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Advances in Respiratory Medicine

Justyna M Sobczak, Patryk A Sobczak, Katarzyna K Torbiarczyk, Joanna MIłkowska-Dymanowska, Adam Antczak, Paweł Górski, Adam J Białas, Wojciech Piotrowski
December 30, 2018: Advances in Respiratory Medicine
Paolo Solidoro, Francesco Guerrera
The role of interventional pulmonology in both the diagnostic and therapeutic aspects of haemopthysis is far to be completely defined. Even if we have to differentiate massive from mild and moderate bleeding it seems to be reasonable to asses that a bronchoscopy (fiberoptic or rigid) can be safely proposed in skilled centers with a wide range of immediate therapeutical interventional options, whether pneumological, either radiological or surgical.
December 30, 2018: Advances in Respiratory Medicine
Michał Zieliński, Piotr Sitek, Dariusz Ziora
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with poor prognosis. Although the underlying mechanisms are not fully understood, IPF is connected with lung cancer development, which farther worsens the prognosis. Various papers report IPF and cancer coexistence in 9.8% to even 82% of patients depending on observation period. Contrary to already established guidelines in the general population, there are no widely accepted recommendations on lung cancer treatment in IPF population. At the same time, various oncologic interventions can result in acute exacerbation of IPF...
December 30, 2018: Advances in Respiratory Medicine
Milan Sova, Samuel Genzor, Vítězslav Kolek, Filip Čtvrtlík, Amjad Ghazal Asswad, Ondřej Zela, Zdeněk Tauber
Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases (CVD) are commonly interconnected, and this coincidence negatively influences patients' mortality and morbidity. On the basis of the current available data originating mainly from cardiovascular studies epicardial fat (EF) has been proposed as a marker of cardiovascular risk. This review is focused on a potential role of epicardial fat as a new biomarker for risk stratification of COPD patients. Epicardial fat may present an important link between chronic obstructive pulmonary disease and cardiovascular diseases, mainly coronary artery disease...
December 30, 2018: Advances in Respiratory Medicine
Víctor A Santos, Gabriel J Tobón, Carlos A Cañas
Here the cases of three female patients who received long-term rituximab treatment for seropositive, erosive and deforming rheumatoid arthritis was reported. After rituximab treatment, they presented with recurrent sinusitis and pneumonia, followed by the subsequent development of bronchiectasis. A temporal relationship between rituximab treatment and the onset of respiratory complications was exposed as a possible pathogenic mechanism.
December 30, 2018: Advances in Respiratory Medicine
Isabel San Martin, Sada Elena Zarikian, Mercedes Herranz, Laura Moreno-Galarraga
Mycoplasma pneumoniae is a common respiratory pathogen, especially in children, responsible for community-acquired pneumonia. Although, in most cases, infections caused by this bacterium follow a benign self-limited clinical course, cases of severe respiratory infections have been reported. We present two pediatric cases of necrotizing pneumonia due to Mycoplasma pneumoniae. Both patients initially presented with low-grade fever, cough and mild respiratory symptoms, however, imaging techniques showed necrotizing pneumonia...
December 30, 2018: Advances in Respiratory Medicine
Masoud Nazemiyeh, Akbar Sharifi, Horiyeh Shojaan, Maryam Mohammadi, Sina Abdkarimi, Morteza Gojazadeh
INTRODUCTION: Early maladaptive schemas (EMSs) that are being shaped through the early period of development of humans have been reported to affect the functions of asthmatic patients. This study focuses on the probable relationship between the personality schemas and areas with severity of asthma. MATERIAL AND METHODS: Fifty asthmatic patients were entered this descriptive cross-sectional study in Tabriz University of Medical Sciences from March to August, 2016...
December 30, 2018: Advances in Respiratory Medicine
Sylwia Kwiatkowska, Ewa Augustynowicz-Kopeć, Maria Korzeniewska-Koseła, Dorota Filipczak, Paweł Gruszczyński, Anna Zabost, Magdalena Klatt, Małgorzata Sadkowska-Todys
INTRODUCTION: During the last decades the prevalence of NTM infections has increased, especially in developed countries. The aim of the study was to provide an overview on all NTM isolated from clinical samples in Poland between 2013 and 2017. MATERIAL AND METHODS: The study comprised 2799 clinical specimens, mostly respiratory accessed in the reference laboratory of National Tuberculosis and Lung Diseases Research Institute in Warsaw and in the Wielkopolska Center of Pulmonology and Thoracic Surgery, Poland, 2013-2017...
December 30, 2018: Advances in Respiratory Medicine
Marek Przybyszowski, Kinga Paciorek, Weronika Zastrzeżyńska, Agnieszka Gawlewicz-Mroczka, Anna Trojan-Królikowska, Anna Orłowska, Jerzy Soja, Wiesław Pawlik, Krzysztof Sładek
INTRODUCTION: Airway remodeling is an important factor in persistent obstruction in severe asthma. High resolution computed tomography (HRCT) is an effective method of detecting changes in airway structure. Our aim was to use HRCT to assess changes in airway remodeling in patients with severe allergic asthma who are treated with omalizumab. MATERIAL AND METHODS: In 12 patients with severe allergic asthma, HRCT was performed before and after treatment with omalizumab...
December 30, 2018: Advances in Respiratory Medicine
Konrad Leszek Mendrala, Dariusz Gajniak, Tomasz Cyzowski, Tomasz Czober, Danuta Gierek, Ewa Kucewicz-Czech
INTRODUCTION: Monitoring lung function during pneumonia is essential for the evaluation of the effectiveness of therapy in ICU patients. Among various bedside techniques, two particularly interesting are the lung ultrasound and the transpulmonary thermodilution technique. In this observational single center study we want to assess the correlation between the lung ultrasound examination (LUS) and transpulmonary thermodilution volumetric parameters such as extravascular lung water index (EVLWI) and pulmonary vascular permeability index (PVPI)...
December 30, 2018: Advances in Respiratory Medicine
Marta Dąbrowska, Elżbieta Magdalena Grabczak, Dorota Rojek, Anna Łobacz, Karolina Klimowicz, Olga Truba, Aleksandra Rybka, Antoni Krzeski, Rafał Krenke
INTRODUCTION: The efficacy of management of chronic cough in adults is limited. Speech therapy is one of the few therapeutic methods which seems to be useful in patients with persistent chronic cough. However, the method has not been available in Poland so far. The aim of the study was to implement speech therapy and assess its efficacy in the management of patients with difficult-to-treat chronic cough. MATERIAL AND METHODS: Patients, who were diagnosed and managed due to difficult-to-treat chronic cough, were enrolled into the study...
December 30, 2018: Advances in Respiratory Medicine
Monika Szturmowicz, Izabela Siemion-Szcześniak, Dorota Wyrostkiewicz, Magdalena Klatt, Sylwia Brzezińska, Anna Zabost, Anna Lewandowska, Dorota Filipczak, Karina Oniszh, Agnieszka Skoczylas, Ewa Augustynowicz-Kopeć, Jan Kuś
INTRODUCTION: An increasing incidence rate of respiratory isolates of non-tuberculous mycobacteria (NTM) has been noted recently in most European countries as well as in the US. Despite many publications, there is no consensus concerning the importance of different factors in promoting NTM lung disease (NTMLD). The aim of the present retrospective study was to analyse patients with positive NTM respiratory isolates in search of factors predisposing to NTMLD. MATERIAL AND METHODS: 73 patients, 23 males, 50 females, median age 62...
December 30, 2018: Advances in Respiratory Medicine
Olivier Moquet, Hakim Kherouf, Geoffroy de Faverges, Pierre Dumont, Evelyne Bourgerette, Tu N'Guyen
INTRODUCTION: We studied the characteristics of the screening procedure for alpha-1 antitrypsin at Nevers Hospital (France), together with the performance of serum protein gel electrophoresis for the fortuitous detection of patients with deficiency. MATERIAL AND METHODS: We carried out a retrospective study of requests for alpha-1 antitrypsin determination referred to the laboratory during 3 years. We compared these requests with the numbers of patients seen at the hospital and requiring screening according to international recommendations...
September 2, 2018: Advances in Respiratory Medicine
Teresa Grzelak, Klaudia Mikołajczyk
Cystic fibrosis - CF - is the most common recessively autosomally and inherited disorder in the Caucasian population. It is incurable, multi-systemic disease with progressive course. CF is caused by CFTR gene mutation, the product of which is Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). CF patients are exposed to fat-soluble vitamins deficiency, including vitamin D. It is due to the fat malabsorption (caused by exacerbation exocrine pancreatic insufficiency), decreased sun exposure (caused by receiving antibiotics photophobia), reduction of adipose tissue and insufficient supply with food...
August 15, 2018: Advances in Respiratory Medicine
Maciej Liczek, Iga Panek, Piotr Damiański, Olga Jęczeń, Jędrzej Jaźwiec, Piotr Kuna, Michał Panek
The aim of the study was to find out scientific evidence on the possible use of the combined angiotensin II receptor antagonist and neprilysin inhibitors (ARNI) in patients with right heart failure (RHF) in the course of chronic obstructive pulmonary disease (COPD). It has been proven that a lack of neprilysin or its reduced expression in hypoxia leads to exacerbation of pulmonary arterial remodelling (PAR) or pulmonary hypertension (PH) in the mechanism related to the platelet-derived growth factor (PDGF) resulting in the proliferation and migration of pulmonary artery smooth muscle cells and endothelial-to-mesenchymal transition...
August 15, 2018: Advances in Respiratory Medicine
Magdalena Latos, Magdalena Ryba, Elżbieta Lazar, Marek Ochman
Hemorrhagic telangiectasia (HHT) is a disease of initially mild course - manifesting with recurrent nosebleeds and increased fatigue. Nevertheless, its progression can deteriorate patient's health. Solid organ transplantation becomes the only therapeutic option to save a life. Case series describes 19 years old female patient, who was diagnosed with HHT and qualified for lung transplantation. She meets Curacao criteria for HHT (¾). Her health deteriorated significantly to the point of the referral to Covered for Blind Review...
August 15, 2018: Advances in Respiratory Medicine
Małgorzata Dybowska, Monika Szturmowicz, Paweł Kuca, Barbara Kazanecka, Janusz Burakowski, Cezary Czajka, Franciszek Grzegorczyk, Renata Langfort, Barbara Burakowska, Piotr Rudziński, Witold Tomkowski
Background Neoplastic pericardial effusion (NPE) represents a common cause of morbidity and mortality in patient with cancer. NPE presents frequently as cardiac tamponade, requiring urgent pericardiocentesis or pericardiotomy, with subsequent pericardial fluid drainage. Despite high effectiveness of such procedures, the recurrence of effusion is noted in 30- 60% of patients. Intrapericardial therapy with cisplatin was found to be effective in NPE due to lung and breast cancer. Its role in cardiac tamponade due to renal cancer is unknown...
August 15, 2018: Advances in Respiratory Medicine
Rupali Malik, Ilavarasi Vanidassane, Neelima Jain
Background - Reduced lung function in diabetes has been described for long but its clinical importance is not yet clear. Also, limited literature is available regarding its association with sugar control, and its correlation with inflammatory markers. Thus, we aimed to study the pulmonary function test abnormalities and systemic inflammation in type 2 diabetes mellitus. Methods 100 patients of type 2 diabetes were divided into two groups depending on control of diabetes (group A-HbA1C≤7% and group B-HbA1C >7%)...
August 15, 2018: Advances in Respiratory Medicine
Mohammad Davoodi, Boshra Rezvankhah, Keivan Gohari Moghadam, Amir Pejman Hashemi Taheri
BACKGROUND AND AIMS: The risk of pulmonary thromboembolism (PTE) in patients with exacerbated chronic obstructive pulmonary disease (e-COPD) is higher than in non-COPD states. This study aimed to evaluate the prevalence and the parameters that are critical for finding the incidence of PTE in patients with e-COPD. METHODS: This cross-sectional study was performed on 68 consecutive patients with the e-COPD, referred to the Pulmonary Disease Department at the Shariati Hospital in Tehran between 2013 and 2014...
August 15, 2018: Advances in Respiratory Medicine
Dmytro Butov, Yurii Feshchenko, Mykhailo Kuzhko, Mykola Gumeniuk, Tetiana Butova
The purpose of our study was to examine the efficacy and safety of intravenous chemotherapy during intensive treatment phase for patients with newly diagnosed pulmonary tuberculosis (pulmonary TB). MATERIALS AND METHODS: The study involved 92 patients with newly diagnosed pulmonary TB aged between 20 years and 68 years. All patient with newly diagnosed pulmonary TB and chemosensitive tuberculosis were enrolled in this study. The patients were allocated to two groups. The first (control) group of 46 patients received standard chemotherapy orally...
August 15, 2018: Advances in Respiratory Medicine
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