journal
https://read.qxmd.com/read/38049198/prevalence-of-non-convulsive-seizures-and-electroencephalographic-abnormalities-in-critically-ill-patients-a-retrospective-observational-study
#1
JOURNAL ARTICLE
Bipin Karki, Pramesh S Shrestha, Ninadini Shrestha, Olita Shilpakar, Subhash P Acharya, Ashru Neupane
OBJECTIVE: Electroencephalographic (EEG) abnormalities especially non-convulsive status epilepticus (NCSE), have been found to be associated with worse outcomes in critically ill patients. We aimed to assess the prevalence of non-convulsive seizures and electroencephalographic abnormalities in critically ill patients. Furthermore, we aimed to investigate any association between the type of EEG abnormality and outcomes including ICU mortality and successful ICU discharge. METHODS: This was a cross-sectional observational study carried out among critically ill patients in a mixed medical-surgical ICU from January 1st, 2018 to May 15th, 2020...
December 4, 2023: Epilepsia Open
https://read.qxmd.com/read/38049197/pharmacokinetics-and-safety-of-brivaracetam-in-neonates-with-repeated-electroencephalographic-seizures-a-multicenter-open-label-single-arm-study
#2
JOURNAL ARTICLE
Ronit Pressler, Geraldine Boylan, Eugene Dempsey, Kerstin Alexandra Klotz, Walter Krauwinkel, Edgar Will, Diego Morita, Florin Floricel, Jan-Peer Elshoff, John van den Anker
OBJECTIVE: To evaluate the pharmacokinetics (PK), safety and tolerability of brivaracetam (BRV) in neonates with repeated electroencephalographic seizures not controlled with previous antiseizure medications (ASMs). METHODS: Phase 2/3, multicenter, open-label, single-arm study (N01349/NCT03325439) in neonates with repeated electroencephalographic seizures (lasting ≥10 seconds) confirmed by video-electroencephalography, and inadequate seizure control with ≥1 ASMs...
December 4, 2023: Epilepsia Open
https://read.qxmd.com/read/38044839/status-of-epilepsy-care-delivery-and-referral-in-clinics-hospitals-and-epilepsy-centers-in-japan-a-nationwide-survey
#3
JOURNAL ARTICLE
Kentaro Tokumoto, Kiyohito Terada, Norihiko Kawaguchi, Takuji Nishida, Mitsuhiko Yamano, Tomoo Aoyagi, Yuji Tadokoro, Naotaka Usui, Yushi Inoue
OBJECTIVE: Collaboration among medical facilities is crucial to deliver comprehensive epilepsy care to a diverse and large population of people with epilepsy. We conducted a survey among medical facilities of various sizes throughout Japan to investigate the status of epilepsy care delivery, functioning, and referral. METHODS: With the cooperation of the Japan Neurological Society (1,428 facilities), Japanese Neurosurgical Society (3,489 specialists), and Epilepsy Care Network (948 facilities), a questionnaire was mailed to 5,865 locations that provide epilepsy care in Japan...
December 4, 2023: Epilepsia Open
https://read.qxmd.com/read/38041607/the-role-of-the-glymphatic-system-and-perivascular-spaces-as-a-potential-biomarker-for-post-stroke-epilepsy
#4
REVIEW
Gernot Hlauschek, John-Paul Nicolo, Benjamin Sinclair, Meng Law, Clarissa L Yasuda, Fernando Cendes, Morten Ingvar Lossius, Patrick Kwan, Lucy Vivash
Stroke is one of the most common causes of acquired epilepsy, which can also result in disability and increased mortality rates particularly in elderly patients. No preventive treatment for post-stroke epilepsy is currently available. Development of such treatments has been greatly limited by the lack of biomarkers to reliably identify high risk patients. The glymphatic system, including perivascular spaces (PVS) is the brain's waste clearance system and enlargement or asymmetry of PVS (ePVS) is hypothesized to play a significant role in the pathogenesis of several neurological conditions...
December 2, 2023: Epilepsia Open
https://read.qxmd.com/read/38018342/fenfluramine-increases-survival-and-reduces-markers-of-neurodegeneration-in-a-mouse-model-of-dravet-syndrome
#5
JOURNAL ARTICLE
John Cha, Gregory Filatov, Steven J Smith, Arnold R Gammaitoni, Amélie Lothe, Thadd Reeder
OBJECTIVE: In patients with Dravet syndrome (DS), fenfluramine reduced convulsive seizure frequency and provided clinical benefit in nonseizure endpoints (e.g., executive function, survival). In zebrafish mutant scn1 DS models, chronic fenfluramine treatment preserved neuronal cytoarchitecture prior to seizure onset and prevented gliosis; here, we extend these findings to a mammalian model of DS (Scn1a+/- mice) by evaluating the effects of fenfluramine on neuroinflammation (degenerated myelin, activated microglia) and survival...
November 28, 2023: Epilepsia Open
https://read.qxmd.com/read/38017670/investigating-the-effect-of-hippocampal-sclerosis-on-parietal-memory-network
#6
JOURNAL ARTICLE
Silke Ethofer, Monika Milian, Michael Erb, Sabine Rona, Jürgen Honegger, Thomas Ethofer
OBJECTIVE: We aimed to investigate differences in episodic memory networks between patients with temporal lobe epilepsy (TLE) due to hippocampal sclerosis and healthy controls, especially with regards to the parietal memory network (PMN), as well as their relation to neuropsychological memory performance after mesial temporal resection. METHODS: 28 healthy subjects as well as 21 patients with TLE (12 left, 9 right) were investigated using a spatial memory fMRI paradigm, which has been shown to activate the PMN...
November 28, 2023: Epilepsia Open
https://read.qxmd.com/read/38017663/perprise-a-prospective-non-interventional-study-of-perampanel-as-only-adjunctive-treatment-in-patients-with-primary-or-secondarily-generalized-tonic-clonic-seizures-first-interim-analysis
#7
JOURNAL ARTICLE
Bernhard J Steinhoff, Tobias Goldmann, Edgar Kockelmann, Yaroslav Winter
OBJECTIVE: To report the interim results of the PERPRISE study (Study 509; NCT04202159), which is evaluating perampanel as the only adjunctive anti-seizure medication (ASM) in adults with focal to bilateral tonic-clonic seizures (FBTCS) or primary generalized tonic-clonic seizures (GTCS). METHODS: PERPRISE is an ongoing 12-month multicenter, prospective, observational, non-interventional study of perampanel in a real-world setting in Germany. Patients are aged ≥18 years with FBTCS or GTCS due to focal or idiopathic generalized epilepsy...
November 28, 2023: Epilepsia Open
https://read.qxmd.com/read/38016924/identification-of-metabolic-biomarkers-of-chronic-vagus-nerve-stimulation-vns-in-subjects-with-drug-resistant-epilepsy-dre
#8
JOURNAL ARTICLE
Claudia Manca, Roberta Coa, Elisabetta Murru, Gianfranca Carta, Giovanni Pinna, Roberto Sanfilippo, Lorenzo Polizzi, Marco Pistis, Paolo Follesa, Monica Puligheddu, Sebastiano Banni
Neuromodulation by means of vagus nerve stimulation (VNS) therapy, reduces seizure frequency and improves quality of life in subjects with drug-resistant epilepsy (DRE), yet its molecular mechanism remains unclear. This study investigates the impact of chronic VNS on lipid bioactive metabolites and fatty acids (FA) in the plasma and red blood cells of seven subjects with DRE. By measuring expression levels of peroxisome proliferator-activated receptor α (PPARα) and sirtuin1 (SIRT1) genes - key regulators in energy and lipid metabolism - and lipid profiles before and after various stages of VNS, this study identifies potential mechanisms by which VNS may reduce seizure frequency...
November 28, 2023: Epilepsia Open
https://read.qxmd.com/read/38016915/epilepsy-and-neurocysticercosis-in-rural-areas-of-the-bolivian-chaco-what-has-changed-during-the-last-30%C3%A2-years
#9
JOURNAL ARTICLE
Alessandra Nicoletti, Calogero Edoardo Cicero, Valeria Todaro, Chiara Colli, Francesco Cosmi, Mariella Anselmi, Cintia Caicedo, Estela Vilte, Walter Mario Camargo, Alessandro Bartoloni, Elizabeth Blanca Crespo Gomez, Loretta Giuliano
OBJECTIVE: Neurocysticercosis (NCC) is considered the major cause of epilepsy in endemic regions. In the rural areas of the Bolivian Chaco prevalence of NCC among people with epilepsy (PWE) was 27.4%, according to a population-based survey carried out in 1994. Aim of the study was to estimate the prevalence of Epilepsy Associated with Tonic-Clonic Seizures (EATCS) and to evaluate the prevalence of NCC among PWE in the rural communities of the Bolivian Chaco after 30 years. METHODS: Twenty-two rural communities (total population 12,852) were involved in the study...
November 28, 2023: Epilepsia Open
https://read.qxmd.com/read/38009286/clinical-and-genetic-analysis-of-infants-with-pontocerebellar-hypoplasia-type-6-caused-by-rars2-variations
#10
JOURNAL ARTICLE
Shichao Zhao, Ruofei Lian, Liang Jin, Mengchun Li, Tianming Jia, Falin Xu, Kaixian Du, Lijun Wang, Qiliang Guo, Yan Dong
OBJECTIVE: Defects in RARS2 cause cerebellopontine hypoplasia type 6 (Pontocerebellar Hypoplasia Type 6, PCH6, OMIM: #611523), a rare autosomal recessive inherited mitochondrial disease. Here, we report two male patients and their respective family histories. METHODS: We describe the clinical presentation and magnetic resonance imaging (MRI) findings of these patients. Whole-exome sequencing was used to identify the genetic mutations. RESULTS: One patient showed hypoglycemia, high lactic acid levels (fluctuating from 6...
November 27, 2023: Epilepsia Open
https://read.qxmd.com/read/37969060/efficacy-and-safety-of-a-smartphone-application-based-treatment-of-ketogenic-diet-in-pediatric-refractory-epilepsy
#11
JOURNAL ARTICLE
Wei Li, Wei Gu, Chao Liang, Fulai Tu, Le Ding, Xiaopeng Lu, Hu Guo, Guo Zheng, Chunfeng Wu
OBJECTIVE: We aimed to find predictors for smartphone application based Ketogenic Diet (KD) treatment effectiveness and safety. METHODS: The efficacy was evaluated according to the reduction of seizure frequency after the intervention of KD, safety was evaluated based on adverse effects. The ordinal logistic regression analysis was used to explore the influencing factors of efficacy. RESULTS: The study sample included 116 males and 65 females with a median age of 2...
November 15, 2023: Epilepsia Open
https://read.qxmd.com/read/37968869/stereo-electroencephalography-guided-three-dimensional-radiofrequency-thermocoagulation-for-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis-a-retrospective-study-with-long-term-follow-up
#12
JOURNAL ARTICLE
Kaiwei Li, Jianwei Shi, Penghu Wei, Xiaosong He, Yongzhi Shan, Guoguang Zhao
OBJECTIVE: Stereotactic electroencephalography-guided three-dimensional radiofrequency thermocoagulation (SEEG-3D RFTC) is a minimally invasive treatment for medial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). This study aimed to investigate the long-term prognosis after SEEG-3D RFTC treatment in patients with MTLE-HS. METHODS: This single-center retrospective study included 28 patients with MTLE-HS treated with SEEG-3D RFTC from January 2016 to May 2018...
November 15, 2023: Epilepsia Open
https://read.qxmd.com/read/37943144/effectiveness-and-safety-of-mono-and-add-on-perampanel-in-pediatric-patients-with-epilepsy-experience-from-a-single-center-retrospective-study
#13
JOURNAL ARTICLE
Yue Li, Hong-Li Guo, Hu Ya-Hui, Jie Wang, Zhang Yuan-Yuan, Jian Huang, Jing Xu, Chen Jing, Lu Xiao-Peng, Chen Feng
OBJECTIVE: To evaluate the effectiveness and safety of perampanel (PER) monotherapy (MT) or add-on therapy (AT) in Chinese children with epilepsy, as well as to evaluate the data from routine therapeutic drug monitoring (TDM) of PER for these pediatric patients. METHODS: This retrospective and observational study was carried out on children with epilepsy (n = 340) from 2020 to 2022 at the Children's Hospital of Nanjing Medical University. Outcome measures were the responder rate (50% or greater seizure reduction), long-term efficacy, and tolerability (number and types of adverse events) in MT and AT groups...
November 9, 2023: Epilepsia Open
https://read.qxmd.com/read/37943122/a-5-year-old-boy-with-super-refractory-status-epilepticus-and-ranbp2-variant-warranting-life-saving-hemispherotomy
#14
JOURNAL ARTICLE
Barbora Straka, Miroslav Koblížek, Barbora Heřmanovská, Radka Valkovičová, Lenka Krsková, Markéta Kalinová, Markéta Vlčková, Josef Zámečník, Petra Laššuthová, Lucie Sedláčková, David Staněk, Alice Maulisová, Michal Tichý, Martin Kynčl, Pavel Kršek
Focal cortical dysplasia (FCD) represents the most common cause of drug-resistant epilepsy in adult and pediatric surgical series. However, genetic factors contributing to severe phenotypes of FCD remain unknown. We present a patient with an exceptionally rapid development of drug-resistant epilepsy evolving in super-refractory status epilepticus. We performed multiple clinical (serial EEG, MRI), biochemical (metabolic and immunological screening), genetic (WES from blood- and brain-derived DNA) and histopathological investigations...
November 9, 2023: Epilepsia Open
https://read.qxmd.com/read/37943120/status-epilepticus-in-braf-related-cardio-facio-cutaneous-syndrome-focus-on-neuroimaging-clues-to-physiopathology
#15
JOURNAL ARTICLE
Elisa Musto, Maria Luigia Gambardella, Marco Perulli, Michela Quintiliani, Chiara Veredice, Tommaso Verdolotti, Giovanna Berté, Chiara Leoni, Roberta Onesimo, Silvia Maria Pulitanò, Marco Tartaglia, Giuseppe Zampino, Ilaria Contaldo, Domenica Immacolata Battaglia
OBJECTIVE: Cardio-facio-cutaneous syndrome (CFCS) is a genetic disorder due to variants affecting genes coding key proteins of the Ras/MAPK signalling pathway. Among the different features of CFCS, neurological involvement, including cerebral malformations and epilepsy, represents a common and clinically relevant aspect. Status epilepticus (SE) is a recurrent feature, especially in a specific subgroup of CFCS patients with developmental and epileptic encephalopathy (DEE) and history of severe pharmacoresistant epilepsy...
November 9, 2023: Epilepsia Open
https://read.qxmd.com/read/37926917/spatial-and-amplitude-dynamics-of-neurostimulation-insights-from-the-acute-intrahippocampal-kainate-seizure-mouse-model
#16
JOURNAL ARTICLE
Thomas J Foutz, Nicholas Rensing, Lirong Han, Dominique M Durand, Michael Wong
OBJECTIVE: Neurostimulation is an emerging treatment for patients with drug-resistant epilepsy, which is used to suppress, prevent, and terminate seizure activity. Unfortunately, after implantation and despite best clinical practice, most patients continue to have persistent seizures even after years of empirical optimization. The objective of this study is to determine optimal spatial and amplitude properties of neurostimulation in inhibiting epileptiform activity in an acute hippocampal seizure model...
November 5, 2023: Epilepsia Open
https://read.qxmd.com/read/37921029/epilepsia-open-welcome-to-the-inaugural-lived-experience-editor-and-editorial-interns
#17
EDITORIAL
Aristea S Galanopoulou
No abstract text is available yet for this article.
November 3, 2023: Epilepsia Open
https://read.qxmd.com/read/37920967/association-between-retinal-thickness-and-disease-characteristics-in-adult-epilepsy-a-cross-sectional-oct-evaluation
#18
JOURNAL ARTICLE
Luisa Delazer, Han Bao, Michael Lauseker, Livia Stauner, Georg Nübling, Julian Conrad, Soheyl Noachtar, Joachim Havla, Elisabeth Kaufmann
OBJECTIVE: Thinning of the peripapillary retinal nerve fiber layer (p-RNFL), as measured by optical coherence tomography (OCT), was recently introduced as a promising marker for cerebral neuronal loss in people with epilepsy (PwE). However, its clinical implication remains to be elucidated. We thus aimed to (1) systematically characterize the extent of the retinal neuroaxonal loss in a broad spectrum of unselected PwE and (2) to evaluate the main clinical determinants. METHODS: In this prospective study, a spectral-domain OCT evaluation was performed on 98 well-characterized PwE and 85 healthy controls (18-55 years of age)...
November 3, 2023: Epilepsia Open
https://read.qxmd.com/read/37920928/interrater-reliability-of-interictal-eeg-waveforms-in-lennox-gastaut-syndrome
#19
JOURNAL ARTICLE
Derek K Hu, Mandeep Rana, David J Adams, Linda Do, Daniel W Shrey, Shaun A Hussain, Beth A Lopour
OBJECTIVE: Identification of EEG waveforms is critical for diagnosing Lennox-Gastaut Syndrome (LGS) but is complicated by the progressive nature of the disease. Here, we assess the interrater reliability (IRR) among pediatric epileptologists for classifying EEG waveforms associated with LGS. METHODS: A novel automated algorithm was used to objectively identify epochs of EEG with transient high power, which were termed events of interest (EOIs). The algorithm was applied to EEG from 20 LGS subjects and 20 healthy controls during NREM sleep, and 1350 EOIs were identified...
November 3, 2023: Epilepsia Open
https://read.qxmd.com/read/37920923/prospective-study-of-cenobamate-on-cognition-affectivity-and-quality-of-life-in-focal-epilepsy
#20
JOURNAL ARTICLE
Judit Catalán-Aguilar, Kevin G Hampel, Irene Cano-López, Mercedes Garcés, Alejandro Lozano-García, Paula Tormos-Pons, Esperanza González-Bono, Vicente Villanueva
OBJECTIVE: Cenobamate is a recently approved antiseizure medication that proved to be safe and effective in randomized controlled trials. However, little is known about its impact on some areas frequently affected in epilepsy. For this reason, we explored the effects of cenobamate in cognitive performance, as well as on negative affectivity and quality of life in a sample of patients with drug-resistant epilepsy. METHODS: Two prospective cohort studies were carried out...
November 3, 2023: Epilepsia Open
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