journal
https://read.qxmd.com/read/38444744/surface-engineered-nanohybrids-in-plasmonic-photothermal-therapy-for-cancer-regulatory-and-translational-challenges
#1
REVIEW
Monalisha Debnath, Sujit Kumar Debnath, Mangal Vishnu Talpade, Shweta Bhatt, Prem Prakash Gupta, Rohit Srivastava
Plasmonic materials as non-invasive and selective treatment strategies are gaining increasing attention in the healthcare sector due to their remarkable optical and electronic properties, where the interface between matter and light becomes enhanced and highly localized. Some attractive applications of plasmonic materials in healthcare include drug delivery to target specific tissues or cells, hence reducing the side effects of the drug and improving their efficacy; enhancing the contrast and resolution in bioimaging; and selectively heating and destroying the cancerous cells while parting the healthy cells...
2024: Nanotheranostics
https://read.qxmd.com/read/38444743/recent-trends-in-bio-nanomaterials-and-non-invasive-combinatorial-approaches-of-photothermal-therapy-against-cancer
#2
REVIEW
Nitisha Beniwal, Anamika Verma, Chandra Lekha Putta, Aravind Kumar Rengan
In 2020, approximately 10 million deaths worldwide were attributed to cancer, making it the primary cause of death globally. Photothermal therapy (PTT) is one of the novel ways to treat and abolish cancer. PTT significantly impacts cancer theranostics compared to other therapies like surgery, chemotherapy, and radiotherapy due to its remarkable binding capability to tumor sites and lower invasiveness into normal healthy tissues. PTT relies on photothermal agents (PTAs), which generate heat by absorbing the near-infrared (NIR) light and destroying cancer cells...
2024: Nanotheranostics
https://read.qxmd.com/read/38444742/a-lipo-polymeric-hybrid-nanosystem-with-metal-enhanced-fluorescence-for-targeted-imaging-of-metastatic-breast-cancer
#3
JOURNAL ARTICLE
Tejaswini Appidi, Rajalakshmi P Sivasankaran, Shubham A Chinchulkar, Paloma Patra, Kavipriya Murugaiyan, Bantal Veeresh, Aravind Kumar Rengan
Cancer metastasis plays a major role in failure of therapeutic avenues against cancer. Owing to metastasis, nearly 70-80% of stage IV breast cancer patients lose their lives. Nanodrug delivery systems are playing a critical role in the therapy of metastatic cancer in the recent times. This paper reports the enhanced permeation and retention (EPR) based targeting of metastatic breast cancer using a novel nano lipo-polymeric system (PIR-Au NPs). The PIR-Au NPs demonstrated an increase in fluorescence by virtue of surface coating with gold, owing to the metal enhanced fluorescence phenomenon as reported in our earlier reports...
2024: Nanotheranostics
https://read.qxmd.com/read/38444741/recurring-sars-cov-2-variants-an-update-on-post-pandemic-co-infections-and-immune-response
#4
REVIEW
Ashmit Verma, Anjali Manojkumar, Anupam Dhasmana, Manish K Tripathi, Meena Jaggi, Subhash C Chauhan, Deepak S Chauhan, Murali M Yallapu
The post-pandemic era following the global spread of the SARS-CoV-2 virus has brought about persistent concerns regarding recurring coinfections. While significant strides in genome mapping, diagnostics, and vaccine development have controlled the pandemic and reduced fatalities, ongoing virus mutations necessitate a deeper exploration of the interplay between SARS-CoV-2 mutations and the host's immune response. Various vaccines, including RNA-based ones like Pfizer and Moderna, viral vector vaccines like Johnson & Johnson and AstraZeneca, and protein subunit vaccines like Novavax, have played critical roles in mitigating the impact of COVID-19...
2024: Nanotheranostics
https://read.qxmd.com/read/38444740/integrable-magnetic-fluid-hyperthermia-systems-for-3d-magnetic-particle-imaging
#5
JOURNAL ARTICLE
André Behrends, Huimin Wei, Alexander Neumann, Thomas Friedrich, Anna C Bakenecker, Jochen Franke, Kulthisa Sajjamark, Oliver Buchholz, Sébastien Bär, Ulrich G Hofmann, Matthias Graeser, Thorsten M Buzug
Background: Combining magnetic particle imaging (MPI) and magnetic fluid hyperthermia (MFH) offers the ability to perform localized hyperthermia and magnetic particle imaging-assisted thermometry of hyperthermia treatment. This allows precise regional selective heating inside the body without invasive interventions. In current MPI-MFH platforms, separate systems are used, which require object transfer from one system to another. Here, we present the design, development and evaluation process for integrable MFH platforms, which extends a commercial MPI scanner with the functionality of MFH...
2024: Nanotheranostics
https://read.qxmd.com/read/38444739/chitosan-nanoplatform-for-the-co-delivery-of-palbociclib-and-ultra-small-magnesium-nanoclusters-dual-receptor-targeting-therapy-and-imaging
#6
JOURNAL ARTICLE
Abhishesh Kumar Mehata, Virendra Singh, Vikas, Prachi Srivastava, Biplob Koch, Manoj Kumar, Madaswamy S Muthu
Theranostic nanoparticles have gained significant attention in cancer diagnosis and therapy. In this study, estrone (ES) and folic acid (FA) functionalized single and dual receptor targeted theranostic chitosan nanoparticles were developed for breast cancer imaging and therapy. These nanoparticles (NPs) were loaded with palbociclib (PB) and ultra-small magnesium nanoclusters (UMN). The developed nontargeted theranostic NPs (PB-UMN-CS-NPs), estrogen receptor targeted theranostic NPs (PB-UMN-CS-ES-NPs), folate receptor targeted theranostic NPs (PB-UMN-CS-FA-NPs), and dual targeted theranostic NPs (PB-UMN-CS-ES-FA-NPs) have particle sizes of 178...
2024: Nanotheranostics
https://read.qxmd.com/read/38328615/biodegradable-nanocomposite-of-zns-mn-quantum-dots-immobilized-graphene-oxide-for-bioimaging-applications
#7
JOURNAL ARTICLE
Pavithra Kurungottu, Midhun Ben Thomas, Mahesh M Lalitha, Prathiksha Ganesh, Divya Prakash Gnanadhas, Dipshika Chakravortty, Ashok M Raichur, Rajendra Kurapati
Developing a biocompatible and biodegradable graphene-based fluorescent nanoprobe with the ability to visualize live cells could be interesting for intracellular imaging and monitoring the efficiency of chemotherapy. Herein, we report a biodegradable and biocompatible hybrid fluorescent graphene oxide (GO)-ZnS(Mn) composite synthesized via in situ growth of ZnS(Mn) quantum dots (QDs) on the surface of GO in the aqueous medium. The prepared 'GO-ZnS(Mn)' composite was characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA) and high-resolution transmission electron microscopy (HR-TEM) along with selected area electron diffraction (SAED)...
2024: Nanotheranostics
https://read.qxmd.com/read/38328614/nanoparticles-for-thrombus-diagnosis-and-therapy-emerging-trends-in-thrombus-theranostics
#8
REVIEW
Samridhi, Aseem Setia, Abhishesh Kumar Mehata, Vishnu Priya, Aditi Pradhan, Pragya Prasanna, Syam Mohan, Madaswamy S Muthu
Cardiovascular disease is one of the chief factors that cause ischemic stroke, myocardial infarction, and venous thromboembolism. The elements that speed up thrombosis include nutritional consumption, physical activity, and oxidative stress. Even though the precise etiology and pathophysiology remain difficult topics that primarily rely on traditional medicine. The diagnosis and management of thrombosis are being developed using discrete non-invasive and non-surgical approaches. One of the emerging promising approach is ultrasound and photoacoustic imaging...
2024: Nanotheranostics
https://read.qxmd.com/read/38164505/three-dimensional-in-vitro-model-of-bone-metastases-of-neuroblastoma-as-a-tool-for-pharmacological-evaluations
#9
JOURNAL ARTICLE
Sanja Aveic, Max Seidelmann, Roswitha Davtalab, Diana Corallo, Michael Vogt, Stephan Rütten, Horst Fischer
In vitro metastatic models are foreseen to introduce a breakthrough in the field of preclinical screening of more functional small-molecule pharmaceuticals and biologics. To achieve this goal, the complexity of current in vitro systems requests an appropriate upgrade to approach the three-dimensional (3D) in vivo metastatic disease. Here, we explored the potential of our 3D β-tricalcium phosphate (β-TCP) model of neuroblastoma bone metastasis for drug toxicity assessment. Tailor-made scaffolds with interconnected channels were produced by combining 3D printing and slip casting method...
2024: Nanotheranostics
https://read.qxmd.com/read/38164504/drug-delivery-for-neurodegenerative-diseases-is-a-problem-but-lipid-nanocarriers-could-provide-the-answer
#10
REVIEW
Md Rajdoula Rafe
Neurodegenerative disorders encompass diseases that involve the degeneration of neurons, particularly those within the central nervous system. These are the most commonly observed disorders among the geriatric population. The treatment or management of this condition presents additional challenges due to therapeutics that may not be as effective as desired. The primary obstacle that often hinders the efficacy of therapy is the existence of a blood-brain barrier (BBB). The BBB serves as a vital safeguard for the brain, effectively obstructing the passage of drugs into the brain cells...
2024: Nanotheranostics
https://read.qxmd.com/read/38164503/gold-polymer-nanomaterials-a-promising-approach-for-enhanced-biomolecular-imaging
#11
REVIEW
Panangattukara Prabhakaran Praveen Kumar, Ritu Mahajan
Gold nanoparticles (AuNPs) possess unique optical properties, making them highly attractive nanomaterials for biomedical research. By exploiting the diverse optical characteristics of various gold nanostructures, significant enhancements can be achieved in biosensing and biomedical imaging fields. The potential of AuNPs can be enhanced by creating hybrid nanocomposites with polymers, which offer supplementary functionalities, responsiveness, and enhanced biocompatibility. Moreover, polymers can modify the surface charges of AuNPs, thereby improving or controlling the efficiency of cellular uptake and the distribution of these nanoparticles within the body...
2024: Nanotheranostics
https://read.qxmd.com/read/38164502/theranostic-phthalocyanine-and-naphthalocyanine-nanoparticles-for-photoacoustic-imaging-and-photothermal-therapy-of-tumors
#12
JOURNAL ARTICLE
Yiran Tian, Nicole Carrillo-Malani, Kailin Feng, Joann Miller, Theresa M Busch, Karthik M Sundaram, Zhiliang Cheng, Ahmad Amirshaghaghi, Andrew Tsourkas
Background: Phthalocyanine (PC) and naphthalocyanine (NC) dyes have long garnered interest as theranostic agents for optical imaging and phototherapy due to their near-infrared absorbance, photostability, imaging contrast, and proven safety in clinical trials. Yet, only a small fraction of these dyes has been evaluated as photothermal therapy (PTT) agents for cancer treatment. Methods: Nearly 40 distinct NC and PC dyes were encapsulated within polymeric PEG-PCL micelles via oil-in-water emulsions. The optimal NC/PC-loaded micelle formulations for PTT and photoacoustic (PA) imaging were identified through in vivo and in vitro studies...
2024: Nanotheranostics
https://read.qxmd.com/read/38164501/choice-of-nanoparticles-for-theranostics-engineering-surface-coating-to-nanovalves-approach
#13
REVIEW
Rajendra Prasad, Kaliaperumal Selvaraj
Surface engineered nanoparticles (metallic and nonmetallic) have gained tremendous attention for precise imaging and therapeutics of cell/tumors at molecular and anatomic levels. These tiny agents have shown their specific physicochemical properties for early-stage disease diagnosis and cancer theranostics applications (imaging and therapeutics by a single system). For example, gold nanorods (AuNRs) demonstrate better photothermal response and radiodensity for theranostics applications. However, upon near infrared light exposure these AuNRs lose their optical property which is characteristic of phototherapy of cancer...
2024: Nanotheranostics
https://read.qxmd.com/read/38164500/radioactive-gold-nanoparticles-coated-with-bsa-a-promising-approach-for-prostate-cancer-treatment
#14
JOURNAL ARTICLE
Angélica Bueno Barbezan, Wilmmer Alexander Arcos Rosero, Daniel Perez Vieira, Maria Eduarda Zaganin Rigo, Giovana Dias da Silva, Alex Alves Rodrigues, Luís Fernando de Almeida, Fábio Fernando Alves da Silva, Andy González Rivera, Natanael Gomes da Silva, Emerson S Bernardes, Carlos Alberto Zeituni, Maria Elisa C M Rostelato
Background: Nanotechnology has revolutionized medicine, especially in oncological treatments. Gold nanoparticles (AuNPs) stand out as an innovative alternative due to their biocompatibility, potential for surface modification, and effectiveness in radiotherapeutic techniques. Given that prostate cancer ranks as one of the leading malignancies among men, there's a pressing need to investigate new therapeutic approaches. Methods: AuNPs coated with bovine serum albumin (BSA) were synthesized and their cytotoxicity was assessed against prostate tumor cell lines (LNCaP and PC-3), healthy prostate cells (RWPE-1), and endothelial control cells (HUVEC) using the MTS/PMS assay...
2024: Nanotheranostics
https://read.qxmd.com/read/38164499/fibrin-targeted-phase-shift-microbubbles-for-the-treatment-of-microvascular-obstruction
#15
JOURNAL ARTICLE
Soheb Anwar Mohammed, Muhammad Wahab Amjad, Maria F Acosta, Xucai Chen, Linda Lavery, Dillon Hanrahan, Evan C Unger, Emmanuelle J Meuillet, John J Pacella
Rationale: Microvascular obstruction (MVO) following percutaneous coronary intervention (PCI) is a common problem associated with adverse clinical outcomes. We are developing a novel treatment, termed sonoreperfusion (SRP), to restore microvascular patency. This entails using ultrasound-targeted microbubble cavitation (UTMC) of intravenously administered gas-filled lipid microbubbles (MBs) to dissolve obstructive microthrombi in the microvasculature. In our prior work, we used standard-sized lipid MBs. In the present study, to improve upon the efficiency and efficacy of SRP, we sought to determine the therapeutic efficacy of fibrin-targeted phase shift microbubbles (FTPSMBs) in achieving successful reperfusion of MVO...
2024: Nanotheranostics
https://read.qxmd.com/read/38164498/enrichment-of-sweat-derived-extracellular-vesicles-of-human-and-bacterial-origin-for-biomarker-identification
#16
JOURNAL ARTICLE
Artem Zhyvolozhnyi, Anatoliy Samoylenko, Geneviève Bart, Anna Kaisanlahti, Jenni Hekkala, Olha Makieieva, Feby Pratiwi, Ilkka Miinalainen, Mika Kaakinen, Ulrich Bergman, Prateek Singh, Tuomas Nurmi, Elham Khosrowbadi, Eslam Abdelrady, Sakari Kellokumpu, Susanna Kosamo, Justus Reunanen, Juha Röning, Jussi Hiltunen, Seppo J Vainio
Sweat contains biomarkers for real-time non-invasive health monitoring, but only a few relevant analytes are currently used in clinical practice. In the present study, we investigated whether sweat-derived extracellular vesicles (EVs) can be used as a source of potential protein biomarkers of human and bacterial origin. Methods: By using ExoView platform, electron microscopy, nanoparticle tracking analysis and Western blotting we characterized EVs in the sweat of eight volunteers performing rigorous exercise...
2024: Nanotheranostics
https://read.qxmd.com/read/37650012/synthesis-of-polycationic-nanoparticles-for-microbial-inhibition-and-killing
#17
JOURNAL ARTICLE
Swati Saini, Aruna Kukrety, Pratima Ashok Patel, Umesh Kumar, T Senthilkumar
Antimicrobial polymers (AMP) appear to be a promising candidate to deal with the current scenario of bacterial resistance against conventional drugs and antibiotics as they mainly depend on disrupting the bacterial membrane. This work investigates the effect of polycations bearing aromatic and aliphatic pendant cationic groups on the antimicrobial performance of AMP. A radical polymerization strategy was adopted to synthesize two different copolymers and convert them into polycations upon post-modification...
2023: Nanotheranostics
https://read.qxmd.com/read/37650011/magnetic-resonance-imaging-and-iron-oxide-nanoparticles-in-the-era-of-personalized-medicine
#18
REVIEW
Mahbuba Rahman
Medical imaging is an important factor for diagnosis. It can be used to diagnose patients, differentiate disease stages, and monitor treatment regimens. Although different imaging technologies are available, MRI is sensitive over other imaging modalities as it is capable of deep tissue penetration allowing to image the anatomical, structural, and molecular level of diseased organs. Thus, it can be used as screening tool for disease staging. One of the important components of imaging is contrast agents which are used to increase the sensitivity of MRI technology...
2023: Nanotheranostics
https://read.qxmd.com/read/37426882/peelable-microneedle-patches-deliver-fibroblast-growth-factors-to-repair-skin-photoaging-damage
#19
JOURNAL ARTICLE
Guojun Yang, Shiqi Hu, Haiyue Jiang, Ke Cheng
Rationale: UV light deeply penetrates the dermis, leading to inflammation and cell death with prolonged exposure. This is a major contributor to skin photoaging. In the pharmaceutical field, fibroblast growth factors (FGFs) have gained popularity for enhancing skin quality as they facilitate tissue remodeling and re-epithelization. Nonetheless, their effectiveness is significantly hindered by limited absorption. Methods: We have successfully created a dissolving microneedle (MN) patch that contains hyaluronic acid (HA) loaded with FGF-2 and FGF-21...
2023: Nanotheranostics
https://read.qxmd.com/read/37426881/spatial-analysis-of-nanoparticle-distribution-in-human-breast-xenografts-reveals-nanoparticles-targeted-to-cancer-cells-localized-with-tumor-associated-stromal-cells
#20
JOURNAL ARTICLE
Sean Healy, Elizabeth T Henderson, Suqi Ke, Jacqueline Kelly, Brian W Simons, Chen Hu, Robert Ivkov, Preethi Korangath
The biological influence of physicochemical parameters of "targeted" nanoparticles on their delivery to cancer tumors remains poorly understood. A comparative analysis of nanoparticle distributions in tumors following systemic delivery across several models can provide valuable insights. Methods: Bionized nanoferrite nanoparticles (iron oxide core coated with starch), either conjugated with a targeted anti-HER2 antibody (BH), or unconjugated (BP), were intravenously injected into athymic nude or NOD-scid gamma (NSG) female mice bearing one of five human breast cancer tumor xenografts growing in a mammary fat pad...
2023: Nanotheranostics
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