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Derek Reichel, Manisha Tripathi, J Manuel Perez
Biological interactions between tumor-associated macrophages (TAMs), cancer cells and other cells within the tumor microenvironment contribute to tumorigenesis, tumor growth, metastasis and therapeutic resistance. TAMs can remodel the tumor microenvironment to reduce growth barriers such as the dense extracellular matrix and shift tumors towards an immunosuppressive microenvironment that protects cancer cells from targeted immune responses. Nanoparticles can interrupt these biological interactions within tumors by altering TAM phenotypes through a process called polarization...
2019: Nanotheranostics
Ling Ye, Rui Hu, Liwei Liu, Jianwei Liu, Jing Liu, Hongyan Chen, Yazhuo Hu, Yaqian Liu, Xin Liu, Cui Liu, Danny Jian Hang Tng, Yuanguang Meng, Junle Qu, Mark T Swihart, Ken-Tye Yong
Rationale: Despite growing use of engineered nanomaterials (ENM) in applications from electronics to medicine, the potential risk to human health remains a critical concern within clinical use. ENM exposure during pregnancy can potentially cause reproductive toxicity even at levels that produce no measurable harm to animals in normal conditions. Methods: Phospholipid micelle-encapsulated CdSe/CdS/ZnS semiconductor nanocrystals with an average hydrodynamic diameter of 60 nm were intravenously injected during pregnancy in both rodent and nonhuman primate animal models...
2019: Nanotheranostics
Liqun Huang, Chang Xu, Peng Xu, Yu Qin, Mengwei Chen, Qishuai Feng, Jing Pan, Qian Cheng, Feng Liang, Xiaofei Wen, Ying Wang, Yufang Shi, Yu Cheng
Targeted delivery of nanomedicines into the tumor site and improving the intratumoral distribution remain challenging in cancer treatment. Here, we report an effective transportation system utilizing both of mesenchymal stem cells (MSCs) and their secreted microvesicles containing assembled gold nanostars (GNS) for targeted photothermal therapy of prostate cancer. The stem cells act as a cell carrier to actively load and assemble GNS into the lysosomes. Accumulation of GNS in the lysosomes facilitates the close interaction of nanoparticles, which could result in a 20 nm red-shift of surface plasmon resonance of GNS with a broad absorption in the near infrared region...
2019: Nanotheranostics
Aswathy Ravindran Girija, Sivakumar Balasubramanian
Theragnostics is considered as an emerging treatment strategy that integrates therapeutics and diagnostics thus allowing delivery of therapeutics and simultaneous monitoring of the progression of treatment. Among the different types of inorganic nanomaterials that are being used for nanomedicine, core shell mesoporous silica nanoparticles have emerged as promising multifunctional nanoplatform for theragnostic application. Research in the design of core/shell mesoporous silica nanoparticles is steadily diversifying owing to the various interesting properties of these nanomaterials that are advantageous for advanced biomedical applications...
2019: Nanotheranostics
Yupeng Shi, Flavien Guenneau, Xiaolin Wang, Christophe Hélary, Thibaud Coradin
Multifunctional nanomaterials combining diagnosis and therapeutic properties have attracted a considerable attention in cancer research. Yet some important challenges are still to be faced, including an optimal coupling between these two types of properties that would be effective within complex biological tissues. To address these points, we have prepared novel nanoplatforms associating controlled drug delivery of doxorubicin and Magnetic Resonance Imaging (MRI) contrast-enhancement that exhibit high specificity towards cancer cells compared to normal cells and evaluated them both in 2D cultures and within 3D tissue-like biomimetic matrices...
2018: Nanotheranostics
Samantha T Tucci, Jai W Seo, Hamilton Kakwere, Azadeh Kheirolomoom, Elizabeth S Ingham, Lisa M Mahakian, Sarah Tam, Spencer Tumbale, Mo Baikoghli, R Holland Cheng, Katherine W Ferrara
Squalenoylation of gemcitabine, a front-line therapy for pancreatic cancer, allows for improved cellular-level and system-wide drug delivery. The established methods to conjugate squalene to gemcitabine and to form nanoparticles (NPs) with the squalenoylated gemcitabine (SqGem) conjugate are cumbersome, time-consuming and can be difficult to reliably replicate. Further, the creation of multi-functional SqGem-based NP theranostics would facilitate characterization of in vivo pharmacokinetics and efficacy. Methods : Squalenoylation conjugation chemistry was enhanced to improve reliability and scalability using tert-butyldimethylsilyl (TBDMS) protecting groups...
2018: Nanotheranostics
Feng Yin, Tommy Anderson, Nishtha Panwar, Kang Zhang, Swee Chuan Tjin, Beng Koon Ng, Ho Sup Yoon, Junle Qu, Ken-Tye Yong
Transition metal dichalcogenides (TMDCs) are categorized as novel two-dimensional (2D) nanomaterials with unique physical and chemical properties, bearing varied applications in medical and materials sciences. However, only a few works report the application of TMDCs for gene therapy in cancer treatment. Here, we engineer a multi-gene delivery system based on functionalized monolayer MoS2 , which can co-deliver HDAC1 and KRAS small interfering RNAs (siRNAs) to Panc-1 cancer cells for combinational cancer therapy...
2018: Nanotheranostics
Yongmei Zhao, Nicholas L Fletcher, Tianqing Liu, Anna C Gemmell, Zachary H Houston, Idriss Blakey, Kristofer J Thurecht
Targeted nanomedicines offer many advantages over macromolecular therapeutics that rely only on passive accumulation within the tumour environment. The aim of this work was to investigate the in vivo anticancer efficiency of polymeric nanomedicines that were conjugated with peptide aptamers that show high affinity for receptors on many cancer cells. In order to assess the ability for the nanomedicine to treat cancer and investigate how structure affected the behavior of the nanomedicine, three imaging modalities were utilized, including in vivo optical imaging, multispectral optoacoustic tomography (MSOT) and ex vivo confocal microscopy...
2018: Nanotheranostics
Shuxin Li, Wei Cong, Amirhossein Hakamivala, YiHui Huang, Joseph Borrelli, Liping Tang
Osteoarthritis is typically caused by cartilage injury, followed by localized inflammatory responses and tissue deterioration. Early treatment of osteoarthritis is often impossible due to the lack of diagnostic options. Recent studies have supported that different imaging probes can be used for arthritis detection in mice. However, none of these diagnostic tools have been tested on human articular cartilage. To fill this gap, an optical imaging probe was developed to target activated macrophages and the accumulation of imaging probes on tissue was used to assess the severity of human osteoarthritis...
2018: Nanotheranostics
Valeriy M Paramonov, Diti Desai, Helene Kettiger, Veronika Mamaeva, Jessica M Rosenholm, Cecilia Sahlgren, Adolfo Rivero-Müller
The concept of delivering nanoformulations to desired tissues by means of targeting membrane receptors of high local abundance by ligands anchored to the nanocarrier has gained a lot of attention over the last decade. Currently, there is no unanimous opinion on whether surface functionalization of nanocarriers by targeting ligands translates into any real benefit in terms of pharmacokinetics or treatment outcomes. Having examined the published nanocarriers designed to engage with somatostatin receptors, we realized that in the majority of cases targetability claims were not supported by solid evidence of targeting ligand-targeted receptor coupling, which is the very crux of a targetability concept...
2018: Nanotheranostics
Kai Li, Carmel T Chan, Hossein Nejadnik, Olga D Lenkov, Cody Wolterman, Ramasamy Paulmurugan, Huaxiao Yang, Sanjiv Sam Gambhir, Heike E Daldrup-Link
Purpose: Stem cell transplants are an effective approach to repair large bone defects. However, comprehensive techniques to monitor the fate of transplanted stem cells in vivo are lacking. Such strategies would enable corrective interventions at an early stage and greatly benefit the development of more successful tissue regeneration approaches. In this study, we designed and synthesized a dual-modality imaging probe (Feru-AFC) that can simultaneously localize transplanted stem cells and diagnose immune rejection-induced apoptosis at an early stage in vivo ...
2018: Nanotheranostics
Shellie S Knights-Mitchell, Marek Romanowski
Precise control of drug release from nanoparticles can improve efficacy and reduce systemic toxicity associated with administration of certain medications. Here, we combined two phenomena, photothermal conversion in plasmon resonant gold coating and thermal sensitivity of liposome compositions, to achieve a drug delivery system that rapidly releases doxorubicin in response to external stimulus. Methods: Thermosensitive liposomes were loaded with doxorubicin and gold-coated to produce plasmon resonant drug delivery system...
2018: Nanotheranostics
Liang Zhang, Haixin Cui
Among all cancers, lung cancer is one of the most common and serious types of cancer. It is challenging for site-specific delivery of anticancer therapeutics to tumor cells. Herein, we developed a novel"smart" dual-targeting liposomal platform to respond to the highly expressed hyaluronidase (HAase) in the tumor microenvironment and improve tumor targeting and antitumor efficacy. Methods: In our design, the HA was used as a sensitive linker between a liposomal lipid and long chain PEG block to synthesize three functional conjugates in order to prepare"smart" liposomal platform modified with epidermal growth factor receptor (EGFR) antibody (GE11) and cell-penetrating peptide (TATp)...
2018: Nanotheranostics
Ling Kong, Jiayi Li, Jilong Wang, Yue Hu, Peijun Meng, Yamin Xiong, Peili Huang
Objective: Quantum dots (QDs) has widely applied in the field of science, whose potential toxic effect has increasingly become a focus concern we need pay attention to in public health. The purpose of this article was to explore the toxicity mechanism with oxidative damage from treatment with QDs at the molecular level through a gene microarray. Methods: Mice were administered aqueously synthesized cadmium telluride QDs (CdTe aqQDs) via intravenous tail injection of a 2 µmol/kg solution (based on the molar mass of Cd), and their kidneys were collected at 1 day in strict accordance with the programs used for treated mice...
2018: Nanotheranostics
Moritz F Kircher
No abstract text is available yet for this article.
2018: Nanotheranostics
Edyta Swider, Khalid Daoudi, Alexander H J Staal, Olga Koshkina, N Koen van Riessen, Eric van Dinther, I Jolanda M de Vries, Chris L de Korte, Mangala Srinivas
Photoacoustic imaging (PAI) is an emerging biomedical imaging technique that is now coming to the clinic. It has a penetration depth of a few centimeters and generates useful endogenous contrast, particularly from melanin and oxy-/deoxyhemoglobin. Indocyanine green (ICG) is a Food and Drug Administration-approved contrast agents for human applications, which can be also used in PAI. It is a small molecule dye with limited applications due to its fast clearance, rapid protein binding, and bleaching effect. Methods: Here, we entrap ICG in a poly(lactic- co -glycolic acid) nanoparticles together with a perfluorocarbon (PFC) using single emulsion method...
2018: Nanotheranostics
Syue-Liang Lin, Zi-Rong Chen, C Allen Chang
To perform photothermal therapy (PTT) and luminescence imaging by a single wavelength NIR light irradiation, we have designed and prepared a novel nanocomposite incorporating the IR806 photothermal sensitizers (PTS) into the core-shell-shell NaYF4 :Yb,Er@ NaYF4 :Yb@NaYF4 :Yb,Nd up-conversion nanoparticles (UCNPs). Irradiation with the 793 nm near-infrared (NIR) laser, the Nd3+ ions in the UCNPs were sensitized to up-convert energy via Yb3+ to the Er3+ ions to emit visible light at 540 nm and 654 nm, as well as to down-convert energy to the Yb3+ ions to emit NIR light at 980 nm...
2018: Nanotheranostics
Erdong Li, Yanmei Yang, Guangyu Hao, Xuan Yi, Shaohua Zhang, Yue Pan, Bengang Xing, Mingyuan Gao
In this study, we report novel multifunctional nanoagents for in vivo enzyme-responsive anticancer drug delivery and magnetic resonance imaging (MRI), based on mesoporous silica coated iron oxide nanoparticles (Fe3 O4 @MSNs). The anticancer drug, DOX, was encapsulated in the porous cavities with a MMP-2 enzyme responsive peptide being covalently linked to the nanoparticles surface. The in vitro experiment results indicated that the enzyme responsive nanoagents own high specificity for controlled drug release in the cell line with high MMP-2 expression...
2018: Nanotheranostics
Yun Liu, Yu Qi, Chunyang Yin, Shunhao Wang, Shuping Zhang, An Xu, Wei Chen, Sijin Liu
Rationale: Graphene oxide (GO) has shown great promises in biomedical applications, such as drug delivery and thermotherapeutics, owing to its extraordinary physicochemical properties. Nonetheless, current biomedical applications of GO materials are premised on the basis of predesigned functions, and little consideration has been given to the influence of bio-transformation in the physiological environment on the physicochemical properties and predesigned functionalities of these materials. Hence, it is crucial to uncover the possible influence on GO's physicochemical properties and predesigned functionalities for better applications...
2018: Nanotheranostics
Shuyao Li, Shuwei Liu, Lu Wang, Min Lin, Rui Ge, Xing Li, Xue Zhang, Yi Liu, Lening Zhang, Hongchen Sun, Hao Zhang, Bai Yang
Polypyrrole (PPy) nanoparticles (NPs) possess high near-infrared absorption and good biosafety, showing the potentials as photothermal therapeutic materials. However, the single function and the weak diagnostic function limit the further combination with other functional units to achieve theranostics. In this work, polyaminopyrrole (PPy-NH2 ) is demonstrated as the alternative of PPy for preparing NPs. Because of the amino group, metal ions, such as Cu(II) and Fe(III) can be loaded in PPy-NH2 NPs, which extends the applications in multimodal theranostics...
2018: Nanotheranostics
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