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International Journal of Retina and Vitreous

Carolina Pádua Rocha de Souza, Luiz Guilherme Marchesi Mello, Fernando Gomez, Eduardo Morizot
Background: To describe the clinical and multimodal imaging findings of a Brazilian family with Best vitelliform macular dystrophy. Methods: A retrospective chart review of a Brazilian family was conducted and complementary fundus images (color photography, autofluorescence, fluorescein angiography and optical coherence tomography) were analyzed. Results: Seven patients had typical macular lesions at different stages of Best vitelliform macular dystrophy...
2019: International Journal of Retina and Vitreous
Giuseppe Casalino, Vasuki Sivagnanavel, Samir Dowlut, Pearse A Keane, Usha Chakravarthy
Background: To report the clinical course and the multimodal retinal imaging of a spontaneous retinal pigment epithelial (RPE) tear in a type 2 choroidal neovascularization (CNV) secondary to age-related macular degeneration treated with anti-vascular endothelial growth factor (VEGF) treatment. Case presentation: A 74 year-old man presented with visual acuity deterioration in the right eye. Multimodal retinal imaging showed a predominantly classic (type 2) CNV complicated by a spontaneous RPE tear...
2019: International Journal of Retina and Vitreous
M W Rodrigues, D B Cavallini, C Dalloul, C L Shields, R Jorge
Background: The congenital simple hamartoma of the retinal pigment epithelium is a benign lesion and previous observations with noninvasive imaging have detected potential photoreceptor abnormalities and retinal function interplay. Case presentation: A 35-year-old woman was found to have an asymptomatic, solitary, circumscribed, pigmented lesion in her left eye. The patient underwent ophthalmic examination including multimodal evaluation with fluorescein angiography, near-infrared reflectance scanning laser ophthalmoscopy, blue autofluorescence, enhanced-depth imaging spectralis B-scan optical coherence tomography (EDI-SBOCT), en face OCT angiography (OCT-A) and microperimetry plus adaptive optics imaging...
2019: International Journal of Retina and Vitreous
Anthony B Daniels, Kevin K Veverka, Shriji N Patel, LuAnne Sculley, Garvin Munn, Jose S Pulido
Background: We sought to compare the accuracy of standard and novel echographic methods for computing intraocular tumor largest basal diameter (LBD). Design: Multicenter, retrospective cohort study. Subjects: All patients presenting with new diagnosis of uveal melanoma (UM). Methods: Ultrasounds were obtained for all patients, and axial length (AL) was measured for a subset of patients. LBD was calculated as: (1) a single chord measured on B scan ultrasound (one-chord method [1CM]), or (2) by subdividing the basal diameter into two chords, which were summated (two-chord method [2CM]), or (3) by a mathematically-derived formula (MF) based on geometric relationships...
2019: International Journal of Retina and Vitreous
Luiz H Lima, Michel E Farah, Glenwood Gum, Pamela Ko, Ricardo A Pontes de Carvalho
[This corrects the article DOI: 10.1186/s40942-018-0131-1.].
2019: International Journal of Retina and Vitreous
Alireza Khodabandeh, Kiyanoosh Shahraki, Ramak Roohipoor, Hamid Riazi-Esfahani, Mehdi Yaseri, Houshang Faghihi, Fatemeh Bazvand
Background: To evaluate microvascular changes and quantitative parameters in patients with central retinal vein occlusion (CRVO) by using optical coherence tomography angiography (OCTA) and finding difference between presumably ischemic and non ischemic CRVO. Methods: Patients with CRVO (31) and healthy control (20) were enrolled in this observational case control study. The OCTA was done for each patient and control subject. In macular area 2 images were taken for each eye (3 × 3 mm and 8 × 8 mm)...
2018: International Journal of Retina and Vitreous
Ramesh Venkatesh, Bharathi Bavaharan, Naresh Kumar Yadav, Kumar Saurabh, Priya Srinivasan, Padmalini Mahendradas, Vishma Prabhu, Rupak Roy
Background: To describe the multicolour (MC) imaging characteristics associated with choroidal osteomas (CO) and their secondary complications. Methods: Retrospective descriptive case series of eleven eyes of ten patients with CO. Findings of multicolour imaging were correlated with visual acuity, clinical features, lesion characteristics and findings from other imaging modalities. Results: Infrared reflectance (IR) images showed calcified CO lesions as hyporeflectance (dark) areas while decalcified lesions were seen as iso reflectance (normal) areas...
2018: International Journal of Retina and Vitreous
Serena Fragiotta, Talia R Kaden, K Bailey Freund
Background: Aneurysmal type 1 neovascularization (AT1) is a term recently introduced to better describe the aneurysmal dilatation that may arise from neovascular lesions, more commonly known as polypoidal choroidal vasculopathy. The proposed term, AT1, includes an expanded clinical spectrum of aneurysmal (polypoidal) lesions observed in both different ethnicities and associated with varied clinical phenotypes. Case presentation: A 61-year-old woman of European descent was referred for a new, asymptomatic retinal hemorrhage found on routine examination...
2018: International Journal of Retina and Vitreous
Mohamed A Hamid, Mitul C Mehta, Baruch D Kuppermann
Background: Prader-Willi syndrome (PWS) is a genetic disease caused by loss of expression of the paternally inherited copy of several genes on the long arm of chromosome 15. Ophthalmic manifestations of PWS include strabismus, amblyopia, nystagmus, hypopigmentation of the iris and choroid, diabetic retinopathy, cataract and congenital ectropion uvea. An overlap between PWS and oculocutaneous albinism (OCA) has long been recognized and attributed to deletion of OCA2 gene located in PWS critical region (PWCR)...
2018: International Journal of Retina and Vitreous
Fukutaro Mano, Stephen A LoBue, Kuo-Chung Chang, Tomiya Mano
Background: To report the multimodal imaging and histology of a case of metastatic esophageal cancer with vitreoretinal involvement resembling acute retinal necrosis (ARN) in a patient receiving systemic chemotherapy. Case presentation: A 69-year-old Japanese man with a history of stage 4 esophageal carcinoma, treated with three cycles of 5-fluorouracil (5-FU) and cisplatin (CDDP) chemotherapy as well as 30 sessions of radiation therapy, presented with new onset of blurry vision in the right eye (OD)...
2018: International Journal of Retina and Vitreous
Madhu Nath, Nabanita Halder, Parijat Chandra, Sundararajan Baskar Singh, Ashok Kumar Deorari, Atul Kumar, Thirumurthy Velpandian
Background and objectives: The study investigated the intravitreal safety and vitreous disposition of lisinopril, an angiotensin converting enzyme inhibitor in rabbits for its projected use in retinopathy. Methods: For the safety study, following the baseline ERG recording and fundus photography, 40 µg/50 µl of lisinopril sterile injection was injected unilaterally in the rabbit eyes (n = 4), where other eye served as a control. The electroretinogram and fundus images were obtained at 24, 48, 72 and 168 h following the intravitreal injection...
2018: International Journal of Retina and Vitreous
Abdullah Ozkaya, Gurkan Erdogan, Gokhan Demir
Background: To evaluate the surgical outcomes of vitrectomy in patients with foveal herniation associated with epiretinal membrane (ERM). Methods: This was a retrospective case series. The patients who had a foveal herniation associated with ERM, underwent vitrectomy, and had a minimum follow-up period of 12 months were included. The visual and anatomical outcomes were assessed during the first 12 months of follow-up and at the last follow-up visit. The main outcome measure was the reorganization pattern of foveal pit at month 12...
2018: International Journal of Retina and Vitreous
Sukriti Ahuja, Sandeep Saxena, Carsten H Meyer, Jagjit S Gilhotra, Levent Akduman
Background: To evaluate the association of central subfield thickness (CST) and cube average thickness (CAT) with ellipsoid zone (EZ) disruption on spectral domain optical coherence tomography (SD-OCT) in patients of diabetic retinopathy (DR). Methods: Cross sectional study including consecutive patients of type 2 diabetes mellitus [without DR (No DR, n = 97); non-proliferative DR (NPDR, n = 91); proliferative DR (PDR, n = 83)] and healthy controls (n = 82) was undertaken...
2018: International Journal of Retina and Vitreous
Julia de Lima Farah, Ronaldo Sano, Ieda Maria Longo Maugéri, Daniela Teixeira, Mayari Eika Ishimura, Gabriela Martins, Lycia M J Mimica, Cely Barreto da Silva, Carsten H Meyer, João Rafael de Oliveira Dias, Gabriel Costa de Andrade, Michel Eid Farah
Purpose: To investigate the binding affinity, stability, and sterility of aflibercept and ziv-aflibercept to vascular endothelial growth factor (Holash et al. in Proc Natl Acad Sci USA 99(17):11393-11398, 2002. 10.1073/pnas.172398299) after compounding and storage for up to 28 days at 4 °C and - 8 °C. Methods: Tuberculin-type 1-mL syringes were prepared containing aflibercept (40 mg/mL) and ziv-aflibercept (25 mg/mL). Samples were stored at 4 °C and - 8 °C for 0, 14, and 28 days and evaluated for the binding affinity of anti-VEGF to VEGF and stability using enzyme-linked immunosorbent assays...
2018: International Journal of Retina and Vitreous
Rafael B de Araújo, Breno M S Azevedo, Thais S Andrade, Maria F Abalem, Mário L R Monteiro, Pedro C Carricondo
Background: Pupil dilation and mydriasis maintenance throughout vitreoretinal surgeries are important to allow satisfactory fundus visualization and reduce risk of complications. The purpose of this study is to evaluate the role of subconjunctival epinephrine 0.1% injection in mydriasis maintenance during vitrectomy. Methods: Ninety-nine consecutive patients undergoing vitrectomy were enrolled. All subjects were preoperatively dilated with tropicamide 1%. Each patient was randomly allocated either in the epinephrine or placebo group...
2018: International Journal of Retina and Vitreous
Salman Sarwar, Muhammad Hassan, Mohamed K Soliman, Muhammad Sohail Halim, Mohammad Ali Sadiq, Rubbia Afridi, Aniruddha Agarwal, Diana V Do, Quan Dong Nguyen, Yasir J Sepah
Background: Vessel flow density (VFD) may provide important information regarding perfusion status. Diurnal variation in VFD of choriocapillaris has not been reported in literature. In the index study, optical coherence tomography angiography (OCTA) was used to assess the diurnal variation of the VFD in the choriocapillaris of subjects with no known ocular disease. Methods: Fifty eyes with no known ocular disease (25 subjects) were included. OCTA images were acquired using AngioVue (Optovue, Fremont, CA, USA) at two different time points on a single day: 9:00 AM and 6:00 PM...
2018: International Journal of Retina and Vitreous
Jose S Pulido, Lauren A Dalvin, Timothy W Olsen, Fukutaro Mano, Michael Yu, Carol L Shields
Background: To describe a case of von Hippel-Lindau disease with peripheral retinal nonperfusion. Case presentation: A 66-year-old female with known cerebellar and midbrain hemangioblastomas was evaluated for a retinal hemangioblastoma in the right eye. She underwent widefield fluorescein angiography, which showed hyperfluorescence localized to the hemangioblastoma surrounded by peripheral retinal nonperfusion in the same quadrant. Conclusions: Further widefield imaging studies are required to determine if peripheral retinal nonperfusion is a common finding in von Hippel-Lindau disease...
2018: International Journal of Retina and Vitreous
Ogugua Ndubuisi Okonkwo, Adekunle Olubola Hassan, Olufemi Oderinlo, Michael Ekuoba Gyasi
Aim: To report the long-term outcome of the management of a series of culture proven post pars plana vitrectomy endophthalmitis in which the infective agent was in the silicone oil used as an endotamponade. The isolates were Burkholderia cepacia and Pseudomonas aeruginosa . Method: A retrospective interventional reporting of a series consisting of a cluster of five cases. Cases: Five consecutive patients received the same batch of 5000-centistoke silicone oil as endotamponade at the conclusion of vitreoretinal surgery and presented with features of acute intraocular inflammation, which was due to an infective cause...
2018: International Journal of Retina and Vitreous
Irini Chatziralli, Aikaterini Vlachodimitropoulou, Chrysoula Daoula, Christina Vrettou, Eleni Galani, George Theodossiadis, Panagiotis Theodossiadis
Purpose: The purpose of this review is to examine the role of eplerenone in the treatment of central serous chorioretinopathy (CSCR). Methods: A comprehensive search of the PubMed database has been conducted regarding eplerenone for CSCR, while studies using spironolactone were excluded. Articles and book chapters cited in the reference lists of articles obtained by this method were reviewed and included when considered appropriate, while the retrieved articles were filtered manually to exclude duplicates...
2018: International Journal of Retina and Vitreous
Vikas Ambiya, Ashok Kumar, V K Baranwal, Gaurav Kapoor, Amit Arora, Nidhi Kalra, Jyoti Sharma
Background: To evaluate subfoveal choroidal thickness (SFCT) change in diabetes and in various grades of diabetic retinopathy (DR) in comparison to age-matched healthy subjects. Methods: This prospective observational study included 100 eyes of diabetic patients without DR (group D), 100 eyes with DR (group R), and 100 eyes of healthy subjects (group N). The assessment included demographics, duration of diabetes, comprehensive ocular examination, fundus photography with/without fundus fluorescein angiography, spectral domain optical coherence tomography with enhanced depth imaging to assess SFCT...
2018: International Journal of Retina and Vitreous
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