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Journals Open Access Rheumatology : Res...

Open Access Rheumatology : Research and Reviews

https://read.qxmd.com/read/37465162/spectrum-of-and-factors-associated-with-eye-disorders-among-rheumatoid-arthritis-patients-attending-tertiary-hospital-in-uganda
#21
JOURNAL ARTICLE
Eunice Headcraph, Immaculate Atukunda, Mark Kaddumukasa, Lydia Nakiyingi, Rebecca Claire Lusobya, Anne Ampaire-Musika, Caroline Otike, Elizabeth Nagawa, Paul Juma, Fransisco Msonge, Juliet Otiti-Sengeri
BACKGROUND: Ocular morbidities associated with rheumatoid arthritis (RA) have not received much attention in Africa, particularly in sub-Saharan Africa. They are among the commonest (40%) extra-articular organ involvement in RA. If undiagnosed, there is a potential risk of them causing visual impairment or blindness. There is no documented study in Uganda on the magnitude of eye disorders among RA patients. AIM: To determine the spectrum of eye disorders and associated factors among patients with RA attending Mulago National Referral Hospital...
2023: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/37273763/expert-opinion-guidance-on-the-detection-of-early-connective-tissue-diseases-in-interstitial-lung-disease
#22
JOURNAL ARTICLE
Rajaie Namas, Mohamed Elarabi, Fouad Fayad, Aqeel A Muhanna Ghanem, Adeeba Al-Herz, Waleed Hafiz, Abhay Joshi, Mira Merashli, Jad Okais, Imad Uthman, Khuloud Saleh Essa, Mohammed A Omair
There is a significant variation in symptoms and clinical presentation of connective tissue disorders (CTD) associated with interstitial lung disease (ILD) (CTD-ILD). This presents difficulties in the diagnosis and treatment of CTD-ILD. Early detection and treatment of CTD-ILD using a multidisciplinary approach have been shown to enhance patient outcomes. This exercise aims to explore clinical components to develop a screening tool for pulmonologists for early detection of CTD in ILD and to provide a framework for a multidisciplinary approach in managing CTD-ILD...
2023: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/37214354/incidence-and-predictors-of-an-abnormal-liver-function-test-among-674-systemic-sclerosis-patients-a-cohort-study
#23
JOURNAL ARTICLE
Kookwan Sawadpanich, Palinee Promasen, Pisaln Mairiang, Wattana Sukeepaisarnjareon, Apichat Sangchan, Tanita Suttichaimongkol, Kawin Tangvoraphonkchai, Chingching Foocharoen
BACKGROUND: Abnormal liver function tests (LFTs) can indicate cirrhosis or liver cancer leading to mortality among systemic sclerosis (SSc) patients. No recent studies have investigated the clinical predictors of an abnormal LFT in SSc. We aimed to determine the incidence of abnormal LFT (including from hepatitis and cholestasis) and to identify its clinical predictors in SSc patients. METHODS: An historical cohort was conducted on 674 adult SSc patients who attended the Scleroderma Clinic, Khon Kaen University, between January 2012 and November 2019 and who underwent routine screening for LFT...
2023: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/37214353/overview-on-the-link-between-the-complement-system-and-auto-immune-articular-and-pulmonary-disease
#24
REVIEW
Paola Triggianese, Paola Conigliaro, Erica De Martino, Benedetta Monosi, Maria Sole Chimenti
Complement system (CS) dysregulation is a key factor in the pathogenesis of different autoimmune diseases playing a central role in many immune innate and adaptive processes. Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by ta breach of self-tolerance leading to a synovitis and extra-articular manifestations. The CS is activated in RA and seems not only to mediate direct tissue damage but also play a role in the initiation of RA pathogenetic mechanisms through interactions with citrullinated proteins...
2023: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/37192954/prevalence-and-predictors-of-remission-and-sustained-remission-in-patients-with-rheumatoid-arthritis-from-the-united-arab-emirates-a-two-year-prospective-study
#25
JOURNAL ARTICLE
Jamal Al-Saleh, Ahlam Almarzooqi, Ahmed A Negm
AIM: To estimate the prevalence of remission and sustained remission for more than 12 months in a cohort of patients with rheumatoid arthritis in the United Arab Emirates and explore predictors of remission and sustained remission in these patients. METHODS: A two-year prospective study conducted in Dubai Hospital (January 1, 2018-December 31, 2019) included all consecutive patients with rheumatoid arthritis attending the rheumatology clinic. Patients with a Simplified Disease Activity Index ≤3...
2023: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/37143703/diagnostic-performance-of-anti-topoisomerase-i-anti-th-to-antibody-and-anti-fibrillarin-using-immunoblot-method-in-systemic-sclerosis-related-interstitial-lung-disease-patients
#26
JOURNAL ARTICLE
Verina Logito, Anna Tjandrawati, Adhi Kristianto Sugianli, Nina Tristina, Sumartini Dewi
PURPOSE: Systemic Sclerosis related Interstitial Lung Disease (SSc-ILD) is the most common clinical manifestation of SSc with a high morbidity and mortality rate. However, the Thorax High-Resolution Computed Tomography (HCRT) as the gold standard diagnostic tool for SSc-ILD is not widely equipped in health-care facilities. Recently, specific autoantibody examination (anti-topoisomerase-1 (ATA), anti-Th/To antibody, and anti-fibrillarin) has been studied and used for SSc-ILD diagnosis...
2023: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36987530/diagnosis-and-treatment-of-calcium-pyrophosphate-deposition-cppd-disease-a-review
#27
REVIEW
Sharon Cowley, Geraldine McCarthy
Calcium Pyrophosphate Dihydrate (CPPD) crystal-related arthropathies are a common cause of acute and chronic arthritis caused by the deposition of calcium pyrophosphate crystals in joints and soft tissues, resulting in inflammation and joint damage. They present with a wide spectrum of clinical manifestations and often present challenges to diagnosis and management as they commonly affect older co-morbid patients. The challenges are compounded by a lack of a well-defined description of CPPD. However, an international expert-driven process is underway to develop CPPD classification criteria...
2023: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36945659/assessing-the-burden-of-osteoarthritis-in-africa-and-the-middle-east-a-rapid-evidence-assessment
#28
REVIEW
Jamal Al Saleh, Hani Almoallim, Bassel Elzorkany, Ali Al Belooshi, Omar Batouk, Mohamed Fathy, Nora Vainstein, Abdullah M Kaki
INTRODUCTION/OBJECTIVES: This rapid evidence assessment (REA) was conducted to assess the burden of weight-bearing joint osteoarthritis in the developing countries of Africa and the Middle East. METHODS: Our REA methodology used a standardized search strategy to identify observational studies, published between January 1, 2010, and April 23, 2020, reporting on outcomes pertaining to the epidemiology and humanistic or economic burden of weight-bearing osteoarthritis...
2023: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36733437/barriers-to-the-diagnosis-of-early-inflammatory-arthritis-a-literature-review
#29
REVIEW
Liliana Saraiva, Catia Duarte
The early identification of patients with inflammatory arthritis and their referral to rheumatologists in order to establish a diagnosis and to start treatment plays a crucial role in patient outcomes. However, it is recognized that a large proportion of patients with inflammatory arthritis are diagnosed very late, losing the opportunity to start treatment in the very early stages of disease, resulting in a worse prognosis. This delay depends on several factors related to the patient, the disease, socio-demographic and health system aspects...
2023: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36726480/depression-in-saudi-patients-with-rheumatoid-arthritis
#30
JOURNAL ARTICLE
Samar Alharbi
PURPOSE: Depression is the most common psychiatric disorder associated with rheumatoid arthritis (RA). However, little is known about its prevalence and risk factors among Saudi patients, specifically. Therefore, this study sought to determine the prevalence and predictors of depression in patients with RA in Saudi Arabia. PATIENTS AND METHODS: A cross-sectional study was conducted with patients registered at the Saudi Charitable Association for Rheumatic Diseases...
2023: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36571105/micronutrient-deficiencies-in-systemic-sclerosis-a-scoping-review
#31
REVIEW
Audrey D Nguyen, Zsuzsanna H McMahan, Elizabeth R Volkmann
PURPOSE: The primary aim is to identify the micronutrient deficiencies commonly reported in SSc. The exploratory aim is to evaluate associations between micronutrient deficiencies and SSc clinical manifestations. PATIENT AND METHODS: We conducted a scoping review of all published reports on SSc and nutrition in PubMed from its inception to August 2020. Clinical trials, observational studies, meta-analyses, and case series (with ≥20 cases) containing data on nutritional deficiency and SSc were included...
2022: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36536922/efficacy-and-safety-of-rituximab-therapy-for-lupus-nephritis-among-sle-female-patients-a-retrospective-hospital-based-study
#32
JOURNAL ARTICLE
Khansa Osama Abdelkarim Aloub, Noha Ibrahim Ahmed Eltahirm, Elnour Mohammed Elagib, Mohammed Elmujtba Adam Essa, Mustafa Mohammed Ali Hussein
BACKGROUND: Renal affection in systemic lupus erythematosus (SLE) is a high-risk manifestation in which novel treatment strategies are required, particularly in patients who show lower response to conventional therapy. Rituximab has been used as an off-label treatment for lupus nephritis (LN) for the last ten years. This study aims to assess the outcome of the use of rituximab to treat LN patients. METHODS: A retrospective cross-sectional study included 40 LN patients on Rituximab therapy who attended the Rheumatology clinic at Omdurman Military Hospital, Khartoum, Sudan...
2022: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36532865/serum-collagen-triple-helix-repeat-containing-1-levels-are-related-to-radiological-affection-and-disease-activity-in-rheumatoid-arthritis
#33
JOURNAL ARTICLE
Eman Mostafa Nassef, Hemmat Ahmed Elabd, Hala Mohamed Elzomor, Basma Mohamed Mohamed Ali El Nagger, Amira Shahin Ibrahim, Amal Hussein Ibrahim, Hend Gamal Kotb, Donia Ahmed Hassan, Rasha Elsayed Mohamed Abd ElAziz, Eman El Sayed Mohamed
BACKGROUND: Rheumatoid arthritis (RA) is a common systemic inflammatory disease. Collagen triple helix repeat containing-1 (CTHRC1) is a unique gene product able to reduce collagen deposition. The present study aimed to assess CTHRC1 level in RA patients and to uncover its relation to clinical, laboratory and radiological findings. METHODS: The study included 60 adult RA patients. In addition, there were 60 control subjects who included patients with osteoarthritis (n = 20) and reactive arthritis (n = 20) and healthy controls (n = 20)...
2022: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36440103/anti-ribosomal-p-antibody-association-with-neuropsychiatric-lupus-in-sudanese-patients-attending-rheumatology-clinic-in-omdurman-military-hospital
#34
JOURNAL ARTICLE
Ziryab Imad Taha, Israa Abdelghani Awad Ibrahim, Salih Boushra Hamza, Yassin A Abdalla, Elnour M Elagib, Husam A M Ali, Sara Joseph, Jimmy William
PURPOSE: To assess and establish the relationship between neuropsychiatric systemic lupus erythematosus (NPSLE) involvement and serological biomarkers like antiribosomal-P antibodies. PATIENTS AND METHODS: This is an analytical cross-sectional hospital-based study conducted on patients attending Omdurman Military Hospital from July 2019 to December 2019. A total of 90 patients were enrolled, 30 of whom had NPSLE compared with 60 SLE patients without NPSLE. SLE diagnosis was established based on the revised SLICC criteria (presence of at least 4 criteria) for SLE classification, with neuropsychiatric manifestations defined based on the ACR nomenclature...
2022: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36426199/better-clinical-results-in-rheumatoid-arthritis-patients-treated-under-a-multidisciplinary-care-model-when-compared-with-a-national-rheumatoid-arthritis-registry
#35
JOURNAL ARTICLE
Pedro Santos-Moreno, Gabriel-Santiago Rodríguez-Vargas, Susan Martínez, Linda Ibatá, Laura Villarreal-Peralta, Anggie Aza-Cañon, Manuel Rivero, Pedro Rodriguez, Adriana Rojas-Villarraga
PURPOSE: To describe clinical characteristics and effectiveness of health care in patients with rheumatoid arthritis (RA) as part of a multidisciplinary care model (MCM) in a specialized rheumatology center, compared with the results of a national registry of RA (NARRA) as evidence of real-world management. PATIENTS AND METHODS: We conducted a real-world study (July 1, 2018 to June 30, 2019) based on an analysis of electronic health records of a cohort of RA patients managed with the "Treat-to-Target" strategy in a specialized rheumatology center in Colombia with an MCM, compared with the NARRA that includes different models of usual care...
2022: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36388145/metabolic-abnormalities-cardiovascular-disease-and-metabolic-syndrome-in-adult-rheumatoid-arthritis-patients-current-perspectives-and-clinical-implications
#36
REVIEW
Pedro Santos-Moreno, Gabriel-Santiago Rodríguez-Vargas, Susan Martínez, Linda Ibatá, Adriana Rojas-Villarraga
Aim: Rheumatoid arthritis is a prevalent worldwide disease, associated with an increased risk of multiple metabolic abnormalities that generate a higher disease burden. Objective: To gather the available evidence on the epidemiology, pathophysiology, current perspectives, clinical implications and prognosis of metabolic abnormalities in patients with rheumatoid arthritis. Methods: This is a narrative literature review. Search was conducted in PubMed, OVID, and Taylor & Francis databases, using the following MeSH terms: "Arthritis Rheumatoid", "Metabolic Diseases", and "Metabolic Syndrome"...
2022: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36281321/gastrointestinal-manifestations-in-patients-with-systemic-lupus-erythematosus
#37
REVIEW
Samar Alharbi
Systemic lupus erythematosus (SLE) is an autoimmune disorder of unknown etiology. Women of childbearing age are affected approximately nine times more often than men. Its presentation and course are highly variable, ranging from mild to fulminant systemic disease. Any organ can be affected by SLE. Although less common than in other systems, such as the skin, joints, and kidneys, 40%-60% of SLE patients have gastrointestinal (GI) involvement. SLE can affect any part of the GI tract, from the mouth to the anus...
2022: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36276408/venous-thromboembolism-in-rheumatoid-arthritis-the-added-effect-of-disease-activity-to-traditional-risk-factors
#38
REVIEW
Mohammed A Omair, Sara A Alkhelb, Sadeen E Ezzat, Ayah M Boudal, Mohammed K Bedaiwi, Ibrahim Almaghlouth
Many epidemiological studies have shown an increased risk of venous thromboembolism (VTE) in patients with rheumatoid arthritis (RA). RA and VTE share some background factors, such as increasing age, smoking, and obesity. At the same time, other VTE factors, such as knee replacement and oral contraceptive pills, occur commonly in RA patients. In addition, the chronic inflammatory state of RA might hypothetically lead to endothelial injury and a hypercoagulable state. Two critical pathophysiological pathways lead to VTE...
2022: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36276407/prevalence-clinical-manifestations-and-treatment-pattern-of-patients-with-rheumatoid-arthritis-attending-the-rheumatology-clinic-at-tikur-anbessa-specialized-hospital-ethiopia-a-cross-sectional-study
#39
JOURNAL ARTICLE
Zerihun Bogale, Yeweyenhareg Feleke
Background: Rheumatoid arthritis (RA) is an a chronic inflammatory disease characterized by symmetric polyarticular inflammation that can lead to progressive joint damage. It is said to be rare among black Africans, even though there have been limited reports from some African countries and no study has been done on RA in Ethiopia. This study determined the prevalence, clinical features, and treatment of rheumatoid arthritis in Tikur Anbessa Specialized Hospital (TASH). Methods: A cross-sectional study design was conducted on diagnosed patients with RA attending the rheumatology clinic at TASH from November 2018 to February 2019...
2022: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/36217356/tofacitinib-inhibits-stat-phosphorylation-and-matrix-metalloproteinase-3-9-and-13-production-by-c28-i2-human-juvenile-chondrocytes
#40
JOURNAL ARTICLE
Jessica R Thorpe, Rachel A Wilson, Sam Mesiano, Charles J Malemud
Purpose: This in vitro study was designed to determine the effect of the pan-Janus kinase inhibitor, Tofacitinib, on basal and interleukin-6 (IL-6)-induced signal transducers and activators of transcription (STAT) phosphorylation and matrix metalloproteinase (MMP) gene expression and MMP production by C28/I2 human chondrocytes. Methods: C28/I2 chondrocytes were grown to a confluent high-density and treated either with recombinant human IL-6 (rhIL-6; 10-20ng/mL) or maintained in the basal state for up to 60 min...
2022: Open Access Rheumatology: Research and Reviews
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