Mariana Andrawus, Gil Ben David, Ivana Terziyska, Lital Sharvit, Aviv Bergman, Nir Barzilai, Srilakshmi M Raj, Diddahally R Govindaraju, Gil Atzmon
No abstract text is available yet for this article.
June 18, 2024: GeroScience
Nate P Bachman, Nathaniel B Ketelhut, Michael Blomquist, Janée D Terwoord
Rho-kinase has been implicated in the development of hypertension in preclinical studies and may contribute to age-related blood pressure elevation. This study tested the hypothesis that Rho-kinase contributes to elevated systolic blood pressure (SBP) in healthy older adults. Young (18-30 years, 6F/6M) and older (60-80 years, 7F/6M) adults were enrolled in a double-blind, placebo-controlled crossover study using intravenous fasudil infusion to inhibit Rho-kinase. Fasudil lowered SBP in older adults compared to placebo (saline) (2-h post-infusion: 125 ± 4 vs...
June 18, 2024: GeroScience
Maud van Dinther, Paulien H M Voorter, Eleana Zhang, Sander M J van Kuijk, Jacobus F A Jansen, Robert J van Oostenbrugge, Walter H Backes, Julie Staals
Growing evidence indicates an important role of neurovascular unit (NVU) dysfunction in the pathophysiology of cerebral small vessel disease (cSVD). Individually measurable functions of the NVU have been correlated with cognitive function, but a combined analysis is lacking. We aimed to perform a unified analysis of NVU function and its relation with cognitive performance. The relationship between NVU function in the white matter and cognitive performance (both latent variables composed of multiple measurable variables) was investigated in 73 patients with cSVD (mean age 70 ± 10 years, 41% women) using canonical correlation analysis...
June 18, 2024: GeroScience
Elena Ciaglia, Francesco Montella, Albino Carrizzo, Valentina Lopardo, Roberta Maria Esposito, Cristina Basile, Antonio Damato, Massimiliano De Lucia, Anna Maciag, Gaia Spinetti, Maria Serena Milella, Davide Maselli, Carmine Vecchione, Annibale Alessandro Puca
Beyond their activity in hemostasis and thrombosis, recent advances attribute platelets a pro-youthful role capable to attenuate immune senescence and age-related neuroinflammation. Previous studies from our group associated a polymorphic haplotype variant in the BPIFB4 gene (LAV-BPIFB4) with exceptional longevity. Transfer of the LAV-BPIFB4 in preclinical models has proved strategic to cope with frailty conditions, aging-related events, e.g., cardiovascular ones, and immune dysfunction mainly through a favorable conditioning of the immune system...
June 17, 2024: GeroScience
Simon Haefliger, Olga Chervova, Christopher Davies, Chet Loh, Roberto Tirabosco, Fernanda Amary, Nischalan Pillay, Steve Horvath, Stephan Beck, Adrienne M Flanagan, Iben Lyskjær
Recently, DNA methylation clocks have been proven to be precise age predictors, and the application of these clocks in cancer tissue has revealed a global age acceleration in a majority of cancer subtypes when compared to normal tissue from the same individual. The polycomb repressor complex 2 plays a pivotal role in the aging process, and its targets have been shown to be enriched in CpG sites that gain methylation with age. This complex is further regulated by the chromatin remodeling complex SWItch/Sucrose Non-Fermentable and its core subunit, notably the tumor suppressor gene SMARCB1, which under physiological conditions inhibits the activity of the polycomb repressor complex 2...
June 16, 2024: GeroScience
Adam B Cornwell, Yun Zhang, Manjunatha Thondamal, David W Johnson, Juilee Thakar, Andrew V Samuelson
Dietary restriction (DR), the process of decreasing overall food consumption over an extended period of time, has been shown to increase longevity across evolutionarily diverse species and delay the onset of age-associated diseases in humans. In Caenorhabditis elegans, the Myc-family transcription factors (TFs) MXL-2 (Mlx) and MML-1 (MondoA/ChREBP), which function as obligate heterodimers, and PHA-4 (orthologous to FOXA) are both necessary for the full physiological benefits of DR. However, the adaptive transcriptional response to DR and the role of MML-1::MXL-2 and PHA-4 remains elusive...
June 15, 2024: GeroScience
Alexander Lischke, Rike Pahnke, Anna Mäder, Andrew K Martin, Marcus Meinzer
Older adults have difficulties to detect the intentions, thoughts, and feelings of others, indicating an age-associated decline of socio-cognitive abilities that are known as "mentalizing". These deficits in mental state recognition are driven by neurofunctional alterations in brain regions that are implicated in mentalizing, such as the right temporo-parietal junction (rTPJ) and the dorso-medial prefrontal cortex (dmPFC). We tested whether focal transcranial current stimulation (tDCS) of the rTPJ and dmPFC has the potential to eliminate mentalizing deficits in older adults...
June 15, 2024: GeroScience
Ágnes Dóra Sándor, Zsófia Czinege, András Szabó, Eszter Losoncz, Krisztina Tóth, Zsuzsanna Mihály, Péter Sótonyi, Béla Merkely, Andrea Székely
There are controversial data about the effect of carotid endarterectomy regarding postoperative cognitive function. Our aim was to analyze the effect of cerebral tissue saturation monitored by near-infrared spectroscopy (NIRS) on cognitive function. Perioperative data of 103 asymptomatic patients undergoing elective carotid surgery under general anesthesia were analyzed. Preoperatively and 3 months after the operation, MMSE (Mini Mental State Examination) and MoCA (Montreal Cognitive Assessment) tests were conducted...
June 15, 2024: GeroScience
Borna Rapčan, Manshu Song, Azra Frkatović-Hodžić, Tea Pribić, Jakov Vuk, Anđelo Beletić, Maja Hanić, Julija Jurić, Petra Tominac, Josip Milas, Vedrana Ivić, Sven Viland, Sara Bonet, Branko Šego, Marija Heffer, Wei Wang, Michael P Snyder, Gordan Lauc
Ageing is a complex biological process with variations among individuals, leading to the development of ageing clocks to estimate biological age. Glycans, particularly in immunoglobulin G (IgG), have emerged as potential biomarkers of ageing, with changes in glycosylation patterns correlating with chronological age.For precision analysis, three different plasma pools were analysed over 26 days in tetraplicates, 312 samples in total. In short-term variability analysis, two cohorts were analysed: AstraZeneca MFO cohort of 26 healthy individuals (median age 20) and a cohort of 70 premenopausal Chinese women (median age 22...
June 14, 2024: GeroScience
Samantha J Russell, Karen Parker, Andrea Lehoczki, David Lieberman, Indu S Partha, Serena J Scott, Linda R Phillips, Mindy J Fain, Janko Ž Nikolich
Long COVID, also known as PASC (post-acute sequelae of SARS-CoV-2), is a complex infection-associated chronic condition affecting tens of millions of people worldwide. Many aspects of this condition are incompletely understood. Among them is how this condition may manifest itself in older adults and how it might impact the older population. Here, we briefly review the current understanding of PASC in the adult population and examine what is known on its features with aging. Finally, we outline the major gaps and areas for research most germane to older adults...
June 14, 2024: GeroScience
Lauren A Wimer, Asia Davis-Castillo, Sofiya Galkina, Serban Ciotlos, Cavan Patterson, Leandro Prado, Maria Castro Munoz, Nicolas Martin, Sharon Epstein, Nicholas Schaum, Simon Melov
Translational research is commonly performed in the C57B6/J mouse strain, chosen for its genetic homogeneity and phenotypic uniformity. Here, we evaluate the suitability of the white-footed deer mouse (Peromyscus leucopus) as a model organism for aging research, offering a comparative analysis against C57B6/J and diversity outbred (DO) Mus musculus strains. Our study includes comparisons of body composition, skeletal muscle function, and cardiovascular parameters, shedding light on potential applications and limitations of P...
June 14, 2024: GeroScience
Lucia Torres-Simon, Alberto Del Cerro-León, Miguel Yus, Ricardo Bruña, Lidia Gil-Martinez, Alberto Marcos Dolado, Fernando Maestú, Juan Arrazola-Garcia, Pablo Cuesta
White matter hyperintensities of vascular origin (WMH) are commonly found in individuals over 60 and increase in prevalence with age. The significance of WMH is well-documented, with strong associations with cognitive impairment, risk of stroke, mental health, and brain structure deterioration. Consequently, careful monitoring is crucial for the early identification and management of individuals at risk. Luckily, WMH are detectable and quantifiable on standard MRI through visual assessment scales, but it is time-consuming and has high rater variability...
June 13, 2024: GeroScience
Francesco Neri, Selma N Takajjart, Chad A Lerner, Pierre-Yves Desprez, Birgit Schilling, Judith Campisi, Akos A Gerencser
Cellular senescence is a major driver of aging and age-related diseases. Quantification of senescent cells remains challenging due to the lack of senescence-specific markers and generalist, unbiased methodology. Here, we describe the Fully-Automated Senescence Test (FAST), an image-based method for the high-throughput, single-cell assessment of senescence in cultured cells. FAST quantifies three of the most widely adopted senescence-associated markers for each cell imaged: senescence-associated β-galactosidase activity (SA-β-Gal) using X-Gal, proliferation arrest via lack of 5-ethynyl-2'-deoxyuridine (EdU) incorporation, and enlarged morphology via increased nuclear area...
June 13, 2024: GeroScience
Benjamin A Kugler, Colton R Lysaker, Edziu Franczak, Brittany M Hauger, Vivien Csikos, Julia A Stopperan, Julie A Allen, John A Stanford, Lauren G Koch, Steven L Britton, John P Thyfault, Heather M Wilkins
Low aerobic capacity is strongly associated with all-cause mortality and risk for Alzheimer's disease (AD). Individuals with early dementia and AD have lower aerobic capacity compared to age-matched controls. The mechanism by which aerobic capacity influences AD risk is unknown but is likely mediated by sexual dimorphism and tissue-level differences in mitochondrial energetics. Here, we used rats selectively bred for large differences in intrinsic aerobic exercise capacity. Brain tissue from 18-month and 24-month-old female and male low-capacity runner (LCR) and high-capacity runner (HCR) rats were analyzed for markers of mitochondrial function and AD-associated pathologies...
June 13, 2024: GeroScience
Hugo Bonnefous, Jérôme Teulière, François-Joseph Lapointe, Philippe Lopez, Eric Bapteste
Few studies have systematically analyzed how old aging is. Gaining a more accurate knowledge about the natural history of aging could however have several payoffs. This knowledge could unveil lineages with dated genetic hardware, possibly maladapted to current environmental challenges, and also uncover "phylogenetic modules of aging," i.e., naturally evolved pathways associated with aging or longevity from a single ancestry, with translational interest for anti-aging therapies. Here, we approximated the natural history of the genetic hardware of aging for five model fungal and animal species...
June 12, 2024: GeroScience
Emily W Waigi, Laena Pernomian, Alexia M Crockett, Tiago J Costa, Paul Townsend, R Clinton Webb, Joseph A McQuail, Cameron G McCarthy, Fiona Hollis, Camilla F Wenceslau
Increasing evidence shows that cardiovascular diseases (CVDs) are associated with an increased risk of cognitive impairment and Alzheimer's diseases (AD). It is unknown whether systemic vascular dysfunction occurs prior to the development of AD, if this occurs in a sex-dependent manner, and whether endothelial cells play a role in the deposition of amyloid beta (Aβ) peptides. We hypothesized that vascular dysfunction occurs prior to the onset of amyloid pathology, thus escalating its progression. Furthermore, endothelial cells from female mice will present with an exacerbated formation of Aβ peptides due to an exacerbated pressure pulsatility...
June 11, 2024: GeroScience
Lucía Rodríguez-Fernández, Candela Zorzo, Jorge L Arias
Aging is a multifactorial biological process that may be associated with cognitive decline. Photobiomodulation (PBM) is a non-pharmacological therapy that shows promising results in the treatment or prevention of age-related cognitive impairments. The aim of this review is to compile the preclinical and clinical evidence of the effect of PBM during aging in healthy and pathological conditions, including behavioral analysis and neuropsychological assessment, as well as brain-related modifications. 37 studies were identified by searching in PubMed, Scopus, and PsycInfo databases...
June 11, 2024: GeroScience
Fangyu Liu, Jennifer A Schrack, Jeremy Walston, Rasika A Mathias, B Gwen Windham, Morgan E Grams, Josef Coresh, Keenan A Walker
Physical frailty is a syndrome that typically manifests in later life, although the pathogenic process causing physical frailty likely begins decades earlier. To date, few studies have examined the biological signatures in mid-life associated with physical frailty later in life. Among 4,189 middle-aged participants (57.8 ± 5.0 years, 55.8% women) from the Atherosclerosis Risk in Community (ARIC) study, we evaluated the associations of 4,955 plasma proteins (log 2-transformed and standardized) measured using the SomaScan platform with their frailty status approximately 20 years later...
June 10, 2024: GeroScience
Daniel L Smith, Sharon E Mitchell, Maria S Johnson, Victoria K Gibbs, Stephanie Dickinson, Beate Henschel, Rui Li, Kathryn A Kaiser, Daniella E Chusyd, Andrew W Brown, David B Allison, John R Speakman, Tim R Nagy
Caloric restriction (CR) results in reduced energy and protein intake, raising questions about protein restriction's contribution to CR longevity benefits. We kept ad libitum (AL)-fed male C57BL/6J mice at 27°C (AL27) and pair-fed (PF) mice at 22°C (22(PF27)). The 22(PF27) group was fed to match AL27 while restricted for calories due to cold-induced metabolism. The 22(PF27) mice had significantly lower body weight, lean mass, fat mass, leptin, IGF-1, and TNF-α levels than AL27 mice (p<0.001 for all)...
June 8, 2024: GeroScience
Johnny Hudson, Tammi Kaeberlein, Akashdeep Mahal, Nelson Wong, Mina Ghorbanifarajzadeh, Frank Radella, Anar Isman, Andy Nyquist, Sajad Zalzala, George Haddad, Matt Kaeberlein, Jonathan Y An
Rapamycin (sirolimus) is an FDA approved drug with immune modulating properties that is being prescribed off-label in adults as a preventative therapy to maintain healthspan. We recently published one of the first reports on 333 adults with a history of off-label rapamycin use. Along with presenting evidence that rapamycin can be used safely in adults of normal health status, we discovered that about 26% of rapamycin users also reported oral health changes. Given the recent evidence highlighting the potential benefits of rapamycin and its derivatives in enhancing oral health, we conducted a secondary data analysis to profile the oral health of off-label rapamycin users, the true incidence of mouth sores, and present specific case studies of periodontal bone loss quantification using an FDA-approved artificial intelligence platform...
June 6, 2024: GeroScience
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