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Translational Pediatrics

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https://read.qxmd.com/read/30881903/surgical-septal-myectomy-for-obstructive-hypertrophic-cardiomyopathy-during-infancy
#1
COMMENT
Julia Schleihauf, Julie Cleuziou, Cordula M Wolf
No abstract text is available yet for this article.
January 2019: Translational Pediatrics
https://read.qxmd.com/read/30881902/transition-clinics-an-observational-study-of-themes-important-to-young-people-with-inflammatory-bowel-disease
#2
Shwan Karim, Jody A Porter, Andrew McCombie, Richard B Gearry, Andrew S Day
Background: Transition from paediatric to adult services can be stressful and potentially disruptive for adolescents diagnosed with inflammatory bowel disease (IBD). This study aimed to ascertain transition-related factors relevant to young people in New Zealand. Methods: Adolescents diagnosed with IBD prior to their 16th birthday were asked to participate in focus groups to generate transition-related themes. These themes were used to develop a questionnaire, which was then administered to a second group of young patients...
January 2019: Translational Pediatrics
https://read.qxmd.com/read/30881901/quality-improvement-in-healthcare-for-patients-with-inflammatory-bowel-disease
#3
REVIEW
Michael Georgy, Yasser Negm, Wael El-Matary
Since inflammatory bowel diseases (IBD) are chronic disorders with typical remission and relapses and no cure, maintaining high quality of provided healthcare to patients with IBD plays a major role in the management and reducing disease-related morbidity. To hone process-based quality indicators in order to ameliorate quality of care, the indicators must be based on high quality evidence and expert consensus. ImproveCareNow (ICN) group gave us a great example of quality improvement (QI) by gaining experience in how to exercise, apply and implement QI methods in the care of children with IBD...
January 2019: Translational Pediatrics
https://read.qxmd.com/read/30881900/predicting-and-preventing-complications-in-children-with-inflammatory-bowel-disease
#4
REVIEW
Zubin Grover
Paediatric-onset inflammatory bowel disease (IBD) is associated with greater disease burden and morbidity compared to adult-onset IBD. Accurate risk prediction for a complicated disease course in childhood onset IBD is essential for making the best treatment choices. Complicating course in IBD is closely linked with choice of therapies and treatment targets. In this review article, we examine risk factors of complicated disease course in children with IBD in the era of increasing use of biologics and tighter treatment targets...
January 2019: Translational Pediatrics
https://read.qxmd.com/read/30881899/personalising-medicine-in-inflammatory-bowel-disease-current-and-future-perspectives
#5
REVIEW
James J Ashton, Enrico Mossotto, Sarah Ennis, R Mark Beattie
Up to 25% of inflammatory bowel disease (IBD) presents during childhood, often with severe and extensive disease, leading to significant morbidity including delayed growth and nutritional impairment. The classical approach to management has centred on differentiation into Crohn's disease (CD) or ulcerative colitis (UC), with subsequent treatment based on symptoms, results and complications. However, IBD is a heterogeneous condition with substantial variation in phenotype, disease course and outcome, so whilst effective treatment exists one size does not fit all...
January 2019: Translational Pediatrics
https://read.qxmd.com/read/30881898/antibiotics-in-inflammatory-bowel-diseases-do-we-know-what-we-re-doing
#6
REVIEW
Oren Ledder
Despite the revolution in inflammatory bowel disease (IBD) treatment over the past two decades with the advent of biological therapies, there remains a substantial proportion of patients with inadequate or unsustained response to existent therapies. The overwhelming focus of IBD therapeutics has been targeting mucosal immunity, however with the developing evidence base pointing to the role of gut microbes in the inflammatory process, renewed focus should be placed on the impact of manipulating the microbiome in IBD management...
January 2019: Translational Pediatrics
https://read.qxmd.com/read/30881897/single-high-dose-oral-vitamin-d3-treatment-in-new-zealand-children-with-inflammatory-bowel-disease
#7
Natalie G Martin, Tarah Rigterink, Mustafa Adamji, Catherine L Wall, Andrew S Day
Background: High-dose oral vitamin D (stoss) is a novel treatment in children with inflammatory bowel disease (IBD). Vitamin D supplementation may have benefits in IBD beyond bone health including reduced disease activity and improvements in inflammatory markers. The aim of this study was to retrospectively assess the efficacy, safety and impact on disease activity of single oral high-dose vitamin D3 therapy in New Zealand (NZ) children with IBD and vitamin D deficiency. Methods: In this retrospective chart review, children with IBD and vitamin D deficiency [serum 25-OH vitamin D level (25-OHD) <50 nmol/L] in Christchurch, NZ, who were managed with single high-dose vitamin D3 therapy were identified...
January 2019: Translational Pediatrics
https://read.qxmd.com/read/30881896/ferric-carboxymaltose-in-the-treatment-of-iron-deficiency-in-pediatric-inflammatory-bowel-disease
#8
Nicholas Carman, Richard Muir, Peter Lewindon
Background: Iron deficiency (ID) with or without anemia is a common complication of pediatric inflammatory bowel disease (IBD), causing significant morbidity. Despite this, ID remains prevalent and undertreated, related in part to questions surrounding optimal formulation and route of administration. Ferric carboxymaltose (FCM) is a recent formulation of intravenous iron, allowing higher doses and rapid infusion times. This study aims to demonstrate the efficacy and safety of FCM in paediatric patients with IBD, and explore the differences between patients with active and quiescent disease...
January 2019: Translational Pediatrics
https://read.qxmd.com/read/30881895/recommendation-of-plant-based-diets-for-inflammatory-bowel-disease
#9
EDITORIAL
Mitsuro Chiba, Hajime Ishii, Masafumi Komatsu
No abstract text is available yet for this article.
January 2019: Translational Pediatrics
https://read.qxmd.com/read/30881894/growth-failure-in-pediatric-onset-inflammatory-bowel-disease-mechanisms-epidemiology-and-management
#10
REVIEW
Takashi Ishige
Impairment of growth is recognized as one of the most significant complications of inflammatory bowel disease (IBD) in pediatric patients. The reported incidence of growth failure at diagnosis is 15-40% in pediatric onset Crohn's disease (CD) and 3-10% in ulcerative colitis (UC). Growth failure is associated with decreased appetite, abdominal symptoms, malabsorption due to mucosal inflammation, growth hormone (GH) resistance due to inflammation, and even genetic factors. Several population-based studies and cohort studies suggest that patients with pre-pubertal onset CD have a higher risk of growth failure at disease onset...
January 2019: Translational Pediatrics
https://read.qxmd.com/read/30881893/the-difference-in-extraintestinal-manifestations-of-inflammatory-bowel-disease-for-children-and-adults
#11
REVIEW
Hyo-Jeong Jang, Ben Kang, Byung-Ho Choe
Extraintestinal manifestations (EIMs) are frequently observed in adult and pediatric patients with inflammatory bowel disease (IBD). The most common EIMs involve the joints, skin, and eyes, but they can affect various organs and result in significant morbidity. Since EIMs can appear years before the diagnosis of IBD is made, clinicians should be aware of their various manifestations to help decrease diagnostic delay of IBD and establish appropriate treatment plans.
January 2019: Translational Pediatrics
https://read.qxmd.com/read/30881892/inflammatory-bowel-disease-in-children
#12
EDITORIAL
Andrew S Day
No abstract text is available yet for this article.
January 2019: Translational Pediatrics
https://read.qxmd.com/read/30460190/an-evidence-based-standardized-protocol-for-anticoagulation-following-congenital-heart-surgery
#13
EDITORIAL
Catherine Deshaies, Nancy Poirier, Paul Khairy
No abstract text is available yet for this article.
October 2018: Translational Pediatrics
https://read.qxmd.com/read/30460189/optimal-exposure-for-closure-of-ventricular-septal-defects-through-the-tricuspid-valve
#14
EDITORIAL
Ali Dodge-Khatami
No abstract text is available yet for this article.
October 2018: Translational pediatrics
https://read.qxmd.com/read/30460188/when-is-early-septal-myectomy-in-children-with-hypertrophic-cardiomyopathy-justified
#15
EDITORIAL
Neha Bansal, Paul Barach, Shahnawaz M Amdani, Steven E Lipshultz
No abstract text is available yet for this article.
October 2018: Translational Pediatrics
https://read.qxmd.com/read/30460187/a-new-approach-to-risk-stratification-using-fetal-mri-to-predict-outcomes-in-congenital-diaphragmatic-hernia-the-preliminary-retrospective-single-institutional-study
#16
Akiko Yokoi, Satoko Ohfuji, Seiji Yoshimoto, Yusuke Sugioka, Yoshinobu Akasaka, Toru Funakoshi
Background: Congenital diaphragmatic hernia (CDH) is a condition with a wide range of severity. Prenatal diagnosis is essential to optimize postnatal management, especially for severe cases. The lung to head ratio (LHR) and liver herniation estimated by prenatal ultrasound has been used as prenatal predictors in CDH. However, reliability of these factors remains to be proven and prediction of outcome from prenatal imaging is still challenging. We propose our new stratification system using lung to liver signal intensity ratio (LLSIR) in fetal MRI, which has been shown to be related to pulmonary maturation...
October 2018: Translational Pediatrics
https://read.qxmd.com/read/30460186/always-ready-always-prepared-preparing-for-the-next-pandemic
#17
REVIEW
Mitchell Hamele, Katie Neumayer, Jill Sweney, W Bradley Poss
A future global pandemic is likely to occur and planning for the care of critically ill children is less robust than that for adults. This review covers the current state of federal and regional resources for pediatric care in pandemics, a strategy for pandemic preparation in pediatric intensive care units and regions focusing on stuff, space, staff and systems, considerations in developing surge capacity and triage protocols, special circumstances such as highly infectious and highly lethal pandemics, and a discussion of ethics in the setting of pediatric critical care in a pandemic...
October 2018: Translational pediatrics
https://read.qxmd.com/read/30460185/pediatric-palliative-care-in-the-intensive-care-unit-and-questions-of-quality-a-review-of-the-determinants-and-mechanisms-of-high-quality-palliative-care-in-the-pediatric-intensive-care-unit-picu
#18
REVIEW
Sara Rhodes Short, Rachel Thienprayoon
This article reviews the state and practice of pediatric palliative care (PC) within the pediatric intensive care unit (PICU) with specific consideration of quality issues. This includes defining PC and end of life (EOL) care. We will also describe PC as it pertains to alleviating children's suffering through the provision of "concurrent care" in the ICU environment. Modes of care, and attendant strengths, of both the consultant and integrated models will be presented. We will review salient issues related to the provision of PC in the PICU, barriers to optimal practice, parental, and staff perceptions...
October 2018: Translational pediatrics
https://read.qxmd.com/read/30460184/going-back-to-the-ward-transitioning-care-back-to-the-ward-team
#19
REVIEW
Lori A Herbst, Sanyukta Desai, Dan Benscoter, Karen Jerardi, Katie A Meier, Angela M Statile, Christine M White
Transition of care from the intensive care unit (ICU) to the ward is usually an indication of the patient's improving clinical status, but is also a time when patients are particularly vulnerable. The transition between care teams poses a higher risk of medical error, which can be mitigated by safe and complete patient handoff and medication reconciliation. ICU readmissions are associated with increased mortality as well as ICU and hospital length of stay (LOS); however tools to accurately predict ICU readmission risk are limited...
October 2018: Translational Pediatrics
https://read.qxmd.com/read/30460183/early-mobilization-in-the-pediatric-intensive-care-unit
#20
REVIEW
Tracie C Walker, Sapna R Kudchadkar
Survivors of critical illness often experience multiple morbidities that start in the intensive care unit and impact their quality of life after discharge. Reduced physical function, cognitive decline, feeding disorders, and psychological stress are just a few of the potential complications. Many of these morbidities can lead to a reduced quality of life and lifelong impediments. Early mobilization, an intervention that is intended to maintain or restore musculoskeletal strength in the critically ill, has the potential to also yield positive psychological and cognitive benefits...
October 2018: Translational pediatrics
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