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JOURNAL ARTICLE
Marco Valgimigli, Felice Gragnano, Mattia Branca, Anna Franzone, Bruno R da Costa, Usman Baber, Takeshi Kimura, Yangsoo Jang, Joo-Yong Hahn, Qiang Zhao, Stephan Windecker, Charles M Gibson, Hirotoshi Watanabe, Byeong-Keuk Kim, Young Bin Song, Yunpeng Zhu, Pascal Vranckx, Shamir Mehta, Kenji Ando, Sung Jin Hong, Hyeon-Cheol Gwon, Patrick W Serruys, George D Dangas, Eùgene P McFadden, Dominick J Angiolillo, Dik Heg, Paolo Calabrò, Peter Jüni, Roxana Mehran
IMPORTANCE: Among patients undergoing percutaneous coronary intervention (PCI), it remains unclear whether the treatment efficacy of P2Y12 inhibitor monotherapy after a short course of dual antiplatelet therapy (DAPT) depends on the type of P2Y12 inhibitor. OBJECTIVE: To assess the risks and benefits of ticagrelor monotherapy or clopidogrel monotherapy compared with standard DAPT after PCI. DATA SOURCES: MEDLINE, Embase, TCTMD, and the European Society of Cardiology website were searched from inception to September 10, 2023, without language restriction...
March 20, 2024: JAMA Cardiology
#22
JOURNAL ARTICLE
Sharlene M Day
No abstract text is available yet for this article.
March 13, 2024: JAMA Cardiology
#23
JOURNAL ARTICLE
Pil Hyung Lee, Soon Jun Hong, Hyun-Sook Kim, Young Won Yoon, Jong-Young Lee, Seung-Jin Oh, Ji Sung Lee, Soo-Jin Kang, Young-Hak Kim, Seong-Wook Park, Seung-Whan Lee, Cheol Whan Lee
IMPORTANCE: Although intravascular ultrasonography (IVUS) guidance promotes favorable outcomes after percutaneous coronary intervention (PCI), many catheterization laboratories worldwide lack access. OBJECTIVE: To investigate whether systematic implementation of quantitative coronary angiography (QCA) to assist angiography-guided PCI could be an alternative strategy to IVUS guidance during stent implantation. DESIGN, SETTING, AND PARTICIPANTS: This randomized, open-label, noninferiority clinical trial enrolled adults (aged ≥18 years) with chronic or acute coronary syndrome and angiographically confirmed native coronary artery stenosis requiring PCI...
March 13, 2024: JAMA Cardiology
#24
JOURNAL ARTICLE
Ajay J Kirtane, Roxana Mehran
No abstract text is available yet for this article.
March 13, 2024: JAMA Cardiology
#25
JOURNAL ARTICLE
Joel T Rämö, Shinwan Kany, Cody R Hou, Samuel F Friedman, Carolina Roselli, Victor Nauffal, Satoshi Koyama, Juha Karjalainen, Mahnaz Maddah, Aarno Palotie, Patrick T Ellinor, James P Pirruccello
IMPORTANCE: Epicardial and pericardial adipose tissue (EPAT) has been associated with cardiovascular diseases such as atrial fibrillation or flutter (AF) and coronary artery disease (CAD), but studies have been limited in sample size or drawn from selected populations. It has been suggested that the association between EPAT and cardiovascular disease could be mediated by local or paracrine effects. OBJECTIVE: To evaluate the association of EPAT with prevalent and incident cardiovascular disease and to elucidate the genetic basis of EPAT in a large population cohort...
March 13, 2024: JAMA Cardiology
#26
JOURNAL ARTICLE
Iva Minga, Vinesh Appadurai, Vera Rigolin
No abstract text is available yet for this article.
March 13, 2024: JAMA Cardiology
#27
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 6, 2024: JAMA Cardiology
#28
JOURNAL ARTICLE
River Jiang, Christopher C Cheung, Marta Garcia-Montero, Brianna Davies, Jason Cao, Damian Redfearn, Zachary M Laksman, Steffany Grondin, Joseph Atallah, Carolina A Escudero, Julia Cadrin-Tourigny, Shubhayan Sanatani, Christian Steinberg, Jacqueline Joza, Robert Avram, Rafik Tadros, Andrew D Krahn
IMPORTANCE: Congenital long QT syndrome (LQTS) is associated with syncope, ventricular arrhythmias, and sudden death. Half of patients with LQTS have a normal or borderline-normal QT interval despite LQTS often being detected by QT prolongation on resting electrocardiography (ECG). OBJECTIVE: To develop a deep learning-based neural network for identification of LQTS and differentiation of genotypes (LQTS1 and LQTS2) using 12-lead ECG. DESIGN, SETTING, AND PARTICIPANTS: This diagnostic accuracy study used ECGs from patients with suspected inherited arrhythmia enrolled in the Hearts in Rhythm Organization Registry (HiRO) from August 2012 to December 2021...
March 6, 2024: JAMA Cardiology
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JOURNAL ARTICLE
Rishi K Patel, Francesco Bandera, Lucia Venneri, Aldostefano Porcari, Yousuf Razvi, Adam Ioannou, Liza Chacko, Ana Martinez-Naharro, Muhammad U Rauf, Daniel Knight, James Brown, Aviva Petrie, Ashutosh Wechalekar, Carol Whelan, Helen Lachmann, Vivek Muthurangu, Marco Guazzi, Philip N Hawkins, Julian D Gillmore, Marianna Fontana
IMPORTANCE: Cardiopulmonary exercise testing (CPET) has an established role in the assessment of patients with heart failure. However, data are lacking in patients with transthyretin (ATTR) amyloidosis. OBJECTIVE: To use CPET to characterize the spectrum of functional phenotypes in patients with ATTR amyloidosis and assess their association with the cardiac amyloid burden as well as the association between CPET parameters and prognosis. DESIGN, SETTING AND PARTICIPANTS: This single-center study evaluated patients diagnosed with ATTR amyloidosis from May 2019 to September 2022 who underwent CPET at the National Amyloidosis Centre...
March 6, 2024: JAMA Cardiology
#30
JOURNAL ARTICLE
Maria Bosserdt, Lina M Serna-Higuita, Gudrun Feuchtner, Bela Merkely, Klaus F Kofoed, Theodora Benedek, Patrick Donnelly, José Rodriguez-Palomares, Andrejs Erglis, Cyril Štechovský, Gintare Šakalyte, Nada Cemerlic Adic, Matthias Gutberlet, Jonathan D Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kepka, Radosav Vidakovic, Marco Francone, Malgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca Saba, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Bálint Szilveszter, Per E Sigvardsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtech Suchánek, Antanas Jankauskas, Filip Adic, Michael Woinke, Mark Hensey, Iñigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandar N Neskovic, Massimo Mancone, Donata Kusmierz, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Maurizio Porcu, Michael Fisher, Melinda Boussoussou, Charlotte Kragelund, Rosca Aurelian, Stephanie Kelly, Bruno Garcia Del Blanco, Ainhoa Rubio, Pál Maurovich-Horvat, Jens D Hove, Ioana Rodean, Susan Regan, Hug Cuellar-Calabria, Levente Molnár, Linnea Larsen, Roxana Hodas, Adriane E Napp, Robert Haase, Sarah Feger, Mahmoud Mohamed, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Melanie Estrella, Peter Martus, Harold C Sox, Marc Dewey
IMPORTANCE: The effectiveness and safety of computed tomography (CT) and invasive coronary angiography (ICA) in different age groups is unknown. OBJECTIVE: To determine the association of age with outcomes of CT and ICA in patients with stable chest pain. DESIGN, SETTING, AND PARTICIPANTS: The assessor-blinded Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) randomized clinical trial was conducted between October 2015 and April 2019 in 26 European centers...
February 28, 2024: JAMA Cardiology
#31
JOURNAL ARTICLE
Aeron M Small, Giorgio E M Melloni, Frederick K Kamanu, Brian A Bergmark, Marc P Bonaca, Michelle L O'Donoghue, Robert P Giugliano, Benjamin M Scirica, Deepak Bhatt, Elliott M Antman, Itamar Raz, Stephen D Wiviott, Buu Truong, Peter W F Wilson, Kelly Cho, Christopher J O'Donnell, Eugene Braunwald, Steve A Lubitz, Patrick Ellinor, Gina M Peloso, Christian T Ruff, Marc S Sabatine, Pradeep Natarajan, Nicholas A Marston
IMPORTANCE: Polygenic risk scores (PRSs) have proven to be as strong as or stronger than established clinical risk factors for many cardiovascular phenotypes. Whether this is true for aortic stenosis remains unknown. OBJECTIVE: To develop a novel aortic stenosis PRS and compare its aortic stenosis risk estimation to established clinical risk factors. DESIGN, SETTING, AND PARTICIPANTS: This was a longitudinal cohort study using data from the Million Veteran Program (MVP; 2011-2020), UK Biobank (2006-2010), and 6 Thrombolysis in Myocardial Infarction (TIMI) trials, including DECLARE-TIMI 58 (2013-2018), FOURIER (TIMI 59; 2013-2017), PEGASUS-TIMI 54 (2010-2014), SAVOR-TIMI 53 (2010-2013), SOLID-TIMI 52 (2009-2014), and ENGAGE AF-TIMI 58 (2008-2013), which were a mix of population-based and randomized clinical trials...
February 28, 2024: JAMA Cardiology
#32
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 28, 2024: JAMA Cardiology
#33
JOURNAL ARTICLE
Amber B Tang, Nicholas K Brownell, Jacob S Roberts, Amier Haidar, Antonia Osuna-Garcia, David J Cho, Pooya Bokhoor, Gregg C Fonarow
IMPORTANCE: Implementation of guideline-directed medical therapy (GDMT) in real-world practice remains suboptimal. It is unclear which interventions are most effective at addressing current barriers to GDMT in patients with heart failure with reduced ejection fraction (HFrEF). OBJECTIVE: To perform a systematic review to identify which types of system-level initiatives are most effective at improving GDMT use among patients with HFrEF. EVIDENCE REVIEW: PubMed, Embase, Cochrane, CINAHL, and Web of Science databases were queried from January 2010 to November 2023 for randomized clinical trials that implemented a quality improvement intervention with GDMT use as a primary or secondary outcome...
February 21, 2024: JAMA Cardiology
#34
JOURNAL ARTICLE
Michael J LaMonte, Andrea Z LaCroix, Steve Nguyen, Kelly R Evenson, Chongzhi Di, Marcia L Stefanick, Eric T Hyde, Blake Anuskiewicz, Charles B Eaton
IMPORTANCE: Heart failure (HF) prevention is paramount to public health in the 21st century. OBJECTIVE: To examine incident HF and its subtypes with preserved ejection fraction (HFpEF) and reduced EF (HFrEF) according to accelerometer-measured physical activity (PA) and sedentary time. DESIGN, SETTING, AND PARTICIPANTS: This was a prospective cohort study, the Objective Physical Activity and Cardiovascular Health (OPACH) in Older Women study, conducted from March 2012 to April 2014...
February 21, 2024: JAMA Cardiology
#35
JOURNAL ARTICLE
Matthew J Feinstein
No abstract text is available yet for this article.
February 21, 2024: JAMA Cardiology
#36
JOURNAL ARTICLE
Michael T Lu, Heather Ribaudo, Borek Foldyna, Markella V Zanni, Thomas Mayrhofer, Julia Karady, Jana Taron, Kathleen V Fitch, Sara McCallum, Tricia H Burdo, Kayla Paradis, Sandeep S Hedgire, Nandini M Meyersohn, Christopher DeFilippi, Carlos D Malvestutto, Audra Sturniolo, Marissa Diggs, Sue Siminski, Gerald S Bloomfield, Beverly Alston-Smith, Patrice Desvigne-Nickens, Edgar T Overton, Judith S Currier, Judith A Aberg, Carl J Fichtenbaum, Udo Hoffmann, Pamela S Douglas, Steven K Grinspoon
IMPORTANCE: Cardiovascular disease (CVD) is increased in people with HIV (PWH) and is characterized by premature noncalcified coronary plaque. In the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE), pitavastatin reduced major adverse cardiovascular events (MACE) by 35% over a median of 5.1 years. OBJECTIVE: To investigate the effects of pitavastatin on noncalcified coronary artery plaque by coronary computed tomography angiography (CTA) and on inflammatory biomarkers as potential mechanisms for MACE prevention...
February 21, 2024: JAMA Cardiology
#37
JOURNAL ARTICLE
Janneke W C M Mulder, Tycho R Tromp, Mutaz Al-Khnifsawi, Dirk J Blom, Krysztof Chlebus, Marina Cuchel, Laura D'Erasmo, Antonio Gallo, G Kees Hovingh, Ngoc Thanh Kim, Jiang Long, Frederick J Raal, Willemijn A M Schonck, Handrean Soran, Thanh-Huong Truong, Eric Boersma, Jeanine E Roeters van Lennep
IMPORTANCE: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition characterized by extremely increased low-density lipoprotein (LDL) cholesterol levels and premature atherosclerotic cardiovascular disease (ASCVD). Heterozygous familial hypercholesterolemia (HeFH) is more common than HoFH, and women with HeFH are diagnosed later and undertreated compared to men; it is unknown whether these sex differences also apply to HoFH. OBJECTIVE: To investigate sex differences in age at diagnosis, risk factors, lipid-lowering treatment, and ASCVD morbidity and mortality in patients with HoFH...
February 14, 2024: JAMA Cardiology
#38
JOURNAL ARTICLE
Aeron M Small, Ashley Pournamdari, Giorgio E M Melloni, Benjamin M Scirica, Deepak L Bhatt, Itamar Raz, Eugene Braunwald, Robert P Giugliano, Marc S Sabatine, Gina M Peloso, Nicholas A Marston, Pradeep Natarajan
IMPORTANCE: Elevated lipoprotein(a) (Lp[a]) is a putative causal risk factor for atherosclerotic cardiovascular disease (ASCVD). There are conflicting data as to whether Lp(a) may increase cardiovascular risk only in the presence of concomitant inflammation. OBJECTIVE: To investigate whether Lp(a) is associated with cardiovascular risk independent of high-sensitivity C-reactive protein (hs-CRP) in both primary and secondary prevention populations. DESIGN, SETTING, AND PARTICIPANTS: This cohort study uses data from 3 distinct cohorts, 1 population-based cohort and 2 randomized clinical trials...
February 14, 2024: JAMA Cardiology
#39
JOURNAL ARTICLE
Patricia Palau, Rafael de la Espriella, Julia Seller, Enrique Santas, Eloy Domínguez, Vicent Bodí, Juan Sanchis, Eduardo Núñez, Antoni Bayés-Genís, Vicente Bertomeu-González, Markus Meyer, Julio Núñez
IMPORTANCE: Increasing the patient's heart rate (HR) has emerged as a therapeutic option in patients with heart failure with preserved ejection fraction (HFpEF). However, the evidence is conflicting, and the profile of patients who benefit most from this strategy remains unclear. OBJECTIVE: To assess the association of β-blocker treatment withdrawal with changes in the percentage of predicted peak oxygen consumption (VO2) across indexed left ventricular diastolic (iLVEDV) and indexed left ventricular systolic volumes (iLVESV), and left ventricular ejection fraction (LVEF) in patients with HFpEF and chronotropic incompetence...
February 7, 2024: JAMA Cardiology
#40
JOURNAL ARTICLE
Jérôme Antonelli, Jean-Philippe Verhoye, Raphaël P Martins
No abstract text is available yet for this article.
February 7, 2024: JAMA Cardiology
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