journal
https://read.qxmd.com/read/38939039/a-transcriptomic-biomarker-predicting-linezolid-associated-neuropathy-during-treatment-of-drug-resistant-tuberculosis
#1
JOURNAL ARTICLE
Nika Zielinski, Dragos Baiceanu, Antonela Dragomir, Jan Heyckendorf, Elmira Ibraim, Niklas Köhler, Christoph Leschczyk, Cristina Popa, Andrea Rachow, Jens Sachsenweger, Patricia Sanchez Carballo, Dagmar Schaub, Hajo Zeeb, Begna Tulu, Andrew R DiNardo, Christoph Lange, Maja Reimann
BACKGROUND: Neuropathic adverse events occur frequently in linezolid-containing regimens, some of which remain irreversible after drug discontinuation. OBJECTIVE: We aimed to identify and validate a host RNA-based biomarker that can predict linezolid-associated neuropathy before multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment initiation and to identify genes and pathways that are associated with linezolid-associated neuropathy. METHODS: Adult patients initiating MDR/RR-TB treatment including linezolid were prospectively enrolled in 3 independent cohorts in Germany...
2024: Pathogens & Immunity
https://read.qxmd.com/read/38933606/characteristics-and-functions-of-infection-enhancing-antibodies-to-the-n-terminal-domain-of-sars-cov-2
#2
JOURNAL ARTICLE
Ruth I Connor, Mrunal Sakharkar, C Garrett Rappazzo, Chengzi I Kaku, Nicholas C Curtis, Seungmin Shin, Wendy F Wieland-Alter, Jordan Wentworth, Daniel W Mielcarz, Joshua A Weiner, Margaret E Ackerman, Laura M Walker, Jiwon Lee, Peter F Wright
BACKGROUND: Fcγ-receptor (FcγR)-independent enhancement of SARS-CoV-2 infection mediated by N-terminal domain (NTD)-binding monoclonal antibodies (mAbs) has been observed in vitro , but the functional significance of these antibodies in vivo is less clear. METHODS: We characterized 1,213 SARS-CoV-2 spike (S)-binding mAbs derived from COVID-19 convalescent patients for binding specificity to the SARS-CoV-2 S protein, VH germ-line usage, and affinity maturation...
2024: Pathogens & Immunity
https://read.qxmd.com/read/38807656/the-gut-and-the-translocated-microbiomes-in-hiv-infection-current-concepts-and-future-avenues
#3
REVIEW
Krystelle Nganou-Makamdop, Daniel C Douek
It is widely acknowledged that HIV infection results in disruption of the gut's mucosal integrity partly due a profound loss of gastrointestinal CD4+ T cells that are targets of the virus. In addition, systemic inflammation and immune activation that drive disease pathogenesis are reduced but not normalized by antiretroviral therapy (ART). It has long been postulated that through the process of microbial translocation, the gut microbiome acts as a key driver of systemic inflammation and immune recovery in HIV infection...
2024: Pathogens & Immunity
https://read.qxmd.com/read/38779368/evaluation-of-an-automated-wall-mounted-far-ultraviolet-c-light-technology-for-continuous-or-intermittent-decontamination-of-candida-auris-on-surfaces
#4
JOURNAL ARTICLE
Samir Memic, Claire E Kaple, Jennifer L Cadnum, Curtis J Donskey
BACKGROUND: Technologies that provides safe and effective decontamination of surfaces and equipment between episodes of manual cleaning could be an important advance in efforts to prevent transmission of the emerging fungal pathogen Candida auris . METHODS: We tested the efficacy of a novel wall-mounted far ultraviolet-C (UV-C) light technology that delivers far UV-C, when people are not detected within the field of illumination, against C. auris isolates from clades I, II, III, and IV using a quantitative disk carrier test method...
2024: Pathogens & Immunity
https://read.qxmd.com/read/38774127/interview-with-drew-weissman-2023-nobel-laureate-in-physiology-or-medicine
#5
JOURNAL ARTICLE
Michael M Lederman, Neil S Greenspan
No abstract text is available yet for this article.
2024: Pathogens & Immunity
https://read.qxmd.com/read/38774126/invasive-and-non-invasive-clinical-haemophilus-influenzae-type-a-isolates-activate-differentiated-hl-60-cells-in-vitro
#6
JOURNAL ARTICLE
Courtney L Ferris, Marina Ulanova
BACKGROUND: The effective elimination of encapsulated bacteria like Haemophilus influenzae type a (Hia) relies on immune mechanisms such as complement-mediated opsonophagocytosis by neutrophils in coordination with opsonization by anti-capsular antibodies. This study evaluated if Hia could activate the immune response through neutrophils and if these responses differed between encapsulated versus unencapsulated or invasive versus non-invasive strains. METHODS: HL-60-derived neutrophil-like cells (dHL-60), differentiated with 1...
2024: Pathogens & Immunity
https://read.qxmd.com/read/38765786/defining-the-effects-of-pkc-modulator-hiv-latency-reversing-agents-on-natural-killer-cells
#7
JOURNAL ARTICLE
Melanie Dimapasoc, Jose A Moran, Steve W Cole, Alok Ranjan, Rami Hourani, Jocelyn T Kim, Paul A Wender, Matthew D Marsden, Jerome A Zack
BACKGROUND: Latency reversing agents (LRAs) such as protein kinase C (PKC) modulators can reduce rebound-competent HIV reservoirs in small animal models. Furthermore, administration of natural killer (NK) cells following LRA treatment improves this reservoir reduction. It is currently unknown why the combination of a PKC modulator and NK cells is so potent and whether exposure to PKC modulators may augment NK cell function in some way. METHODS: Primary human NK cells were treated with PKC modulators (bryostatin-1, prostratin, or the designed, synthetic bryostatin-1 analog SUW133), and evaluated by examining expression of activation markers by flow cytometry, analyzing transcriptomic profiles by RNA sequencing, measuring cytotoxicity by co-culturing with K562 cells, assessing cytokine production by Luminex assay, and examining the ability of cytokines and secreted factors to independently reverse HIV latency by co-culturing with Jurkat-Latency (J-Lat) cells...
2024: Pathogens & Immunity
https://read.qxmd.com/read/38746756/safety-efficacy-and-pharmacokinetics-of-combination-sars-cov-2-neutralizing-monoclonal-antibodies-bms-986414-c135-ls-and-bms-986413-c144-ls-administered-subcutaneously-in-non-hospitalized-persons-with-covid-19-in-a-phase-2-trial
#8
JOURNAL ARTICLE
Katya C Corado, Kara W Chew, Mark J Giganti, Ying Mu, Courtney V Fletcher, Judith S Currier, Eric S Daar, David A Wohl, Jonathan Z Li, Carlee B Moser, Justin Ritz, Arzhang Cyrus Javan, Gene Neytman, Marina Caskey, Michael D Hughes, Davey M Smith, Joseph J Eron
BACKGROUND: Outpatient COVID-19 monoclonal antibody (mAb) treatment via subcutaneous delivery, if effective, overcomes the logistical burdens of intravenous administration. METHODS: ACTIV-2/A5401 was a randomized, masked placebo-controlled platform trial where participants with COVID-19 at low risk for progression were randomized 1:1 to subcutaneously administered BMS-986414 (C135-LS) 200 mg, plus BMS-986413 (C144-LS) 200 mg, (BMS mAbs), or placebo. Coprimary outcomes were time to symptom improvement through 28 days; nasopharyngeal SARS-CoV-2 RNA below the lower limit of quantification (LLoQ) on days 3, 7, or 14; and treatment-emergent grade 3 or higher adverse events (TEAEs) through 28 days...
2024: Pathogens & Immunity
https://read.qxmd.com/read/38690563/harnessing-bacterial-extracellular-vesicle-immune-effects-for-cancer-therapy
#9
REVIEW
Irem Karaman, Asmita Pathak, Defne Bayik, Dionysios C Watson
There are a growing number of studies linking the composition of the human microbiome to disease states and treatment responses, especially in the context of cancer. This has raised significant interest in developing microbes and microbial products as cancer immunotherapeutics that mimic or recapitulate the beneficial effects of host-microbe interactions. Bacterial extracellular vesicles (bEVs) are nano-sized, membrane-bound particles secreted by essentially all bacteria species and contain a diverse bioactive cargo of the producing cell...
2024: Pathogens & Immunity
https://read.qxmd.com/read/38690562/transmission-of-severe-acute-respiratory-syndrome-coronavirus-2-among-residents-and-employees-in-a-veterans-affairs-community-living-center-a-42-month-prospective-cohort-study
#10
JOURNAL ARTICLE
Chetan Jinadatha, Lucas D Jones, Jennifer M Hailes, Emma K Marshall, Munok Hwang, Jennifer L Cadnum, Hosoon Choi, Piyali Chatterjee, Ernest R Chan, Peter A Zimmerman, Nadim G El Chakhtoura, Elie A Saade, Curtis J Donskey
BACKGROUND: Understanding routes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in long-term care facilities is essential for the development of effective control measures. METHODS: Between March 1, 2020, and August 31, 2023, we identified coronavirus disease 2019 (COVID-19) cases among residents and employees in a Veterans Affairs community living center that conducted routine screening for asymptomatic COVID-19. Contact tracing was conducted to identify suspected transmission events, and whole genome sequencing was performed to determine the relatedness of SARS-CoV-2 samples...
2024: Pathogens & Immunity
https://read.qxmd.com/read/38576545/erratum-to-historical-highlight-the-chemical-characterization-of-the-pneumococcal-transforming-principle
#11
Neil S Greenspan
[This corrects the article DOI: 10.20411/pai.v8i2.687.].
2024: Pathogens & Immunity
https://read.qxmd.com/read/38550613/chimeric-antigen-receptor-car-t-cell-therapy-for-non-hodgkin-s-lymphoma
#12
REVIEW
Maria Florencia Giraudo, Zachary Jackson, Indrani Das, Olubukola M Abiona, David N Wald
This review focuses on the use of chimeric antigen receptor (CAR)-T cell therapy to treat non-Hodgkin's lymphoma (NHL), a classification of heterogeneous malignant neoplasms of the lymphoid tissue. Despite various conventional and multidrug chemotherapies, the poor prognosis for NHL patients remains and has prompted the utilization of groundbreaking personalized therapies such as CAR-T cells. CAR-T cells are T cells engineered to express a CAR that enables T cells to specifically lyse tumor cells with extracellular expression of a tumor antigen of choice...
2024: Pathogens & Immunity
https://read.qxmd.com/read/38505662/erratum-to-progress-note-2024-curing-hiv-not-in-my-lifetime-or-just-around-the-corner
#13
Justin Harper, Michael R Betts, Mathias Lichterfeld, Michaela Müller-Trutwin, David Margolis, Katharine J Bar, Jonathan Z Li, Joseph M McCune, Sharon R Lewin, Deanna Kulpa, Santiago Ávila-Ríos, Dázon Dixon Diallo, Michael M Lederman, Mirko Paiardini
[This corrects the article DOI: 10.20411/pai.v8i2.665.].
2023: Pathogens & Immunity
https://read.qxmd.com/read/38486922/time-to-think-antifungal-resistance-increased-antifungal-resistance-exacerbates-the-burden-of-fungal-infections-including-resistant-dermatomycoses
#14
JOURNAL ARTICLE
Thomas S McCormick, Mahmoud Ghannoum
Increased antifungal resistance is exacerbating the burden of invasive fungal infections, as well as potentially contributing to the increase in resistant dermatomycoses. In this commentary, we focus on antifungal drug resistance, in contrast to antibacterial resistance. We provide a brief historical perspective on the emergence of antifungal resistance and propose measures for combating this growing health concern. The increase in the incidence of invasive and cutaneous fungal infections parallels advancements in medical interventions, such as immunosuppressive drugs, to manage cancer and reduce organ rejection following transplant...
2023: Pathogens & Immunity
https://read.qxmd.com/read/38455668/progress-note-2024-curing-hiv-not-in-my-lifetime-or-just-around-the-corner
#15
JOURNAL ARTICLE
Justin Harper, Michael R Betts, Mathias Lichterfeld, Michaela Müller-Trutwin, David Margolis, Katharine J Bar, Jonathan Z Li, Joseph M McCune, Sharon R Lewin, Deanna Kulpa, Dázon Dixon Diallo, Michael M Lederman, Mirko Paiardini
Once a death sentence, HIV is now considered a manageable chronic disease due to the development of antiretroviral therapy (ART) regimens with minimal toxicity and a high barrier for genetic resistance. While highly effective in arresting AIDS progression and rendering the virus untransmissible in people living with HIV (PLWH) with undetectable viremia (U=U) [1, 2]), ART alone is incapable of eradicating the "reservoir" of resting, latently infected CD4+ T cells from which virus recrudesces upon treatment cessation...
2023: Pathogens & Immunity
https://read.qxmd.com/read/38434447/the-chemical-characterization-of-the-pneumococcal-transforming-principle
#16
JOURNAL ARTICLE
Neil S Greenspan
No abstract text is available yet for this article.
2023: Pathogens & Immunity
https://read.qxmd.com/read/38420260/hiv-productively-infects-highly-differentiated-and-exhausted-cd4-t-cells-during-aids
#17
JOURNAL ARTICLE
Clayton Faua, Axel Ursenbach, Anne Fuchs, Stéphanie Caspar, Frédérick Jegou, Yvon Ruch, Baptiste Hoellinger, Elodie Laugel, Aurélie Velay, David Rey, Samira Fafi-Kremer, Pierre Gantner
BACKGROUND: Throughout HIV infection, productively infected cells generate billions of viral particles and are thus responsible for body-wide HIV dissemination, but their phenotype during AIDS is unknown. As AIDS is associated with immunological changes, analyzing the phenotype of productively infected cells can help understand HIV production during this terminal stage. METHODS: Blood samples from 15 untreated viremic participants (recent infection, n=5; long-term infection, n=5; active opportunistic AIDS-defining disease, n=5) and 5 participants virologically controlled on antiretroviral therapy (ART) enrolled in the Analysis of the Persistence, Reservoir and HIV Latency (APRIL) study (NCT05752318) were analyzed...
2023: Pathogens & Immunity
https://read.qxmd.com/read/38361525/replication-and-injury-associated-with-sars-cov-2-in-cultured-hepatocytes
#18
JOURNAL ARTICLE
Suman Pradhan, Susan D Rouster, Jason T Blackard, Gary E Dean, Kenneth E Sherman
BACKGROUND: Liver dysfunction is one of the hallmarks of SARS-CoV-2 infection. The mechanism(s) of hepatic injury in SARS-CoV-2 infection remains controversial with some reporting viral replication and cellular injury and others suggesting lack of replication and injury due to non-cytopathogenic etiologies. To investigate this further, we evaluated SARS-CoV-2 replication in immortalized hepatic cell lines and primary hepatocytes, examined whether cell injury was associated with apoptotic pathways, and also determined the effect of the antiviral remdesivir on these processes...
2023: Pathogens & Immunity
https://read.qxmd.com/read/38347963/stable-levels-of-antibodies-against-unrelated-toxoid-vaccines-after-covid-19-covid-19-infection-does-not-affect-toxoid-vaccine-antibody-levels
#19
JOURNAL ARTICLE
Suvi T Jokiranta, Simo Miettinen, Sami Salonen, Lauri Kareinen, Ruut Uusitalo, Essi M Korhonen, Jenni Virtanen, Ilkka Kivistö, Kirsi Aaltonen, Dina A Mosselhy, Tinja Lääveri, Anu Kantele, T Petteri Arstila, Hanna Jarva, Olli Vapalahti, Santtu Heinonen, Eliisa Kekäläinen
BACKGROUND: Lymphopenia is common in COVID-19. This has raised concerns that COVID-19 could affect the immune system akin to measles infection, which causes immune amnesia and a reduction in protective antibodies. METHODS: We recruited COVID-19 patients (n = 59) in Helsinki, Finland, and collected plasma samples on 2 to 3 occasions during and after infection. We measured IgG antibodies to diphtheria toxin, tetanus toxoid, and pertussis toxin, along with total IgG, SARS-CoV-2 spike protein IgG, and neutralizing antibodies...
2023: Pathogens & Immunity
https://read.qxmd.com/read/38292079/machine-learning-bolsters-evidence-that-d1-nef-and-tat-influence-hiv-reservoir-dynamics
#20
JOURNAL ARTICLE
LaMont Cannon, Sophia Fehrman, Marilia Pinzone, Sam Weissman, Una O'Doherty
BACKGROUND: The primary hurdle to curing HIV is due to the establishment of a reservoir early in infection. In an effort to find new treatment strategies, we and others have focused on understanding the selection pressures exerted on the reservoir by studying how proviral sequences change over time. METHODS: To gain insights into the dynamics of the HIV reservoir we analyzed longitudinal near full-length sequences from 7 people living with HIV between 1 and 20 years following the initiation of antiretroviral treatment...
2023: Pathogens & Immunity
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