Chelsea Maguire, Pietro Crivello, Katharina Fleischhauer, Dylan Isaacson, Aurora Casillas, Cynthia S M Kramer, Hannah C Copley, Sebastiaan Heidt, Vasilis Kosmoliaptsis, Maria Meneghini, Michael Gmeiner, Jesse Schold, Yoram Louzoun, Anat R Tambur
Prolonging the lifespan of transplanted organs is critical to combat the shortage of this life-saving resource. Chronic rejection, with irreversible demise of the allograft, is often caused by the development of donor-specific HLA antibodies. Currently, enumerating molecular (amino acid) mismatches between recipient and donor is promoted to identify patients at higher risk of developing HLA antibodies, for use in organ allocation, and immunosuppression-minimization strategies. We have counseled against the incorporation of such approaches into clinical use and hypothesized that not all molecular mismatches equally contribute to generation of donor-specific immune responses...
April 2024: HLA