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Journal of Pharmaceutical Health Care and Sciences

Daisuke Nango, Yukifumi Hirose, Makoto Goto, Hirotoshi Echizen
Background: There have been debates about the association between the administration of glucocorticoids and the development of acute pancreatitis, since many anecdotal cases of this adverse event were affected either by concomitant diseases (such as systemic lupus erythematosus, SLE) that may develop acute pancreatitis without glucocorticoid treatment or by co-administered drugs with high risk for the event. The aim of the present study was to explore whether disproportionally elevated signals of developing acute pancreatitis may be detected in patients receiving glucocorticoids as compared those receiving other drugs...
2019: Journal of Pharmaceutical Health Care and Sciences
Eri Wakai, Kenji Ikemura, Hiroko Sugimoto, Takuya Iwamoto, Masahiro Okuda
Background: Magnesium oxide (MgO), an antacid and laxative, is widely used in Japan to treat constipation and peptic ulcers. Because serum Magnesium (Mg) levels are elevated in elderly and/or patients with renal failure, its periodic monitoring is recommended for patients prescribed MgO, in order to prevent MgO-induced hypermagnesemia. However, there is little information regarding the factors contributing to the development of MgO-induced hypermagnesemia. In the present study, we retrospectively investigated the risk factors of hypermagnesemia in patients prescribed MgO...
2019: Journal of Pharmaceutical Health Care and Sciences
Hiroki Uda, Yukio Suga, Eriko Toriba, Angelina Yukiko Staub, Tsutomu Shimada, Yoshimichi Sai, Masami Kawahara, Ryo Matsusita
Background: Medical staff should promptly administer antimicrobials to patients with febrile neutropenia (FN) to decrease the mortality related to cancer chemotherapy. Corticosteroids, which are used in cancer chemotherapy, have a fever-suppressive effect. This effect could lead to a blunt fever response and any local signs of infection, especially in patients receiving multiday corticosteroid administration. The aim of this study was to determine whether multiday corticosteroid administration in cancer chemotherapy delays the diagnosis of and antimicrobial treatment for FN...
2019: Journal of Pharmaceutical Health Care and Sciences
Kana Hashimoto, Koki Urata, Ayano Yoshida, Reiko Horiuchi, Naoto Yamaaki, Kunimasa Yagi, Kunizo Arai
Background: The self-management of type 2 diabetes mellitus (T2DM), which involves adherence to medical instructions on diet and nutritional advice, physical activity, medication regimen, and weight and stress management, is necessary for the treatment of T2DM.In this study, we investigated the relationship between patients' perceptions of their disease and their adherence to their medications. And we attempted to determine whether distinct subphenotypes of behavioral change of medication adherence can be discerned based on a patients' perceptions...
2019: Journal of Pharmaceutical Health Care and Sciences
Noor Kifah Al-Tameemi, Azmi Sarriff
Background: Medication therapy management (MTM) service provides set of clinical activities to optimize therapeutic outcomes for patients. It requires the collaboration between patient, pharmacist and other healthcare providers to ensure safe and effective use of medicines. The objective of the current study was to assess Hospital Pulau Pinang pharmacists' knowledge, attitude and practice on MTM service. Methods: A self-administrated validated survey was carried out among all pharmacists working at Hospital Pulau Pinang...
2019: Journal of Pharmaceutical Health Care and Sciences
Haruna Hatahira, Shiori Hasegawa, Sayaka Sasaoka, Yamato Kato, Junko Abe, Yumi Motooka, Akiho Fukuda, Misa Naganuma, Satoshi Nakao, Ririka Mukai, Kazuyo Shimada, Kouseki Hirade, Takeshi Kato, Mitsuhiro Nakamura
Background: Falls are a common but serious problem in older adults, and may lead to fractures and bleeding. As many factors, such as medication, aging, and comorbid diseases may simultaneously affect fall-related adverse events (AEs) in older adults, we evaluated the association between fall-related AEs and the use of medication, aging, and comorbid diseases using the Japanese Adverse Drug Event Report (JADER) database. Methods: We analyzed reports of fall-related AEs associated with α-blockers, diuretics, calcium channel blockers, central nervous system (CNS)-active drugs (opioids, benzodiazepines, hypnotics and sedatives, non-selective monoamine reuptake inhibitors, and selective serotonin reuptake inhibitors (SSRI)) in the JADER database using the reporting odds ratio (ROR)...
2018: Journal of Pharmaceutical Health Care and Sciences
Yuichi Tasaka, Akihiro Tanaka, Daiki Yasunaga, Takashige Asakawa, Hiroaki Araki, Mamoru Tanaka
Background: Pharmaceutical intervention enables safe and effective pharmacotherapy by avoiding of adverse drug reactions (ADRs) and efficacy attenuations. Many prescriptions require optimization, and pharmaceutical interventions are inextricably associated with the prevention of potential drug-related problems (DRPs). Although the analysis and understanding of pharmaceutical interventions can lead to improvement in prescription, the analysis of routine pharmaceutical interventions in Japan in insufficient...
2018: Journal of Pharmaceutical Health Care and Sciences
Hisanori Shimizu, Kenichi Suzuki, Takeshi Uchikura, Daiki Tsuji, Takeharu Yamanaka, Hironobu Hashimoto, Koichi Goto, Reiko Matsui, Nobuhiko Seki, Toshikazu Shimada, Shunya Ikeda, Naoki Ikegami, Toshihiro Hama, Nobuyuki Yamamoto, Tadanori Sasaki
Background: We conducted an economic assessment using test data from the phase III TRIPLE study, which examined the efficacy of a 5-hydroxytryptamine 3 receptor antagonist as part of a standard triplet antiemetic regimen including aprepitant and dexamethasone in preventing chemotherapy-induced nausea and vomiting in patients receiving cisplatin-based highly emetogenic chemotherapy (HEC). Methods: We retrospectively investigated all medicines prescribed for antiemetic purposes within 120 h after the initiation of cisplatin administration during hospitalization...
2018: Journal of Pharmaceutical Health Care and Sciences
Toshinori Hirai, Ryuichi Ogawa, Ryosuke Yamaga, Toshimasa Itoh
Background: S-1 (a combination of tegafur, gimeracil, and oteracil) is used to treat various cancers. Bone marrow suppression is a dose-limiting toxicity of S-1. The relationship between relative dose intensity (RDI) and bone marrow suppression has not been investigated. Hence, we aimed to elucidate the threshold for RDI to identify bone marrow suppression induced by S-1. Methods: In this retrospective cohort study, patients who initiated S-1 treatment at Tokyo Women's Medical University, Medical Center East between June 2015 and June 2017 were included...
2018: Journal of Pharmaceutical Health Care and Sciences
Masahiro Kondo, Taku Naiki, Yuji Hotta, Yuko Yamamoto, Yosuke Sugiyama, Takahiro Yasui, Kazunori Kimura
Background: To our knowledge, no studies have evaluated the safety of carboplatin (CBDCA)-based chemotherapy in hemodialysis patients > 80 years-old. In addition, the impact of CBDCA-based chemotherapy on such elderly patients' quality of life (QOL) is unknown. We report a case of gemcitabine plus CBDCA chemotherapy treatment in an 81-year-old man with metastatic urothelial carcinoma undergoing hemodialysis. Case presentation: The optimal CBDCA dose and hemodialysis timing were determined by monitoring the measured area under the concentration-time curve (AUC) of CBDCA...
2018: Journal of Pharmaceutical Health Care and Sciences
Takahiro Ito, Kazuhiro Yamamoto, Fuminori Ohsawa, Ikuo Otsuka, Akitoyo Hishimoto, Ichiro Sora, Midori Hirai, Ikuko Yano
Background: Risperidone is mainly metabolized by cytochrome P450 (CYP) 2D6 in the liver. The gene encoding CYP2D6 is highly polymorphic. The average steady-state plasma concentration of risperidone active moiety is higher in the CYP2D6 intermediate metabolizers (IMs) compared with that in the extensive metabolizers (EMs). An association between drug-induced extrapyramidal symptoms scale (DIEPSS) score and CYP2D6 polymorphisms has not been reported to date. This study investigates the association of CYP2D6 polymorphisms with the severity of extrapyramidal symptoms in schizophrenia patients receiving risperidone therapy...
2018: Journal of Pharmaceutical Health Care and Sciences
Satsuki Hashimoto, Kyoko Honda, Kohei Fujita, Yuka Miyachi, Kazuya Isoda, Ko Misaka, Yukio Suga, Satoshi Kato, Hiroyuki Tsuchiya, Yukio Kato, Masaki Okajima, Takumi Taniguchi, Tsutomu Shimada, Yoshimichi Sai
Background: Combination therapy of linezolid (LZD) and rifampicin (RFP) may be more effective than monotherapy for treating gram-positive bacterial infections, but several studies have suggested that RFP decreases LZD exposures, thereby increasing the risk of therapeutic failure and emergence of LZD-resistant strains. However, the mechanism of the drug-drug interaction between LZD and RFP is unknown. Methods: We conducted a prospective, open-label, uncontrolled clinical study in Japanese patients receiving LZD and RFP to evaluate the effect of coadministered RFP on the concentration of LZD...
2018: Journal of Pharmaceutical Health Care and Sciences
Yoshihito Morimoto, Kumika Miyawaki, Reisuke Seki, Kazuhiro Watanabe, Masayoshi Hirohara, Takao Shinohara
Background: Vinorelbine is known to be effective in the treatment of non-small cell lung cancer and breast cancer. However, venous irritation is a common side effect. Although there have been some reports on risk factors for venous irritation in patients receiving vinorelbine, the factors evaluated have been limited and the results inconclusive. The aim of this study was to identify risk factors for venous irritation in patients receiving vinorelbine, and factors likely associated with venous irritation, including new factors such as hot compress with a hot towel  for prevention of venous irritation...
2018: Journal of Pharmaceutical Health Care and Sciences
Rei Tanaka, Hiroshi Ishikawa, Tetsu Sato, Michihiro Shino, Katsuhiro Omae, Tetsumi Sato, Iwao Osaka
Background: Appropriate prophylactic rescue dosing of opioids is considered effective for cancer pain relief, but no study has reported the safety of such prophylactic rescue. We compared the safety of prophylactic rescue dosing of immediate-release oral opioids with that of regular rescue dosing. Methods: The study included 103 cancer patients who used either immediate-release morphine syrup or immediate-release oxycodone powder at Shizuoka Cancer Center between January and December 2016...
2018: Journal of Pharmaceutical Health Care and Sciences
Kohhei Maeda, Masao Yamaguchi, Hiroyuki Nagase, Nobuhiro Yasuno, Fumio Itagaki, Machiko Watanabe
Background: The utility and effectiveness of inhalational asthma therapy in patients with a permanent tracheostomy has not been established. Previously, a few studies reported the use of nebulizer-type inhalers for treating these patients. Symbicort® Turbuhaler® (Symbicort) is an orally inhaled dry powder containing the corticosteroid budesonide and the bronchodilator formoterol. There are no reports describing the successful use of Symbicort in patients with a permanent tracheostomy...
2018: Journal of Pharmaceutical Health Care and Sciences
Kuninori Iwayama, Junpei Kimura, Aya Mishima, Ayuko Kusakabe, Ko-Ichi Ohtaki, Yoshiko Tampo, Nobumasa Hayase
Background: It is well known that low-dose, long-term macrolide therapy is effective against chronic inflammatory airway diseases. Oxidative stress is considered to be a key pathogenesis factor in those diseases. However, the mechanism of action of low-dose, long-term macrolide therapy remains unclear. We have reported that clarithromycin (CAM), which is a representative macrolide antibiotic, could inhibit hydrogen peroxide (H2 O2 )-induced reduction of the glutathione (GSH)/glutathione disulfide (GSSG) ratio in human small airway epithelial cells (SAECs), via the maintenance of GSH levels through an effect on γ-glutamylcysteine synthetase (γ-GCS) expression...
2018: Journal of Pharmaceutical Health Care and Sciences
Yuki Hanai, Kazuhiro Matsuo, Takayoshi Kosugi, Ayumu Kusano, Hayato Ohashi, Itsuki Kimura, Shinobu Hirayama, Yuta Nanjo, Yoshikazu Ishii, Takahiro Sato, Taito Miyazaki, Kenji Nishizawa, Takashi Yoshio
Background: Since both the antibacterial effects and common adverse effects of colistin are concentration-dependent, determination of the most appropriate dosage regimen and administration method for colistin therapy is essential to ensure its efficacy and safety. We aimed to establish a rapid and simple high-performance liquid chromatography (HPLC)-based system for the clinical determination of colistin serum concentrations. Methods: Extraction using a solid-phase C18 cartridge, derivatisation with 9-fluorenylmethyl chloroformate, and elution with a short reversed-phase Cl8 column effectively separated colistin from an internal standard...
2018: Journal of Pharmaceutical Health Care and Sciences
Satoru Nihei, Junya Sato, Hideaki Komatsu, Kazushige Ishida, Toshimoto Kimura, Takashi Tomita, Kenzo Kudo
Background: The efficacy of sodium azulene sulfonate L-glutamine (GA) in treating oral mucositis caused by the administration of anticancer agents has not been previously elucidated. Therefore, this prospective comparative study was conducted to evaluate the efficacy of GA in treating oral mucositis caused by chemotherapy regimens involving fluorinated pyrimidine anticancer drugs. Methods: The subjects of this study were patients with oral mucositis of grade 2 or higher while on outpatient chemotherapy regimens involving fluorinated pyrimidine anticancer drugs for colorectal or breast cancer...
2018: Journal of Pharmaceutical Health Care and Sciences
Yukio Suga, Nana Ikeda, Manami Maeda, Angelina Yukiko Staub, Tsutomu Shimada, Miwa Yonezawa, Hironori Kitade, Hideyuki Katsura, Morihiro Okada, Junko Ishizaki, Yoshimichi Sai, Ryo Matsushita
Background: Vascular pain is a common adverse drug reaction in colorectal cancer patients receiving peripheral venous administration of oxaliplatin. The aim of this work was to identify risk factors for vascular pain, and to examine whether currently used treatments reduce its incidence. Methods: We conducted a multicenter retrospective study in Japanese colorectal cancer patients receiving peripheral venous administration of oxaliplatin. The effects of various treatments (administration of analgesics, addition of dexamethasone to the infusion solution for pH adjustment, dilution of the infusion solution, or use of hot gel for warming the injection site) on the incidence of vascular pain were assessed...
2018: Journal of Pharmaceutical Health Care and Sciences
Daiki Hira, Asami Suzuki, Yusuke Kono, Kosuke Shimokawa, Serika Matsuoka, Ken-Yuh Hasumoto, Hiroyuki Kawahara, Masahide Onoue, Takuya Fujita, Tomonobu Okano, Mikio Kakumoto
Background: Colloidal saccharated iron oxide injection is used for the treatment of iron deficiency anemia in patients with a poor oral intake. Because of the poor stability of the colloid particle, there have been concerns regarding its compatibility with various injections in clinical practice. To assess the stability of colloidal saccharated iron oxide in normal saline as a diluent, pharmaceutical stability analyses were conducted using various concentrations of glucose and sodium chloride (NaCl)...
2018: Journal of Pharmaceutical Health Care and Sciences
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