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Journal of Global Oncology

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https://read.qxmd.com/read/30779600/clinical-characteristics-and-treatment-outcomes-of-patients-with-advanced-germ-cell-tumor-treated-at-a-tertiary-cancer-center-in-brazil
#1
Vitor Florin Vasconcellos, Diogo Assed Bastos, Allan A Lima Pereira, Gabriel Yoshiyuki Watarai, Bruno Rodriguez Pereira, Adriana de Godoy, Jamile Almeida-Silva, David Queiroz Borges Muniz, Giuliano Betoni Guglielmetti, William Carlos Nahas, Carlos Dzik
PURPOSE: Reported treatment outcomes for patients with advanced germ cell tumors (aGCT) are based mainly on series from developed nations. Data from low- and middle-income countries are underrepresented. MATERIAL AND METHODS: From 2000 to 2015, a retrospective analysis identified 300 patients with aGCT treated at our institution. Kaplan-Meier methods were used for analysis of progression-free survival (PFS) and overall survival (OS) according to the International Germ Cell Consensus Classification Group (IGCCCG)...
February 2019: Journal of Global Oncology
https://read.qxmd.com/read/30763144/engagement-in-hiv-care-and-access-to-cancer-treatment-among-patients-with-hiv-associated-malignancies-in-uganda
#2
Daniel H Low, Warren Phipps, Jackson Orem, Corey Casper, Rachel A Bender Ignacio
PURPOSE: Health system constraints limit access to HIV and cancer treatment programs in sub-Saharan Africa. Limited access and continuity of care affect morbidity and mortality of patients with cancer and HIV. We assessed barriers in the care cascade of comorbid HIV and cancer. PATIENTS AND METHODS: Structured interviews were conducted with 100 adult patients with HIV infection and new diagnoses of cancer at the Uganda Cancer Institute. Participants completed follow-up questionnaires after 1 year to assess ongoing engagement with and barriers to care...
February 2019: Journal of Global Oncology
https://read.qxmd.com/read/30735433/reirradiation-for-recurrent-nasopharyngeal-carcinomas-experience-from-an-academic-tertiary-center-in-a-low-to-middle-income-country
#3
Ryan Anthony F Agas, Kelvin Ken L Yu, Paolo G Sogono, Lester Bryan A Co, J C Kennetth M Jacinto, Warren R Bacorro, Michael Benedict A Mejia
PURPOSE: The objectives of this study were to report the oncologic outcomes and the treatment-related toxicities after reirradiation (re-RT) for recurrent nasopharyngeal carcinoma (rNPC) at our institution and to apply a recently published prognostic model for survival in rNPC in our cohort. PATIENTS AND METHODS: Thirty-two patients with rNPC treated at the authors' institution with re-RT were retrospectively reviewed. Treatment modalities for re-RT were intensity-modulated radiotherapy (n = 14), three-dimensional conformal radiotherapy (n = 9), single-fraction stereotactic radiosurgery (n = 6), fractionated stereotactic radiotherapy (n = 2), and high dose rate intracavitary brachytherapy (n = 1)...
February 2019: Journal of Global Oncology
https://read.qxmd.com/read/30715958/population-screening-for-cancer-in-high-income-settings-lessons-for-low-and-middle-income-economies
#4
Philippe Autier, Richard Sullivan
No abstract text is available yet for this article.
February 2019: Journal of Global Oncology
https://read.qxmd.com/read/30707665/adjuvant-hysterectomy-in-patients-with-residual-disease-after-radiation-for-locally-advanced-cervical-cancer-a-prospective-longitudinal-study
#5
Shahana Pervin, Farzana Islam Ruma, Khadija Rahman, Jannatul Ferdous, Rifat Ara, Mollah Mohamed Abu Syed, Annekathryn Goodman
PURPOSE: The aim of the study was to evaluate the efficacy of hysterectomy in the control of pelvic disease in patients with post-irradiated residual cervical cancer. PATIENTS AND METHODS: Forty patients were treated at either National Institute of Cancer Research and Hospital (NICRH) or Delta Cancer Hospital in Dhaka, Bangladesh, with International Federation of Gynecology and Obstetrics stage IIB to IIIB disease with residual disease after the following: either concurrent chemoradiation with or without brachytherapy, induction chemotherapy and external-beam radiotherapy (EBRT) with or without brachytherapy, or only EBRT...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30707664/brca-testing-dichotomy-in-saudi-arabia
#6
Atlal Abusanad
No abstract text is available yet for this article.
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30707663/patients-lost-to-follow-up-for-cervical-cancer-in-the-limbe-regional-hospital
#7
Robert Tchounzou, André Gaetan Simo Wambo, Théophile Nana Njamen, Ingrid Ofakem Ilick, Humphry Tatah Neng, François Dadao, Albert Mouelle Sone
PURPOSE: Cervical cancer constitutes a public health problem in Cameroon where it represents 13.8% of cancers in women. We wanted to evaluate compliance with cervical cancer care with a focus on patients who are lost to follow-up from the time that symptoms suggestive of cervical cancer are clinically recognized to treatment. PATIENTS AND METHODS: Sociodemographic data, attitude toward diagnosis and treatment, and reason for discontinuing care were recorded and analyzed for a period of 5 years from January 2010 to December 2015...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30707662/treatment-outcomes-of-pediatric-patients-with-ewing-sarcoma-in-a-war-torn-nation-a-single-institute-experience-from-iraq
#8
Sazgar S Majeed, Hawzheen A Muhammad, Jalil S Ali, Hassanain H Khudhair, Ayah Said, Shkar O Arif, Karzan M Murad, Ali H Gendari, Bamo M Muhsin, Shwan A Mohammed, Layth Mula-Hussain
PURPOSE: Ewing sarcoma (ES) is a relatively rare, highly malignant tumor of the musculoskeletal system. It is the second most common malignant bone tumor in children and adolescents in the age group of 5 to 20 years. The aim of this study was to identify the treatment outcomes of pediatric patients with ES in Sulaimani governorate, Iraq. PATIENTS AND METHODS: This was a retrospective study that reviewed the medical records of pediatric patients with ES who were managed between 2009 and 2015, with follow-up until late 2017...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30694738/cervical-cancer-treatment-delays-and-associated-factors-in-a-cohort-of-women-from-a-developing-country
#9
Ileia Ferreira da Silva, Ilce Ferreira da Silva, Rosalina Jorge Koifman
PURPOSE: To estimate treatment delays and associated factors among women diagnosed with cervical cancer who were treated at the main cancer center in Rio de Janeiro, Brazil. MATERIALS AND METHODS: A retrospective cohort study was performed comprising 865 women newly diagnosed with cervical cancer between 2012 and 2014. Times from diagnosis to treatment initiation (less than or equal to 60 days) and from diagnosis to treatment ending (less than or equal to 120 days) were analyzed according to the Brazilian law for the treatment of patients with cancer...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30694737/high-preponderance-of-braf-v600e-mutation-in-papillary-thyroid-carcinoma-among-filipinos-a-clinicopathologic-study
#10
Gerard Anthony M Espiritu, Joemarie T Malana, Arlie Jean Grace V Dumasis, Daphne C Ang
PURPOSE: BRAF mutation in papillary thyroid carcinoma (PTC) is associated with an aggressive phenotype, with varying incidence. We evaluated the prevalence of BRAF mutations in PTC among Filipino patients and their correlation with clinicopathologic characteristics. PATIENTS AND METHODS: Clinicopathologic data were retrieved from 64 sequential patients who underwent thyroidectomy from June 2016 to December 2016. BRAF mutation testing was performed using Sanger sequencing...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30689495/knowledge-summaries-for-comprehensive-breast-cancer-control-feedback-from-target-audiences-in-kenya
#11
Mishka Kohli Cira, Jo Anne Zujewski, Allison Dvaladze, Nathan R Brand, Amanda L Vogel
PURPOSE: Comprehensive breast cancer control programs are needed to decrease breast cancer mortality, but few tools exist to assist stakeholders in limited-resource settings. The Knowledge Summaries for Comprehensive Breast Cancer Control (KSBCs) are a series of evidence-based publications intended to support cancer control planning at various resource levels. The goals of this evaluation research study were to learn about the extent to which the KSBCs could be useful to policymakers, health care providers, and breast cancer advocates in Kenya, and whether introducing the KSBCs led to their uptake, and if so, how they were used...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30676841/is-the-fixed-dose-intravenous-trastuzumab-policy-warranted-in-limited-resource-settings
#12
Loay Kassem, Kyrillus S Shohdy, Ahmad M Abdel-Azeez, Hanaa Attia
No abstract text is available yet for this article.
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30668271/cisplatin-fluorouracil-in-bolus-injection-and-leucovorin-in-first-line-therapy-for-advanced-gastric-cancer-as-an-alternative-to-protocols-with-infusional-fluorouracil
#13
Rafael C Coelho, Pedro D P Abreu, Mariana R Monteiro, Ana Paula Stramosk, Alvaro Henrique I Garces, Andreia Cristina Melo, Marcia S Graudenz, Carlos Jose C Andrade
PURPOSE: Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer death worldwide. Platinum agents and fluoropyrimidines are the main compounds used in the first-line setting for advanced GC. Given the activity of fluorouracil (FU) bolus, the PFL protocol, a chemotherapy regimen combining cisplatin, FU bolus, and leucovorin, was incorporated at the Brazilian National Cancer Institute, because this schedule does not require hospitalization or infusion pumps...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30668270/cancer-control-at-the-district-hospital-level-in-sub-saharan-africa-an-educational-and-resource-needs-assessment-of-general-practitioners
#14
Allison N Martin, Kelly-Mariella Kaneza, Amol Kulkarni, Pacifique Mugenzi, Rahel Ghebre, David Ntirushwa, André M Ilbawi, Lydia E Pace, Ainhoa Costas-Chavarri
PURPOSE: The WHO framework for early cancer diagnosis highlights the need to improve health care capacity among primary care providers. In Rwanda, general practitioners (GPs) at district hospitals (DHs) play key roles in diagnosing, initiating management, and referring suspected patients with cancer. We sought to ascertain educational and resource needs of GPs to provide a blueprint that can inform future early cancer diagnosis capacity-building efforts. METHODS: We administered a cross-sectional survey study to GPs practicing in 42 Rwandan DHs to assess gaps in cancer-focused knowledge, skills, and resources, as well as delays in the referral process...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30657735/patients-with-breast-cancer-report-from-a-national-hospital-based-cancer-registry-in-argentina-2012-to-2016
#15
María Graciela Abriata, Guillermo Raúl Macías
PURPOSE: To describe sociodemographic, epidemiologic, and clinical characteristics of patients who were diagnosed with breast cancer and registered in the Institutional Tumor Registry of Argentina (RITA) as of April 2016. METHODS: This was an observational, descriptive case study in patients who were diagnosed with breast cancer between April 2012 and April 2016 and registered in RITA. Quantitative and qualitative analyses were done, including delay from symptoms to first consultation, delay from diagnosis to treatment (opportunities), as well as patients' survival (Kaplan-Meier and log-rank tests)...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30629457/fully-automatic-treatment-planning-for-external-beam-radiation-therapy-of-locally-advanced-cervical-cancer-a-tool-for-low-resource-clinics
#16
Kelly Kisling, Lifei Zhang, Hannah Simonds, Nazia Fakie, Jinzhong Yang, Rachel McCarroll, Peter Balter, Hester Burger, Oliver Bogler, Rebecca Howell, Kathleen Schmeler, Mike Mejia, Beth M Beadle, Anuja Jhingran, Laurence Court
PURPOSE: The purpose of this study was to validate a fully automatic treatment planning system for conventional radiotherapy of cervical cancer. This system was developed to mitigate staff shortages in low-resource clinics. METHODS: In collaboration with hospitals in South Africa and the United States, we have developed the Radiation Planning Assistant (RPA), which includes algorithms for automating every step of planning: delineating the body contour, detecting the marked isocenter, designing the treatment-beam apertures, and optimizing the beam weights to minimize dose heterogeneity...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30615540/hes1-protein-modulates-human-papillomavirus-mediated-carcinoma-of-the-uterine-cervix
#17
Richa Tripathi, Gayatri Rath, Vishwas Sharma, Showket Hussain, Shashi Sharma, Mausumi Bharadwaj, Ravi Mehrotra
PURPOSE: Cervical cancer (CC) is the most common cancer affecting women worldwide. Human papillomavirus (HPV) infection is a major contributing factor for the development of CC. The development of CC occurs progressively from precancer stages to cancerous stages (ie, invasive squamous cell carcinoma [ISCC] and adenocarcinoma [ADC]). ADC is a rare form of CC that develops from the mucinous endocervical epithelium. It is believed that the downstream targets of Notch signaling contribute to the etiology of CC...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30589597/paper-analytic-device-to-detect-the-presence-of-four-chemotherapy-drugs
#18
Madeline Smith, Ayenew Ashenef, Marya Lieberman
A paper analytic device, the chemoPAD, was developed and validated to visually detect methotrexate, doxorubicin, cisplatin, and oxaliplatin at concentrations commonly found in injectable dosage forms. By testing residual solution after patient treatment, the chemoPAD can be used to monitor drug quality without restriction of patient access to medication. The chemoPAD is produced by wax printing on Ahlstrom paper to create separate reaction areas and deposits small amounts of chemicals to create color changes in response to different active pharmaceutical ingredients (APIs)...
December 2018: Journal of Global Oncology
https://read.qxmd.com/read/30589596/barriers-and-opportunities-of-oncofertility-practice-in-nine-developing-countries-and-the-emerging-oncofertility-professional-engagement-network
#19
Mahmoud Salama, Lauren Ataman-Millhouse, Fabio Sobral, Guillermo Terrado, Anibal Scarella, Maria T Bourlon, Satish Kumar Adiga, Karthik S Udupa, Nalini Mahajan, Madhuri Patil, Chris Venter, Georgia Demetriou, Ramiro Quintana, Gabriela Rodriguez, Tomas Quintana, Luz Viale, Yuly Andrea Remolina Bonilla, July Andrea Russi Noguera, Juan Carlos Velásquez Velásquez, Jennifer Ivonne Dominguez Pineda, Mario Daniel Castro Aldecoa, Murid Javed, Hamad Al Sufyan, Nonso Daniels, Adegbite A Ogunmokun, Teresa K Woodruff
PURPOSE: Oncofertility practice continues to grow in developing countries despite the lack of health care services, especially those related to cancer care. The purpose of this study is to further explore oncofertility practice in these countries and identify opportunities for field-wide coalescence. METHODS: We generated a survey to learn more about oncofertility practice in nine developing countries within our Oncofertility Consortium Global Partners Network-Mexico, Colombia, Guatemala, Argentina, Chile, Nigeria, South Africa, Saudi Arabia, and India...
December 2018: Journal of Global Oncology
https://read.qxmd.com/read/30582434/bone-marrow-transplantation-in-patients-with-acute-leukemia-in-cuba-results-from-the-last-30-years-and-new-opportunities-through-international-collaboration
#20
José Carnot Uria, Calixto Hernández Cruz, Jorge Muñío Perurena, Wilfredo Torres Yribar, Jesús Diego de la Campa, Concepción Del Castillo Carrillo, Yusaima Rodríguez Fraga, Julio A López Silva, Kali Cepero Llauger, Ibis K Pardo Ramírez, Aliette García García, Karen Sweiss, Pritesh R Patel, Damiano Rondelli
Blood and marrow transplantation (BMT) has been performed in Cuba for over 30 years with limited resources and without international relationships. Researchers from University of Illinois at Chicago and Hermanos Ameijeiras Hospital (HAH) in Havana collaborated on retrospectively analyzing 101 consecutive patients with adult acute leukemia who received BMT at HAH from June 1986 to January 2016. Of these, 82 had acute myeloid leukemia (AML) and 19 had acute lymphoblastic leukemia (ALL). BMT eligibility criteria included prior morphologic complete remission, no severe comorbidities, and age between 16 and 60 years...
December 2018: Journal of Global Oncology
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