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Journals Signal Transduction and Target...

Signal Transduction and Targeted Therapy

https://read.qxmd.com/read/38782919/dead-box-helicase-17-ddx17-protects-cardiac-function-by-promoting-mitochondrial-homeostasis-in-heart-failure
#1
JOURNAL ARTICLE
Mingjing Yan, Junpeng Gao, Ming Lan, Que Wang, Yuan Cao, Yuxuan Zheng, Yao Yang, Wenlin Li, Xiaoxue Yu, Xiuqing Huang, Lin Dou, Bing Liu, Junmeng Liu, Hongqiang Cheng, Kunfu Ouyang, Kun Xu, Shenghui Sun, Jin Liu, Weiqing Tang, Xiyue Zhang, Yong Man, Liang Sun, Jianping Cai, Qing He, Fuchou Tang, Jian Li, Tao Shen
DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understood. We generated cardiomyocyte-specific Ddx17-knockout mice (Ddx17-cKO), cardiomyocyte-specific Ddx17 transgenic mice (Ddx17-Tg), and various models of cardiomyocyte injury and heart failure (HF). DDX17 is downregulated in the myocardium of mouse models of heart failure and cardiomyocyte injury. Cardiomyocyte-specific knockout of Ddx17 promotes autophagic flux blockage and cardiomyocyte apoptosis, leading to progressive cardiac dysfunction, maladaptive remodeling and progression to heart failure...
May 24, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38778067/peripheral-immune-cell-derived-matrix-metalloprotease-8-mmp8-brain-trafficking-promotes-depression-like-behavior
#2
LETTER
Dietmar Spengler, Theo Rein
No abstract text is available yet for this article.
May 22, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38778010/high-resolution-spatiotemporal-mapping-a-comprehensive-view-of-eukaryotic-cell-cycle-proteome-dynamics
#3
LETTER
Jing Zou, Ziran Qin, Long Zhang
No abstract text is available yet for this article.
May 22, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38773064/development-of-pharmacological-immunoregulatory-anti-cancer-therapeutics-current-mechanistic-studies-and-clinical-opportunities
#4
REVIEW
Nanhao Yin, Xintong Li, Xuanwei Zhang, Shaolong Xue, Yu Cao, Gabriele Niedermann, You Lu, Jianxin Xue
Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment, but challenges related to resistance and toxicity still remain. Due to the advancement of immuno-oncology, an increasing number of novel immunoregulatory targets and mechanisms are being revealed, with relevant therapies promising to improve clinical immunotherapy in the foreseeable future. Therefore, comprehending the larger picture is important. In this review, we analyze and summarize the current landscape of preclinical and translational mechanistic research, drug development, and clinical trials that brought about next-generation pharmacological immunoregulatory anti-cancer agents and drug candidates beyond classical immune checkpoint inhibitors...
May 22, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38763973/tumor-biomarkers-for-diagnosis-prognosis-and-targeted-therapy
#5
REVIEW
Yue Zhou, Lei Tao, Jiahao Qiu, Jing Xu, Xinyu Yang, Yu Zhang, Xinyu Tian, Xinqi Guan, Xiaobo Cen, Yinglan Zhao
Tumor biomarkers, the substances which are produced by tumors or the body's responses to tumors during tumorigenesis and progression, have been demonstrated to possess critical and encouraging value in screening and early diagnosis, prognosis prediction, recurrence detection, and therapeutic efficacy monitoring of cancers. Over the past decades, continuous progress has been made in exploring and discovering novel, sensitive, specific, and accurate tumor biomarkers, which has significantly promoted personalized medicine and improved the outcomes of cancer patients, especially advances in molecular biology technologies developed for the detection of tumor biomarkers...
May 20, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38760366/parp1-dna-co-condensation-the-driver-of-broken-dna-repair
#6
REVIEW
Xiang Wei, Fangfang Zhou, Long Zhang
DNA double-strand break (DSB) sites that prevent the disjunction of broken DNA ends are formed through poly (ADP-ribose) (PAR) polymerase 1 (PARP1)-DNA co-condensation. The co-condensates apply mechanical forces to hold the DNA ends together and generate enzymatic activity for the synthesis of PAR. PARylation can promote the release of PARP1 from DNA ends and recruit various proteins, such as Fused in sarcoma (FUS) proteins, thereby stabilizing broken DNA ends and preventing their separation.
May 17, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38755119/sintilimab-anti-pd-1-antibody-plus-chidamide-histone-deacetylase-inhibitor-in-relapsed-or-refractory-extranodal-natural-killer-t-cell-lymphoma-scent-a-phase-ib-ii-study
#7
MULTICENTER STUDY
Yan Gao, Haixia He, Xueping Li, Liling Zhang, Wei Xu, Ru Feng, Wenyu Li, Yin Xiao, Xinxiu Liu, Yu Chen, Xiaoxiao Wang, Bing Bai, Huijing Wu, Qingqing Cai, Zhiming Li, Jibin Li, Suxia Lin, Yanxia He, Liqin Ping, Cheng Huang, Jiaying Mao, Xiujin Chen, Baitian Zhao, Huiqiang Huang
Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma (RR-ENKTL), however, the complete response (CR) rate and the duration of response (DOR) need to be improved. This phase 1b/2 study investigated the safety and efficacy of sintilimab, a fully human anti-PD-1 antibody, plus chidamide, an oral subtype-selective histone deacetylase inhibitor in 38 patients with RR-ENKTL. Expected objective response rate (ORR) of combination treatment was 80%. Patients received escalating doses of chidamide, administered concomitantly with fixed-dose sintilimab in 21-days cycles up to 12 months...
May 17, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38755160/recent-advances-in-treatment-of-follicular-lymphoma-efficacy-of-pi3k%C3%AE-%C3%AE-inhibitor-tq-b3525
#8
LETTER
Takuya Watanabe
No abstract text is available yet for this article.
May 16, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38744846/mitochondrial-dysfunction-mechanisms-and-advances-in-therapy
#9
REVIEW
Yao Zong, Hao Li, Peng Liao, Long Chen, Yao Pan, Yongqiang Zheng, Changqing Zhang, Delin Liu, Minghao Zheng, Junjie Gao
Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression. Particularly, mitochondrial dysfunctions are identified in many common pathologies, including cardiovascular diseases, neurodegeneration, metabolic syndrome, and cancer. However, the multifaceted nature and elusive phenotypic threshold of mitochondrial dysfunction complicate our understanding of their contributions to diseases. Nonetheless, these complexities do not prevent mitochondria from being among the most important therapeutic targets...
May 15, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38744811/2-apqc-a-small-molecule-activator-of-sirtuin-3-sirt3-alleviates-myocardial-hypertrophy-and-fibrosis-by-regulating-mitochondrial-homeostasis
#10
JOURNAL ARTICLE
Fu Peng, Minru Liao, Wenke Jin, Wei Liu, Zixiang Li, Zhichao Fan, Ling Zou, Siwei Chen, Lingjuan Zhu, Qian Zhao, Gu Zhan, Liang Ouyang, Cheng Peng, Bo Han, Jin Zhang, Leilei Fu
Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide+ (NAD+ )-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumulating evidence has recently revealed that SIRT3 plays its critical roles in cardiac fibrosis, myocardial fibrosis and even heart failure (HF), through its deacetylation modifications. Accordingly, discovery of SIRT3 activators and elucidating their underlying mechanisms of HF should be urgently needed...
May 15, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38740785/enhanced-potency-of-an-igm-like-nanobody-targeting-conserved-epitope-in-sars-cov-2-spike-n-terminal-domain
#11
JOURNAL ARTICLE
Bo Liu, Honghui Liu, Pu Han, Xiaoyun Wang, Chunmei Wang, Xinxin Yan, Wenwen Lei, Ke Xu, Jianjie Zhou, Jianxun Qi, Ruiwen Fan, Guizhen Wu, Wen-Xia Tian, George F Gao, Qihui Wang
Almost all the neutralizing antibodies targeting the receptor-binding domain (RBD) of spike (S) protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged or emerging variants, such as Omicron and its sub-variants. This suggests that highly conserved epitopes are crucial for the development of neutralizing antibodies. Here, we present one nanobody, N235, displaying broad neutralization against the SARS-CoV-2 prototype and multiple variants, including the newly emerged Omicron and its sub-variants...
May 13, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38740763/safety-immunogenicity-and-protective-effect-of-sequential-vaccination-with-inactivated-and-recombinant-protein-covid-19-vaccine-in-the-elderly-a-prospective-longitudinal-study
#12
JOURNAL ARTICLE
Hong-Hong Liu, Yunbo Xie, Bao-Peng Yang, Huan-Yue Wen, Peng-Hui Yang, Jin-E Lu, Yan Liu, Xi Chen, Meng-Meng Qu, Yang Zhang, Wei-Guo Hong, Yong-Gang Li, Junliang Fu, Fu-Sheng Wang
The safety and efficacy of COVID-19 vaccines in the elderly, a high-risk group for severe COVID-19 infection, have not been fully understood. To clarify these issues, this prospective study followed up 157 elderly and 73 young participants for 16 months and compared the safety, immunogenicity, and efficacy of two doses of the inactivated vaccine BBIBP-CorV followed by a booster dose of the recombinant protein vaccine ZF2001. The results showed that this vaccination protocol was safe and tolerable in the elderly...
May 13, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38735995/structural-basis-of-negative-regulation-of-crispr-cas7-11-by-tpr-chat
#13
JOURNAL ARTICLE
Tian Hong, Qinghua Luo, Haiyun Ma, Xin Wang, Xinqiong Li, Chongrong Shen, Jie Pang, Yan Wang, Yuejia Chen, Changbin Zhang, Zhaoming Su, Haohao Dong, Xiaodi Tang
CRISPR‒Cas7-11 is a Type III-E CRISPR-associated nuclease that functions as a potent RNA editing tool. Tetratrico-peptide repeat fused with Cas/HEF1-associated signal transducer (TPR-CHAT) acts as a regulatory protein that interacts with CRISPR RNA (crRNA)-bound Cas7-11 to form a CRISPR-guided caspase complex (Craspase). However, the precise modulation of Cas7-11's nuclease activity by TPR-CHAT to enhance its utility requires further study. Here, we report cryo-electron microscopy (cryo-EM) structures of Desulfonema ishimotonii (Di) Cas7-11-crRNA, complexed with or without the full length or the N-terminus of TPR-CHAT...
May 13, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38734691/sars-cov-2-aberrantly-elevates-mitochondrial-bioenergetics-to-induce-robust-virus-propagation
#14
JOURNAL ARTICLE
Hye Jin Shin, Wooseong Lee, Keun Bon Ku, Gun Young Yoon, Hyun-Woo Moon, Chonsaeng Kim, Mi-Hwa Kim, Yoon-Sun Yi, Sangmi Jun, Bum-Tae Kim, Jong-Won Oh, Aleem Siddiqui, Seong-Jun Kim
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a 'highly transmissible respiratory pathogen, leading to severe multi-organ damage. However, knowledge regarding SARS-CoV-2-induced cellular alterations is limited. In this study, we report that SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral infection. SARS-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNA-nucleocapsid cluster, thereby abnormally promoting mitochondrial elongation and the OXPHOS process, followed by enhancing ATP production...
May 11, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38724491/effect-of-plateletcrit-and-methylenetetrahydrofolate-reductase-mthfr-c677t-genotypes-on-folic-acid-efficacy-in-stroke-prevention
#15
JOURNAL ARTICLE
Yuncong Shi, Zhengzhipeng Zhang, Binyan Wang, Yu Wang, Xiangyi Kong, Yong Sun, Aimin Li, Yimin Cui, Yan Zhang, Jianping Li, Yong Huo, Hui Huang
Previous studies have shown that low platelet count combined with high plasma total homocysteine (tHcy) increased stroke risk and can be lowered by 73% with folic acid. However, the combined role of other platelet activation parameters and the methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on stroke risk and folic acid treatment benefit remain to be examined. This study aimed to investigate if platelet activation parameters and MTHFR genotypes jointly impact folic acid treatment efficacy in first stroke prevention...
May 10, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38724561/robust-neutralization-of-sars-cov-2-variants-including-jn-1-and-ba-2-87-1-by-trivalent-xbb-vaccine-induced-antibodies
#16
LETTER
Xun Wang, Shujun Jiang, Wentai Ma, Yanliang Zhang, Pengfei Wang
No abstract text is available yet for this article.
May 9, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38719840/unveiling-the-culprit-the-fusobacterium-lineage-that-populates-colorectal-cancer
#17
JOURNAL ARTICLE
Johannes Betge, Matthias P Ebert
No abstract text is available yet for this article.
May 8, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38714712/a-pathological-joint-liver-axis-mediated-by-matrikine-activated-cd4-t-cells
#18
JOURNAL ARTICLE
Junzhi Yi, Hui Zhang, Fangyuan Bao, Zhichu Chen, Yuliang Zhong, Tianning Ye, Xuri Chen, Jingyi Qian, Mengya Tian, Min Zhu, Zhi Peng, Zongyou Pan, Jianyou Li, Zihao Hu, Weiliang Shen, Jiaqi Xu, Xianzhu Zhang, Youzhi Cai, Mengjie Wu, Hua Liu, Jing Zhou, Hongwei Ouyang
The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint damage, combined with joint bleeding (hemarthrosis), exhibits a worse liver function compared with healthy control. With mouse model, hemarthrosis induces both cartilage degeneration and remote liver damage. Next, we found that hemarthrosis induces the upregulation in ratio and differentiation towards Th17 cells of CD4+ T cells in peripheral blood and spleen...
May 8, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38714686/car-t-overdrive-harnessing-inosine-for-metabolic-rewiring-and-stemness-induction
#19
LETTER
Martí Farrera-Sal, Michael Schmueck-Henneresse
No abstract text is available yet for this article.
May 7, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38710734/dietary-selection-of-commensal-protists-expanding-host-immunity-by-impacting-trans-kindom-competition-with-bacteria
#20
JOURNAL ARTICLE
Bo Li, Min Wu, Huaqiong Li
No abstract text is available yet for this article.
May 6, 2024: Signal Transduction and Targeted Therapy
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