Sophia Leduc, Maxim De Schepper, François Richard, Marion Maetens, Anirudh Pabba, Kristien Borremans, Joris Jaekers, Emily Latacz, Gitte Zels, Ali Bohlok, Karen Van Baelen, Ha Linh Nguyen, Tatjana Geukens, Luc Dirix, Denis Larsimont, Sophie Vankerckhove, Eva Santos, Rui Caetano Oliveira, Kristòf Dede, Janina Kulka, Székely Borbala, Ferenc Salamon, Lilla Madaras, A Marcell Szasz, Valerio Lucidi, Yannick Meyer, Baki Topal, Cornelis Verhoef, Jennie Engstrand, Carlos Fernandez Moro, Marco Gerling, Imane Bachir, Elia Biganzoli, Vincent Donckier, Giuseppe Floris, Peter Vermeulen, Christine Desmedt
Liver is the third most common organ for breast cancer (BC) metastasis. Two main histopathological growth patterns (HGP) exist in liver metastases (LM): desmoplastic and replacement. Although a reduced immunotherapy efficacy is reported in patients with LM, tumor-infiltrating lymphocytes (TIL) have not yet been investigated in BCLM. Here, we evaluate the distribution of the HGP and TIL in BCLM, and their association with clinicopathological variables and survival. We collect samples from surgically resected BCLM (n = 133 patients, 568 H&E sections) and post-mortem derived BCLM (n = 23 patients, 97 H&E sections)...
December 15, 2023: NPJ Breast Cancer