Priya Patel, Areej Alghamdi, Gary Shaw, Christopher Legge, Maggie Glover, Danielle Freeman, Harry Hodgetts, Erica Wilson, Faith Howard, Sarah Staniland, Aneurin J Kennerley, Duncan Wood, Robert Moorehead, Charlotte Hadfield, Ola Rominiyi, Jon Griffin, Spencer J Collis, Sam Hyde, Marcus Crossley, Martyn Paley, Munitta Muthana
Delivering therapies to deeply seated brain tumours (BT) is a major clinical challenge. Magnetic drug targeting (MDT) could overcome this by rapidly transporting magnetised drugs directly into BT. We have developed a magnetic device for application in murine BT models using an array of neodymium magnets with a combined strength of 0.7T. In a closed fluidic system, the magnetic device trapped magnetic nanoparticles (MNP) up to distances of 0.8cm. In mice, the magnetic device guided intravenously administered MNP (<50nm) from the circulation into the brain where they localised within mouse BT...
2023: Nanotheranostics