journal
https://read.qxmd.com/read/38481517/c3-glomerulopathy-novel-treatment-paradigms
#1
REVIEW
Blanca Tarragon Estebanez, Andrew S Bomback
C3 glomerulopathy (C3G) is diagnosed by kidney biopsy, with immunofluorescence showing isolated or dominant C3 staining, indicating hyperactivity of the alternative complement pathway as the key driver of glomerular injury. Therefore, the lesion is defined by its complement-mediated pathogenesis as much as its histological pattern. As a bevy of complement-targeting agents are moving through development and clinical trials, we review the evolution in treatment paradigms for C3G. Here we survey the limited efficacy of noncomplement targeting therapy before focusing on the work being done on targeting various components of the complement cascade in aiming to provide disease-specific therapy...
March 2024: KI Reports
https://read.qxmd.com/read/38481516/familial-variability-of-disease-severity-in-adult-patients-with-adpkd
#2
JOURNAL ARTICLE
Elhussein A E Elhassan, Patrick O'Kelly, Kane E Collins, Omri Teltsh, Francesca Ciurli, Susan L Murray, Claire Kennedy, Stephen F Madden, Katherine A Benson, Gianpiero L Cavalleri, Peter J Conlon
INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic nephropathy and has striking familial variability of disease severity. METHODS: To better comprehend familial phenotypic variability, we analyzed clinical and pedigree data on 92 unrelated ADPKD kindreds with ≥2 affected individuals ( N  = 292) from an Irish population. All probands underwent genetic sequencing. Age at onset of kidney failure (KF), decline in estimated glomerular filtration rate (eGFR), predicting renal outcome in polycystic kidney disease (PROPKD) score, and imaging criteria were used to assess and grade disease severity as mild, intermediate, or severe...
March 2024: KI Reports
https://read.qxmd.com/read/38481515/the-role-of-sodium-glucose-cotransporter-2-inhibitors-in-the-treatment-paradigm-of-ckd-in-africa-an-african-association-of-nephrology-panel-position-paper
#3
JOURNAL ARTICLE
Faical Jarraya, Abdou Niang, Hussein Bagha, Elliot Koranteng Tannor, Ernest Kiswaya Sumaili, Davy Ip Min Wan, Mogamat-Yazied Chothia, Yewondwossen Tadesse Mengistu, Francois Folefack Kaze, Ifeoma Isabella Ulasi, Saraladevi Naicker, Mohamed Hany Hafez, Kouame Hubert Yao
No abstract text is available yet for this article.
March 2024: KI Reports
https://read.qxmd.com/read/38481514/development-of-a-kidney-prognostic-score-in-a-japanese-cohort-of-patients-with-antineutrophil-cytoplasmic-autoantibody-vasculitis
#4
JOURNAL ARTICLE
Rei Takeda, Kazuya Takahashi, Andreas Kronbichler, Daiichiro Akiyama, Shunichiro Hanai, Yoshiaki Kobayashi, Ayako Matsuki, Takeshi Umibe, Chisaki Ito, Toyohiko Sugimoto, Takao Sugiyama, Shun Yoshida, Yasuhide Nishio, Ikuo Nukui, Ayumu Nakashima, Hanae Wakabayashi, Katsuhiko Asanuma, Shunsuke Furuta, Hiroshi Nakajima, Daiki Nakagomi
INTRODUCTION: Glomerulonephritis is frequent in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and crucial to disease outcomes. We conducted a detailed assessment of renal pathology in Japanese patients with AAV, and developed a new score that would predict renal outcome. METHODS: Two hundred twenty-one patients who were diagnosed with AAV and underwent a kidney biopsy were enrolled. Data on glomerular, tubular, interstitial, and vascular lesions from kidney biopsies were analyzed; the 3 established classification and prognostic scoring systems (Berden Classification, Mayo Clinic/RPS Chronicity Score [MCCS], and ANCA Renal Risk Score [ARRS]) were validated...
March 2024: KI Reports
https://read.qxmd.com/read/38481513/digital-ischemia-as-a-rare-manifestation-of-c3-glomerulopathy-associated-with-monoclonal-gammopathy
#5
JOURNAL ARTICLE
Alistair Baber, Paul Legendre, Sophie Chauvet, Alexandre Karras, Samuel Deshayes, Antoine Huart, Marguerite Vignon, Kathleen Dessaix, Baptiste Hervier, Bruno Legallicier, Nicolas Martin Silva, Véronique Frémeaux-Bacchi, Benjamin Terrier
No abstract text is available yet for this article.
March 2024: KI Reports
https://read.qxmd.com/read/38481512/targeting-gut-microbiome-with-prebiotic-in-patients-with-ckd-the-targut-ckd-study
#6
JOURNAL ARTICLE
Michael B Sohn, Bei Gao, Cynthia Kendrick, Anvesha Srivastava, Tamara Isakova, Jennifer J Gassman, Linda F Fried, Myles Wolf, Alfred K Cheung, Kalani L Raphael, Patricia Centron Vinales, John P Middleton, Ana Pabalan, Dominic S Raj
INTRODUCTION: Disruption of gut microbiota underpins some of the metabolic alterations observed in chronic kidney disease (CKD). METHODS: In a nonrandomized, open-label, 3-phase pilot trial, with repeated measures within each phase, we examined the efficacy of oligofructose-enriched inulin (p-inulin) in changing the gut microbiome and their metabolic products in 15 patients with CKD. The stability of microbiome and metabolome was studied during the pretreatment phase (8 weeks), a p-inulin treatment phase (12 weeks), and a post treatment phase (8 weeks) of the study...
March 2024: KI Reports
https://read.qxmd.com/read/38481511/barriers-to-care-new%C3%A2-medications-and-ckd
#7
EDITORIAL
Dana Kim, Vlado Perkovic, Sradha Kotwal
No abstract text is available yet for this article.
March 2024: KI Reports
https://read.qxmd.com/read/38481510/describing-and-explaining-adpkd-variability-within-families
#8
EDITORIAL
Sai Santhoshini Achi, Andrew J Mallett
No abstract text is available yet for this article.
March 2024: KI Reports
https://read.qxmd.com/read/38481509/corrigendum-to-worldwide-exploration-of-renal-replacement-outcomes-collaborative-in-kidney-disease-we-rock-kidney-international-reports-volume-8-issue-8-august-2023-pages-1542-1552
#9
Shina Menon, Kelli A Krallman, Ayse A Arikan, Dana Y Fuhrman, Stephen M Gorga, Theresa Mottes, Nicholas Ollberding, Zaccaria Ricci, Natalja L Stanski, David T Selewski, Danielle E Soranno, Michael Zappitelli, Huaiyu Zang, Katja M Gist
[This corrects the article DOI: 10.1016/j.ekir.2023.05.026.].
March 2024: KI Reports
https://read.qxmd.com/read/38481508/women-s-access-to-kidney-transplantation
#10
EDITORIAL
Jessica L Harding
No abstract text is available yet for this article.
March 2024: KI Reports
https://read.qxmd.com/read/38481507/novel-colorimetric-and-light-scatter-methods-to-identify-and-manage-peritoneal-dialysis-associated-peritonitis-at-the-point-of-care
#11
JOURNAL ARTICLE
Nishal Govindji-Bhatt, Stephnie M Kennedy, Michael G Barker, Darren Kell, Duncan Henderson, Nicholas Goddard, Ana Yepes Garcia, Adam S Milner, Tom Willett, Ryan Griffiths, Peter Foster, William Kilgallon, Rachel Cant, Christopher G Knight, David Lewis, Richard Corbett, Habib Akbani, Graham Woodrow, Bhrigu Sood, Osasuyi Iyasere, Simon Davies, Junaid Qazi, Anand Vardhan, Laura Gillis, Martin Wilkie, Curtis B Dobson
INTRODUCTION: Peritoneal dialysis (PD)-related peritonitis (PDRP) is a common cause of transfer to hemodialysis, patient morbidity, and is a risk factor for mortality. Associated patient anxiety can deter selection of PD for renal replacement therapy. Diagnosis relies on hospital laboratory tests; however, this might be achieved earlier if such information was available at the point-of-care (POC), thereby significantly improving outcomes. The presence of culturable microbes and the concentration of leukocytes in effluent both aid peritonitis diagnosis, as specified in the International Society for Peritoneal Dialysis (ISPD) diagnostic guidelines...
March 2024: KI Reports
https://read.qxmd.com/read/38481506/transporting-sodium-glucose-cotransporter-2-inhibitors-to-the-african-continent-challenges-and-solutions
#12
EDITORIAL
Valerie A Luyckx, Urmila Anandh
No abstract text is available yet for this article.
March 2024: KI Reports
https://read.qxmd.com/read/38481505/complement-and-podocytopathies-do%C3%A2-we-have-a-new-biomarker
#13
EDITORIAL
Miquel Blasco, Andrew S Bomback
No abstract text is available yet for this article.
March 2024: KI Reports
https://read.qxmd.com/read/38481504/circulating-oxalate-levels-in-short-bowel-syndrome-as-a-severity-marker-of-ckd
#14
JOURNAL ARTICLE
Christophe Grocholski, Cécile Chambrier, Madeleine Lauverjat, Cécile Acquaviva, Nadia Abid, Charlotte Bergoin, Fitsum Guebre-Egziabher, Justine Bacchetta, Laurence Derain-Dubourg, Aurélie De Mul, Sandrine Lemoine
INTRODUCTION: Patients with short bowel syndrome (SBS) may exhibit enteric hyperoxaluria (EH), and the prevalence of oxalate nephropathy in SBS is likely underestimated. Plasma oxalate (POx) is a surrogate of systemic oxalate deposition and, consequently, may increase the risk of developing chronic kidney disease (CKD). The main objective of this study was to explore the distribution of POx levels in patients with SBS. METHODS: Patients followed for SBS were recruited prospectively in the OXAGO study (NCT04119765) to assess POx during their annual renal follow-up including iohexol clearance...
March 2024: KI Reports
https://read.qxmd.com/read/38481503/hybrid-immunity-overcomes-defective-immune-response-to-covid-19-vaccination-in-kidney-transplant-recipients
#15
JOURNAL ARTICLE
Nicolas Gemander, Delphine Kemlin, Stéphanie Depickère, Natasha S Kelkar, Pieter Pannus, Shilpee Sharma, Alexandra Waegemans, Véronique Olislagers, Daphnée Georges, Emilie Dhondt, Margarida Braga, Leo Heyndrickx, Johan Michiels, Anaïs Thiriard, Anne Lemy, Marylène Vandevenne, Maria E Goossens, André Matagne, Isabelle Desombere, Kevin K Ariën, Margaret E Ackerman, Alain Le Moine, Arnaud Marchant
INTRODUCTION: Comorbidities and immunosuppressive therapies are associated with reduced immune responses to primary COVID-19 mRNA vaccination in kidney transplant recipients (KTRs). In healthy individuals, prior SARS-COV-2 infection is associated with increased vaccine responses, a phenotype called hybrid immunity. In this study, we explored the potential influence of immune suppression on hybrid immunity in KTRs. METHODS: Eighty-two KTRs, including 59 SARS-CoV-2-naïve (naïve KTRs [N-KTRs]) and 23 SARS-CoV-2-experienced (experienced KTRs [E-KTRs]) patients, were prospectively studied and compared to 106 healthy controls (HCs), including 40 SARS-CoV-2-naïve (N-HCs) and 66 SARS-CoV-2-experienced (E-HCs) subjects...
March 2024: KI Reports
https://read.qxmd.com/read/38481502/evaluation-of-the-risk-prediction-models-in-predicting-kidney-outcomes-in-antiglomerular-basement-membrane-disease
#16
JOURNAL ARTICLE
Huang Kuang, Yi-Yang Zhao, Jin-Wei Wang, Zhao Cui, Ming-Hui Zhao, Xiao-Yu Jia
INTRODUCTION: A previous study showed that the renal risk score (RRS) was transferrable to antiglomerular basement membrane (anti-GBM) disease and proposed a risk stratification according to the need of renal replacement therapy (RRT) and the percentage of normal glomeruli (N). Herein, we analyzed the risk factors associated with kidney outcomes in patients with biopsy-proven anti-GBM disease and evaluated these 2 prognosis systems. METHODS: A total of 120 patients with biopsy-proven anti-GBM disease with complete clinicopathologic and outcome data were analyzed...
March 2024: KI Reports
https://read.qxmd.com/read/38481501/ecological-momentary-assessment-to-explore-fatigue-mood-and-physical-activity-levels-in-people-receiving-peritoneal-dialysis
#17
JOURNAL ARTICLE
Brett Tarca, Shilpanjali Jesudason, Thomas P Wycherley, Richard Le Leu, Michelle Ovenden, Anthony Meade, Paul N Bennett, Terry Boyle, Katia E Ferrar
INTRODUCTION: Fatigue is a frequent and debilitating symptom that contributes to poor quality of life for people receiving peritoneal dialysis. Ecological momentary assessment using mobile technology (mEMA) is a novel survey technique that can collect symptom data in real-time and has not been trialed in a peritoneal dialysis cohort. The study aimed to explore real-time fluctuations and associations between fatigue, mood, and physical activity using mEMA. METHODS: Adults receiving peritoneal dialysis completed fatigue and mood scales, via a mobile application (app), 5 times daily for 7 days and, concurrently wore an accelerometer...
March 2024: KI Reports
https://read.qxmd.com/read/38481500/barriers-to-optimal-kidney-health-among-indigenous-peoples
#18
EDITORIAL
Swasti Chaturvedi, Maria Eugenia Victoria Bianchi, Aminu Bello, Harley Crowshoe, Jaquelyne T Hughes
No abstract text is available yet for this article.
March 2024: KI Reports
https://read.qxmd.com/read/38481499/thiamine-deficiency-related-rhabdomyolysis-an-exploration-through-a-case-series
#19
JOURNAL ARTICLE
Sobia Nisar, Ozaifa Kareem, Umar Muzaffer, Masood Tanvir, Rouhail Hijazi, Rabia Nazir Ahmed, Afrah Nasir, Mohd Ashraf Ganaie
No abstract text is available yet for this article.
March 2024: KI Reports
https://read.qxmd.com/read/38481498/the-role-of-peer-support-for-minoritized-individuals-with-kidney-disease
#20
EDITORIAL
Katherine Rizzolo, Ladan Golestaneh
No abstract text is available yet for this article.
March 2024: KI Reports
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