journal
https://read.qxmd.com/read/38752206/pubertal-suppression-in-early-puberty-followed-by-testosterone-mildly-increases-final-height-in-transmasculine-youth
#1
JOURNAL ARTICLE
Rebecca W Persky, Danielle Apple, Nadia Dowshen, Elyse Pine, Jax Whitehead, Ellis Barrera, Stephanie A Roberts, Jeremi Carswell, Dana Stone, Sandra Diez, James Bost, Pallavi Dwivedi, Veronica Gomez-Lobo
CONTEXT: Treatment for transmasculine youth (TMY) can involve testosterone treatment and is sometimes preceded by gonadotropin-releasing hormone agonist (GnRHa) treatment for puberty blockade. GnRHas can increase final height in birth-assigned females with central precocious puberty. Maximizing final adult height (FAH) is an important outcome for many TMY. OBJECTIVE: Our objective was to determine how GnRHa treatment before testosterone impacts FAH. METHODS: Retrospective cohort study at 5 US transgender health clinics...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38752205/letter-to-the-editor-from-landrigan-et-al-chemicals-used-in-plastic-materials-an-estimate-of-the-attributable-disease-burden-and-costs-in-the-united-states
#2
JOURNAL ARTICLE
Philip J Landrigan, Maureen Cropper, Sarah Dunlop, Yongjoon Park, Christos Symeonides
No abstract text is available yet for this article.
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38752204/response-to-letter-to-the-editor-from-landrigan-et-al-chemicals-used-in-plastic-materials-an-estimate-of-the-attributable-disease-burden-and-costs-in-the-united-states
#3
JOURNAL ARTICLE
Leonardo Trasande, Kevin Park, Vladislav Obsekov, Michael Belliveau
No abstract text is available yet for this article.
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38745826/medullary-thyroid-cancer-epidemiology-and-characteristics-according-to-data-from-the-marne-ardennes-register-1975-2018
#4
JOURNAL ARTICLE
Sarah Caillé, Adeline Debreuve-Theresette, Géraldine Vitellius, Sophie Deguelte, Luigi La Manna, Mohamad Zalzali
CONTEXT: Medullary thyroid cancer (MTC) is a rare disease. OBJECTIVE: The main objective of our study was to analyze the incidence evolution of MTC with a follow-up of more than 40 years. Further, a descriptive and survival analysis was performed according to the Kaplan-Meier analysis. DESIGN SETTING AND PATIENTS: This is a retrospective epidemiological study using data from the Marne-Ardennes registry from 1975 to 2018. Two hundred sixty patients with MTC were included...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38745825/functional-analysis-of-a-novel-hnf4a-variant-identified-in-a-patient-with-mody1
#5
JOURNAL ARTICLE
Shuntaro Morikawa, Hui Ling Ko, Ee Chee Ren, Kazuya Hara, Naoya Kaneko, Nozomi Hishimura, Akie Nakamura, Atsushi Manabe
CONTEXT: HNF4A-maturity-onset diabetes of the young (MODY1) is a relatively rare subtype of monogenic diabetes caused by loss of function of the HNF4A gene, which encodes the transcription factor HNF4α. HNF4α is known to form heterodimers, and the various combinations of isoforms that make up these heterodimers have been reported to result in a diversity of targeted genes. However, the function of individual HNF4α variant isoforms and the heterodimers comprising both wild-type (WT) and variant HNF4α have not yet been assessed...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38745824/germline-variants-in-sporadic-pituitary-adenomas
#6
JOURNAL ARTICLE
Ali S Alzahrani, Abdulghani Bin Nafisah, Meshael Alswailem, Balgees Alghamdi, Burair Alsaihati, Hussain Aljafar, Batoul Baz, Hindi Alhindi, Yosra Moria, Muhammad Imran Butt, Abdulrahman Ghiatheddin Alkabbani, Omalkhaire M Alshaikh, Anhar Alnassar, Ahmed Bin Afeef, Reem AlQuraa, Rawan Alsuhaibani, Omar Alhadlaq, Fayha Abothenain, Yasser A Altwaijry
CONTEXT: Data on germline genetics of pituitary adenomas (PAs) using whole-exome sequencing (WES) are limited. OBJECTIVE: This study investigated the germline genetic variants in patients with PAs using WES. METHODS: We studied 134 consecutive functioning (80.6%) and nonfunctioning (19.4%) PAs in 61 female (45.5%) and 73 male patients (54.5%). Their median age was 34 years (range, 11-85 years) and 31 patients had microadenomas (23.0%) and 103 macroadenomas (77%)...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38741940/letter-to-the-editor-from-j-finsterer-explaining-long-covid-a-pioneer-cross-sectional-study-supporting-the-endocrine-hypothesis
#7
JOURNAL ARTICLE
Josef Finsterer
No abstract text is available yet for this article.
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38741939/thyroid-related-hormones-and-hypertension-incidence-in-middle-aged-and-older-hispanic-latino-adults-the-hchs-sol-study
#8
JOURNAL ARTICLE
Chibuzor Abasilim, Victoria Persky, Robert M Sargis, Maria Argos, Martha Daviglus, Sally Freels, Jianwen Cai, Konstantina Tsintsifas, Carmen R Isasi, Brandilyn A Peters, Gregory A Talavera, Bharat Thyagarajan, Mary E Turyk
BACKGROUND: Thyroid-related hormones act to regulate metabolic pathways and blood pressure (BP). However, the relationship of TSH and peripheral thyroid hormones and the role of the hypothalamic-pituitary-thyroid axis on hypertension development is not fully understood. We assessed sex-specific associations of thyroid-related hormones with BP and hypertension in Hispanic/Latino adults followed for 6 years. METHODS: We studied 1789 adults, ages 45 to 74, free of diabetes at baseline from a subcohort of the Hispanic Community Health Study/Study of Latinos...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38737592/pitfalls-in-the-diagnostic-evaluation-of-pheochromocytomas
#9
JOURNAL ARTICLE
Gustavo F C Fagundes, Madson Q Almeida
Pheochromocytomas and paragangliomas (PPGLs), rare neuroendocrine tumors arising from chromaffin cells, present a significant diagnostic challenge due to their clinical rarity and polymorphic symptomatology. The clinical cases demonstrate the importance of an integrated approach that combines clinical assessment, biochemical testing, and imaging to distinguish PPGLs from mimicking conditions, such as obstructive sleep apnea and interfering medication effects, which can lead to false-positive biochemical results...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38721111/letter-to-the-editor-from-de-zegher-and-ib%C3%A3-%C3%A3-ez-distinct-reproductive-phenotypes-segregate-with-differences-in-body-weight-in-adolescent-polycystic-ovary-syndrome
#10
JOURNAL ARTICLE
Francis de Zegher, Lourdes Ibáñez
No abstract text is available yet for this article.
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38721110/response-to-letter-to-the-editor-from-de-zegher-and-ib%C3%A3-%C3%A3-ez-distinct-reproductive-phenotypes-segregate-with-differences-in-body-weight-in-adolescent-polycystic-ovary-syndrome
#11
JOURNAL ARTICLE
https://read.qxmd.com/read/38721109/concordance-of-blood-glucose-and-cgm-during-a-pilot-trial-of-automated-insulin-delivery-in-type-1-diabetes-pregnancies
#12
JOURNAL ARTICLE
Ravinder Jeet Kaur, Carol J Levy, Kristin Castorino, Christina M Wood-Wentz, Shafaq R Rizvi, Basak Ozaslan, Grenye O'Malley, Mari Charisse Trinidad, Camilla Levister, Mei Mei Church, Donna Desjardins, Selassie Ogyaadu, Corey Reid, Kent R Bailey, Francis J Doyle, Jordan E Pinsker, Eyal Dassau, Yogish C Kudva
BACKGROUND: Customized and standard automated insulin delivery (AID) systems for use in pregnancies of women with preexisting type 1 diabetes (T1D) are being developed and tested to achieve pregnancy appropriate continuous glucose monitoring (CGM) targets. Guidance on the use of CGM for treatment decisions during pregnancy in the United States is limited. METHODS: Ten pregnant women with preexisting T1D participated in a trial evaluating at-home use of a pregnancy-specific AID system...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38715590/screening-cutoff-values-for-the-detection-of-aldosterone-producing-adenoma-by-lc-ms-ms-and-a-novel-noncompetitive-cleia
#13
JOURNAL ARTICLE
Yoshikiyo Ono, Yuta Tezuka, Kei Omata, Ryo Morimoto, Yuto Yamazaki, Sota Oguro, Kei Takase, Akihiro Ito, Tatsunari Yoshimi, Satoshi Kojima, Sadayoshi Ito, Hironobu Sasano, Takashi Suzuki, Tetsuhiro Tanaka, Hideki Katagiri, Fumitoshi Satoh
CONTEXT: Detecting patients with surgically curable aldosterone-producing adenoma (APA) among hypertensive individuals is clinically pivotal. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the ideal method of measuring plasma aldosterone concentration (PAC) because of the inaccuracy of conventional chemiluminescent enzyme immunoassay (CLEIA). However, LC-MS/MS is expensive and requires expertise. We have developed a novel noncompetitive CLEIA (NC-CLEIA) for measuring PAC in 30 minutes...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38715589/long-term-pegvisomant-therapy-of-acromegaly-effects-on-bone-density-turnover-and-microstructure-using-hrpqct
#14
JOURNAL ARTICLE
Adriana P Kuker, Sanchita Agarwal, Elizabeth Shane, Juliana Bicca, Eliza B Geer, Serge Cremers, Elzbieta Dworakowski, Adi Cohen, Thomas L Nickolas, Emily M Stein, Pamela U Freda
CONTEXT: Fracture rate is increased in patients with active acromegaly and those in remission. Abnormalities of bone microstructure are present in patients with active disease and persist despite biochemical control after surgery. Effects of treatment with the GH receptor antagonist pegvisomant on bone microstructure were unknown. METHODS: We studied 25 patients with acromegaly (15 men, 10 women). In 20, we evaluated areal bone mineral density (BMD) by dual-energy X-ray absorptiometry and bone turnover markers (BTMs) longitudinally, before and during pegvisomant treatment...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38712328/implication-of-pappalysins-and-stanniocalcins-in-the-bioavailability-of-igf-i-in-children-with-type-1-diabetes-mellitus
#15
JOURNAL ARTICLE
María Güemes, Álvaro Martín-Rivada, Beatriz Corredor, Patricia Enes, Sandra Canelles, Vicente Barrios, Jesús Argente
CONTEXT: Anomalies in the growth hormone (GH)/insulin-like growth factor (IGF) axis, are common in children with type 1 diabetes mellitus (T1DM), even in those reaching a normal or near-normal final height. However, concentrations of the IGF bioavailability regulatory factors (pappalysins [PAPP-As] and stanniocalcins [STCs]) have not been reported in children with T1DM. OBJECTIVE: To determine serum concentrations of PAPP-As and STCs in children at diagnosis of T1DM and after insulin treatment and the correlation of these factors with other members of the GH/IGF axis, beta-cell insulin reserve, auxology, and nutritional status...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38698871/twin-pregnancy-complicated-by-gestational-diabetes-mellitus-maternal-and-neonatal-outcomes
#16
JOURNAL ARTICLE
Devika Das, Hannah E Christie, Moustafa Hegazi, Marina Takawy, Karina A Pone, Adrian Vella, Aoife M Egan
CONTEXT: The risk of gestational diabetes mellitus (GDM) in twin pregnancies is more than double that of singleton pregnancies. Although twin pregnancies present unique challenges for fetal growth and prenatal management, the approach to GDM diagnosis and treatment is the same regardless of plurality. Data on pregnancy outcomes for individuals with GDM and a twin pregnancy are limited and conflicting. OBJECTIVE: To describe the maternal characteristics associated with GDM in twin pregnancies and to assess the associated pregnancy outcomes compared to twin pregnancies unaffected by GDM...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38698870/restoring-ovarian-fertility-and-hormone-function-recent-advancements-ongoing-efforts-and-future-applications
#17
REVIEW
Elizabeth L Tsui, Hannah B McDowell, Monica M Laronda
The last 20 years have seen substantial improvements in fertility and hormone preservation and restoration technologies for a growing number of cancer survivors. However, further advancements are required to fill the gaps for those who cannot use current technologies or to improve the efficacy and longevity of current fertility and hormone restoration technologies. Ovarian tissue cryopreservation (OTC) followed by ovarian tissue transplantation (OTT) offers those unable to undergo ovarian stimulation for egg retrieval and cryopreservation an option that restores both fertility and hormone function...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38698869/clinical-impact-of-new-reference-intervals-for-the-roche-prolactin-ii-immunoassay
#18
JOURNAL ARTICLE
Erin Earll, Bradley R Javorsky, Jenna Sarvaideo, Joely A Straseski, Robert D Nerenz
CONTEXT: The Roche prolactin immunoassay is used throughout the world. It reports higher values than the Siemens immunoassay but the manufacturer-defined reference intervals are similar. Patient results are often above the Roche upper limit but within the Siemens interval, causing diagnostic confusion. OBJECTIVE: Establish new reference intervals for the Roche and Siemens prolactin immunoassays. METHODS: We established new reference intervals for the Roche and Siemens immunoassays using 374 specimens from healthy outpatients...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38686391/effect-of-vitamin-d-supplementation-on-muscle-function-in-patients-with-i131-induced-hypothyroidism-a-pilot-randomized-trial
#19
JOURNAL ARTICLE
Sureephan Maneewan, Worapaka Manosroi, Panas Jesadaporn, Mattabhorn Phimphilai, Pratchaya Tipduangta
BACKGROUND: There is a lack of data regarding the effect of vitamin D supplements in patients with I131-induced hypothyroidism. The primary aim of this study was to investigate the effect of vitamin D supplements on muscle function, and the secondary aim was to observe the effect on body composition, insulin resistance, and quality of life (QOL) in patients with I131-induced hypothyroidism. METHODS: In this pilot randomized placebo-controlled trial, patients with I131-induced hypothyroidism on a stable dose of levothyroxine were enrolled and allocated into 2 groups to receive oral vitamin D 20 000 IU weekly or placebo for 24 weeks...
April 6, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38660142/sex-and-ethnicity-related-differences-in-pheochromocytoma-paraganglioma
#20
COMMENT
Peter Istvan Turai, Peter Igaz
No abstract text is available yet for this article.
April 6, 2024: Journal of the Endocrine Society
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