the amounts of generated monocytes and macrophages, and their phagocytic capabilities and chemotaxic reactions are impacted as well...
September 2018: Clinical and experimental hepatology
Krzysztof Tomasiewicz, Robert Flisiak, Waldemar Halota, Jerzy Jaroszewicz, Dariusz Lebensztejn, Wojciech Lisik, Piotr Małkowski, Małgorzata Pawłowska, Anna Piekarska, Krzysztof Simon, Olga Tronina
The Polish Group of Experts for Non-Alcoholic Fatty Liver Disease (PGE-NAFLD) is a multidisciplinary team of hepatology experts established by the Polish Association for the Study of Liver and the Polish Society of Epidemiology and Infectious Diseases. The recommendations for the management of non-alcoholic fatty liver disease have been developed by a group of experts in hepatology under the auspices of the Polish Association for the Study of Liver and the Polish Society of Epidemiology and Infectious Diseases...
September 2018: Clinical and experimental hepatology
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