Naibedya Dutta, Joe A Gerke, Sofia F Odron, Joseph D Morris, Adam Hruby, Juri Kim, Toni Castro Torres, Sarah J Shemtov, Jacqueline G Clarke, Michelle C Chang, Hooriya Shaghasi, Marissa N Ray, Maxim Averbukh, Sally Hoang, Maria Oorloff, Athena Alcala, Matthew Vega, Hemal H Mehta, Max A Thorwald, Phillip Crews, Marc Vermulst, Gilberto Garcia, Tyler A Johnson, Ryo Higuchi-Sanabria
Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine sponge C. mycofijiensis and its more stable semisynthetic analog 8-O-acetylmycothiazole (8-OAc) as potent and selective chemical probes based on their high efficiency to inhibit ETC complex I function. Similar to rotenone (Rote), MTZ, a newly employed ETC complex I inhibitor, exhibited higher cytotoxicity against cancer cell lines compared to certain non-cancer cell lines...
April 3, 2024: GeroScience