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Open Medicine (Warsaw, Poland)

Ivan Kushkevych, Dani Dordević, Monika Vítězová
Lower intraluminal colonic pH is an indication for the development of inflammatory bowel disease including active ulcerative colitis. Involvement of intestinal sulfate-reducing bacteria in decreasing bowel pH by the production of H2 S and acetate as well as their sensitivity has never been reported before. The study of the relative pH and survival of Desulfovibrio piger Vib-7 by monitoring sulfate reduction parameters was the aim of this work. Monitoring was done through the measurement of bacterial growth (biomass), dissimilatory sulfate reduction parameters: sulfate consumption, lactate oxidation, hydrogen sulfide and acetate production...
2019: Open Medicine (Warsaw, Poland)
Neringa Jucevičiūtė, Birutė Žilaitienė, Rosita Aniulienė, Virginija Vanagienė
Depression and bipolar disorder are two major psychiatric illnesses whose pathophysiology remains elusive. Newly emerging data support the hypothesis that the dysfunction of the immune system might be a potential factor contributing to the development of these mental disorders. The most common organ affected by autoimmunity is the thyroid; therefore, the link between autoimmune thyroid disorders and mental illnesses has been studied since the 1930s. The aim of this review is to discuss the associations between thyroid autoimmunity, depression and bipolar disorder...
2019: Open Medicine (Warsaw, Poland)
Jian Yi, Lan Xiao, Sheng-Qiang Zhou, Wen-Jiang Zhang, Bai-Yan Liu
Folate metabolism makes a crucial contribution towards late-onset Alzheimer's disease (LOAD). Moreover, methylenetetrahydrofolate reductase (MTHFR) constitutes the primary enzyme of the folate pathway. We hypothesize that there is an association of C677T polymorphism in the MTHFR gene with the susceptibility to LOAD. Previous published research has investigated the link between the MTHFR C677T polymorphisms and LOAD susceptibility; nevertheless, the findings have continued to be not only controversial, but also indecisive...
2019: Open Medicine (Warsaw, Poland)
Umit Y Malkan, Ibrahim C Haznedaroglu
We aim to report a CML case that had fluid retention and serum creatinine increase under long-term imatinib mesylate (IM) treatment. A 68-year-old woman was diagnosed with chronic myeloid leukemia, and IM was started in 2002 with a dose of 400 mg/day. She had achieved complete hematological, molecular and cytogenetic remission under IM treatment. In September 2015, her creatinine level was 1.7 mg/dl. In May 2016, she was admitted to our hospital with dyspnea. Hypervolemia secondary to fluid retention was detected in our patient...
2019: Open Medicine (Warsaw, Poland)
Hong-Ying Zhao, Jing-Min Cheng
Background: The associations between incidence of acute myocardial infarction (AMI) and the ambient temperature were mixed in prior studies. Methods: Data of 2033 consecutive admissions of AMI in a central tertiary hospital in North China from 1st Jan 2003 to 31st Dec 2011 were collected. The weather data in this period were from the local meteorological department. Based on the ambient temperature information, we defined several ambient temperature indices, including daily average temperature, extremely low temperature, and daily temperature range, then characterized the independent associations between them and the incidence of AMI...
2019: Open Medicine (Warsaw, Poland)
Junko Yamaguchi, Akihiro Noda, Akira Utagawa, Atsushi Sakurai, Kosaku Kinoshita
Herein, we report a pediatric case of acute paradoxical cerebral embolism complicated by serious acute pulmonary embolism that was caused by an extremely small patent foramen ovale (PFO). The patient had no medical history suggestive of any other reason. Paradoxical cerebral embolism may occur even with an extremely small PFO because of the increased right-side pressure of the heart and a resulting right-to-left shunt from the acute pulmonary embolism. Although pediatric cases of pulmonary embolism are rare, when diagnosed, clinicians should consider the risk of a concurrent paradoxical cerebral embolism resulting from a latent PFO...
2019: Open Medicine (Warsaw, Poland)
Jiali Hao, Wenjie Xie, Hui Li, Runsheng Li
Prostate cancer (PCa) is the second most diagnosed cancer in Western male population. In this study, we insert mK5 (the mutational kringle5 of human plasminogen) into a DD3-promoted (differential display code 3) oncolytic adenovirus to construct OncoAd.mK5.DD3. E1A.dE1B, briefly, OAd .DD3.mK5. DD3 is one of the most prostate cancer specific promoters which can transcriptionally control adenoviral replication. mK5 has been proved to be able to inhibit the tumor angiogenesis and inhibit cell proliferation. Our results suggested that targeting PCa with OAd ...
2019: Open Medicine (Warsaw, Poland)
Umit Yavuz Malkan, Salih Aksu
The aim of this study is to investigate the effective therapeutic combination of recombinant VIIa(Novoseven) and factor eight inhibitor bypass activity(FEIBA) drugs for the bleedings of adult hemophiliac patients with inhibitors.19 bleeding episodes of 5 hemophilia A patients who were using bypassing agents and followed-up between 2008 and 2016 in Hacettepe Hematology Department were analyzed retrospectively. In 11, 5 and 3 bleeding episodes, FEIBA, recombinant factor VIIa and FEIBA+recombinant factor VIIa were given to the patients, respectively...
2018: Open Medicine (Warsaw, Poland)
Marius Kryzauskas, Vytautas Lipnickas, Simonas Uselis, Donatas Danys, Kestutis Strupas
Giant pseudocyst is a very rare complication after incisional hernia repair with mesh. We present a case of 54-year-old male patient with a giant pseudocyst, which developed after incisional hernia repair with mesh. A patient was discussed during multidisciplinary team meeting and operative treatment was suggested to the patient. Extirpation of the cyst was accomplished. There was observed no defect in the abdominal wall. The patient was discharged on the 7th postoperative day. Ultrasonography two weeks after discharge again showed fluid collection...
2018: Open Medicine (Warsaw, Poland)
Guo-Yao Sang, Zhao-Yun Chen, Cun-Ren Meng, Tian Tian, Zhao-Xia Zhang
Objective: We assessed the correlation between serum carbohydrate antigen 125 (CA125) and carotid intima-media thickness (cIMT) in patients with coronary artery disease (CAD). Methods: We collected 518 CAD patients from the cardiovascular disease center in our hospital, and all cIMT values were measured in patients with CAD. Results: The serum CA125 concentrations were found to be increased in CAD patients with early carotid atherosclerosis compared with patients without early carotid atherosclerosis (20...
2018: Open Medicine (Warsaw, Poland)
Ningning Dang, Xianguang Meng, Shanshan Ma, Qian Zhang, XiYa Sun, Jingjing Wei, Shuhong Huang
Objective: To investigate the effect of MDA-19 on progression of melanoma, and explore the relevant mechanism. Methods: The melanoma cell lines, M14 and UACC257, were treated with different concentrations of MDA-19, then CCK8, clone formation assay, Transwell and flow cytometry assays were performed to examine cell proliferation, migration, invasion and apoptosis, respectively. The expression of apoptosis-related proteins (Bcl-2, Bax and caspase 3 P17), EMT and signaling pathway-related proteins were also detected by Western blot...
2018: Open Medicine (Warsaw, Poland)
Yuanqiang Lin, Zhixia Sun, Hui Wang, Meihan Liu
Objective: To investigate the effect of gastrointestinal function on the incidence of ventilator-associated pneumonia (VAP) in critically ill patients. Methods: From August 2012 to June 2016, 160 critically ill patients in the ICU (Intensive Care Unit) of our hospital were selected as the research group; patients were divided equally into an observation group and a control group, 80 patients in each group, based on the random draw envelope principle. The control group was given a nasogastric tube for gastric feeding, the observation group was given a dual lumen gastrointestinal enteral device for gastric feeding; the two groups' enteral nutrition observation time was 7d; any changes in patient condition and prognosis were recorded...
2018: Open Medicine (Warsaw, Poland)
Hui Huang, Zhandong Li, Chuansheng Huang, Jun Rao, Qin Xie, Wenhao Cui, Fangfang Tou, Zhi Zheng
Objective: To investigate the expression and clinical significance of CD5 and CD43 in diffuse large B cell lymphoma (DLBCL) (unspecified). Methods: Sixty - five patients with diagnosed DLBCL were enrolled. The expressions of CD5, CD43, CD10, Bcl-6 and Mun-1 were detected by immuno histochemistry. The relationship between CD5 and CD43 and clinicopathological features and prognosis of DLBCL was analyzed. Results: In sixty - five adult DLBCL patients , 6 cases of DLBCL (9...
2018: Open Medicine (Warsaw, Poland)
Feng Liu, Chenyu Wang, Rongzhen Wang, Wenge Wang, Min Li
Objective: To investigate the clinical pathology and prognosis & outcome of Henoch-Schonlein purpura nephritis (HSPN) with renal interstitial lesions. Methods: All 148 patients were analyzed for clinical, renal pathological, and prognostic features. Patients with no, mild, and moderate- severe renal tubulo-interstitial lesions were included in group A, B and C, respectively. Results: The estimated glomerular filtration rate (eGFR) of group B was significantly lower than that of group A...
2018: Open Medicine (Warsaw, Poland)
Werner Tiefenthaler, Joshua Colvin, Bernhard Steger, Karl P Pfeiffer, Patrizia L Moser, Janette Walde, Ingo H Lorenz, Christian Kolbitsch
Background: Bispectral index (BIS) monitoring of depth of anesthesia has pioneered the field for more recent monitoring devices like the A-line ARX Index (AAI) or the state (SE) and response entropy (RE) monitoring devices. Following an observational design the present study aimed to simultaneously compare in the same patient recorded BIS, AAI and entropy values. Methods: Data from patients (n = 32) undergoing minor gynecological operations were analyzed. For all patients, standardized anesthesia was used...
2018: Open Medicine (Warsaw, Poland)
Supat Chamnanchanunt, Ponlapat Rojnuckarin
Travel- related thromboembolism reflects the relationship between venous thromboembolism (VTE) and long-haul flights. Although this condition is rare, it may cause significant morbidity and mortality. Therefore, travelers should be evaluated for the risks for thrombosis. Travel physicians should employ a clinical risk score and select in vestigations, prophylaxis, and treatment that are appropriate for each individual. This review summarizes current VTE clinical risk scores and patient management from various reliable guidelines...
2018: Open Medicine (Warsaw, Poland)
Aneta Cymbaluk-Płoska, Anita Chudecka-Głaz, Agnieszka Sompolska-Rzechuła, Kamila Rasinska, Paulina Dubiel, Janusz Menkiszak
Ovarian cancer is characterised by the greatest mortality among all tumors of the reproductive tract. This study included 246 patients which consisted of 136 women with ovarian cancer without genetic mutation and 110 women with benign ovarian cysts. We created two mathematical logic models containing positive and negative risk factors of ovarian cancer such as: age at last menstruation cycle, patient age, OC, HRT, smoking, education status, and alcohol consumption. The calculated cut-off point for the first model was 0...
2018: Open Medicine (Warsaw, Poland)
Ruiqiang Wang, Bowen Zheng, Biyue Wang, Pupu Ma, Fengmei Chen, Lin Tang
Chronic intestinal pseudo-obstruction (CIPO) is a functional gastrointestinal disorder with symptoms of ileus. CIPO can either be idiopathic or secondary to other diseases such as systemic lupus erythematosus (SLE). SLE is involved in many parts of the gastrointestinal system with variable clinical presentations. Reports about reduplicated CIPO as a complication of SLE is infrequent. A 49-year-old female suffering from clinical symptoms of ileus has been hospitalized 3 times over 1 year. Her examination results showed no observation of mechanical obstruction...
2018: Open Medicine (Warsaw, Poland)
Junko Yamaguchi, Kosaku Kinoshita, Marina Hirabayashi, Satoshi Hori, Makoto Furukawa, Atsushi Sakurai
Many reports focus on the probability of intracranial hemorrhage as a complication after recombinant tissue plasminogen activator (rt-PA) therapy. However, thromboembolic complications are not well discussed. We experienced a case in which severe thromboembolic complications occurred in the right radial and right ulnar artery. Arterial fibrillation was observed in this case. If multiple thrombi exist in the atrium or ventricle, multiple small embolic particles may appear following thrombolytic therapy, and that may be a potential risk of secondary thromboembolic complications due to incomplete dissolution of thrombi...
2018: Open Medicine (Warsaw, Poland)
Márton István Dénes, Valentin Nădășan, Călin Molnar, Șerban Bancu, Cristian Oliviu Borz, Zoltán Ábrám
Background: The aim of the study was to assess the awareness of colorectal cancer (CRC) patients about CRC screening methods and to investigate the relationship between awareness, socio-demographic characteristics and the stage in which patients with CRC are diagnosed. Methods: The observational cross-sectional study included 275 CRC patients admitted between 2014 and 2016 to two surgical clinics from Tîrgu Mureş, Romania. Study variables were collected via face-to-face interview and from patients' observation sheets...
2018: Open Medicine (Warsaw, Poland)
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