William M McFadden, Mary C Casey-Moore, Grant A L Bare, Karen A Kirby, Xin Wen, Gencheng Li, Hua Wang, Ryan L Slack, Alexa A Snyder, Zachary C Lorson, Isabella L Kaufman, Maria E Cilento, Philip R Tedbury, Milan Gembicky, Arthur J Olson, Bruce E Torbett, K Barry Sharpless, Stefan G Sarafianos
Of the targets for HIV-1 therapeutics, the capsid core is a relatively unexploited but alluring drug target due to its indispensable roles throughout virus replication. Because of this, we aimed to identify "clickable" covalent modifiers of the HIV-1 capsid protein (CA) for future functionalization. We screened a library of fluorosulfate compounds that can undergo sulfur(VI) fluoride exchange (SuFEx) reactions, and five compounds were identified as hits. These molecules were further characterized for antiviral effects...
March 21, 2024: Cell Chemical Biology