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Fertility Research and Practice

Arnold M Mahesan, Seifeldin Sadek, Hadi Ramadan, Silvina Bocca, Anthea B M Paul, Laurel Stadtmauer
Background: To assess knowledge and attitudes regarding elective oocyte cryopreservation among female undergraduate students (UG) and medical students (MS) in Eastern Virginia. Methods: An anonymous cross-sectional study surveying female UG at a local university and MS at our academic medical center in May of 2017. The survey contained questions on demographic information, interest in fertility preservation, and knowledge about age related changes in fertility. Results: There were 74 of 102 female UG and 95 of 117 female MS who responded, for a response rate of 73 and 81% respectively...
2019: Fertility Research and Practice
Benjamin Jang, Aaron Rohr, Paras P Vakharia, Zachary Collins, Courtney Marsh, Isabella Herrera, Thomas Fahrbach
Introduction: Ovarian transposition is a procedure that can help preserve fertility for female patients requiring radiation in the abdominopelvic region. However, the displacement of ovaries from its original anatomic location can make oocyte retrieval challenging. Case presentation: A 24-year-old nulligravid patient recently diagnosed with colorectal carcinoma [CRC] underwent ovarian transposition prior to radiation. After radiation and chemotherapy, she began in vitro fertilization [IVF] by reproductive endocrinology and infertility physicians...
2019: Fertility Research and Practice
Ayo Stephen Adebowale
Background: High fertility rate has been consistently reported in Nigeria. The three major ethnic groups in Nigeria, Hausa/Fulani, Igbo, and Yoruba have different socio-cultural identities particularly those that relate to fertility but fertility index is often reported at the national level. This paper examined ethnic differences in fertility and identified its determinants in Nigeria. Method: This cross-sectional design study focused on 23,140 women aged 15-49 years...
2019: Fertility Research and Practice
Gayathree Murugappan, Lora Shahine, Ruth B Lathi
Background: Ovarian reserve testing is not routinely performed in the evaluation of recurrent pregnancy loss (RPL). The objective of this study was to determine if AMH levels are predictive of live birth rate in RPL patients pursuing expectant management (EM). Methods: Retrospective cohort study of RPL patients. Patients tried to conceive spontaneously for 12 calendar months or until they achieved a live birth, whichever occurred first. All patients with the intent to conceive were included regardless of final outcome...
2019: Fertility Research and Practice
Christina D Yarrington, Davidson H Hamer, Wendy Kuohung, Aviva Lee-Parritz
Background: Sexual transmission of Zika virus is well documented and pregnant women are advised to abstain or use barrier protection if a sexual partner has risk for Zika infection. However, to date there has not been a documented case of the congenital Zika syndrome resulting from sexual transmission. Case presentation: A 32 year-old woman who had not traveled to any area with local Zika transmission in years became pregnant via frozen embryo transfer. Her husband traveled to Haiti several times prior to embryo transfer and during the pregnancy...
2019: Fertility Research and Practice
Conor Harrity, Lyuda Shkrobot, David Walsh, Kevin Marron
Background: The origins of adverse reproductive outcome can be multifactorial, but the contribution of the maternal immune system is considered debatable. Elevated intracellular cytokine ratios have been proposed, although not universally supported, as a marker for immunological dysfunction in implantation and early pregnancy. Poor patient selection or inadequate treatment or testing may be confounding factors. Specific immunomodulation, in carefully selected sub-populations of ART patients with poor reproductive history, despite transfer of good quality blastocysts, may potentially improve clinical outcomes...
2018: Fertility Research and Practice
Paula C Brady, Rose L Molina, Michael G Muto, Brenna Stapp, Serene S Srouji
Background: Heterotopic pregnancies implanted in a rudimentary uterine horn account for 1 in 2-3 million gestations, and confer significant risk of morbidity due to uterine rupture and hemorrhage. Case presentation: A 34-year-old nullipara presented with acute pelvic pain at 17 weeks of gestation with dichorionic-diamniotic twins, one in each horn of an anomalous uterus first diagnosed in pregnancy as bicornuate. Three-dimensional ultrasound and MRI revealed myometrial disruption in the left rudimentary uterine horn, and the patient underwent an uncomplicated abdominal hemi-hysterectomy...
2018: Fertility Research and Practice
Joe Mee Chan, Alvin Isaac Sukumar, Magendra Ramalingam, Surinder Singh Ranbir Singh, Mohamad Farouk Abdullah
Background: Chances of pregnancy in relation to endometrial thickness (EMT) remain elusive albeit some literatures suggest poorer pregnancy outcomes below the threshold of 6-7 mm, notwithstanding others perceive detrimental effect at thicker EMT. We aim to examine the implication of EMT on pregnancy outcomes using a cut-off of 8 mm and further explore for any effect of 'thick' EMT in our patient population. Methods: This was a retrospective cohort study performed for 162 women to assess the associations between EMT on the human chorionic ganadotropin (hCG) trigger day and pregnancy outcomes in infertile patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) and autologous fresh embryo transfer (ET) in controlled ovarian stimulation (COS) cycles under an assisted reproductive technology (ART) shared-care programme between public and private institutions from January 2012 through December 2016...
2018: Fertility Research and Practice
Paulino Ariho, Allen Kabagenyi, Abel Nzabona
Background: Studies on fertility in Uganda have attributed fertility reduction to a shift in the overall characteristics of women of reproductive age. It is not clear whether the reduction in fertility is due to changing socioeconomic and demographic characteristics over time or stems from the shifts in the reproductive behavior of women. In this paper we examine how fertility rates have changed between 2006 and 2011 and whether these changes have resulted from changing characteristics or from changing reproductive behavior of women...
2018: Fertility Research and Practice
A V Dolinko, L V Farland, S A Missmer, S S Srouji, C Racowsky, E S Ginsburg
Background: Cancer treatments have significant negative impacts on female fertility, but the impact of cancer itself on fertility remains to be clarified. While some studies have shown that compared with healthy women, those with cancer require higher doses of gonadotropins resulting in decreased oocyte yields, others have shown comparable oocyte yields between the two groups. The purpose of this study is to evaluate whether there is an association between any cancer and/or type of cancer, and response to ovarian stimulation for egg and embryo banking...
2018: Fertility Research and Practice
Thomas Obinchemti Egbe, Fidelia Mbi Kobenge, Metogo Mbengono Junette Arlette, Eugene Belley-Priso
Background: Pyosalpinges (a complication of pelvic inflammatory disease) is infection of the fallopian tubes and the morbidity associated with it has major health implications. We are reporting a case of pyosalpinges diagnosed after hysterosalpingography and managed by laparoscopic surgery at the Douala General Hospital, Cameroon. Case presentation: A 29-year-old single woman, an assistant nurse of the Douala tribe in Cameroon. She is G1P0010 and came to our attention because of secondary infertility of three years duration...
2018: Fertility Research and Practice
Kevin Marron, John F Kennedy, Conor Harrity
Background: Raised intracellular cytokine ratios (CKR) are proposed as a significant risk factor for adverse reproductive outcome. An elevated cytokine ratio, such as between TNFa and/or IFNg to IL-10 is associated with recurrent miscarriage (RM). The use of pharmacological immunomodulators such as TNFα inhibitors in these patients is controversial and not generally recommended due to a lack of conclusive data supporting their use. We evaluated whether the use of anti-oxidants/dietary supplements as an alternative could positively influence CKR's in ART patients...
2018: Fertility Research and Practice
Jason Franasiak, Daniel Kaser, Linnea Goodman, George Patounakis, Caroline Juneau, Scott Morin, Shelby Neal, William Schlaff, Richard Scott
Background: Advanced subspecialty training in reproductive endocrinology and infertility (REI) entails a competitive application process with many data points considered. It is not known what components weigh more heavily for applicants. Thus, we sought to study the REI fellow applicant and compare 1) those who apply but do not receive an interview, 2) those who receive an interview but do not match, and 3) those who successfully match. Methods: This retrospective cohort study was conducted at a single REI fellowship program from 2013 to 2017...
2017: Fertility Research and Practice
Amal Yaseen Zaman, Serdar Coskun, Ahmed Abdullah Alsanie, Khalid Arab Awartani
Background: The requirement for luteal phase support (LPS) in stimulated IVF cycles is well established, however drug choice, and route of administration and duration of use are not. This report evaluates patients' preference and satisfaction by using either vaginal or intramuscular (IM) progesterone (P) supplementation for luteal phase support after in vitro fertilization and embryo transfer (IVF-ET). Methods: It is a prospective cohort study done in a reproductive and infertility unit in a tertiary care hospital from March 2013 through February 2015 for four hundred and nine patients undergoing IVF-ET...
2017: Fertility Research and Practice
Shongkour Roy, Sharif Mohammed Ismail Hossain
BACKGROUND: The aim of this study was to examine the fertility differential of women age 15 to 49 using data from Bangladesh Demographic and Health Survey 2014- a survey of women who were born from 1963 to 1999. METHODS: The secondary data analysis was carried out using the BDHS 2014 in order to discuss differences in childbearing practices in Bangladesh. Descriptive statistics were used to analyze the data including education level, geographic location, and religion...
2017: Fertility Research and Practice
Sabahat Rasool, Duru Shah
Diminished fertility and poor ovarian response pose a conundrum to the experts in the field of reproductive medicine. There is limited knowledge about the risk factors of diminished ovarian reserve other than the iatrogenic ones. One of the leading causes of infertility in women today is diminished ovarian reserve (DOR). DOR is characterized by a low number of eggs in a woman's ovaries and/or with poor quality of the remaining eggs, which boils down to impaired development of the existing eggs, even with assisted reproductive techniques...
2017: Fertility Research and Practice
Jason Franasiak, Sue Shapses, Wei Sun, Richard Scott, Xiangbing Wang
BACKGROUND: The importance of vitamin D in general health as well as in human reproductive success has been an area of focus. A better understanding of vitamin D metabolism, particularly vitamin D binding protein, is important when elucidating this relationship. METHODS: This case control trial seeks to characterize vitamin D metabolism in infertile patients undergoing natural cycle IVF as compared to normally cycling premenopausal women with proven fertility matched for age and body mass index (BMI)...
2017: Fertility Research and Practice
Elizabeth Asch, Jesse Wei, Koenraad J Mortele, Kathryn Humm, Kim Thornton, Deborah Levine
BACKGROUND: To determine if asymmetric ovarian edema on non-contrast MRI can be used to distinguish torsed from non-torsed stimulated ovaries in pregnant women. METHODS: In this retrospective study, our radiology database was searched for women who were pregnant and who had undergone ovarian stimulation and underwent MRI abdomen/pelvis from 1/2000-12/2012. At our institution, ultrasound is typically performed as a first line study for pregnant women with pelvic pain, with MR for those patients with indeterminate findings...
2017: Fertility Research and Practice
Nega Mihret Alazbih, Getachew Nibret Tewabe, Tariku Dejene Demissie
BACKGROUND: The overall decline of fertility in Amhara National Regional State between 2000 and 2011 was the highest in Ethiopia. The aim of the present study was to determine the most significant proximate determinant of fertility change during the last decade in the region using Bongaarts' model. METHODS: The sources of data were the 2000, 2005, and 2011 Ethiopia Demographic and Health Surveys. The model indices were calculated for each survey. Decomposition of fertility change into components of proximal determinants was also carried out...
2017: Fertility Research and Practice
Selma Sen, Aynur Cetinkaya, Aysel Cavuslar
BACKGROUND: The objective of this study was to design and develop the Perception Scale of Barriers to Contraceptive Use (PSBCU) as a measurement tool for the qualitative assessment of the barriers and obstacles women perceived with regard to contraceptive use or low rates of contraceptive use in women using family planning services. METHOD: The data for this methodological study were collected using the face-to-face interview technique from 320 married women between the ages of 15-49 who were attending clinics at the Hafsa Sultan Hospital, CBU...
2017: Fertility Research and Practice
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