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Open Access Macedonian Journal of Medical Sciences

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https://read.qxmd.com/read/30745987/quality-of-life-in-psoriasis-vietnamese-patients-treated-with-metformin-in-combination-with-methotrexate
#1
Tam Huynh Thi Xuan, Van Bui Thi, Anh Tran Ngoc, Em Dang Van, Quyet Tran Dang, Thuong Nguyen Van, Phuong Pham Thi Minh, Lan Pham Thi, Nghi Dinh Huu, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
A cross-sectional study was performed on 48 psoriasis Vietnamese patients treated with metformin as an add-on for methotrexate and 48 psoriasis patients treated methotrexate alone. The mean PASI scores were 5.25 ± 5.72. Total QOL scores had a slight difference between patients treated metformin combined with methotrexate and methotrexate alone (62.32 ± 18.1 vs 60.91 ± 19.63). Combined therapy with metformin and methotrexate contributes to significantly improve the quality of life for patients with psoriasis...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745986/the-relationship-between-hla-b27-hla-cw06-hla-dr7-and-psoriatic-arthritis-in-vietnamese-patients-disease-progression-and-therapeutic-burden
#2
Vinh Ngo Minh, Van Bui Thi, Tro Chau Van, Trai Nguyen Ngoc, Anh Tran Ngoc, Em Dang Van, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
We conducted a prospective, cross-sectional study at Ho Chi Minh City Hospital of Dermato Venereology from January 2016 to March 2017 in 40 psoriatic arthritis (PsA) patients to evaluate the disease progression and therapeutic burden about the HLA patterns. Based upon our results, PsA with HLA-B27 (+) had a threat of severe arthritis. PsA with HLA-Cw06 (+) had a higher risk of earlier onset and shorter duration for plaque psoriasis to transform into PsA. HLA-DR7 (+) in PsA delayed the time for conversion from plaque psoriasis into PsA...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745985/successful-treatment-of-intralesional-bleomycin-in-keloids-of-vietnamese-population
#3
Nghi Dinh Huu, Sau Nguyen Huu, Xuan Le Thi, Thuong Nguyen Van, Phuong Pham Thi Minh, Trang Trinh Minh, Tam Hoang Van, Van Tran Cam, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Keloid is an overactive condition of the skin tissue to early lesions characterised by proliferation of fibroblasts, excessive collagen production in the lesion. Treatment of keloids is a big challenge because of the poor response rate and high risk of recurrence after treatment. We found that bleomycin offers promise in the treatment of keloids. AIM: To evaluate the efficacy of bleomycin injected in the injury for keloids treatment. METHODS: The treatment was carried out in 55 patients having 120 keloids of different sizes and locations...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745984/microneedling-therapy-for-atrophic-acne-scar-effectiveness-and-safety-in-vietnamese-patients
#4
Phuong Pham Thi Minh, Diep Dang Bich, Van Nguyen Thi Hai, Thuong Nguyen Van, Van Tran Cam, Tran Hau Khang, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: To evaluate the effectiveness and safety of micro-needling therapy in atrophic acne scar treatment. METHOD: A prospective, single centred study was implemented in a total of 31 patients suffering from atrophic acne scar grade 2 to 4 of Goodman and Baron scaring grading system was recruited. They were treated by microneedle derma roller every week in 3 months. The scars were evaluated by a magic system camera and by dermatologists clinically using Goodman and Baron scaring grading system, and Lipper and Perez score at baseline, at final treatment, 1 month and 2 months after the final treatment...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745983/the-effectiveness-of-oral-mini-pulse-methylprednisolonein-the-treatment-of-alopecia-areata-in-vietnam
#5
Phuong Trinh Thi, Anh Tran Lan, Phuong Tran Thu Ha, Thuong Nguyen Van, Phuong Pham Thi Minh, Hao Nguyen Trong, Tro Chau Van, Nghi Dinh Huu, Van Tran Cam, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Systemic corticosteroid is used to treat alopecia areata, but it is associated with side effects. Mini-pulse therapy is thought to be effective but able to reduce side effects. AIM: The study aimed to evaluate the effectiveness of oral mini-pulse methylprednisolone in the treatment of alopecia areata. METHODS: Patients received methylprednisolone 16 mg orally for 2 consecutive days every week. RESULTS: After 3 months, among patients, 40% recovered well, and 55...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745982/successful-treatment-of-freckles-by-alex-trivantage-laser-wavelight-755-nm-in-vietnamese-patients
#6
Sau Nguyen Huu, Cap Lam Van, Thuong Nguyen Van, Tan Nguyen Manh, Phuong Pham Thi Minh, Son Nguyen Hong, Nghi Dinh Huu, Van Tran Cam, Kiem Pham Cao, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
OBJECTIVES: This study aims to evaluate the effectiveness of Alex Trivantage laser wavelength 755 nm (ATL) in the treatment of freckles at Hanoi Hospital of Dermatology and Venereology, Vietnam. PATIENTS AND METHODS: A group of 30 patients with freckles were treated by ATL (Alex Trivantage-Candela Co America) with spots size 3 mm, wavelength 755 mm, and energy 5-6 j/cm2 . All the patients were treated 2 times with 4-weeks interval. The results were evaluated at 4, 8, and 12 weeks after treatment...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745981/successful-treatment-of-vitiligo-vietnamese-patients-with-vitilinex%C3%A2-herbal-bio-actives-in-combination-with-phototherapy
#7
Thuong Nguyen Van, Trang Trinh Minh, Doanh Le Huu, Sau Nguyen Huu, Tung Vu Thanh, Nghi Dinh Huu, Van Tran Cam, My Le Huyen, Khang Tran Hau, Hao Nguyen Trong, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Vitiligo is an acquired pigmentary disease, that causes progressive loss of melanocytes, resulting in hypopigmented skin patches. Current treatments aim at stopping the disease progression and achieving repigmentation of the amelanotic areas. Corticosteroids, surgery, topical immunomodulators, total depigmentation of normal pigmented skin and phototherapy are current treatment options for vitiligo although phototherapy remains the treatment of choice. There is no documented evidence that herbal bio-active products may also be effective treatment options for vitiligo...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745980/efficacy-of-oral-low-dose-isotretinoin-in-the-treatment-of-acne-vulgaris-in-vietnam
#8
Thanh Le Thai Van, Phuong Nguyen Minh, Phuong Tran Thi Thuy, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Oral isotretinoin is an effective therapy for acne. However, isotretinoin can induce hyperhomocysteinemia and decreased serum folic acid level, which may be a risk for cardiovascular disease and thrombosis, as well as psychoses. Besides, many recent types of research emphasise the safety and effects of the low dose isotretinoin therapy. AIM: The aim of our study was to evaluate the effect of the low-dose isotretinoin on the plasma homocysteine and serum folic acid level in the Vietnamese population...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745979/successful-treatment-of-intralesional-triamcilonon-acetonide-injection-in-keloid-patients
#9
Nghi Dinh Huu, Sau Nguyen Huu, Xuan Le Thi, Thuong Nguyen Van, Phuong Pham Thi Minh, Trang Trinh Minh, Tam Hoang Van, Van Tran Cam, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: Evaluation the effect of intralesional corticosteroid injection on keloid, at the National Hospital of Dermatology and Venereology from 1/2009 to 12/2009. METHODS: A group of 65 patients with keloid were randomly assigned into three groups. In the studied group, 33 patients were intralesionally injected 7.5 mg/1 cm2 of TCA. In the control group, TAC 32 patients were intralesionally injected 15 mg/1 cm2 of TCA. The result was evaluated basing on the criteria of Henderson (1998) and El-Tonsy (1996)...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745978/efficacy-of-azole-antifungal-in-treatment-of-pityriasis-versicolor
#10
Van Tran Cam, Thuong Nguyen Van, Khang Tran Hau, Doanh Le Huu, Phuong Pham Thi Minh, Sau Nguyen Huu, Thu Nguyen Minh, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: Compare itraconazole alone, fluconazole combined with ketoconazole and ketoconazole in the treatment of patients with pityriasis versicolor. MATERIAL AND METHODS: A group of 240 pityriasis versicolor patients (confirmed with KOH and culture) were classified into 3 groups: Fluconazole 300 mg a week and 2% ketoconazole foam twice a week for 2 weeks (Category I), Itraconazole 200 mg daily for one week (category II); Ketoconazole 2% foam daily for 2 weeks (Category 3)...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745977/efficacy-of-10-potassium-hydroxide-solution-versus-10-salicylic-acid-ointment-in-treatment-of-molluscum-contagiosum-the-low-cost-dermatologic-therapy-in-vietnam
#11
Sau Nguyen Huu, Minh Nguyen Quang, Thuong Nguyen Van, Kiem Pham Cao, Hien Do Thi Thu, Lan Pham Thi, Van Tran Cam, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Molluscum contagiosum is a common viral disease primarily affecting children. AIM: The objective is to compare the efficacy of 10% potassium hydroxide (KOH) solution versus 10% salicylic pomade in the treatment of molluscum contagiosum. METHODS: Clinical trials on 70 patients were randomised into 2 groups: 39 patients treated with 10% KOH solution and 31 patients treated with 10% salicylic pomade. The evaluation was based on the complete clearance of lesions, side effects and complications of the drug...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745976/efficacy-of-baff-in-monitoring-treatment-response-in-early-vietnamese-systemic-sclerosis-patients
#12
Vu Nguyet Minh, Khang Tran Hau, Matsushita Takashi, Vinh Nguyen Ha, Long Hoang Bao, My Le Huyen, Doanh Le Huu, Thuong Nguyen Van, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: B-cell activating factor (BAFF) is considered to have a role in the pathogenesis of systemic sclerosis (SSc). AIM: We conducted a longitudinal study on early SSc patients to determine the change in BAFF serum level after treatment and its association with organ involvements. METHODS: A total of 46 patients (32 diffuse, 14 limited) were recruited, among which 35 patients (24 diffuse, 11 limited) completed 12-month follow-up. RESULTS: Higher pretreatment BAFF levels were observed in patients with positive anti-topoisomerase antibody (ATA) (2252...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745975/the-efficacy-of-a-two-fold-increase-of-h1-antihistamine-in-the-treatment-of-chronic-urticaria-the-vietnamese-experience
#13
Huyen Tran Thi, Lan Pham Thi, Thuong Nguyen Van, Phuong Pham Thi Minh, Hao Nguyen Trong, Tro Chau Van, Sau Nguyen Huu, Trang Trinh Minh, Nghi Dinh Huu, Tam Hoang Van, Van Tran Cam, My Le Huyen, Khang Tran Hau, Thuy Nguyen Thanh, Phuong Hoang Thi, Linh Nguyen Thuy, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Chronic urticaria, a mast cell-driven condition, is common, debilitating and hard to treat. H1-antihistamines are the first line treatment of chronic urticaria, but often patients do not get satisfactory relief with the recommended dose. European guidelines recommend increased antihistamine doses up to four-fold. AIM: We conducted this study to evaluate the efficacy of increased H1-antihistamine doses up to two-fold in Vietnamese chronic urticaria patients...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745974/the-decline-of-puva-therapy-in-vietnam-effective-treatment-of-narrow-band-uvb-in-vietnamese-vitiligo-patients
#14
Hien Do Thi Thu, Nhung Do Thi Hong, Thuong Nguyen Van, Phuong Pham Thi Minh, Tam Hoang Van, Nghi Dinh Huu, Hao Nguyen Trong, Tro Chau Van, Trai Nguyen Ngoc, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: To examine the efficacy and safety of Narrowband ultraviolet B (NB-UVB) in Vietnamese vitiligo patients. METHODS: We recruited thirty-one patients (14 males, 17 females), aged from 7 to 67 years, with both segmental vitiligo (SV) and non-segmental vitiligo (NSV), treated three times weekly with NB-UVB. The starting dose for adults from 15 years old and children less than 15 years old was 200 mJ/cm2 and 150 mJ/cm2 , respectively, with 50 mJ/cm2 and 20 mJ/cm2 dose increments at each subsequent visit, respectively, until mild erythema lasting less than 24 hrs reported by patient, given for a period of 6 months...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745973/successful-psoriasis-treatment-using-nb-uvb-with-methotrexate-the-vietnamese-experience
#15
Em Dang Van, Thuy Pham Diem, Van Bui Thi, Tam Huynh Thi Xuan, Khai Ly Tuan, Trang Nguyen Quynh, Trang Vu Thu, Thuong Nguyen Van, Sau Nguyen Huu, Phuong Pham Thi Minh, Nghi Dinh Huu, Tam Hoang Van, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: To compare the effectiveness of narrowband ultraviolet B (NBUVB) and oral methotrexate (MTX) to oral MTX alone in Vietnamese psoriasis patients, from May 2016 to May 2018. METHODS: We conducted a non-randomized trial on 70 patients with plaque-type psoriasis of moderate to severe. Thirty-five patients apply NBUVB once/day in 5 days/week for 4 weeks plus oral MTX 7.5 mg/week and 35 patients oral MTX 7.5 mg/week and both two groups treatment for 3 months. The extent of the lesion was assessed by the Psoriasis Area and Severity Index (PASI)...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745972/effectiveness-safety-and-tolerance-of-methotrexate-in-vietnamese-psoriatic-arthritis-patients
#16
Van Bui Thi, Vinh Ngo Minh, Anh Tran Ngoc, Quyet Tran Dang, Diep Le Ngoc, Em Dang Van, Thuong Nguyen Van, Phuong Pham Thi Minh, Hien Do Thi Thu, Nghi Dinh Huu, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: To access the effectiveness, safety and tolerance of methotrexate (MTX) in psoriatic arthritis (PsA) treatment. METHODS: We recruit 37 patients, admitted at HCMC Hospital of Dermato-Venereology from 1/2016 to 3/2017, with MTX dosage ranging from 10 mg to 15 mg per week. RESULTS: Skin lesion response after 12 weeks improved PASI 50: 40.5%, PASI 75: 24.3%. Disease activity score decreased after 12 weeks with ∆DAS28 = -1.43 + 0.79, 37...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745971/antifungal-susceptibility-of-dermatophytes-isolated-from-cutaneous-fungal-infections-the-vietnamese-experience
#17
Tro Chau Van, Khuong Ho Thi Ngoc, Thuong Nguyen Van, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: Evaluate the resistance of dermatophytes to systemic antifungal drugs in the Vietnamese population. METHODS: We enrolled 101 patients with cutaneous dermatophytosis at the Dermato-Venereology hospital in HCMC from August 2016 to March 2017. All the specimens were subjected to direct examination (10% KOH mount) and culture on Sabouraud dextrose agar. In vitro antifungal sensitivity testing was done on species isolated from a culture with broth microdilution method...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745970/superantigens-of-staphylococcus-aureus-colonization-in-atopic-dermatitis-and-treatment-efficacy-of-oral-cefuroxim-in-vietnamese-patients
#18
Tro Chau Van, Thang Nguyen Tat, Anh Tran Lan, Thuong Nguyen Van, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Atopic dermatitis (AD) is a common, chronic, relapsing, genetically determined inflammatory skin disorder. Staphylococcus aureus (S. aureus) plays an important role in the pathogenesis of AD. Atopic skin is susceptible to infection with S. aureus . AIM: This study was aimed to compare the skin S. aureus colonisation status and its secretion of superantigens in adult AD and healthy subjects and to evaluate the efficacy of two treatment regimens (oral cefuroxime plus topical betamethasone dipropionate 0...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745969/efficacy-of-adding-oral-simvastatin-to-topical-therapy-for-treatment-of-psoriasis-the-vietnamese-experience
#19
Hao Nguyen Trong, Thang Nguyen Tat, Tu Tran Nguyen Anh, Nhi Pham Uyen, Thuong Nguyen Van, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Psoriasis, the prevalence of which ranges from 2% to 3% of the general population, has been recently recognised as not only a chronic inflammatory skin disorder but also an immunometabolic systemic disease. Dyslipidemia is one of the most important comorbidities of psoriasis. Statins, frequently used as anti-hyperlipidemic agents, may be beneficial in the treatment of several autoimmune diseases, including psoriasis, due to their anti-inflammatory and immunomodulatory characteristics...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745968/the-efficacy-and-safety-of-hyaluronic-acid-microinjection-for-skin-rejuvenation-in-vietnam
#20
Hao Nguyen Trong, Thao Vu Thi Phuong, Thuong Nguyen Van, Ha Vu Thai, Nghi Dinh Huu, Minh Vu Nguyet, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Aging is an increasing concern of modern society, particularly facial ageing. In recent years, the microinjection technique has increasingly been emphasised as a skin rejuvenation strategy. Hyaluronic acid (HA) plays an important role in the hydration of the extracellular space and can thus improve skin hydration, firmness and viscoelastic properties. AIM: To evaluate the efficacy and safety of HA microinjection in skin rejuvenation. METHODS: We enrolled thirty participants underwent three sessions of HA microinjection involving multiple injections in the face or back of the hands at 2-week intervals...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
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