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Journal of Clinical and Translational Science

Barry S Coller
Clinical and translational science is vitally dependent on the nation's underlying health care policies and programs. In a reciprocal fashion, data generated by clinical and translational research can inform both health policy and health care delivery. It is important, therefore to rate health reform proposals comprehensively on a set of criteria that reflect the broad goals of reform, including the potential impact on clinical and translational science and medical education. I propose that the criteria include achieving universal coverage, reducing administrative costs, retaining one's chosen primary care physician, encouraging care coordination, empowering physicians, freeing industry from choosing and administering health plans, providing choice of specialists and hospitals, providing patient education, preventing patient overuse of services, rationalizing resource allocation, encouraging competition, limiting government's role, supporting medical education, training, and research, and freeing industry to make personnel decisions based on business criteria rather than the impact on health care costs to the company...
October 2018: Journal of Clinical and Translational Science
Andrew L Sussman, Carla Cordova, Mark R Burge
Introduction: Recruitment and engagement for clinical and translational research is challenging, especially among medically underserved and ethnic or racial minority populations. Methods: We present a comprehensive model developed through the Clinical and Translational Science Center at the University of New Mexico Health Sciences Center that addresses three critical aspects of participant recruitment. Results: The components of the model are: 1) Recruitment from within UNM to UNM-centered studies, 2) recruitment from within UNM to community-based studies, and 3) recruitment from outside UNM to UNM-centered studies...
August 2018: Journal of Clinical and Translational Science
Paul A Gilbert, Heidi Haines, Barbara Baquero, Edith A Parker
Introduction: Latinos constitute a hard-to-reach minority population in Iowa. Methods: We used respondent-driven sampling (RDS) to supplement random digit dialing (RDD) to recruit Latinos for a community physical activity intervention. Results: RDS yielded a 59% increase in Latino participation in just two months, with few demographic differences between RDS and RDD groups. Conclusions: RDS may increase recruitment of underrepresented populations and strengthen community engagement; however, it is not a quick fix for underperforming recruitment methods...
August 2018: Journal of Clinical and Translational Science
Alicia K Matthews, Kevin Rak, Emily Anderson, Wendy Bostwick, Jesus Ramirez-Valles, Raymond A Ruiz, Kathryn Macapagal, Karriem S Watson, Rohan D Jeremiah, Amparo Castillo, Wendy Choure
Despite the significant health disparities experienced by lesbian, gay, bisexual and transgender (LGBT) populations, few investigators affiliated with NIH-funded Clinical and Translational Science Award (CTSA) programs are conducting research related to this underserved population. We provide recommendations shared during a half-day workshop aimed at increasing researcher readiness to conduct LGBT research. This workshop was presented as part of a series on conducting research with underserved populations offered by the Recruitment, Retention, and Community Engagement Program of the Center for Clinical and Translational Science at the University of Illinois at Chicago...
August 2018: Journal of Clinical and Translational Science
Scott D Rhodes, Jorge Alonzo, Lilli Mann-Jackson, Amanda E Tanner, Aaron T Vissman, Omar Martinez, Rodrigo Rodriguez-Celedon, Jesus M Garcia, Jorge E Arellano, Eunyoung Y Song, Eugenia Eng, Beth A Reboussin
Introduction: The Latino population in the US is rapidly growing and faces profound health disparities; however, engagement of Latinos in biomedical research remains low. Our community-based participatory research (CBPR) partnership has recruited 2,083 Spanish-speaking Latinos into 21 studies over 15 years. We sought to identify and describe the strategies we have used to successfully recruit and retain Spanish-speaking Latinos in research. Methods: We abstracted and analyzed data from archived study notes, progress reports, team meeting minutes, and in-depth interviews conducted annually from CBPR partnership members...
June 2018: Journal of Clinical and Translational Science
Russell E Glasgow, Bethany M Kwan, Daniel D Matlock
Precision health and big data approaches have great potential, yet such benefits will be realized only when social and behavioral determinants of health and patient preferences are combined with genomic information. Literature review and co-author experiences informed this commentary. Validated health behavior, mental health, and patient preference measures were collected and summarized in real time. Integration of such data into existing data sets will advance precision health, patient-centered care, research, and policy...
June 2018: Journal of Clinical and Translational Science
Armen C Arevian, Doug Bell, Mark Kretzman, Connie Kasari, Shrikanth Narayanan, Carl Kesselman, Shinyi Wu, Paul Di Capua, William Hsu, Mathew Keener, Joshua Pevnick, Kenneth B Wells, Bowen Chung
Predictive analytics in health is a complex, transdisciplinary field requiring collaboration across diverse scientific and stakeholder groups. Pilot implementation of participatory research to foster team science in predictive analytics through a partnered-symposium and funding competition. In total, 85 stakeholders were engaged across diverse translational domains, with a significant increase in perceived importance of early inclusion of patients and communities in research. Participatory research approaches may be an effective model for engaging broad stakeholders in predictive analytics...
June 2018: Journal of Clinical and Translational Science
Christine Denicola, Lisa Altshuler, Gabrielle Denicola, Sondra Zabar
Introduction: Research staff are critical to productive translational research teams, yet their professional development is rarely formally addressed. Methods: We created Strategic Teamwork for Effective Practice Mentor Development Program (STEP-MDP) to promote skills development and build a community of practice. We ran and evaluated the STEP-MDP for 32 participants, which consisted of workshops focusing on team communication and mentorship/coaching skills. Results: We found that STEP-MDP had a long-term positive impact on participants and their teams...
June 2018: Journal of Clinical and Translational Science
Colin A Depp, Alex Howland, Jill Dumbauld, John Fontanesi, David Firestein, Gary S Firestein
Educational tools for application of team science competencies in clinical research are needed. Our interdisciplinary group developed and evaluated acceptability of a virtual world game-based learning tool simulating a multisite clinical trial; performance hinges on effective intrateam communication. Initial implementation with clinical research trainees (n=40) indicates high satisfaction and perceived relevance to team science and research career goals. Game-based learning may play an important role in team science training...
June 2018: Journal of Clinical and Translational Science
Issis J Kelly-Pumarol, Perrin Q Henderson, Julia T Rushing, Joseph E Andrews, Rhonda G Kost, Lynne E Wagenknecht
Introduction: The patient portal may be an effective method for administering surveys regarding participant research experiences but has not been systematically studied. Methods: We evaluated 4 methods of delivering a research participant perception survey: mailing, phone, email, and patient portal. Participants of research studies were identified (n=4013) and 800 were randomly selected to receive a survey, 200 for each method. Outcomes included response rate, survey completeness, and cost...
June 2018: Journal of Clinical and Translational Science
Heidi A Hanson, William W Hay, Jonathan N Tobin, Shari L Barkin, Mark Atkins, Margaret R Karagas, Ann M Dozier, Cynthia Wetmore, Michael W Konstan, James E Heubi
Introduction: Early life exposures affect health and disease across the life course and potentially across multiple generations. The Clinical and Translational Research Institutes (CTSIs) offer an opportunity to utilize and link existing databases to conduct lifespan research. Methods: A survey with Lifespan Domain Taskforce expert input was created and distributed to lead lifespan researchers at each of the 64 CTSIs. The survey requested information regarding institutional databases related to early life exposure, child-maternal health, or lifespan research...
June 2018: Journal of Clinical and Translational Science
Jeffrey W Treem, Margaret Schneider, Robynn L Zender, Dara H Sorkin
Introduction: This study explored the effects of integrating community members into the evaluation of clinical and translational science grants. Methods: The University of California, Irvine Institute for Clinical and Translational Sciences (ICTS) engaged 21 community reviewers alongside scientific reviewers in a 2-stage process of evaluating research proposals. In Stage 1 reviewers scored proposals, and during Stage 2 two study sections convened: one a mix of community reviewers and scientific reviewers, and one only engaging scientific reviewers...
June 2018: Journal of Clinical and Translational Science
Susanne Schmidt, Laura Aubree Shay, Can Saygin, Hung-da Wan, Karen Schulz, Robert A Clark, Paula K Shireman
Each year our Clinical and Translational Science Award pilot projects program awards approximately $500,000 in translational pilot funding to advance health in South Texas. We identified needs to improve the timeliness, transparency, and efficiency of the review process by surveying applicants. Lean six sigma methodologies, following a "Define, Measure, Analyze, Improve, Control" approach, were used to streamline the pilot project application and review by identifying and removing bottlenecks from process flows...
June 2018: Journal of Clinical and Translational Science
Alicia K Matthews, Amparo Castillo, Emily Anderson, Marilyn Willis, Wendy Choure, Kevin Rak, Raymond Ruiz
Preparing investigators to competently conduct community-engaged research is critical to achieving Clinical and Translational Science Award (CTSA) program goals. The purpose of this study is to describe the perspectives of members of a long-standing community engagement advisory board (CEAB) on investigators' readiness to engage communities and indicators of investigator competence in community-engaged research, in order to suggest core competencies to guide the development of CTSA-sponsored educational programs...
June 2018: Journal of Clinical and Translational Science
Anne M Libby, David H Ingbar, Kathryn A Nearing, Marc Moss, Judith Albino
The fifth in a 5-part series on the clinical and translational sciences educational pipeline, this paper focuses on strategies for developing leadership capacity among senior faculty and administrators responsible for clinical and translational science (CTS) research. Although progression in academic rank recognizes scientific excellence in research or scholarship, neither disciplinary training nor experience alone prepare senior faculty for the leadership challenges they inevitably face. Yet these faculty are increasingly responsible for multidisciplinary teams working within complex organizations with unclear or conflicting incentives that demand innovation...
June 2018: Journal of Clinical and Translational Science
Jenna Rogers, Christine A Sorkness, Kimberly Spencer, Christine Pfund
As part of their mission, Clinical and Translational Science Award (CTSA) hubs are charged with developing, testing, and disseminating evidence-based practices to other CTSA hubs. Over the past 7 years, the University of Wisconsin-Madison has answered this charge by implementing the facilitator training (FT) initiative for research mentors. Three elements to advance training across the CTSA hubs have been critical: (1) using an FT model to empower others to build research mentor training at their local institutions; (2) tracking implementation of training events across the CTSA hubs over time; and (3) partnering with implementation sites to build local capacity and evaluate the effectiveness and quality of training...
June 2018: Journal of Clinical and Translational Science
M E Blair Holbein, Kevin J Weatherwax, Misty Gravelin, Raymond Hutchinson, George A Mashour
No abstract text is available yet for this article.
June 2018: Journal of Clinical and Translational Science
Ambika Mathur, P Brandt, R Chalkley, L Daniel, P Labosky, C Stayart, F Meyers
Several reports have shown that doctoral and postdoctoral trainees in biomedical research pursue diverse careers that advance science meaningful to society. Several groups have proposed a three-tier career taxonomy to showcase these outcomes. This three-tier taxonomy will be a valuable resource for institutions committed to greater transparency in reporting outcomes, to not only be transparent in reporting their own institutional data but also to lend greater power to a central repository.
April 2018: Journal of Clinical and Translational Science
Angela Byars-Winston, Veronica Y Womack, Amanda R Butz, Richard McGee, Sandra C Quinn, Emily Utzerath, Carrie L Saetermoe, Stephen Thomas
Introduction: Innovative evidence-based-interventions are needed to equip research mentors with skills to address cultural diversity within research mentoring relationships. A pilot study assessed initial outcomes of a culturally tailored effort to create and disseminate a novel intervention titled Culturally Aware Mentoring (CAM) for research mentors. Intervention: Intervention development resulted in four products: a 6hr CAM training curriculum, a facilitator guide, an online pre-training module, and metrics to evaluate the effectiveness of CAM training...
April 2018: Journal of Clinical and Translational Science
M Kathryn Stewart, Nicola Spencer, Anna Huff Davis, Camille Hart, Beatrice Boateng
Introduction: Effective translational research requires engagement and collaboration between communities, researchers, and practitioners. We describe a community scientist academy (CSA) developed at the suggestion of our CTSA's community advisory board to engage and capacitate community members by 1) increasing community members' and patients' understanding about the research process and 2) increasing their access to opportunities to influence and participate in research. A joint CTSA/community planning committee developed this 8-hour workshop including sessions on: 1) research definitions and processes; 2) study design; 3) study implementation; and 4) ways to get involved in research...
April 2018: Journal of Clinical and Translational Science
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