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Journals Biological Psychiatry : Cognit...

Biological Psychiatry : Cognitive Neuroscience and Neuroimaging

https://read.qxmd.com/read/38537777/family-environment-modulates-linkage-of-transdiagnostic-psychiatric-phenotypes-and-dissociable-brain-features-in-the-developing-brain
#1
JOURNAL ARTICLE
Xinyue Huang, Leying Gao, Jiming Xiao, Lei Li, Xiaolong Shan, Huafu Chen, Xiaoqian Chai, Xujun Duan
BACKGROUND: Family environment has long been known for shaping brain function and psychiatric phenotypes, especially in childhood and adolescence. Accumulating neuroimaging evidence suggests that across different psychiatric disorders, common phenotypes might share common neural bases, indicating latent brain-behavior relationships beyond diagnostic categories. However, the influence of family environment on the brain-behavior relationship from a transdiagnostic perspective remains unknown...
March 25, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38522649/sex-differences-in-response-inhibition-related-neural-predictors-of-ptsd-in-recent-trauma-exposed-civilians
#2
JOURNAL ARTICLE
Bibian Borst, Tanja Jovanovic, Stacey L House, Steven E Bruce, Nathaniel G Harnett, Alyssa R Roeckner, Timothy D Ely, Lauren A M Lebois, Dmitri Young, Francesca L Beaudoin, Xinming An, Thomas C Neylan, Gari D Clifford, Sarah D Linnstaedt, Laura T Germine, Kenneth A Bollen, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Lauren A Hudak, Jose L Pascual, Mark J Seamon, Elizabeth M Datner, Claire Pearson, David A Peak, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Paulina Sergot, Leon D Sanchez, Steven E Harte, Karestan C Koenen, Ronald C Kessler, Samuel A McLean, Kerry J Ressler, Jennifer S Stevens, Sanne J H van Rooij
BACKGROUND: Females are more likely to develop posttraumatic stress disorder (PTSD) than males. Impaired inhibition has been identified as mechanism for PTSD development, but studies on the potential sex differences of this neurobiological mechanism and how it relates to PTSD severity and progression are sparse. Here we examined sex differences in neural activation during response inhibition and PTSD following recent trauma. METHODS: Participants (N= 205, 138 female sex assigned at birth) were recruited from emergency departments within 72 hours of a traumatic event...
March 22, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38467303/anxiety-symptoms-in-young-children-are-associated-with-a-maladaptive-neurobehavioral-profile-of-error-responding
#3
JOURNAL ARTICLE
Ann M Iturra-Mena, Jason Moser, Dana E Díaz, Sherry Y H Chen, Katherine Rosenblum, Maria Muzik, Kate D Fitzgerald
BACKGROUND: Childhood anxiety symptoms have been linked with alterations in cognitive control and error-processing, yet the diverse findings on neural markers of anxiety in young children, varying by severity and developmental stages, suggest a need for a wider perspective. Integrating new neural markers with established ones like the Error-Related Negativity (ERN), the Error Positivity (Pe) and frontal theta, could clarify this association. Error-Related Alpha Suppression (ERAS) is a recently proposed index of post-error attentional engagement not yet explored in anxious children...
March 9, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38461964/alterations-of-functional-connectivity-dynamics-in-affective-and-psychotic-disorders
#4
JOURNAL ARTICLE
Linnea Hoheisel, Lana Kambeitz-Ilankovic, Julian Wenzel, Shalaila S Haas, Linda A Antonucci, Anne Ruef, Nora Penzel, Frauke Schultze-Lutter, Theresa Lichtenstein, Marlene Rosen, Dominic B Dwyer, Raimo K R Salokangas, Rebekka Lencer, Paolo Brambilla, Stephan Borgwardt, Stephen J Wood, Rachel Upthegrove, Alessandro Bertolino, Stephan Ruhrmann, Eva Meisenzahl, Nikolaos Koutsouleris, Gereon R Fink, Silvia Daun, Joseph Kambeitz
BACKGROUND: Psychosis and depression patients exhibit widespread neurobiological abnormalities. The analysis of dynamic functional connectivity (dFC), allows for the detection of changes in complex brain activity patterns, providing insights into common and unique processes underlying these disorders. METHODS: In the present study, we report the analysis of dFC in a large patient sample including 127 clinical high-risk patients (CHR), 142 recent-onset psychosis (ROP) patients, 134 recent-onset depression (ROD) patients, and 256 healthy controls (HC)...
March 8, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38432622/transdiagnostic-mood-anxiety-and-trauma-symptom-factors-in-alcohol-use-disorder-neural-correlates-across-three-brain-networks
#5
JOURNAL ARTICLE
Lea-Tereza Tenekedjieva, Daniel M McCalley, Andrea N Goldstein-Piekarski, Leanne M Williams, Claudia B Padula
BACKGROUND: Alcohol use disorder (AUD) is associated with high rates of trauma, mood, and anxiety disorders. Individual symptoms highly overlap across diagnoses, highlighting the need for a transdiagnostic approach. Further, there is limited research on how transdiagnostic psychopathology impacts the neural correlates of AUD. Thus, we aimed to identify symptom factors spanning diagnoses and how they relate to the neurocircuitry of addiction. METHODS: Eighty-six Veterans with AUD completed self-report measures and reward, incentive salience and cognitive control fMRI tasks...
March 1, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38417787/associations-among-birthweight-adrenarche-brain-morphometry-and-cognitive-function-in-preterm-children-aged-9-11-years
#6
JOURNAL ARTICLE
Weibin Ji, Guanya Li, Yang Hu, Wenchao Zhang, Jia Wang, Fukun Jiang, Yaqi Zhang, Feifei Wu, Xiaorong Wei, Yuefeng Li, Xinbo Gao, Peter Manza, Nora D Volkow, Gene-Jack Wang, Yi Zhang
BACKGROUND: Preterm infants with low birthweight are at heightened risk of developmental sequelae, including neurological and cognitive dysfunction that can persist into adolescence or adulthood. In addition, preterm birth and low birthweight can provoke changes in endocrine and metabolic processes that likely impact brain health throughout development. However, few studies have examined associations among birthweight, pubertal endocrine process, long-term neurological and cognitive development...
February 26, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38417786/individualized-functional-brain-system-topologies-and-major-depression-relations-among-patch-sizes-and-clinical-profiles-and-behavior
#7
JOURNAL ARTICLE
Matthew D Sacchet, Poorvi Keshava, Shane W Walsh, Ruby M Potash, Meiling Li, Hesheng Liu, Diego A Pizzagalli
BACKGROUND: Neuroimaging studies of major depression have been typically conducted using group-level approaches. However, given interindividual differences in brain systems, there is a need for individualized approaches to brain systems mapping and putative links toward diagnosis, symptoms, and behavior. METHOD: We used an iterative parcellation approach to map individualized brain systems in 328 participants from a multi-site, placebo-controlled clinical trial...
February 26, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38417785/effects-of-gaba-sex-and-stress-on-reward-learning-in-current-and-remitted-major-depression
#8
JOURNAL ARTICLE
Jessica M Duda, Amelia D Moser, Maria Ironside, Kaylee E Null, Laura M Holsen, Chun S Zuo, Fei Du, Shiba M Esfand, Xi Chen, Sarah Perlo, Christine E Richards, Rachel Lobien, Madeline Alexander, Madhusmita Misra, Jill M Goldstein, Diego A Pizzagalli
BACKGROUND: Neurocognitive factors including aberrant reward learning, blunted gamma-aminobutyric acid (GABA), and potentiated stress sensitivity have been linked to anhedonia, a hallmark depressive symptom, possibly in a sex-dependent manner. However, past research has not investigated the putative associations among these factors nor the extent to which they represent trait- or state-based vulnerabilities for depression. METHODS: Young adults with current major depressive disorder, (MDD; N=44), remitted MDD (rMDD; N=42), and healthy control participants (HC; N=44), stratified by sex, underwent magnetic resonance spectroscopy to assess GABA+ (macromolecular contaminated), and then a reward learning task before and after acute stress...
February 26, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38401881/cognitive-signatures-of-depressive-and-anhedonic-symptoms-and-affective-states-using-computational-modeling-and-neurocognitive-testing
#9
JOURNAL ARTICLE
Nadja R Ging-Jehli, Manuel Kuhn, Jacob M Blank, Pranavan Chanthrakumar, David C Steinberger, Zeyang Yu, Todd M Herrington, Daniel G Dillon, Diego A Pizzagalli, Michael J Frank
BACKGROUND: Deeper phenotyping may improve our understanding of depression. Because depression is heterogeneous, extracting cognitive signatures associated with severity of depressive symptoms, anhedonia, and affective states is a promising approach. METHODS: Sequential sampling models (SSMs) decomposed behavior from an adaptive approach-avoidance conflict (AAC) task into computational parameters quantifying latent cognitive signatures. Fifty unselected participants completed clinical scales and the AAC task by either approaching or avoiding trials offering monetary rewards and electric shocks...
February 22, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38387698/expectancy-effects-in-psychedelic-trials
#10
REVIEW
Balázs Szigeti, Boris Heifets
Clinical trials of psychedelic compounds like psilocybin, LSD and DMT have forced a reconsideration of how non-drug factors, like participant expectations, are measured and controlled in mental health research. As doses of these profoundly psychoactive substances increase, so does the difficulty in concealing the treatment condition in the classic double-blind, placebo-controlled trial design. As widespread public enthusiasm for the promise of psychedelic therapy grows, so do questions regarding whether, and how much, trial results are biased by positive expectancy...
February 20, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38378127/altered-lateral-prefrontal-cortex-functioning-during-emotional-interference-resistance-is-associated-with-affect-lability-in-adults-with-persisting-symptoms-of-adhd-from-childhood
#11
JOURNAL ARTICLE
Amar Ojha, Neil P Jones, Teague Henry, Amelia Versace, Elizabeth M Gnagy, Heather M Joseph, Brooke S G Molina, Cecile D Ladouceur
BACKGROUND: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention and/or impulsivity/hyperactivity. ADHD, especially when persisting into adulthood, often includes emotional dysregulation, such as affect lability; however, the neural correlates of emotionality in adults with heterogenous ADHD symptom persistence remain unclear. METHODS: The present study sought to determine shared and distinct functional neuroanatomical profiles of neural circuitry during emotional interference resistance using an Emotional Faces N-Back task while adult participants with persisting (n = 47), desisting (n = 93) or no childhood ADHD symptoms (n = 42) underwent functional magnetic resonance imaging (fMRI) scans...
February 18, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38341085/altered-states-and-social-bonds-effects-of-mdma-and-serotonergic-psychedelics-on-social-behavior-as-a-mechanism-underlying-substance-assisted-therapy
#12
REVIEW
Yasmin Schmid, Anya K Bershad
BACKGROUND: There has been renewed interest in the use of 3,4-methylenedioxy-methamphetamine (MDMA) and serotonergic psychedelics in the treatment of multiple psychiatric disorders. Many of these compounds are known to produce prosocial effects, but how these effects relate to therapeutic efficacy and the extent to which prosocial effects are unique to a particular drug class is unknown. METHODS: In this article, we present a narrative overview and compare evidence for the prosocial effects of MDMA and serotonergic psychedelics to elucidate shared mechanisms that may underlie the therapeutic process...
February 8, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38336169/perceptual-observer-modeling-reveals-likely-mechanisms-of-face-expression-recognition-deficits-in-depression
#13
JOURNAL ARTICLE
Fabian A Soto, Christopher G Beevers
BACKGROUND: Deficits in face emotion recognition are well-documented in depression, but the underlying mechanisms are poorly understood. Psychophysical observer models provide a way to precisely characterize such mechanisms. Using model-based analyses, we test two hypotheses about how depression might reduce sensitivity to detect face emotion: via a change in selectivity for visual information diagnostic of emotion, versus a change in signal-to-noise ratio in the system performing emotion detection...
February 7, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38336168/effects-of-apoe-e4-and-neuropathological-diagnoses-on-neuropsychiatric-symptoms-mediation-analyses-and-likely-causation-in-an-integrated-nacc-database
#14
JOURNAL ARTICLE
Terry E Goldberg, D P Devanand, Zhiqian Fang, Hyun Kim, Elizabeth Rueppel, Aren Tucker, Scott Carlson, Seonjoo Lee
BACKGROUND: We sought to identify paths from APOE e4 to neurobehaviors itemized on a neuropsychiatric inventory that involved neuropathologies associated with e4 (amyloid, tau, cerebral amyloid angiopathy, and Lewy bodies) or cognition mediators (memory or global cognitive status), as well as direct paths from e4 to neurobehaviors. METHODS: A total of 1199 cases with available neurobehavioral, cognition and neuropathological data were included. We conducted a series of causal mediation analyses in R in which e4 always served as the independent variable and Neuropsychiatric Inventory (NPI) neurobehavioral items, when included in the mediation, the outcome...
February 7, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38311290/pons-to-cerebellum-hypoconnectivity-along-the-psychosis-spectrum-and-associations-with-sensory-prediction-and-hallucinations-in-schizophrenia
#15
JOURNAL ARTICLE
Samantha V Abram, Jessica P Y Hua, Spero Nicholas, Brian Roach, Sarah Keedy, John A Sweeney, Daniel H Mathalon, Judith M Ford
BACKGROUND: Sensory prediction allows the brain to anticipate and parse incoming self-generated sensory information from externally-generated signals. Sensory prediction breakdowns may contribute to perceptual and agency abnormalities in psychosis (hallucinations, delusions). Pons, a central node in a cortico-ponto-cerebellar-thalamo-cortical circuit, is thought to support sensory prediction. Examination of pons connectivity in schizophrenia and its role in sensory prediction abnormalities is lacking...
February 2, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38311289/an-fmri-meta-analysis-of-childhood-trauma
#16
JOURNAL ARTICLE
Rebecca Ireton, Anna Hughes, Megan Klabunde
BACKGROUND: Traumatic experiences during childhood significantly impact the developing brain and contributes to the development of numerous physical and mental health problems. A comprehensive understanding of the functional impairments within the brain associated with childhood who trauma histories, however, is unknown. Previous fMRI meta-analytical tools required homogeneity in task types and the clinical populations studied, thus, preventing the comprehensive pooling of brain-based deficits present in children who have trauma histories...
February 2, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38301886/serotonergic-psychedelics-a-comparative-review-comparing-the-efficacy-safety-pharmacokinetics-and-binding-profile-of-serotonergic-psychedelics
#17
REVIEW
Friederike Holze, Nirmal Singh, Matthias E Liechti, Deepak Cyril D'Souza
Psychedelic compounds, including psilocybin, LSD, DMT, and 5-MeO-DMT all of which are serotonin (5-HT) 2A receptor agonists are being investigated as potential treatments. This review aims to summarize the current clinical research on these four compounds and mescaline to guide future research. Their mechanism/s of action, pharmacokinetics, pharmacodynamics, efficacy, and safety were reviewed. While evidence for therapeutic indications, with the exception of psilocybin for depression, is still relatively scarce, we noted no differences in psychedelic effects beyond effect duration...
January 30, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38301885/dynamic-changes-in-local-brain-connectivity-and-activity-a-longitudinal-study-in-adolescent-anorexia-nervosa
#18
JOURNAL ARTICLE
Maria Seidel, Daniel Geisler, Joseph A King, Marie Winter, Nico W Poller, Dominic Arold, Katrin Gramatke, Veit Roessner, Stefan Ehrlich
OBJECTIVE: Resting state functional connectivity (RSFC) analysis has been used to study disruptions in neural circuitries underlying eating disorder symptoms. Research has shown RSFC to be altered during the acute phase of anorexia nervosa (AN), but little is known about the biological mechanisms underlying neural changes associated with weight restoration. The goal of the current study was to investigate longitudinal changes in regional homogeneity among neighboring voxels (ReHo), degree centrality (DC; a voxel-wise whole brain correlation coefficient), voxel-mirrored homotopic connectivity (VMHC; measuring the synchronization between hemispheres) and the (fractional) amplitude of low frequency fluctuations (fALFF) associated with weight gain during AN treatment...
January 30, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38280631/childhood-maltreatment-and-amygdala-response-to-interpersonal-threat-in-a-transdiagnostic-adult-sample-the-role-of-trait-dissociation
#19
JOURNAL ARTICLE
Katja I Seitz, Maurizio Sicorello, Marius Schmitz, Noel Valencia, Sabine C Herpertz, Katja Bertsch, Corinne Neukel
BACKGROUND: Childhood maltreatment (CM) confers risk for different mental disorders as well as transdiagnostic symptoms such as dissociation. Aberrant amygdala response to interpersonal threat may link CM to transdiagnostic psychopathology, and has recently been shown to depend on type and developmental timing of CM experiences. Still, most studies on CM and threat-related amygdala response employ categorical disorder-specific perspectives, and fail to consider type and timing of CM exposure...
January 25, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38280630/microdosing-psychedelics-current-evidence-from-controlled-studies
#20
REVIEW
Robin Murphy, Suresh Muthukumaraswamy, Harriet de Wit
Taking regular low doses of psychedelic drugs (microdosing) is a practice that has drawn recent scientific and media attention for its potential psychotherapeutic effects. Yet, controlled studies evaluating this practice have lagged. Here we review recent evidence focusing on studies that were conducted with rigorous experimental control. Studies conducted under laboratory settings using double-blind placebo-controlled procedures and investigator-supplied drug were compiled. The review includes demographic characteristics of the participants and dependent measures include physiological, behavioural, and subjective effects of the drug(s)...
January 25, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
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