journal
https://read.qxmd.com/read/38517206/rapid-in-vivo-evaluation-system-for-cholestasis-related-genes-in-mice-with-humanized-bile-acid-profiles
#1
JOURNAL ARTICLE
Kihiro Wakasa, Ryutaro Tamura, Shuhei Osaka, Hajime Takei, Akihiro Asai, Hiroshi Nittono, Hiroyuki Kusuhara, Hisamitsu Hayashi
BACKGROUND: Pediatric cholestatic liver diseases (Ped-CLD) comprise many ultrarare disorders with a genetic basis. Pharmacologic therapy for severe cases of Ped-CLD has not been established. Species differences in bile acid (BA) metabolism between humans and rodents contribute to the lack of phenocopy of patients with Ped-CLD in rodents and hinder the development of therapeutic strategies. We aimed to establish an efficient in vivo system to understand BA-related pathogenesis, such as Ped-CLD...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38517204/velacur-ace-outperforms-fibroscan-cap-for-diagnosis-of-masld
#2
JOURNAL ARTICLE
Rohit Loomba, Alnoor Ramji, Tarek Hassanein, Eric M Yoshida, Emily Pang, Caitlin Schneider, Michael P Curry, Nezam H Afdhal
BACKGROUND: As the prevalence of metabolic dysfunction-associated steatotic liver disease increases, it is imperative to have noninvasive alternatives to liver biopsy. Velacur offers a non-invasive, point-of-care ultrasound-based method for the assessment of liver stiffness and attenuation. The aim of this study was to perform a head-to-head comparison of liver stiffness and liver fat determined by Velacur and FibroScan using MRI-based measurements as the reference standard. METHODS: This prospective cross-sectional study included 164 adult participants with well-characterized metabolic dysfunction-associated steatotic liver disease...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38517202/microbially-conjugated-bile-salts-found-in-human-bile-activate-the-bile-salt-receptors-tgr5-and-fxr
#3
JOURNAL ARTICLE
Ümran Ay, Martin Leníček, Raphael S Haider, Arno Classen, Hans van Eijk, Kiran V K Koelfat, Gregory van der Kroft, Ulf P Neumann, Carsten Hoffmann, Carsten Bolm, Steven W M Olde Damink, Frank G Schaap
BACKGROUND: Bile salts of hepatic and microbial origin mediate interorgan cross talk in the gut-liver axis. Here, we assessed whether the newly discovered class of microbial bile salt conjugates (MBSCs) activate the main host bile salt receptors (Takeda G protein-coupled receptor 5 [TGR5] and farnesoid X receptor [FXR]) and enter the human systemic and enterohepatic circulation. METHODS: N-amidates of (chenodeoxy) cholic acid and leucine, tyrosine, and phenylalanine were synthesized...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38497942/the-edmonton-symptom-assessment-system-is-a-valid-reliable-and-responsive-tool-to-assess-symptom-burden-in-decompensated-cirrhosis
#4
JOURNAL ARTICLE
John Donlan, Chengbo Zeng, Teresa Indriolo, Lucinda Li, Enya Zhu, Joyce Zhou, Kedie Pintro, Nora Horick, Maria Edelen, Raymond T Chung, Areej El-Jawahri, Nneka N Ufere
BACKGROUND: While there is a growing need for interventions addressing symptom burden in patients with decompensated cirrhosis (DC), the lack of validated symptom assessment tools is a critical barrier. We investigated the psychometric properties of the revised Edmonton Symptom Assessment System (ESAS-r) in a longitudinal cohort of patients with DC. METHODS: Adult outpatients with DC were prospectively recruited from a liver transplant center and completed ESAS-r at baseline and week 12...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38497934/clinical-criteria-accurately-diagnose-severe-but-not-moderate-alcohol-associated-hepatitis-a-systematic-review-and-meta-analysis
#5
JOURNAL ARTICLE
Nipun Verma, Rohit Mehtani, Jacob Martin Haiar, Pranita Pradhan, Ajay Duseja, Gene Young Im, Ashwani K Singal
BACKGROUND: The precision of clinical criteria and the utility of liver biopsy for diagnosis or prognosis remain unclear in patients with alcohol-associated hepatitis (AH). We systematically reviewed the literature to answer these questions. METHODS: Four databases were searched for studies describing the precision of clinical criteria (National Institute on Alcohol Abuse and Alcoholism, European Association for Study of Liver, or classical) and the role of histology in AH...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38497932/granulomatous-liver-diseases
#6
JOURNAL ARTICLE
Maria Mironova, Harish Gopalakrishna, Gian Rodriguez Franco, Steven M Holland, Christopher Koh, David E Kleiner, Theo Heller
A granuloma is a discrete collection of activated macrophages and other inflammatory cells. Hepatic granulomas can be a manifestation of localized liver disease or be a part of a systemic process, usually infectious or autoimmune. A liver biopsy is required for the detection and evaluation of granulomatous liver diseases. The prevalence of granulomas on liver biopsy varies from 1% to 15%. They may be an incidental finding in an asymptomatic individual, or they may represent granulomatous hepatitis with potential to progress to liver failure, or in chronic disease, to cirrhosis...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38497931/racial-and-ethnic-disparities-in-alcohol-associated-liver-disease-in-the-united-states-a-systematic-review-and-meta-analysis
#7
JOURNAL ARTICLE
Ahmad Anouti, Karim Seif El Dahan, Nicole E Rich, Jeremy Louissaint, William M Lee, Sarah R Lieber, Juan Pablo Arab, Bill Y Zhang, Mausam J Patel, Chanattha Thimphittaya, Luis Antonio Díaz, Dyanna L Gregory, Julia Kozlitina, Lisa B VanWagner, Andrea C King, Mack C Mitchell, Amit G Singal, Thomas G Cotter
BACKGROUND: Alcohol-associated liver disease (ALD), encompassing alcohol-associated hepatitis and alcohol-associated cirrhosis, is rising in the United States. Racial and ethnic disparities are evident within ALD; however, the precise nature of these disparities is poorly defined. METHODS: We conducted a search of the PubMed/MEDLINE and EMBASE databases to identify studies published from inception through September 2023 that reported ALD incidence, prevalence, and mortality within the United States, stratified by race and ethnicity...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38497930/er-stress-promotes-mitochondrial-calcium-overload-and-activates-the-ros-nlrp3-axis-to-mediate-fatty-liver-ischemic-injury
#8
JOURNAL ARTICLE
Fei Li, Zhu Guan, Yiyun Gao, Yan Bai, Xinyu Zhan, Xingyue Ji, Jian Xu, Haoming Zhou, Zhuqing Rao
BACKGROUND: Fatty livers are widely accepted as marginal donors for liver transplantation but are more susceptible to liver ischemia and reperfusion (IR) injury. Increased macrophage-related inflammation plays an important role in the aggravation of fatty liver IR injury. Here, we investigate the precise mechanism by which endoplasmic reticulum (ER) stress activates macrophage NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) signaling by regulating mitochondrial calcium overload in fatty liver IR...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38497929/therapeutic-targeting-at-genome-mutations-of-liver-cancer-by-the-insertion-of-hsv1-thymidine-kinase-through-cas9-mediated-editing
#9
JOURNAL ARTICLE
Muhamuda Kader, Wei Sun, Bao-Guo Ren, Yan-Ping Yu, Junyan Tao, Lesley M Foley, Silvia Liu, Satdarshan P Monga, Jian-Hua Luo
BACKGROUND: Liver cancer is one of the most lethal malignancies for humans. The treatment options for advanced-stage liver cancer remain limited. A new treatment is urgently needed to reduce the mortality of the disease. METHODS: In this report, we developed a technology for mutation site insertion of a suicide gene (herpes simplex virus type 1- thymidine kinase) based on type II CRISPR RNA-guided endonuclease Cas9-mediated genome editing to treat liver cancers...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38466884/-18f-alf-nd-bisfapi-pet-imaging-of-fibroblast-activation-protein-as-a-biomarker-to-monitor-the-progression-of-liver-fibrosis
#10
JOURNAL ARTICLE
Hongsheng Li, Ruoxue Dai, Yueqi Huang, Jiawei Zhong, Qingsong Yan, Jiaqi Yang, Kongzhen Hu, Yuhua Zhong
BACKGROUND: Hepatic fibrosis is a progressive disease, which is reversible in the early stages. The current monitoring methods have notable limitations that pose a challenge to early detection. In this study, we evaluated the utility of [18F]AlF-ND-bisFAPI positron emission tomography imaging of fibroblast activation protein (FAP) to monitor the progression of liver fibrosis. METHODS: Two mouse models of liver fibrosis were established by bile duct ligation and carbon tetrachloride administration, respectively...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38466883/validation-of-the-revised-electronic-version-of-rucam-for-diagnosis-of-dili-in-chinese-patients
#11
JOURNAL ARTICLE
Xinyan Zhao, Yan Wang, Rongtao Lai, Xiaojin Wang, Yuecheng Yu, Min Li, Hong Zhao, Zikun Ma, Mengqi Li, Tiantian Guo, Xiao Han, Yao Meng, Mengmeng Zhang, Yu Su, Kunyan Hao, You Deng, Yuanyuan Kong, Zhenyu Li, Qing Xie, Wen Xie, Chengwei Chen, Jidong Jia
BACKGROUND AIMS: The Revised Electronic Causality Assessment Method (RECAM), a computerized update of the Roussel Uclaf Causality Assessment Methodology (RUCAM), was recently proposed. In this study, we validated and compared the utility of the RECAM and RUCAM in Chinese patients with a single conventional or herbal agent-induced liver injury. METHODS: In this retrospective multicenter cohort of well-established DILI and non-DILI patients from 5 centers in China, the diagnostic performance of the RUCAM and RECAM was compared by AUC analysis...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38466882/crosstalk-of-lysyl-oxidase-like-1-and-lysyl-oxidase-prolongs-their-half-lives-and-regulates-liver-fibrosis-through-notch-signal
#12
JOURNAL ARTICLE
Ning Zhang, Aiting Yang, Wen Zhang, Hong Li, Anjian Xu, Xuzhen Yan, Qi Han, Bingqiong Wang, Hong You, Wei Chen
BACKGROUND: Lysyl oxidase (LOX) family members (LOX and LOXL1 to 4) are crucial copper-dependent enzymes responsible for cross-linking collagen and elastin. Previous studies have revealed that LOX and LOXL1 are the most dramatically dysregulated LOX isoforms during liver fibrosis. However, the crosstalk between them and the underlying mechanisms involved in the profibrotic behaviors of HSCs, as well as the progression of liver fibrosis, remain unclear. METHODS: pCol9GFP-HS4,5Tg mice, Loxl1fl/flGfapCre mice, human HSC line, and primary HSCs were enrolled to study the dysregulation pattern, profibrotic roles, and the potential mechanisms of LOX and LOXL1 interaction involved in the myofibroblast-like transition of HSCs and liver fibrogenesis...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38466881/berberine-alleviates-concanavalin-a-induced-autoimmune-hepatitis-in-mice-by-modulating-the-gut-microbiota
#13
JOURNAL ARTICLE
Hao Yang, Qingqing Liu, Haixia Liu, Xing Kang, Haixia Tian, Yongbo Kang, Lin Li, Xiaodan Yang, Peng Ren, Xiaoyu Kuang, Xiaohui Wang, Linzhi Guo, Mingwei Tong, Jieqiong Ma, Weiping Fan
BACKGROUND: Autoimmune hepatitis (AIH) is an immune-mediated liver disease of unknown etiology accompanied by intestinal dysbiosis and a damaged intestinal barrier. Berberine (BBR) is a traditional antibacterial medicine that has a variety of pharmacological properties. It has been reported that BBR alleviates AIH, but relevant mechanisms remain to be fully explored. METHODS: BBR was orally administered at doses of 100 mg⋅kg-1⋅d-1 for 7 days to mice before concanavalin A-induced AIH model establishment...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38466874/the-most-impactful-findings-on-liver-cancer-in-2023
#14
JOURNAL ARTICLE
Jin Lee, Kaisa L Hanley, Gen-Sheng Feng
No abstract text is available yet for this article.
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38437063/erratum-management-of-alcohol-withdrawal-syndrome-in-patients-with-alcohol-associated-liver-disease
#15
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38437062/hepatocellular-carcinoma-cells-downregulate-nadh-ubiquinone-oxidoreductase-subunit-b3-to-maintain-reactive-oxygen-species-homeostasis
#16
JOURNAL ARTICLE
Zhendong Zhang, Qianwei Zhao, Zexuan Wang, Fang Xu, Yixian Liu, Yaoyu Guo, Chenglong Li, Ting Liu, Ying Zhao, Xiaolei Tang, Jintao Zhang
BACKGROUND: HCC is a leading cause of cancer-related death. The role of reactive oxygen species (ROS) in HCC remains elusive. Since a primary ROS source is the mitochondrial electron transport chain complex Ι and the NADH:ubiquinone Oxidoreductase Subunit B3 (NDUFB3), a complex I subunit, is critical for complex I assembly and regulates the associated ROS production, we hypothesize that some HCCs progress by hijacking NDUFB3 to maintain ROS homeostasis. METHODS: NDUFB3 in human HCC lines was either knocked down or overexpressed...
March 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38437061/steroid-responsiveness-in-alcohol-associated-hepatitis-is-linked-to-glucocorticoid-metabolism-mitochondrial-repair-and-heat-shock-proteins
#17
JOURNAL ARTICLE
Josiah Hardesty, Meghan Hawthorne, Le Day, Jeffrey Warner, Dennis Warner, Marina Gritsenko, Aliya Asghar, Andrew Stolz, Timothy Morgan, Craig McClain, Jon Jacobs, Irina A Kirpich
BACKGROUND: Alcohol-associated hepatitis (AH) is one of the clinical presentations of alcohol-associated liver disease. AH has poor prognosis, and corticosteroids remain the mainstay of drug therapy. However, ~40% of patients do not respond to this treatment, and the mechanisms underlying the altered response to corticosteroids are not understood. The current study aimed to identify changes in hepatic protein expression associated with responsiveness to corticosteroids and prognosis in patients with AH...
March 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38437058/the-cell-fate-regulator-dach1-modulates-ferroptosis-through-affecting-p53-slc25a37-signaling-in-fibrotic-disease
#18
JOURNAL ARTICLE
Mei Guo, Yanshuang Zhuang, Yang Wu, Chun Zhang, Xudong Cheng, Dong Xu, Zili Zhang
BACKGROUND: Dachshund homolog 1 (DACH1) is widely acknowledged for its involvement in regulating diverse cell fates, but its precise regulatory mechanism in ferroptosis remains elusive. In this study, we investigated whether DACH1 modulates ferroptosis through affecting P53/solute carrier family 25 member 37 (SLC25A37) signaling in hepatic fibrogenesis. METHODS: CRISPR-Cas9 system was used to knockout DACH1 in HSC to determine the effect of DACH1 on ferroptosis...
March 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38437057/pour-some-sugar-on-me-glycemic-control-and-the-prevention-of-liver-disease
#19
JOURNAL ARTICLE
Vincent L Chen, Jennifer A Flemming
No abstract text is available yet for this article.
March 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38407327/gut-microbiota-and-metabolic-biomarkers-in-metabolic-dysfunction-associated-steatotic-liver-disease
#20
REVIEW
Qichen Long, Fengming Luo, Binghui Li, Ziyang Li, Zhe Guo, Zhiyang Chen, Weimin Wu, Min Hu
Metabolic dysfunction-associated steatotic liver disease (MASLD), a replacement of the nomenclature employed for NAFLD, is the most prevalent chronic liver disease worldwide. Despite its high global prevalence, NAFLD is often under-recognized due to the absence of reliable noninvasive biomarkers for diagnosis and staging. Growing evidence suggests that the gut microbiome plays a significant role in the occurrence and progression of NAFLD by causing immune dysregulation and metabolic alterations due to gut dysbiosis...
March 1, 2024: Hepatology Communications
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