journal
https://read.qxmd.com/read/37151803/combination-of-precipitation-and-size-exclusion-chromatography-as-an-effective-method-for-exosome-like-extracellular-vesicle-isolation-from-pericardial-fluids
#21
JOURNAL ARTICLE
Dhananjie Chandrasekera, Rishi Shah, Isabelle van Hout, Willow De Jonge, Richard Bunton, Dominic Parry, Philip Davis, Rajesh Katare
Extracellular vesicles (EVs), such as exosomes, are nanovesicles that have received significant attention due to their ability to contain various molecular cargos. EVs found in biological fluids have been demonstrated to have therapeutic potential, including as biomarkers. Despite being extensively studied, a significant downfall in EV research is the lack of standardised protocol for its isolation from human biological fluids, where EVs usually exist at low densities. In this study, we tested two well-established EV isolation protocols, precipitation, and size exclusion chromatography (SEC), to determine their efficiency in isolating EVs from the pericardial fluid...
2023: Nanotheranostics
https://read.qxmd.com/read/37151802/current-status-of-cancer-nanotheranostics-emerging-strategies-for-cancer-management
#22
REVIEW
Vivek P Chavda, Avinash Khadela, Yasha Shah, Humzah Postwala, Pankti Balar, Lalit Vora
Cancer diagnosis and management have been a slow-evolving area in medical science. Conventional therapies have by far proved to have various limitations. Also, the concept of immunotherapy which was thought to revolutionize the management of cancer has presented its range of drawbacks. To overcome these limitations nanoparticulate-derived diagnostic and therapeutic strategies are emerging. These nanomaterials are to be explored as they serve as a prospect for cancer theranostics. Nanoparticles have a significant yet unclear role in screening as well as therapy of cancer...
2023: Nanotheranostics
https://read.qxmd.com/read/37151801/indocyanine-green-based-glow-nanoparticles-probe-for-cancer-imaging
#23
JOURNAL ARTICLE
Neeraj Chauhan, Marco Cabrera, Pallabita Chowdhury, Prashanth K B Nagesh, Anupam Dhasmana, Pranav, Meena Jaggi, Subhash C Chauhan, Murali M Yallapu
Indocyanine green (ICG) is one of the FDA-approved near infra-red fluorescent (NIRF) probes for cancer imaging and image-guided surgery in the clinical setting. However, the limitations of ICG include poor photostability, high concentration toxicity, short circulation time, and poor cancer cell specificity. To overcome these hurdles, we engineered a nanoconstruct composed of poly (vinyl pyrrolidone) (PVP)-indocyanine green that is cloaked self-assembled with tannic acid (termed as indocyanine green-based glow nanoparticles probe, ICG-Glow NPs) for the cancer cell/tissue-specific targeting...
2023: Nanotheranostics
https://read.qxmd.com/read/37064614/emergence-of-raman-spectroscopy-as-a-probing-tool-for-theranostics
#24
REVIEW
Ruchi Singh, Vikas Yadav, Ashish Kumar Dhillon, Arti Sharma, Tripti Ahuja, Soumik Siddhanta
Although medical advances have increased our grasp of the amazing morphological, genetic, and phenotypic diversity of diseases, there are still significant technological barriers to understanding their complex and dynamic character. Specifically, the complexities of the biological systems throw a diverse set of challenges in developing efficient theranostic tools and methodologies that can probe and treat pathologies. Among several emerging theranostic techniques such as photodynamic therapy, photothermal therapy, magnetic resonance imaging, and computed tomography, Raman spectroscopy (RS) is emerging as a promising tool that is a label-free, cost-effective, and non-destructive technique...
2023: Nanotheranostics
https://read.qxmd.com/read/37064613/natural-and-synthetic-nanovectors-for-cancer-therapy
#25
REVIEW
Aziz Eftekhari, Carola Kryschi, David Pamies, Sukru Gulec, Elham Ahmadian, Dawid Janas, Soodabeh Davaran, Rovshan Khalilov
Nanomaterials have been extensively studied in cancer therapy as vectors that may improve drug delivery. Such vectors not only bring numerous advantages such as stability, biocompatibility, and cellular uptake but have also been shown to overcome some cancer-related resistances. Nanocarrier can deliver the drug more precisely to the specific organ while improving its pharmacokinetics, thereby avoiding secondary adverse effects on the not target tissue. Between these nanovectors, diverse material types can be discerned, such as liposomes, dendrimers, carbon nanostructures, nanoparticles, nanowires, etc...
2023: Nanotheranostics
https://read.qxmd.com/read/37064612/-in-vivo-study-of-chalcone-loaded-carbon-dots-for-enhancement-of-anticancer-and-bioimaging-potencies
#26
JOURNAL ARTICLE
Mochamad Zakki Fahmi, Yu-Yu Aung, Musbahu Adam Ahmad, Alfinda Novi Kristanti, Satya Candra Wibawa Sakti, Oka Pradipta Arjasa, Hwei Voon Lee
The fluorescent imaging and drug delivery utilizing carbon dots nanomaterials (CDs) have attracted tremendously due to their unique optical ability and outstanding biocompatibility. Herein, we reported a new design of chalcone-loaded carbon dots (Chalcone-APBA-CDs) to serve chalcone transport onto cancer cells and enhance the CDs bioimaging and antitumor activity. The boronic acid was directly introduced to carbon dots (CDs) via pyrolysis process to drive CDs specifically to the cancer cell, and chalcone was mediated on CDs by ultrasonication to perform facile release of the drug delivery model...
2023: Nanotheranostics
https://read.qxmd.com/read/37064611/current-trends-in-nanotheranostics-a-concise-review-on-bioimaging-and-smart-wearable-technology
#27
REVIEW
Amit Kumar Sharma
The area of interventional nanotheranostics combines the use of interventional procedures with nanotechnology for the detection and treatment of physiological disorders. Using catheters or endoscopes, for example, interventional techniques make use of minimally invasive approaches to diagnose and treat medical disorders. It is feasible to increase the precision of these approaches and potency by integrating nanotechnology. To visualize and target various parts of the body, such as tumors or obstructed blood veins, one can utilize nanoscale probes or therapeutic delivery systems...
2023: Nanotheranostics
https://read.qxmd.com/read/37064610/hybrid-inorganic-complexes-as-cancer-therapeutic-agents-in-vitro-validation
#28
JOURNAL ARTICLE
Murlidhar A Betallu, Shaileshkumar R Bhalara, Kailash B Sapnar, Vijay B Tadke, Keerti Meena, Ananya Srivastava, Gopal C Kundu, Mahadeo Gorain
A series of novel mixed transition metal-Magnesium tartarate complexes of general formulation [MMg(C4 H4 O6 )2 . xH2 O] (where M = Mn, Fe, Co, Ni, Cu and Zn) is prepared with bidentate tartarate ligand. The synthesized complexes (C1 to C6) are characterized by various analytical techniques such as Elemental analysis, Thermo gravimetric analysis, FT-IR Spectroscopy, X-ray Diffraction, Magnetic susceptibility study etc. All complexes exhibit the composition MMgL2 where M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) and L = bidentate tartarate ligand...
2023: Nanotheranostics
https://read.qxmd.com/read/37064609/engineering-molecular-nanoprobes-to-target-early-atherosclerosis-precise-diagnostic-tools-and-promising-therapeutic-carriers
#29
REVIEW
Chunfang Zan, Jie An, Zhifang Wu, Sijin Li
Atherosclerosis, an inflammation-driven chronic blood vessel disease, is a major contributor to devastating cardiovascular events, bringing serious social and economic burdens. Currently, non-invasive diagnostic and therapeutic techniques in combination with novel nanosized materials as well as established molecular targets are under active investigation to develop integrated molecular imaging approaches, precisely visualizing and/or even effectively reversing early-stage plaques. Besides, mechanistic investigation in the past decades provides many potent candidates extensively involved in the initiation and progression of atherosclerosis...
2023: Nanotheranostics
https://read.qxmd.com/read/37064608/preclinical-safety-assessment-of-photoluminescent-metal-quantum-clusters-stabilized-with-autologous-serum-proteins-for-host-specific-theranostics
#30
JOURNAL ARTICLE
Kritika Sood, Pranjali Yadav, Manu Jamwal, Reena Das, Asifkhan Shanavas
Host derived serum proteome stabilised red-emitting gold quantum clusters (or Au-QC-NanoSera or QCNS) of size range ~2 nm have been synthesised in a first reported study. The host serum was taken from bovine, murine and human origins to establish the proof of concept. In-vitro biocompatibility with normal murine L929 fibroblast cells and radiosensitisation ability against PLC/PRF/5 hepatoma cells was established. A concentration dependant radiosensitisation effect of QCNS at differential γ-radiation doses was observed with almost 90% killing of cancer cells at a radiation dose of 5Gy...
2023: Nanotheranostics
https://read.qxmd.com/read/37064607/curcumin-nanofiber-pcl-plga-collagen-enhanced-the-therapeutic-efficacy-of-mesenchymal-stem-cells-against-liver-fibrosis-in-animal-model-and-prevented-its-recurrence
#31
JOURNAL ARTICLE
Gehan Abd-Elfatah Tawfeek, Hend Ahmed Kasem, Sherif Elsayed Elshoala
The aim of this study is preconditioning of hBM-MSCs using curcumin modified nanomembrane to optimize therapy of hepatic fibrosis and preventing its recurrence. Methods: The nanomembrane was prepared by electrospinning technique and characterized using conventional method (cur- nanoscaffold and cur+ nanoscaffold). Kinetic release of curcumin was also measured by spectrophotometry. MSCs were isolated from human bone marrow (hBM-MSCs) and cultured on the both nanoscaffolds. We evaluated the in-vivo effect of hBM-MSCs from both nanoscaffold cultures (cur- nanoscaffold/hMSCs and cur+ nanoscaffold/MSCs) on liver fibrosis from its effective and preventive points and we assessed the mechanisms of these effects as in vitro studies as cell proliferation, its effect on hepatogenic differentiation, its effect on paracrine release of hBM-MSCs and in-vivo studying the effect on cell migration, survival, engraftment, fate of transplanted cells, modifying the fibrogenic and inflammatory microenvironments...
2023: Nanotheranostics
https://read.qxmd.com/read/36793354/interventional-nanotheranostics-in-hepatocellular-carcinoma
#32
REVIEW
Vivek P Chavda, Pankti C Balar, Srushti B Patel
Interventional nanotheranostics is a system of drug delivery that does a dual function; along with the therapeutic action, it also does have diagnostic features. This method helps in early detection, targeted delivery, and the least chances of damage to surrounding tissue. It ensures the highest efficiency for the management of the disease. Imaging is the near future for the quickest and most accurate detection of disease. After combing both effective measures, it ensures the most meticulous drug delivery system...
2023: Nanotheranostics
https://read.qxmd.com/read/36793353/longitudinal-nmr-based-serum-metabolomics-to-track-the-potential-serum-biomarkers-of-septic-shock
#33
JOURNAL ARTICLE
Swarnima Pandey, Afzal Azim, Neeraj Sinha
Background: Septic shock, with a prolonged hospital stay, has the highest mortality rate worldwide. There is a need for better management of the disease, which requires time-dependent analysis of alteration occurring in the disease condition and subsequent planning of treatment strategies to curb mortality. Objective: The study aims to identify early metabolic signatures associated with septic shock before treatment and post-treatment. It also entails the progression of patients towards recovery, which clinicians could use to analyze treatment efficacy...
2023: Nanotheranostics
https://read.qxmd.com/read/36793352/nanotheranostics-based-management-of-head-and-neck-cancer
#34
REVIEW
Vivek P Chavda, Pankti C Balar, Srushti B Patel
Head and neck cancer is affecting a large sort of population. Many treatments are available on a regular base, but they have their limitations. Diagnosis in the early stage is essential to cope with the disease which is a limitation in the majority of present diagnostic tools. Many of them are invasive methods that lead to patient discomfort. Interventional nanothernostics is an emerging field in the management of Head and Neck cancer. It facilitates both diagnostic and therapeutic approaches. It also helps with the overall management of the disease...
2023: Nanotheranostics
https://read.qxmd.com/read/36793351/drug-encapsulated-lipid-polymeric-nanohybrid-as-a-chemo-therapeutic-platform-of-cancer
#35
JOURNAL ARTICLE
Rahul Kumar, Vinish Ranjan Srivastava, Supratim Mahapatra, Daphika S Dkhar, Rohini Kumari, Kumari Prerna, Vikash Kumar Dubey, Pranjal Chandra
The focus of this research is to design a bioengineered drug delivery vehicle that is efficient in anti-cancer drug delivery in a controlled manner. The experimental work focuses on constructing a methotrexate-loaded nano lipid polymer system (MTX-NLPHS) that can transport methotrexate (MTX) in MCF-7 cell lines in a controlled manner through endocytosis via phosphatidylcholine. In this experiment, MTX is embedded with polylactic-co-glycolic acid (PLGA) in phosphatidylcholine, which acts as a liposomal framework for regulated drug delivery...
2023: Nanotheranostics
https://read.qxmd.com/read/36793350/high-resolution-synchrotron-k-edge-subtraction-ct-allows-tracking-and-quantifying-therapeutic-cells-and-their-scaffold-in-a-rat-model-of-focal-cerebral-injury-and-can-serve-as-a-reference-for-spectral-photon-counting-ct
#36
JOURNAL ARTICLE
Clément Tavakoli, Elisa Cuccione, Chloé Dumot, Joëlle Balegamire, Salim Aymeric Si-Mohamed, Johoon Kim, Claire Crola-da-Silva, Yves Chevalier, Loïc Boussel, Philippe Douek, David Cormode, Hélène Elleaume, Emmanuel Brun, Marlène Wiart
Background: The objective of this study was to demonstrate that synchrotron K-edge subtraction tomography (SKES-CT) can simultaneously track therapeutic cells and their encapsulating carrier, in vivo, in a rat model of focal brain injury using a dual-contrast agent approach. The second objective was to determine if SKES-CT could be used as a reference method for spectral photon counting tomography (SPCCT). Methods: Phantoms containing different concentrations of gold and iodine nanoparticles (AuNPS/INPs) were imaged with SKES-CT and SPCCT to assess their performances...
2023: Nanotheranostics
https://read.qxmd.com/read/36793349/personalized-biosensors-for-point-of-care-diagnostics-from-bench-to-bedside-applications
#37
EDITORIAL
Pranjal Chandra
The most significant feature of translational point-of-care technology "Personalized biosensors" is that it can be done quickly and by clinical staff who are not trained in clinical laboratory sciences. Rapid test results can quickly give a doctor or other medical worker answers that can help them decide what to do or how to treat a patient. This is helpful almost everywhere, from the emergency room to a patient getting care at home. When a doctor meets a patient for the first time, during a flare-up of a known problem or when a new symptom shows up in a patient who is already being treated, having faster access to test results gives the doctor answers when they are with the patient or are about to see the patient which indicate the importance of point-of-care technologies and their future scope...
2023: Nanotheranostics
https://read.qxmd.com/read/36793348/a-perspective-on-using-organic-molecules-composing-carbon-dots-for-cancer-treatment
#38
REVIEW
Musbahu Adam Ahmad, Yu-Yu Aung, Alfa Akustia Widati, Satya Candra Wibawa Sakti, Sri Sumarsih, Irzaman Irzaman, Brian Yuliarto, Jia-Yaw Chang, Mochamad Zakki Fahmi
Fluorescent Carbon dots (CDs) derived from biologically active sources have shown enhanced activities compared to their precursors. With their prominent potentiality, these small-sized (<10nm) nanomaterials could be easily synthesized from organic sources either by bottom-up or green approach. Their sources could influence the functional groups present on the CDs surfaces. A crude source of organic molecules has been used to develop fluorescent CDs. In addition, pure organic molecules were also valuable in developing practical CDs...
2023: Nanotheranostics
https://read.qxmd.com/read/36793347/gold-nanoparticles-conjugated-with-dendrigraft-poly-l-lysine-and-folate-targeted-poly-ethylene-glycol-for-sirna-delivery-to-prostate-cancer
#39
JOURNAL ARTICLE
Georges Minassian, Esther Ghanem, Roland El Hage, Kamil Rahme
Dendrigraft Poly-L-Lysine (d-PLL) coated gold nanoparticles (AuNPs) were synthesized by reducing Tetrachloroauric acid with ascorbic acid in the presence of d-PLL. AuNPs-d-PLL formed a stable colloidal solution that absorbs light at a maximum wavelength (λmax ) centered at 570 nm as demonstrated by UV-visible (UV-Vis) spectroscopy. From Scanning Electron Microscopy (SEM) analysis, AuNPs-d-PLL were spherical in shape with a mean diameter of 128 ± 47 nm. Dynamic Light scattering (DLS) analysis of the colloidal solution exhibited one size distribution with a hydrodynamic diameter of about 131 nm (size distribution by intensity)...
2023: Nanotheranostics
https://read.qxmd.com/read/36593801/development-of-a-personalised-device-for-systemic-magnetic-drug-targeting-to-brain-tumours
#40
JOURNAL ARTICLE
Priya Patel, Areej Alghamdi, Gary Shaw, Christopher Legge, Maggie Glover, Danielle Freeman, Harry Hodgetts, Erica Wilson, Faith Howard, Sarah Staniland, Aneurin J Kennerley, Duncan Wood, Robert Moorehead, Charlotte Hadfield, Ola Rominiyi, Jon Griffin, Spencer J Collis, Sam Hyde, Marcus Crossley, Martyn Paley, Munitta Muthana
Delivering therapies to deeply seated brain tumours (BT) is a major clinical challenge. Magnetic drug targeting (MDT) could overcome this by rapidly transporting magnetised drugs directly into BT. We have developed a magnetic device for application in murine BT models using an array of neodymium magnets with a combined strength of 0.7T. In a closed fluidic system, the magnetic device trapped magnetic nanoparticles (MNP) up to distances of 0.8cm. In mice, the magnetic device guided intravenously administered MNP (<50nm) from the circulation into the brain where they localised within mouse BT...
2023: Nanotheranostics
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