Amy E DeZern, Johannes B Goll, R Coleman Lindsley, Rafael Bejar, Steffanie H Wilson, Donnie Hebert, H Joachim Deeg, Ling Zhang, Steven D Gore, Tareq Al Baghdadi, Jaroslaw P Maciejewski, Jane Jijun Liu, Eric Padron, Rami S Komrokji, Wael Saber, Gregory A Abel, Steven H Kroft, Alexandra M Harrington, Tyler Grimes, Harrison H Vaughn Reed, Robert S Fulton, Nancy L DiFronzo, Nancy Gillis, Mikkael A Sekeres, Matthew J Walter
The National Heart, Lung, and Blood Institute National MDS Natural History Study (NCT02775383) is a prospective cohort study enrolling cytopenic patients with suspected myelodysplastic syndromes (MDS) to evaluate factors associated with disease. Here, we sequenced 53 genes in bone marrow samples harvested from 1,298 patients diagnosed with myeloid malignancy, including MDS and non-MDS myeloid malignancy, or alternative marrow conditions with cytopenia based on concordance between independent histopathologic reviews (local, centralized, and tertiary to adjudicate disagreements when needed)...
March 22, 2023: Blood Advances