journal
https://read.qxmd.com/read/36844934/dyspnea-in-oncological-patients-a-brain-teaser
#1
REVIEW
Kalliopi Keramida, Athanasios Kostoulas
Dyspnea is one of the most common symptoms in oncological patients with greater prevalence in lung cancer and advanced disease states. Causes of dyspnea can be directly or indirectly associated with cancer, anti-neoplastic therapies and comorbidities unrelated to cancer. Routine screening of dyspnea is suggested for all oncological patients by using unidimensional, simple scales and multidimensional tools to capture more domains affected by this symptom and to assess the effectiveness of interventions. The first step in the treatment algorithm of dyspnea is the identification of potentially reversible causes; if no specific cause is depicted, symptomatic treatment with non-pharmacological and pharmacological interventions is suggested...
February 2023: European Cardiology
https://read.qxmd.com/read/36844933/efficacy-of-ranolazine-to-improve-diastolic-performance-in-heart-failure-with-preserved-ejection-fraction-a-systematic-review-and-meta-analysis
#2
REVIEW
Desak Ketut Sekar Cempaka Putri, Andrianto Andrianto, Makhyan Jibril Al-Farabi, Pandit Bagus Tri Saputra, Ricardo Adrian Nugraha
This article evaluates the efficacy of using ranolazine to improve diastolic performance and exercise capacity in heart failure with preserved ejection fraction. A comprehensive literature review found eight trials where there are no significant difference in peak O2 (p=0.09) and exercise duration (p=0.18) between ranolazine and placebo. The ranolazine group had significantly higher and better diastolic parameters compared to placebo, with a mean difference of 0.45 (95% CI [27.18-39.50]). There were no significant differences for haemodynamic parameters (blood pressure and heart rate) and electrocardiography (QT interval) between ranolazine and placebo...
February 2023: European Cardiology
https://read.qxmd.com/read/36844932/comment-on-the-esc-guidelines-2022-for-the-management-of-patients-with-ventricular-arrhythmias-and-the-prevention-of-sudden-cardiac-death
#3
REVIEW
David Calvo Cuervo
The European Society of Cardiology guidelines for the management of sudden cardiac death and ventricular arrhythmias have been updated. Additions and amendments range from clinical management to invasive procedures, and provide new perspectives on integrated management, genetic testing, stratification of risk, arrhythmia ablation and device therapy among others. Significant improvements have been made, which will result in better care for patients and families.
February 2023: European Cardiology
https://read.qxmd.com/read/38213666/clinical-management-of-non-alcoholic-steatohepatitis-and-the-role-of-the-cardiologist
#4
JOURNAL ARTICLE
Carlos Millán-Rodríguez, Carlos Palacios Castelló, María de Regla Caballero-Valderrama, Gonzalo Barón Esquivias
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of fat-associated liver conditions that increase risk of cardiovascular disease and mortality. The diagnosis and clinical management of NAFLD remain a challenge for cardiologists. Our group performed a systematic review in PubMed of the relationship between NAFLD and cardiovascular disease, identifying 35 relevant articles. NAFLD is likely to be the liver's expression of metabolic syndrome and increases the risk of several cardiovascular diseases, including coronary artery disease, stroke, heart failure and electrical disorders, and chronic kidney disease...
2023: European Cardiology
https://read.qxmd.com/read/38213665/alcohol-and-heart-failure
#5
REVIEW
Debar Rasoul, Ashwin Ajay, Alend Abdullah, Jean Mathew, Benjamin Lee Wei En, Knievel Mashida, Rajiv Sankaranarayanan
Alcohol is the most frequently consumed toxic substance in the world and remains a major global public health issue, with one in three adults consuming it worldwide. Alcohol use is a leading risk factor for disease, contributing to over 60 acute and chronic health conditions, with a particularly complex association with cardiovascular disease. Chronic excessive alcohol consumption is associated with a range of cardiac complications, including decreased myocardial contractility, hypertension, arrhythmias, MI and heart failure...
2023: European Cardiology
https://read.qxmd.com/read/38213664/evidence-based-management-of-left-main-coronary-artery-disease
#6
REVIEW
Gabriel Torres-Ruiz, Nuria Mallofré-Vila, Paola Rojas-Flores, Pablo Carrión-Montaner, Eduard Bosch-Peligero, Daniel Valcárcel-Paz, Ada Cardiel-Perez, Josep Guindo-Soldevila, Antoni Martínez-Rubio
Left main coronary artery disease (LMCAD) is associated with high morbidity and mortality due to the large myocardial mass at risk. Although medical treatment may be an option in selected low-risk patients, revascularisation is recommended to improve survival in the majority of patients presenting with a significant left main stenosis. In the past decade, multiple randomised clinical trials and meta-analyses have compared coronary artery bypass grafting surgery (CABG) versus percutaneous coronary intervention (PCI), finding controversial results...
2023: European Cardiology
https://read.qxmd.com/read/38174218/selection-of-non-vitamin-k-antagonist-oral-anticoagulant-for-stroke-prevention-in-atrial-fibrillation-based-on-patient-profile-perspectives-from-vietnamese-experts-part-2
#7
REVIEW
Minh That Ton, Tri Huynh Quang Ho, Viet Lan Nguyen, Hung Manh Pham, Sy Van Hoang, Nhan Thanh Vo, Thai Quoc Nguyen, Linh Tran Pham, Ton Duy Mai, Thang Huy Nguyen
Part 1 of this review provided an overview of AF in Vietnam, with a particular focus on primary and secondary stroke prevention. Part 2 explores the management of AF in special, high-risk and clinically common patient populations, including those with renal impairment, diabetes, the elderly, and those with coronary artery disease. Furthermore, Part 2 addresses the challenges posed by patients with AF who have a bioprosthetic valve, a group situated in a grey area of consideration. Managing AF in these patient groups presents unique clinical challenges that require careful consideration...
2023: European Cardiology
https://read.qxmd.com/read/38174217/selection-of-non-vitamin-k-antagonist-oral-anticoagulant-for-stroke-prevention-in-atrial-fibrillation-based-on-patient-profile-perspectives-from-vietnamese-experts-part-1
#8
REVIEW
Tri Huynh Quang Ho, Minh That Ton, Viet Lan Nguyen, Hung Manh Pham, Sy Van Hoang, Nhan Thanh Vo, Thai Quoc Nguyen, Linh Tran Pham, Ton Duy Mai, Thang Huy Nguyen
In Asia, especially Vietnam, AF is a common arrhythmia and is linked to a higher risk of stroke and systemic embolism. Anticoagulation therapy for stroke prevention in AF patients can result in bleeding complications. To effectively manage AF, adopting appropriate anticoagulation and addressing modifiable risk factors are crucial. Vietnamese clinicians are particularly interested in non-vitamin K antagonist oral anticoagulants (NOACs), a recent development in AF treatment. However, the lack of head-to-head trials comparing NOACs makes selecting a specific NOAC challenging...
2023: European Cardiology
https://read.qxmd.com/read/38023338/validating-the-prognostic-utility-of-the-abcd-gene-score-in-asian-patients-with-acute-coronary-syndrome-patients-on-clopidogrel
#9
JOURNAL ARTICLE
Cheng Keat Tan, David Bin-Chia Wu, Seh Yi Joseph Tan, Syed Saqib Imran, Xue Ting Wee, Su-Yin Doreen Tan
BACKGROUND: The ABCD-GENE score, which links cytochrome P450 2C19 (CYP2C19) phenotype and high platelet reactivity (HPR) to the risk of major adverse cardiovascular events (MACE) in clopidogrel users, has been validated in white and Japanese populations. The prognostic implications of the score in other Asian cohorts, however, have been largely unchartered. The aim of this study was to validate the prognostic utility of the ABCD-GENE score in a heterogeneous Asian acute coronary syndrome (ACS) cohort...
2023: European Cardiology
https://read.qxmd.com/read/38023337/decreased-noise-and-identification-of-very-low-voltage-signals-using-a-novel-electrophysiology-recording-system
#10
JOURNAL ARTICLE
Josef Kautzner, Petr Peichl, Rune Paamand, Mark D Carlson
AIMS: The interpretation of intracardiac electrograms recorded from conventional electrophysiology recording systems is frequently impacted by powerline (50/60 Hz) noise and distortion due to notch filtering. This study compares unipolar electrograms recorded simultaneously from a conventional electrophysiology recording system and one of two 3D mapping systems (control system) with those from a novel system (ECGenius, CathVision ApS) designed to reduce noise without the need for conventional filtering...
2023: European Cardiology
https://read.qxmd.com/read/37942208/cardiac-involvement-due-to-covid-19-insights-from-imaging-and-histopathology
#11
REVIEW
Valentina O Puntmann, Anastasia Shchendrygina, Carlos Rodriguez Bolanos, Mame Madjiguène Ka, Silvia Valbuena, Andreas Rolf, Felicitas Escher, Eike Nagel
Lingering cardiac symptoms are increasingly recognised complications of severe acute respiratory syndrome coronavirus 2 infection, now referred to as post-acute cardiovascular sequelae of COVID-19 (PASC). In the acute phase, cardiac injury is driven by cytokine release and stems from ischaemic and thrombotic complications, resulting in myocardial necrosis. Patients with pre-existing cardiac conditions are particularly vulnerable. Myocarditis due to a direct viral infection is rare. Chronic symptoms relate to either worsening of pre-existing heart disease (PASC - cardiovascular disease) or delayed chronic inflammatory condition due to heterogenous immune dysregulation (PASC - cardiovascular syndrome), the latter affecting a broad segment of previously well people...
2023: European Cardiology
https://read.qxmd.com/read/37860701/percutaneous-left-atrial-appendage-occlusion-what-the-practising-physician-should-know
#12
REVIEW
Pierluigi Merella, Giuseppe Talanas, Giovanni Lorenzoni, Cristiana Denurra, Enrico Atzori, Gavino Casu
Non-valvular AF is a common clinical condition associated with an increased risk of thromboembolic complications. As a consequence, oral anticoagulant therapy (OAT) is the cornerstone of non-valvular AF management. Despite the well-established efficacy of OAT, many patients cannot receive this preventive therapy due to bleeding or a high risk of bleeding. The fact that more than 90% of thrombi are formed in the left atrial appendage has led to the development of alternative methods to reduce the embolic risk...
2023: European Cardiology
https://read.qxmd.com/read/37860700/the-role-of-triglyceride-rich-lipoproteins-and-their-remnants-in-atherosclerotic-cardiovascular-disease
#13
REVIEW
Mohanad Gabani, Michael D Shapiro, Peter P Toth
Atherosclerotic cardiovascular disease (ASCVD) is the world's leading cause of death. ASCVD has multiple mediators that therapeutic interventions target, such as dyslipidaemia, hypertension, diabetes and heightened systemic inflammatory tone, among others. LDL cholesterol is one of the most well-studied and established mediators targeted for primary and secondary prevention of ASCVD. However, despite the strength of evidence supporting LDL cholesterol reduction by multiple management strategies, ASCVD events can still recur, even in patients whose LDL cholesterol has been very aggressively reduced...
2023: European Cardiology
https://read.qxmd.com/read/37860699/tricuspid-regurgitation-disease-state-and-advances-in-percutaneous-therapy
#14
REVIEW
Qiuyu Martin Zhu, Natalia Berry
Tricuspid regurgitation (TR) is a relatively common finding. There has been growing recognition of the morbidity and adverse prognosis of severe TR, which affects 1.6 million people in the US. However, symptomatic TR remains undertreated despite emerging therapeutic modalities. In this review, the pathophysiological and epidemiological features of TR are examined and the diagnosis, natural history, and clinical presentation are discussed. An overview of TR therapy is provided, including medical and surgical treatments, as well as novel percutaneous approaches...
2023: European Cardiology
https://read.qxmd.com/read/37745168/cardiovascular-disease-and-covid-19-vaccines-a-systematic-review-and-analysis-of-published-cases
#15
REVIEW
Abdulrhman Khaity, Ala' Abdala Mohamad Rababah, Omar A Abdelwahab, Khaled Albakri, Rehab Adel Diab, Nada Mostafa Al-Dardery, Mahmoud Abbassy, Balqees M Al-Hanaqtah, Ahmed K Awad, Tamam Mohamad
As vaccination against COVID-19 became more widespread, side-effects that were not initially detected during clinical trials became more prominent. The aim of this systematic review is to discuss reports of adverse cardiovascular events associated with COVID-19 vaccination. Databases were searched from inception up to August 2022 to identify case reports and case series reporting on patients with cardiovascular disease after COVID-19 vaccination. This study assessed 150 published cases. Of these, 109 were case reports and 41 were case series...
2023: European Cardiology
https://read.qxmd.com/read/37680202/gaps-in-modern-heart-failure-and-chronic-kidney-disease-research
#16
EDITORIAL
Simran Singh Parmar, Vasantha Muthuppalaniappan, Debasish Banerjee
Heart failure and chronic kidney disease are common conditions and often coexist. Modern clinical trials are not entirely representative of heart failure patients in the community with respect to age and sex. Despite this, another group of heart failure patients, those with advanced chronic kidney disease, are even less represented in modern clinical trials. This review summarises the evidence for heart failure therapies across age, sex and severity of chronic kidney disease, and outlines the need for further research in these populations...
2023: European Cardiology
https://read.qxmd.com/read/37655135/comment-on-leadless-pacemakers-current-achievements-and-future-perspectives
#17
EDITORIAL
Zaki Akhtar, Manav Sohal, Mark M Gallagher
No abstract text is available yet for this article.
2023: European Cardiology
https://read.qxmd.com/read/37655134/the-utility-of-ct-coronary-angiography-in-chronic-total-occlusion-percutaneous-coronary-intervention
#18
REVIEW
Firas Yassin, Jawad Khan, Abdul Mozid, Derek Connolly, Vinoda Sharma
Chronic total occlusion (CTO) of the coronary arteries is a relatively common finding in routine coronary angiography. Of late, there has been considerable improvement in the success rate of percutaneous intervention for coronary CTO, attributed to technological advancement and skills development. CT coronary angiogram (CTCA) is a simple, non-invasive, and cost-effective test that aids in the diagnosis and management of coronary artery disease, including CTOs. The development of multi-slice CT and the use of 3D volume rendering images has revolutionised the diagnostic abilities of CTCA, with improvements in imaging quality and detailed anatomical and morphological characterisation of the plaque disease...
2023: European Cardiology
https://read.qxmd.com/read/37655133/leadless-pacemakers-current-achievements-and-future-perspectives
#19
REVIEW
Apostolos Ilias Vouliotis, Paul R Roberts, Polychronis Dilaveris, Konstantinos Gatzoulis, Arthur Yue, Konstantinos Tsioufis
Despite the technological advances in pacemaker technology, the transvenous implanted leads are still considered the Achilles' heel of this rhythm-control therapy. The leadless permanent pacemaker system was developed as an option to bypass the weakness of the transvenous approach. Advances in battery technology and deep miniaturisation of electronics now offer the opportunity to implant the whole pacemaker system into the right ventricle. This review aims to provide a comprehensive report on the advent of leadless pacemakers, their clinical usefulness and the future perspectives of this disruptive and promising technology...
2023: European Cardiology
https://read.qxmd.com/read/37546183/ablation-as-first-line-therapy-for-atrial-fibrillation
#20
REVIEW
Jason G Andrade
AF is a chronic and progressive heart rhythm disorder characterised by exacerbations and remissions. Contemporary guidelines recommend antiarrhythmic drugs (AADs) as the initial therapy for the maintenance of sinus rhythm. However, these medications have modest efficacy and are associated with significant adverse effects. Several recent trials have evaluated catheter ablation as an initial therapy for AF, demonstrating that cryoballoon catheter ablation significantly improves arrhythmia outcomes (e.g. atrial tachyarrhythmia recurrence and arrhythmia burden), produces clinically meaningful improvements in patient-reported outcomes (e...
2023: European Cardiology
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