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Laryngoscope Investigative Otolaryngology

Kiminori Sato, Shun-Ichi Chitose, Fumihiko Sato, Hirohito Umeno
Objective: Clearance of the pharynx by deglutition, which removes matter that could be aspirated, is important in protecting the airways and lungs against aspiration. The deglutition and respiratory phase patterns during sleep in the aged with obstructive sleep apnea syndrome (OSAS) were investigated. Study Design: Retrospective study with case groups. Methods: Ten aged adults with severe OSAS (average age 75, average apnea-hypopnea index 43...
December 2018: Laryngoscope Investigative Otolaryngology
Omer J Ungar, Uri Amit, Oren Cavel, Yahav Oron, Ophir Handzel
Objective: The integrity of the scalp overlying a cochlear implant receiver stimulator (RS) is critical for the long-term survival of the implant. Exposure or extrusion of the device will likely result in the need for its removal. There is a global trend of acceleration of population aging, thus raising the prevalence of cochlear implantation (CI) in the elderly. The aim of this study was to define age-dependent changes in scalp thickness and discuss the implication of that anatomical characteristic for CI in the geriatric population...
December 2018: Laryngoscope Investigative Otolaryngology
Nicklas C Orobello, Carolyn O Dirain, Phillip E Kaufman, Patrick J Antonelli
Objective: To determine if widely available solutions can effectively kill ticks that may be found in the human ear canal. Methods: This study was prospective, controlled and blinded animal study. Lone star ticks ( Amblyomma americanum ), both nymphal and adult, were submerged in one of four preparations (acetone, isopropyl alcohol 70%, ethanol 95%, or 4% lidocaine) in test tubes (n = 20 per group) for 20 minutes. Ticks were agitated by intermittent probing...
December 2018: Laryngoscope Investigative Otolaryngology
Ravi R Shah, Jonathan J Suen, Ilana P Cellum, Jaclyn B Spitzer, Anil K Lalwani
Objective: To demonstrate that brief exposure to subway noise causes temporary threshold shift and is preventable with noise protection. Methods: The study was conducted as a randomized crossover trial. Twenty subjects were randomly assigned to two groups, one with hearing protection and one without. Subjects were exposed to subway platform noise for 15 minutes. Pre- and post-exposure pure tone audiometry (PTA) and otoacoustic emissions were compared. After a washout period, subjects switched hearing protection groups and repeated the process...
December 2018: Laryngoscope Investigative Otolaryngology
Robert A Bertrand, Zhaoxing Huang
Objectives: The aim of this study was to analyze the progression of the audiometric pattern of serial screening tests in companies with hearing conservation program (HCP) to clinical audiometric tests to identify individuals more susceptible to develop cardiovascular diseases (CVDs). The procedure is based on the analysis of various audiometric patterns that have been demonstrated to have a statistically significant relation to certain CVDs. Identifying these individuals, based on pattern progression of hearing loss, could result in earlier detection to prevent disease or decrease its morbidity...
December 2018: Laryngoscope Investigative Otolaryngology
Taketoshi Nogaki, Nevra Keskin, Takahiro Azuma, Michael M Paparella, Joseph B Nadol, Sebahattin Cureoglu
Objective: To investigate the temporal bone histopathology of vasculitis, especially in the vestibular organs, in granulomatosis with polyangitis (GPA). Methods: Using light and differential interference contrast microscopy, we examined 12 human temporal bones from six deceased GPA patients and 12 histopathologically normal human temporal bones from six deceased age-matched patients. Results: In the GPA group, three patients had undergone tympanostomy tube placement...
December 2018: Laryngoscope Investigative Otolaryngology
Gregory J Basura, Xiao-Su Hu, Juan San Juan, Anne-Michelle Tessier, Ioulia Kovelman
Objective: Functional near-infrared spectroscopy (fNIRS) is an emerging noninvasive technology used to study cerebral cortex activity. Being virtually silent and compatible with cochlear implants has helped establish fNIRS as an important tool when investigating auditory cortex as well as cortices involved with hearing and language processing in adults and during child development. With respect to this review article, more recently, fNIRS has also been used to investigate central auditory plasticity following hearing loss and tinnitus or phantom sound perception...
December 2018: Laryngoscope Investigative Otolaryngology
Simon Brisebois, Albert Merati, John Paul Giliberto
Proton pump inhibitors (PPIs) are among the most prescribed classes of drugs in this day and age. These may be beneficial to treat many gastrointestinal conditions, such as gastroesophageal reflux or Barrett's esophagus as well as laryngopharyngeal reflux. However, many reports have emerged in the literature exposing the potential association of PPIs with various risks and complications such as bone fracture, infection, myocardial infarction, renal disease, and dementia. This review highlights many of these potential adverse side effects by exploring relevant publications and addressing the controversies associated with those findings...
December 2018: Laryngoscope Investigative Otolaryngology
Andrew M Vahabzadeh-Hagh, Alexander N Goel, John W Frederick, Gerald S Berke, Jennifer L Long
Background: Tongue fibrosis resulting from head and neck cancer, surgery, radiation, chemotherapy, or a combination thereof devastates one's quality of life. Therapeutic options are limited. Here we investigate human bone marrow-derived multipotent stromal cells (MSC) as a novel injectable treatment for post-injury tongue fibrosis. Methods: MSCs were grown in culture. Eighteen athymic rats underwent unilateral partial glossectomy. After two weeks for scar formation, a single injection was performed in the tongue scar...
December 2018: Laryngoscope Investigative Otolaryngology
James D Thompson, Paul M Harari, Gregory K Hartig
Objective: To evaluate changing age demographics over a 15-year period for patients with HPV-associated oropharyngeal squamous cell carcinoma (OPSCC). Study Design: Retrospective review of patients identified with p16-positive OPSCC at our institution over a 15-year timeframe. Materials/Methods : p16-positive immunohistochemistry was used as a surrogate for HPV-associated OPSCC. Patients were categorized according to year of diagnosis (2002-2010 versus 2011-2016)...
December 2018: Laryngoscope Investigative Otolaryngology
Marci Clark, Pamela Berry, Susan Martin, Nimanee Harris, Dennis Sprecher, Scott Olitsky, Jeffrey B Hoag
Objective: A prospective, qualitative study was conducted to develop a patient-reported outcome measure (PROM) for daily administration via electronic diary (eDiary) to assess the severity of nosebleeds in patients with hereditary hemorrhagic telangiectasia (HHT), in accordance with Food and Drug Administration (FDA) PROM guidance criteria. Methods: Three expert clinicians who treat patients with HHT provided input during instrument development, which comprised: 1) Peer-reviewed literature and instrument review; 2) Development of draft Nosebleed Diary items; 3a) Three rounds of qualitative interviews (two with a paper-based diary, one with an eDiary) with patients with documented severe epistaxis related to HHT, for concept elicitation and cognitive debriefing; 3b) Face validity and translatability assessment; 3c) Patient evaluation of the usability and acceptability of the eDiary device; and 4) Preparation of the final Nosebleed eDiary and conceptual framework...
December 2018: Laryngoscope Investigative Otolaryngology
Manuele Casale, Andrea Costantino, Vittorio Rinaldi, Antonio Forte, Marta Grimaldi, Lorenzo Sabatino, Giuseppe Oliveto, Fabio Aloise, Domenico Pontari, Fabrizio Salvinelli
Objective: Recently smartphones and tablets have spread in developed countries, and healthcare-related apps are growing incredibly in different specialties. The aim of this study is to provide an up-to-date review of the current OtoHNS (otolaryngology-head and neck surgery) apps developed for patients. Methods: This mobile applications review was conducted in September 2017. Relevant apps about OtoHNS were searched in the Apple Store and in the Google Play using various keywords...
December 2018: Laryngoscope Investigative Otolaryngology
Ahmad R Sedaghat, Lloyd P Hoehle, Stacey T Gray
Objectives: The concept of disease control incorporates independent disease characteristics that are longitudinally reflective of disease status and which can be used to make treatment decisions. Chronic rhinosinusitis (CRS) is a chronic condition for which the determination of disease control by both the patient and the treating physician is important. Our objectives were to determine CRS disease characteristics that are associated with patient-reported and physician-rated CRS disease control...
December 2018: Laryngoscope Investigative Otolaryngology
Hitesh Singhavi, Jasjit S Ahluwalia, Irina Stepanov, Prakash C Gupta, Vikram Gota, Pankaj Chaturvedi, Samir S Khariwala
Education regarding the health effects associated with tobacco use has made important progress worldwide over the last few decades. Still, tobacco remains a significant cause of cancer and other diseases. As a result, significant worldwide morbidity and mortality is still attributable to tobacco use in modern times. Research into tobacco products, the carcinogens they contain, and how users metabolize them is an important benefit to the advancement of research aimed at reducing harm associated with tobacco use...
October 2018: Laryngoscope Investigative Otolaryngology
Jonathon O Russell, Christopher R Razavi, Mai G Al Khadem, Michael Lopez, Sejal Saraf, Jason D Prescott, Heather M Starmer, Jeremy D Richmon, Ralph P Tufano
Objectives: The robotic retroauricular approach and transoral endoscopic thyroidectomy vestibular approach (TOETVA) have been employed to avoid anterior neck scarring in thyroidectomy with good success. However, outcomes have yet to be compared between techniques. We compare our initial clinical experience with these approaches for thyroid lobectomy at our institution. Methods: A review of initial consecutive patients who underwent robotic facelift thyroidectomy (RFT) (August 2011-August 2016) at our institution was conducted...
October 2018: Laryngoscope Investigative Otolaryngology
Poupak Fallahi, Silvia Martina Ferrari, Gabriele Materazzi, Francesca Ragusa, Ilaria Ruffilli, Armando Patrizio, Paolo Miccoli, Alessandro Antonelli
Objective: No consistent data are present in literature about the effectiveness of Levothyroxine (L-T4) liquid formulation in patients without malabsorption after thyroidectomy. The aim of this study is to compare the effectiveness of L-T4 liquid formulation, with L-T4 tablets, in thyroid cancer patients after thyroidectomy (without malabsorption or drug interference). Methods: One hundred five patients were recruited; 52 patients were treated with liquid L-T4 formulation, while 53 with L-T4 tablets, at the same dosage (1...
October 2018: Laryngoscope Investigative Otolaryngology
Melodi Koşaner Kließ, Arne Ernst, Jan Wagner, Philipp Mittmann
Objective s: Energy emitting, active middle ear implants (aMEI) have taken more than two decades of research to reach technological sophistication, medical safety, and regulatory approval to become a powerful tool in treating sensorineural, conductive, and mixed hearing loss. The present review covers this era. Data Source: Literature found from searching Pubmed (MEDLINE); EMBASE, SciSearch, German Medical Science Journals and Meetings, and The Cochrane Library; and published as of February 2017...
October 2018: Laryngoscope Investigative Otolaryngology
Makoto Hosoya, Shujiro B Minami, Chieko Enomoto, Tatsuo Matsunaga, Kimitaka Kaga
Objectives: We sought to determine how the pathology altered electrically evoked auditory brainstem responses (EABRs) in patients with hearing loss by evaluating EABRs in auditory neuropathy patients with OTOF mutations comparing with various types of congenital deafness. Methods: We included 15 patients with congenital hearing loss, grouped according to pathology: OTOF mutations (n = 4), GJB2 mutations (n = 4), SLC26A4 mutations (n = 4), or cytomegalovirus infections (n = 3)...
October 2018: Laryngoscope Investigative Otolaryngology
Omer J Ungar, Adi Brenner-Ullman, Oren Cavel, Yahav Oron, Oshri Wasserzug, Ophir Handzel
Hypothesis: There may be an association between a neurovascular conflict (NVC) of the auditory nerve and unilateral sudden sensorineural hearing loss (SSNHL). Background: Compression of cranial nerves by vascular structures can lead to significant symptomatology that may require surgical decompression. Notable examples are trigeminal neuralgia and hemifacial spasm. Magnetic resonance imaging (MRI) is part of the workup for SSNHL, and it may depict an NVC of the auditory nerve...
October 2018: Laryngoscope Investigative Otolaryngology
Maria C Turcotte, Erica G Herzberg, Matina Balou, Sonja M Molfenter
Objectives: Edema is a frequent clinical observation following chemoradiation treatment (CRT) of oral/oropharyngeal cancer and is thought to contribute to post-CRT swallowing impairment. Our aims were to reliably quantify pharyngeal edema pre- and post-CRT from videofluoroscopic (VF) swallowing studies and to explore the relationship between edema and swallowing impairment. Swallowing impairment was captured using patient-reported swallowing outcomes (EAT-10) and with VF confirmation of impairment (DIGEST)...
October 2018: Laryngoscope Investigative Otolaryngology
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