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Journal of Medical Biochemistry

Nada Majkić-Singh
During 15th Belgrade Symposium for Balkan Region (April 11 and 12, 2019, Belgrade, Society of Medical Biochemists of Serbia organized scientific and professional program with aim to discuss laboratory medicine topics of mutual interest for all the countries of the Region, such as: Laboratory Medicine Planning and OrganizationType of Medical Laboratory and StrategyLaboratory Medicine ManagementLeadership SkillsAccreditation and CompetencesEnvironmental Health and SafetyLaboratory Standards in Balkan CountriesExperiences of Young ScientistsStudents Achievements Together with the countries from Balkan Region the countries from our neighborhood as Italy, Austria, Hungary, Cyprus and Israel have been invited to discuss this important topics and exchange the mutual experiances with aim to improve the laboratory medicine in our countries and to help our colleagues to improve daily laboratory practice in our countries...
April 2019: Journal of Medical Biochemistry
Miodrag Dragoj, Jasna Bankovic, Ana Podolski-Renic, Sonja Stojkovic Buric, Milica Pesic, Nikola Tanic, Tijana Stankovic
Background: C-Myc is one of the major cellular oncogenes overexpressed in non-small cell lung carcinoma (NSCLC). Its deregulated expression is necessary but not sufficient for malignant transformation. We evaluated expression of MYC gene in NSCLC patients and its association with alterations in the genes previously identified to be related to NSCLC pathogenesis, PHACTR3 and E2F4 . Methods: We analyzed MYC gene expression by qRT-PCR in 30 NSCLC patients' samples and paired normal lung tissue...
April 2019: Journal of Medical Biochemistry
Gulbuz Sezgin, Guler Ozturk, Rana Turkal, Burcu Caykara
Background: Vitamin D regulates calcium and phosphorus metabolism, and it is essential for bone formation. Several factors can affect vitamin D levels in plasma. In present study we compare vitamin D levels of outpatients, who admit to Maltepe University Hospital between 2011 and 2013 and had vitamin D measurements regarding gender, age, and season. Methods: Hospital records were evaluated to identify the outpatients with vitamin D levels and their gender, age, and vitamin D levels and the seasons of measurements were recorded...
April 2019: Journal of Medical Biochemistry
Wei Zhang, Junlei Chen, Xinxia Li, Yuwen Wang, Jiutong Li
Background: To establish a fast and simple quantitative method for detection of heart-type fatty acid-binding protein (H-FABP) in serum based on a background fluorescence quenching immunochromatographic assay. Methods: A detection card based on the double-antibody sandwich double-antibody method with background fluorescence quenching was developed for quantitative measurement of H-FABP in serum. The optimal concentrations of control for coating the test and control lines were determined as well as the concentrations of gold-labeled antibodies used in preparing the detection system...
April 2019: Journal of Medical Biochemistry
Dragana Milosevic, Violeta Lukic Panin
Background: Diabetes mellitus (DM) with its micro- and macrocomplications is the leading global epidemic of the 21st century. The aim of the research is to determine possible changes in the complete blood count (CBC) parameters depending on glycemic controlin patients with Type 2 diabetes mellitus (T2DM). Methods: The study included a total of 178 patients with T2DM, both gender over the age of 40 years, from the Health Care Center »Dr Milorad Mika Pavlović« Indjija, Serbia...
April 2019: Journal of Medical Biochemistry
Tamer Bego, Adlija Čaušević, Tanja Dujić, Maja Malenica, Zelija Velija-Asimi, Besim Prnjavorac, Janja Marc, Jana Nekvindová, Vladimír Palička, Sabina Semiz
Background: FTO , a gene recently discovered in genomewide associated studies for type 2 diabetes mellitus (T2D), play an important role in the management of energy homeostasis, nucleic acid demethylation and regulation of body fat mass by lipolysis. The aim of this study was to analyze the association of FTO rs8050136 A>C genetic variant with clinical and biochemical parameters of T2D in the population of West Balkan region (Bosnians and Herzegovinians and Kosovars). Methods: The study included 638 patients with T2D and prediabetes and 360 healthy controls of both genders, aged from 40 to 65 years...
April 2019: Journal of Medical Biochemistry
Samar Damiati
Background: Although vitamin D in not a traditional marker for cardiovascular and renal diseases, several studies have proposed a correlation between vitamin D deficiency and these diseases due to the effect of vitamin D on endothelial function. Asymmetric and symmetric dimethyl arginine (ADMA and SDMA, respectively) are endogenous markers of endothelial dysfunction, and are considered as future markers for the assessment of cardiovascular and renal diseases. The present study investigated the association of kidney function tests (urea and creatinine) and dimethylarginine toxins (ADMA and SDMA) in women with vitamin D insufficiency or deficiency...
April 2019: Journal of Medical Biochemistry
Marko Baralić, Voin Brković, Vesna Stojanov, Sanja Stanković, Nataša Lalić, Petar Đurić, Ljubica Đukanović, Milorad Kašiković, Milan Petrović, Marko Petrović, Milan Stošović, Višnja Ležaić
Background: Vascular calcification (VC) is highly prevalent in dialysis (HD) patients, and its mechanism is multifactorial. Most likely that systemic or local inhibitory factor is overwhelmed by promoters of VC in these patients. VC increased arterial stiffness, and left ventricular hypertrophy. Thus, the present study aimed to investigate the association of VC and myocardial remodeling and to analyze their relationship with VC promoters (fibroblast growth factor 23-FGF23, Klotho, intact parathormon-iPTH, vitamin D) in 56 prevalent HD patients (median values: age 54 yrs, HD vintage 82 months)...
April 2019: Journal of Medical Biochemistry
Dragana Popovic, Katarina Lalic, Aleksandra Jotic, Tanja Milicic, Jelena Bogdanovic, Maja Đorđevic, Sanja Stankovic, Veljko Jeremic, Nebojsa M Lalic
Background: We analyzed cardiovascular inflammatory (C-reactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Methods: In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = l0 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N=15 lean controls...
April 2019: Journal of Medical Biochemistry
Mina Radovic, Suzana Bojic, Jelena Kotur-Stevuljevic, Visnja Lezaic, Biljana Milicic, Milos Velinovic, Radmila Karan, Sanja Simic-Ogrizovic
Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary NGAL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as low-risk for developing CSA-AKI...
April 2019: Journal of Medical Biochemistry
Emad K Ahmed, Shaimaa A Fahmy, Heba Effat, Abdel Hady Abdel Wahab
Background: To date few reports have pointed out the role of circulating miRNAs in discriminating metastatic liver tumors from primary hepatocellular (HCC) tumors. Such discrimination will have significant therapeutic and prognostic implications. The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver...
April 2019: Journal of Medical Biochemistry
Dušica Kocijančić Belovic, Snežana Plešinac, Jelena Dotlić, Ana Savić Radojević, Slavica Akšam, Mirjana Marjanović Cvjetićanin, Aleksandar Kocijančić
Background: Gestational hypertension (GH) and pre eclampsia (PE) are the most common gestational complications. Several placental biochemical markers are used to predict GH/PE, but with conflicting results. Methods: The study aim was to estimate the biochemical markers' ability to predict hypertensive disorders in pregnancy. On the first ultrasonographic examination, 104 healthy pregnant women were recruited. At the regular pregnancy check-ups, BMI, blood pressure, occurrence of gestational hypertension (early or late onset), preeclampsia, eclampsia and other complications were recorded...
March 2019: Journal of Medical Biochemistry
Milica Nedeljković, Nikola Tanić, Tatjana Dramićanin, Zorka Milovanović, Snežana Šušnjar, Vedrana Milinković, Ivana Vujović, Mirjana Prvanović, Nasta Tanić
Background: Triple negative breast cancer (TNBC) is characterized by aggressive clinical course and is unresponsive to anti-HER2 and endocrine therapy. TNBC is difficult to treat and is often lethal. Given the need to find new targets for therapy we explored clinicopathological significance of copy number gain of FGFR1 and c-MYC . Our aim was to determine the impact of FGFR1 and c-MYC copy number gain on clinical course and outcome of TNBC. Methods: FGFR1 and c-MYC gene copy number alterations were evaluated in 78 archive TNBC samples using TaqMan based quantitative real time PCR assays...
March 2019: Journal of Medical Biochemistry
Biljana Bozic Nedeljkovic, Goran Loncar, Tjasa Vizin, Zoran Radojicic, Vera Popovic Brkic, Janko Kos
Background: The aim of the study was to investigate the association of Cystatin C (CysC) to biochemical markers of bone turnover and bone mass, and to evaluate its prognostic significance in elderly males with chronic heart failure (CHF). Methods: A prospective cohort study was executed on sixtyeight males (mean age 68±7 years) with mild to moderate CHF, together with 19 of corresponding age- and body mass index-matched healthy individuals who underwent cardio vascular, bone mineral density (BMD), and body com position assessment...
March 2019: Journal of Medical Biochemistry
Jelena Jordovic, Ksenija Bojovic, Jasmina Simonovic-Babic, Vladimir Gasic, Nikola Kotur, Branka Zukic, Marija Vukovic, Sonja Pavlovic, Ivana Lazarevic, Ivana Bekic, Natasa Nikolic, Aleksandar Uroševic, Nikola Mitrovic, Dragan Delic
Background: Chronic hepatitis C (CHC) is a significant cause of liver related morbidity and mortality worldwide. The role of genetics in the host response to hepatitis C virus is not elucidated. Genetic variations in UGT1A1 gene are the most common cause of hereditary unconjugated hyperbilirubinemia-Gilbert syndrome. This is the first study investigating the association of UGT1A1 TA repeats promoter genotypes with the degree of liver injury, viremia and biochemical markers in CHC patients with advanced liver injury and late virological relapse...
March 2019: Journal of Medical Biochemistry
Tatjana Isailovic, Ivana Milicevic, Djuro Macut, Milan Petakov, Sanja Ognjanovic, Bojana Popovic, Ivana Bozic Antic, Tamara Bogavac, Valentina Elezovic Kovacevic, Dusan Ilic, Svetozar Damjanovic
Background: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant cancer syndrome characterized by the occurrence of primary hyperparathyroidism (PHPT), pituitary adenoma (PA) and pancreatic neuroendocrine tumor (pNET). Whether the underlying mutations in MEN1 gene predict clinical presentation of affected heterozygotes or not, is still a matter of a debate. Methods: Clinical and genetic analysis of 90 consecutive MEN1 patients was performed in a retrospective, single - center study...
March 2019: Journal of Medical Biochemistry
Giray Bozkaya, Nuriye Uzuncan, Sibel Bilgili, Ozlem Demirezen
Background: Hemoglobin A1c, (HbA1c) which is the major constituent of glycated hemoglobin, has been used in the follow-up of retrospective glycemia for years and in the diagnosis of diabetes mellitus nowadays. Since the analytical performance of HbA1c should be high likewise all laboratory tests, various quality control measures are used. Sigma metrics is one of these measures and it is the combination of bias, precision and total allowable error that ensures a general evaluation of analytical quality...
March 2019: Journal of Medical Biochemistry
Najdana Gligorovic Barhanovic, Tanja Antunovic, Sreten Kavaric, Aleksandar Djogo, Vesna Kalimanovska Spasojevic
Background: Laboratory thyroid function tests play a central role in the diagnosis of thyroid disorders. The aim of our cross-sectional study was to determine reference values for thyroid tests in a rigorously selected group of Montenegrin females, investigate the impact of possible age-related changes and the influence of the interassay bias between three frequently used immunoassays. Methods: Female subjects were randomly selected, aged between 20 and 69 and 946 of them met the selection criteria...
March 2019: Journal of Medical Biochemistry
Nora Alyahri, Saba Abdi, Wajahatullah Khan, Mohamed Elrobh, Mohammed H Addar, Zeneb A Babay, Mohamed Alanazi, Sooad Aldaihan, Jilani Shaik, Maha Arafah, Narasimha Reddy Parine, Arjumand Warsy
Background: Mutations in BRCA1 gene have been implicated in ovarian cancers, and BRCA testing may be conducted in high-risk women. This study was designed to determine the frequency of three single nucleotide polymorphisms (SNPs) variants in BRCA1 gene and BRCA1 expression in Saudi females with ovarian cancer. Methods: Expression levels of mRNA of BRCA1 gene were studied in 10 ovarian cancer and 10 normal ovarian tissues, by quantitative real time polymerase chain reaction (qPCR)...
March 2019: Journal of Medical Biochemistry
Bojana Popovic, Dejana Popovic, Djuro Macut, Ivana Bozic Antic, Tatjana Isailovic, Sanja Ognjanovic, Tamara Bogavac, Valentina Elezovic Kovacevic, Dusan Ilic, Mirjana Petrovic, Svetozar Damjanovic
Background: Endocrine system plays a major role in both permissive and regulatory activities in order to adequately respond to physical stress of exercise. But level and direction of activation depend on many factors and are not easily interpreted. Methods: We tested a group of male professional athletes (21 water polo players and 15 wrestlers), together with 20 sedentary controls matched by age. All participants took a continuous progressive exercise stress test on a treadmill until exhaustion and plateau of oxygen consumption (VO2 )...
March 2019: Journal of Medical Biochemistry
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