Ophthalmology Retina

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OBJECTIVE: To examine the molecular causes of Schubert-Bornschein (S-B) congenital stationary night blindness (CSNB), clinically characterize in detail, and assess genotype-phenotype correlations for retinal function and structure. DESIGN: Retrospective, longitudinal, single center case series. PARTICIPANTS: 122 patients with S-B CSNB attending Moorfields Eye Hospital, United Kingdom. METHODS: All case notes, results of molecular genetic testing, and optical coherence tomography (OCT) were reviewed...

OBJECTIVE OR PURPOSE: A) To characterize the incidence of kidney failure associated with intravitreal anti-vascular endothelial growth factor (VEGF) exposure, and B) compare the risk of kidney failure in patients treated with ranibizumab, aflibercept, or bevacizumab. DESIGN: Retrospective cohort study across 12 databases in the Observational Health Data Sciences and Informatics (OHDSI) network. SUBJECTS, PARTICIPANTS, AND/OR CONTROLS: Subjects aged ≥18 years with ≥3 monthly intravitreal anti-VEGF medications for a blinding disease (diabetic retinopathy, diabetic macular edema, exudative age-related macular degeneration, or retinal vein occlusion)...

At baseline, visual acuity and the extent of vertical intraretinal fluid were predictive of better visual outcomes for 196 patients with diabetic macular edema who received tightly controlled treatment with 2mg intravitreal aflibercept injections.

PURPOSE: To compare the clinical implications of central bouquet hemorrhages (CBH) to primarily subretinal hemorrhages, both occurring in the setting of pathologic myopia with lacquer crack formation. DESIGN AND SETTING: Multi-center retrospective cohort study PARTICIPANTS: 25 eyes (11 primarily subretinal hemorrhages, 14 CBH) were monitored over a median of 35 months (interquartile range [IQR] 9.50-54). MAIN OUTCOMES MEASURES: Comprehensive ophthalmological examinations and optical coherence tomography (OCT) were reviewed...

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OBJECTIVE: To describe regional variation in microbes causing infectious endogenous endophthalmitis (EE) in the US. DESIGN: This is a retrospective, national database analysis utilizing the 2002-2014 National Inpatient Sample (NIS) database. SUBJECTS, PARTICIPANTS, AND/OR CONTROLS: Using the International Classification of Disease 9 (ICD-9) codes, we identified cases with EE. Cases were stratified regionally into Northeast, South, West, or Midwest...

OBJECTIVE OR PURPOSE: In this study, we aimed to characterize the frequency and distribution of ocular surgeries in patients with inherited retinal diseases (IRDs) and evaluate associated patient and disease factors. DESIGN: Retrospective cohort. PARTICIPANTS: Subjects 18 years and older who were followed at the Johns Hopkins Genetic Eye Disease (GEDi) Center. METHODS: We studied a retrospective cohort of patients with an IRD diagnosis to analyze the occurrence of laser and incisional surgeries...

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PURPOSE: To explore clinical risk factors and optical coherence tomography (OCT) features associated with worse visual acuity (VA), progression of disease, choroidal neovascularization (CNV), and atrophy in eyes with adult-onset foveomacular vitelliform dystrophy (AOFVD). DESIGN: Single-center, retrospective, observational cohort study PARTICIPANTS: Patients seen at Duke Eye Center between January 2012 and May 2023 with a diagnosis of AOFVD confirmed via OCT and fundus autofluorescence...

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PURPOSE: To investigate the frequency and type of artifacts on optical coherence tomography angiography (OCT-A) images and the relationship with clinical features in eyes with diabetic macular edema (DME). DESIGN: Retrospective, cross-sectional comparative study. SUBJECTS: 192 eyes of 140 patients with DME were included. METHODS: Medical records, optical coherence tomography (OCT) and OCT angiography (OCT-A) images (Spectralis, Heidelberg, Germany) and ultra-widefield color fundus photos (Optos California, Optos plc, UK) were evaluated...

OBJECTIVE: To evaluate clinical characteristics impacting surgical outcomes of patients undergoing pars plana vitrectomy (PPV) for complications of proliferative diabetic retinopathy (PDR). DESIGN: Retrospective consecutive observational case series of patients at a large county hospital in Dallas, TX, from 2014-2019. SUBJECTS: 732 patients (933 eyes) undergoing PPV for PDR complications METHODS: Collected data included demographics, surgical indication, adjuvant therapies, intra-operative course, complications, and best corrected visual acuity (BCVA)...

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To determine the relationship between structural biomarkers on optical coherence tomography (OCT) that increases the risk of disease progression and microperimetric retinal sensitivity in patients with intermediate age-related macular degeneration (iAMD) DESIGN: Prospective cross-sectional, observational study PARTICIPANTS: Forty-five eyes of 23 patients with iAMD METHODS: Patients underwent OCT and microperimetry. OCT scans were evaluated for the risk factors intraretinal hyperreflective foci (HRF), hyporeflectivity within drusenoid lesions (HRDL), subretinal drusenoid deposits (SDD), double layer sign (DLS) and drusen volume...