Skin Appendage Disorders

INTRODUCTION: Although Hutchinson's sign can appear associated with benign conditions, dermoscopic findings of non-melanoma eponychium pigmentation have not yet been described in the literature. We report for the first time to our knowledge the dermoscopic findings of an acral nevus located in the proximal nail fold as well as its clinical-dermoscopic-histologic correlation. CASE REPORT: A twenty-year-old patient presented with a homogeneous longitudinal melanonychia on the left-hand thumb, with benign dermoscopic pattern, and an irregular, 6-mm, dark-brown hyperpigmented macule on the adjacent eponychium (Hutchinson's sign)...

INTRODUCTION: Eruptive syringomas (ES) are a rare variant of syringomas, benign adnexal tumors of eccrine sweat glands' ducts. They mostly affect young-to middle-aged women, but rarely they may also occur in the elderly, requiring generally no specific treatment. CASE PRESENTATION: We present the case of a 76-year-old woman with sudden onset of ES. Clinical examination evidenced brown-to-orange papules and plaques on the anterior neck, corresponding dermatoscopically to orange-brownish structureless areas, with barely hinted peripheral incomplete network, superimposed on areas of light pink...

INTRODUCTION: Alopecia areata (AA) is a common autoimmune condition that affects anagen hair follicles. The most commonly recognized theory is that it is a T-cell-mediated autoimmune disorder in a genetically susceptible individual. MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) were thought to play a function in the pathogenesis. The expression of lncRNA HOTAIR and miRNA-205 and their relation to transforming growth factor β1 (TGF-β1) in AA were not studied. AIM: The aim of the studywas to evaluate the role of miRNA-205, lncRNA, HOTAIR, and TGF-β1 levels in AA pathogenesis, clinical course, and severity of AA...

INTRODUCTION: Although hidradenitis suppurativa (HS) is associated with psychosocial comorbidities such as depression as well as modifiable comorbidities such as obesity, rates of psychosocial screening and lifestyle counseling in the USA have not been characterized. METHODS: This cross-sectional study utilized publicly available data from the National Ambulatory Medical Care Survey (NAMCS) between 2008 and 2018 to identify visits with a diagnosis of HS (ICD-9 code 705...

Alopecia is a common feature in several autoimmune diseases. With a wide spectrum of clinical presentations, it may manifest with a scarring or non-scarring nature, in a diffuse, patchy, or localized pattern. We as dermatologists have the opportunity of assessing patients with hair loss who may have an underlying undiagnosed autoimmune disorder. This review aimed to describe the main clinical, trichoscopic, and histopathological features of hair disorders associated with autoimmune diseases.

INTRODUCTION: Alopecia areata (AA) is an autoimmune condition that results in nonscarring hair loss. There is currently only one Food and Drug Administration (FDA)-approved treatment for AA; as a result, a wide range of treatments are commonly administered. This study aimed to determine how patients with AA prioritize treatment characteristics when choosing a therapy. METHODS: A cross-sectional national survey was distributed using the National Alopecia Areata Foundation's (NAAF) email list...

No abstract text is available yet for this article.

INTRODUCTION: Trichofolliculoma is a very rare, benign hamartomatous skin adnexal tumor originating from the hair follicle. The tumor which presents as a papule or nodule is usually observed on the scalp and face. CASE PRESENTATION: We report the case of a 49-year-old female who presented with a solitary papule on the nose. The lesion which was observed macroscopically and dermoscopically compatible with trichofolliculoma was completely removed by punch biopsy. The diagnosis of trichofolliculoma was confirmed histopathologically, and no recurrence was observed in the follow-up...

INTRODUCTION: We analyzed randomized clinical trials (RCTs) evaluating the efficacy of combined therapy with low-level light therapy (LLLT) and topical minoxidil for treatment of androgenetic alopecia (AGA). METHODS: A literature search within PubMed identified RCTs evaluating hair regrowth following LLLT and minoxidil. Selection criteria were 600-1,100 nm wavelengths, treatment time ≥16 weeks, and objective evaluation for hair regrowth. RESULTS: Five RCTs compared LLLT with minoxidil (2% or 5%) to 5% minoxidil treatment or LLLT treatment...

INTRODUCTION: Teledermatology has been shown to improve efficiency and reduce barriers to care for patients. However, teledermatology is limited by the inability to perform diagnostic tests. With proper planning, teletrichoscopy can be utilized with teledermatology to evaluate patients with hair loss. CASE PRESENTATION: Diagnosis of this patient was made using images taken during the televisit, including scalp images taken by the patient using a handheld microscope and images of the hair roots taken by her referring doctor...

Scalp microinfusion is a promising novel drug delivery technique for hair loss treatment. We discuss the MMP® technique and review its possible use in alopecias. MMP® technique provides a small amount of drugs delivered homogeneously into the skin combined with micro-needling and can, therefore, provide optimal delivery. However, literature on this technique is limited to a few case reports despite its wide use in some countries. Further studies are needed to standardize protocols.

INTRODUCTION: Ingrown toenails are one of the common nail problems generally occurs in the big toe area and most often occurs during productive ages. Treatment of ingrowing toenail can be chosen based on the clinical condition of the patient. Nonoperative therapy is not effective in advanced cases in terms of the severity. Improper handling will cause recurrence in this case. CASE PRESENTATION: Six of 8 patients had the ingrown toenail recurrence previously treated using the nail avulsion (onychectomy) without matricectomy...

INTRODUCTION: Alopecia areata (AA) is a common autoimmune disease characterized by non-scarring hair loss. New onsets of AA have been associated with coronavirus disease 2019 (COVID-19). Various skin diseases have already been reported because of the vaccines (the Pfizer-BioNTech COVID-19 vaccine, the Moderna COVID-19 vaccine, the AstraZeneca vaccine) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). CASE PRESENTATION: We report 5 cases of AA after COVID-19 vaccination...

Central centrifugal cicatricial alopecia (CCCA) is a common form of scarring alopecia that affects the crown or vertex of the scalp as centrifugally spreading patches of permanent hair loss. The etiology of CCCA is uncertain. Genetic predisposition, autoimmune diseases, infections (bacterial and fungal), and other idiopathic factors have all been explored as potential risk factors for the development of CCCA. Seborrheic dermatitis (SD) has been identified in a number of studies as the most common concurrent hair disorder seen in patients with CCCA...

No abstract text is available yet for this article.

INTRODUCTION: Physiological changes in skin and hair are common during pregnancy. There are limited data on nail changes during pregnancy. Therefore, our study objectives were to determine prevalence and types of nail changes in pregnant women. METHODS: A prospective study was conducted in the Weill Cornell Obstetrics and Gynecology waiting room, where a 32-question survey was administered to pregnant and nonpregnant patients. RESULTS: There was a total of 167 subjects (73 pregnant, 94 nonpregnant)...

INTRODUCTION: Solitary keratoacanthoma (SKA) is generally considered as a well-differentiated form of squamous cell carcinoma, but it usually runs a benign course and a not aggressive behavior. Diagnostic criteria, prognosis, and treatment of SKA are not fully defined yet. Surgical treatment with fusiform excision represents the gold standard; nonoperative intralesional therapy of KA is uncommon but may provide a valid option in some categories of patients. CASE SERIES PRESENTATION: We report our experience regarding the treatment of SKA with a hybrid treatment consisting of a minimally invasive technique such as curettage followed by intralesional corticosteroid administration in the same session...

No abstract text is available yet for this article.

INTRODUCTION: Differentiating between benign and malignant pathology in melanonychia can be challenging, particularly in paediatric patients as nail biopsies often require general anaesthesia. CASE PRESENTATION: An 11-year-old healthy Vietnamese female presented with a pigmented right third fingernail. It was first noticed at age 1 and had gradually involved the whole nail plate by age 4. On examination, Hutchinson's sign was thought to be positive. Dermatoscopy revealed a variation of colours and spacing of the pigmentation...

BACKGROUND: The Women's Androgenetic Alopecia Quality of Life (WAA-QoL) questionnaire is the only available specific instrument to evaluate QoL in female pattern hair loss (FPHL) patients. It is made of 16 questions with 6 alternatives, is self-administered, and has not yet been adapted or validated to Spanish. OBJECTIVES: The objective of the study was to translate into Spanish, culturally adapt, and validate the WAA-QoL questionnaire. METHODS: The translated version (WAA-QoL-sp) was submitted to 453 general population women by e-mail after authorization by the author, translation, and adaptation to Spanish of the WAA-QoL questionnaire...