journal
https://read.qxmd.com/read/38464887/detection-of-testicular-metastasis-from-renal-cell-carcinoma-on-psma-pet-scan
#1
Theresa Olmstead, Michael Emmerling, Surekha Bantumilli, Mathew Raynor, Matthew E Nielsen, Marc A Bjurlin, Tracy L Rose
The use of prostate-specific membrane antigen-positron emission tomography (PSMA-PET) is becoming more widespread for the diagnosis and management of prostate cancer. Here we report a case of oligometastatic renal cell carcinoma (RCC) to the testes diagnosed incidentally on PSMA-PET imaging. This case demonstrates the potential for diagnosis of nonprostate disease with PSMA-PET imaging, as well as the promising nature of PSMA-PET for the diagnosis and surveillance of RCC. In addition, this case report discusses the rare occurrence of oligometastatic RCC to the testis...
2024: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38450000/the-survival-outcomes-of-the-metastatic-nonclear-cell-renal-cell-carcinoma-in-the-immunotherapy-era-princess-margaret-cancer-centre-experience
#2
JOURNAL ARTICLE
Esmail Al-Ezzi, Abhenil Mittal, Zachary W Veitch, Amer Zahralliyali, Nely Mercy Diaz Mejia, Osama Abdeljalil, Husam Alqaisi, Vikaash Kumar, Aaron R Hansen, Nazanin Fallah-Rad, Srikala S Sridhar
Immunotherapy (IO) with or without targeted therapy (TT) is the standard treatment for patients with metastatic clear cell renal cell carcinoma (RCC). The evidence supporting their use in metastatic nonclear cell renal cell carcinoma (nccRCC) subtypes is based on small prospective trials and retrospective analyses. Here, we report survival outcomes for patients with metastatic nccRCC treated with IO and/or TT at the Princess Margaret Cancer Centre, Toronto, ON, Canada. Demographics, disease characteristics, and survival outcomes were collected retrospectively...
2024: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38449999/inoperable-renal-malignant-glomus-tumor-the-answers-for-all-the-w-s
#3
JOURNAL ARTICLE
Pushkala Surianarayanan, Arun Ramdas Menon, Shriley Sundersingh, Anand Raja
Glomus tumor, arising from glomus bodies (specialized neurovascular structures involved in thermoregulation), commonly occurs in extremities and rarely in viscera. The spectrum of glomus tumors range from benign tumors to tumors with uncertain malignant potential to tumors of the malignant subtype. A vast majority of visceral glomus tumors are benign. Most common visceral tumors arise in the gastrointestinal tract. Glomus tumors of the kidney are a rare entity of which malignant glomus tumors are exceedingly rare...
2024: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38344311/a-narrative-review-of-pheochromocytoma-in-vhl
#4
JOURNAL ARTICLE
Danilo Coco, Silvana Leanza
This systematic review aims to investigate the clinical presentation, diagnostic methods, and management strategies for pheochromocytoma in patients with von Hippel-Lindau (VHL) disease, an autosomal dominant disorder that predisposes individuals to the development of various tumors, including pheochromocytomas. Pheochromocytoma is a rare neuroendocrine tumor of the adrenal medulla that occurs sporadically or as part of an inherited syndrome. The incidence of pheochromocytoma in VHL patients is estimated to be between 10-20%, making it the second most common tumor associated with VHL...
2024: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38304003/vhl-dependence-of-ehhadh-expression-in-a-human-renal-cell-carcinoma-cell-line
#5
JOURNAL ARTICLE
Julia Felicitas Pilz, Marinella Klein, Elke Neumann-Haefelin, Athina Ganner
The von Hippel-Lindau tumor suppressor gene ( VHL ) is mutated in up to 90% of clear cell renal cell carcinoma (ccRCC) cases, thus playing a key role in ccRCC pathogenesis. ccRCC can be classified as a metabolic disease in which alterations in fatty acid metabolism facilitate cancer cell proliferation. Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase (EHHADH) is an enzyme involved in peroxisomal fatty acid degradation. It is primarily expressed in renal proximal tubule cells, presumably the origin of ccRCC...
2024: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38213482/a-rare-site-of-metachronous-metastases-from-renal-cell-carcinoma
#6
Madhuri Nutakki, Kanchan V Murhekar, Shirley Sundersingh, Anand Raja
Secondary metastatic involvement of the testis is a rare occurrence, particularly in cases of metastasis from renal cell carcinoma (RCC). We present a case of metachronous contralateral testicular metastasis from RCC in a 55-year-old man, occurring 2 years after radical nephrectomy. Following a thorough evaluation that ruled out systemic disease, the patient underwent a Chevassu procedure and right inguinal orchidectomy. Histopathological analysis confirmed metastatic involvement of the right testis by RCC...
2024: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38213481/robotic-radical-nephrectomy-with-vena-cava-thrombus-extraction-rrn-vcte-for-renal-cell-carcinoma-a-meta-analysis-of-surgical-technique-and-outcomes
#7
REVIEW
Danilo Coco, Silvana Leanza
Renal cell carcinoma (RCC) with vena cava tumor thrombus is a challenging condition, which requires complex surgical management. Robotic radical nephrectomy with vena cava thrombus extraction (RRN-VCTE) has emerged as a promising and minimally invasive technique. This meta-analysis aims to review the surgical technique and outcomes of RRN-VCTE in patients with RCC and vena cava tumor thrombus. A comprehensive literature search was conducted using databases, including PubMed, Embase, and Cochrane Library. Studies published in English till October 2021 were included...
2024: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38179231/intraoperative-embolization-during-inferior-vena-cava-tumor-thrombectomy-for-renal-cell-carcinoma
#8
Samantha A Roberts, Divyaam Satija, Henry Gold, Mina S Makary, Jing G Wang, Eric A Singer, Tasha Posid, Nahush A Mokadam, Shawn Dason
Intraoperative tumor thrombus embolization is a potentially lethal complication during inferior vena cava (IVC) thrombectomy for renal cell carcinoma (RCC). Intraoperative embolization is uncommonly encountered because IVC thrombectomy surgical technique is focused on avoiding this complication. Nonetheless, early recognition of embolization is essential so that emergent management can be instituted. When available, cardiopulmonary bypass (CPB) and embolectomy should be considered the gold standard for the management of intraoperative embolization...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38162464/preserving-renal-function-without-compromising-oncological-outcomes-a-comparative-study-of-partial-and-total-nephrectomies-in-t3-stage-renal-cell-carcinoma
#9
JOURNAL ARTICLE
Ahmed Alasker, Turki Rashed Alnafisah, Mohammad Alghafees, Areez Shafqat, Belal Nedal Sabbah, Abdullah Alhaider, Abdulrahman Alsayyari, Naif Althonayan, Mohammed AlOtaibi, Salman Bin Ofisan, Mohammed Alghamdi, Nasser Albogami, Abdullah Al-Khayal
The utility of partial nephrectomy (PN) in locally advanced, stage T3 renal cell carcinoma (RCC) is controversial. This retrospective study aimed to review the oncological and functional outcomes of patients with T3a RCC who underwent PN. We included all patients with pT3a stage RCC undergoing either open, laparoscopic, or robotic PN at our center between January 2015 and 2023. A Wilcoxon rank sum test was utilized to compare nephrectomy types (radical nephrectomy [RN] vs PN). Survival analysis was conducted using Kaplan-Meier plots and a log-rank test...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38162463/papillary-renal-cell-carcinoma-demographics-survival-analysis-racial-disparities-and-genomic-landscape
#10
JOURNAL ARTICLE
Asad Ullah, Abdul Qahar Khan Yasinzai, Naema Daino, Bisma Tareen, Zulfiqar Haider Jogezai, Haleema Sadia, Nimra Jamil, Girahnaz Baloch, Adil Karim, Kaleemullah Badini, Agha Wali, Abdul Waheed, Marjan Khan, Bina Asif, Kaleemullah Kakar, Saleh Heneidi, Feroze Sidhwa, Nabin R Karki
Papillary renal cell carcinoma (PRCC) is the second most common histological subtype of renal cell cancer. This research aims to present a large database study highlighting the demographic, clinical, and pathological factors, racial disparities, prognosis, and survival of PRCC. The clinical and demographic data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database, and molecular data was cured from the Catalogue Of Somatic Mutations in Cancer (COSMIC) database. PRCC had a median age of diagnosis at 64 years, with a higher incidence in men (77%), and Whites (68%)...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38145032/exploring-renal-malignancies-in-saudi-arabia-insights-from-a-tertiary-care-center-study
#11
JOURNAL ARTICLE
Ahmed Alasker, Turki Rashed Alnafisah, Mohammad Alghafees, Belal Nedal Sabbah, Areez Shafqat, Abdullah Alhaider, Abdulrahman Alsayyari, Naif Althonayan, Mohammed AlOtaibi, Fisal Tariq Aldokhel, Salman Bin Ofisan, Saud Abdullah Alawad
This retrospective study aims to describe the characteristics of renal cell carcinoma (RCC) in Saudi Arabia, in terms of epidemiology, clinical presentation, tumor subtype, Fuhrman grade, tumor size and stage, and overall survival. A total of 431 adult patients with a histopathological diagnosis of RCC between 2015 and 2023 were included in the analysis. Most patients (72.4%) had clear cell tumors, followed by chromophobe (15.1%) and papillary (12.5%) subtypes. In males, papillary RCC (85.2%) was more common compared to clear cell (59...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38145031/characteristics-of-the-patients-aged-less-than-40-years-operated-for-a-renal-mass
#12
JOURNAL ARTICLE
Abdullah Ilktac, Bayram Dogan, Cevper Ersoz, Ganime Coban, Senad Kalkan
The incidence of renal cell cancer (RCC) is low in individuals aged less than 40 years; however several studies have shown this increasing trend over the years. Hereditary syndromes are associated with RCC and are more frequently observed in early-onset cases. In this study, we investigated the characteristics of the patients, aged less than 40 years, who were operated for a renal mass with the suspicion of RCC. We analyzed patients aged <40 years who underwent partial or radical nephrectomy between January 2012 and December 2022...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/37936865/sarcomatoid-carcinoma-metastasis-to-the-colon-from-a-small-renal-mass-case-report-with-review-of-literature
#13
Shailesh Patidar, Arun Ramdas Menon, Shirley Sundersingh, Ramakrishnan Ayloor Seshadri, Anand Raja
A third of patients with renal cell carcinoma (RCC) present with metastatic disease. Metastasis in RCC from small renal mass (SRM) (≤4 cm) is rare. We report a case of stage cT1a clear-cell RCC with low-risk features on pathology presenting with disproportionately large synchronous solitary metastasis to the transverse colon. He underwent resection of the mass with the involved transverse colon and adjoining mesocolon. Intestinal continuity was restored, following which partial nephrectomy was performed for the right renal tumor...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/37814604/advancing-treatment-frontiers-radiofrequency-ablation-for-small-renal-mass-intermediate-term-results
#14
JOURNAL ARTICLE
Rohit Kumar Singh, Manav Gideon, Rohan Rajendran, Georgie Mathew, Kannan Nair
Our study aims to discern the immediate and intermediate-term oncological outcomes of the patients with small renal mass and who were surgically unfit or were having a bilateral tumor and underwent radiofrequency ablation (RFA) of the mass. We retrospectively and prospectively analyzed the status of the patients who were diagnosed to have small renal masses and were biopsy-proven renal cell carcinoma (RCC) cases, who underwent RFA at our institute from the year 2013 to 2022. Patients were followed-up for 3 years...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/37789903/case-reports-of-tfe3-rearranged-renal-cell-carcinoma-fdg-pet-uptake-might-help-diagnosis
#15
Sho Murakami, Keita Nagawa, Takanori Inui, Aya Yamamoto, Mizuka Suzuki, Fumitaka Koga, Toru Motoi, Yasunobu Takaki
Translocation and transcription factor E3 (TFE3)-rearranged renal cell carcinoma (RCC) is a rare subtype of RCCs characterised by the fusion of the TFE3 transcription factor genes on chromosome Xp11.2 with one of the multiple genes. TFE3-rearranged RCC occurs mainly in children and adolescents, although middle-aged cases are also observed. As computed tomography (CT)/magnetic resonance imaging (MRI) findings of TFE3-rearranged RCC overlap with those of other RCCs, differential diagnosis is often challenging...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/37789902/systemic-treatment-for-advanced-and-metastatic-non-clear-cell-renal-cell-carcinoma-examining-modern-therapeutic-strategies-for-a-notoriously-challenging-malignancy
#16
REVIEW
Jake Drobner, Daniella Portal, Karie Runcie, Yuanquan Yang, Eric A Singer
Non-clear cell renal cell carcinoma (nccRCC) is a heterogeneous group of malignancies that represents 25% of renal cell carcinoma (RCC) cases. Treatment for non-clear cell histologies is mostly based on evidence from small phase II clinical trials or extrapolated from successful therapies in clear cell RCC because of the low incidence of non-clear cell pathology. Advances in genomic profiling have improved clinicians' understanding of molecular targets for nccRCC, such as altered mesenchymal epithelial transition ( MET ) gene status and fumarate hydratase ( FH ) gene inactivation, but patient outcomes remain poor and optimal management of this disease remains unclear...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/37583880/recent-improvements-in-adult-wilms-tumor-diagnosis-and-management-review-of-literature
#17
REVIEW
Vishnupriya Sakthivel, Ismail Z Adeeb, Devashree Vijayabalan
Wilms tumor, also denoted as nephroblastoma, an embryonal type of renal cancer, is the most common cancer that affects children in the first 5 years of life. Wilms tumor is very rarely seen in adults. Both adults and children showcase varied clinical symptoms. The metastasis of tumor in both adults and children are not uncommon. Though histological differences between children and adults are insignificant, the prognosis of adult Wilms tumors compared to children is abysmal. Despite remarkable advancements in oncology, no standard treatment protocol exists for Wilms tumor in adults...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/37555195/von-hippel-lindau-disease-vhl-characteristic-lesions-with-classic-imaging-findings
#18
Suryansh Bajaj, Darshan Gandhi, Divya Nayar, Ali Serhal
Von Hippel-Lindau disease (VHL) is a multisystem cancer syndrome caused by the inactivation of the VHL tumor suppressor gene and involves various organ systems including the central nervous system (CNS), endocrine system, and the kidneys. Tumors seen in patients with VHL disease can be benign or malignant and are usually multifocal, bilateral, and hypervascular in nature. As most lesions associated with VHL are asymptomatic initially, early diagnosis and the institution of an evidence-based surveillance protocol are of paramount importance...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/37555194/hereditary-renal-cell-carcinoma-is-age-an-independent-criterion-for-genetic-testing-a-large-cohort-from-a-latin-america-referral-center
#19
JOURNAL ARTICLE
Tomás Carminatti, Patricio Aitor García Marchiñena, Ignacio Pablo Tobia González, Valeria de Miguel, Marcelo Martín Serra, Pablo Germán Kalfayan, Alberto Manuel Jurado
Although age younger than 46 years has been an independent criterion for genetic testing in hereditary renal cell carcinoma (hRCC), there is a lack of evidence in the literature. This study aims to analyze whether a 46-year-old cut-off should be considered an independent genetic testing criterion and to elucidate risk factors predicting a positive genetic test. Observational study from January 2010 to December 2021. All patients under 46 years with a non-metastatic kidney mass and surgical indication were included...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/37457633/comparison-of-posterior-and-antero-lateral-renal-tumors-in-retroperitoneal-laparoscopic-partial-nephrectomy-a-propensity-score-matching-analysis
#20
JOURNAL ARTICLE
Hakan Anıl, Ali Yıldız, Ahmet Güzel, Serkan Akdemir, Kaan Karamık, Murat Arslan
This study aimed to compare the antero-lateral and posterior localized renal masses in laparoscopic partial nephrectomy with the retroperitoneal approach in terms of operative, functional, and oncological outcomes. Patients who underwent retroperitoneal laparoscopic partial nephrectomy by a single surgeon between January 2013 and January 2021 were included in the study. A one-to-one propensity score matching (PSM) analysis was conducted to obtain two balanced groups. The patients were divided into two groups as posterior and antero-lateral according to the localization of the mass...
2023: Journal of Kidney Cancer and VHL
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