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ERJ Open Research

Sukhwinder Singh Sohal, Mathew Suji Eapen, Vegi G M Naidu, Pawan Sharma
Heat-not-burn (HNB) devices can alter vital physiological functions in the lung. HNB devices may not be a safer option than cigarette smoking or eCig vaping; this does not support the recommendation of their use over other nicotine delivery products.
February 2019: ERJ Open Research
Margarida Correia-Neves, Gabrielle Fröberg, Liudmyla Korshun, Sofia Viegas, Paula Vaz, Nehaben Ramanlal, Judith Bruchfeld, Beston Hamasur, Patrick Brennan, Gunilla Källenius
Tuberculosis (TB) is considered the most onerous of infectious diseases according to recent reports from the World Health Organization. Available tests for TB diagnosis present severe limitations, and a reliable point-of-care (POC) diagnostic test does not exist. Neither is there a test to discern between the different stages of TB, and in particular to predict which patients with Mycobacterium tuberculosis infection and no clinical signs are more at risk of advancing to overt disease. We here review the usefulness of mycobacterial lipoarabinomannan (LAM) as a diagnostic marker for active and latent TB and, also, aspects of the immune response to LAM relevant to such tests...
February 2019: ERJ Open Research
Jeffrey M Haynes, Gregg L Ruppel
The ATS/ERS spirometer calibration standards may not be adequate
February 2019: ERJ Open Research
Nigel S Cook, Konstantinos Kostikas, Jean-Bernard Gruenberger, Bhavik Shah, Purnima Pathak, Vinay Preet Kaur, Alaknanda Mudumby, Rajat Sharma, Florian S Gutzwiller
We utilised social media listening (SML) to obtain patients' perspectives on symptoms, diagnosis and comorbidities associated with chronic obstructive pulmonary disease (COPD) and its impact on patients' quality of life (QoL). A comprehensive search on social media platforms was performed for English language content posted between July 2016 and January 2018 using COPD-related terms. Social Studio, a social media data aggregator tool, was used to capture relevant records. The content was manually curated to analyse and map psychological aspects with descriptive statistics applied on aggregated findings...
February 2019: ERJ Open Research
Lowie E G W Vanfleteren, Iñigo Ojanguren, Claire M Nolan, Frits M E Franssen, Vasileios Andrianopoulos, Aleksandar Grgic, Marlies van Dijk, Dirk Jan Slebos, Luke Daines, Janwillem W H Kocks, Nicolas Kahn
This article contains highlights and a selection of the scientific advances from the European Respiratory Society's Clinical Assembly (Assembly 1 and its five respective groups) that were presented at the 2018 European Respiratory Society International Congress in Paris, France. The most relevant topics from each of the groups will be discussed, covering a wide range of areas including clinical problems, rehabilitation and chronic care, thoracic imaging, interventional pulmonology, and general practice and primary care...
February 2019: ERJ Open Research
Lowie E G W Vanfleteren, Anders Ullman, Anita Nordenson, Anders Andersson, Kristina Andelid, Leonardo M Fabbri
Triple inhaler therapy in COPD might in some real-life situations be useful outside of the strict indications reported by the registration agencies, but at the same time in some other situations it could be better avoided, even when recommended
February 2019: ERJ Open Research
Shikha Gupta, Aman Gupta, Sofiya Rehman, Iclal Ocak, Robyn T Domsic, Frank Schneider, M Patricia George
There is an unexpectedly high incidence of PVOD in patients with SSc-PH-ILD. Presence of PVOD may be an unrecognised contributor to the dismal prognosis of these patients. Early transplant referral should be considered for those with SSc-PH-ILD.
February 2019: ERJ Open Research
Jacob Shujui Hsu, Ruizhong Zhang, Fanny Yeung, Clara S M Tang, John K L Wong, Man-Ting So, Huimin Xia, Pak Sham, Paul K Tam, Miaoxin Li, Kenneth K Y Wong, Maria-Mercè Garcia-Barcelo
Background: Newborns affected with congenital pulmonary airway malformations (CPAMs) may present with severe respiratory distress or remain asymptomatic. While surgical resection is the definitive treatment for symptomatic CPAMs, prophylactic elective surgery may be recommended for asymptomatic CPAMs owing to the risk of tumour development. However, the implementation of prophylactic surgery is quite controversial on the grounds that more evidence linking CPAMs and cancer is needed. The large gap in knowledge of CPAM pathogenesis results in uncertainties and controversies in disease management...
February 2019: ERJ Open Research
Marcia Margaret Menezes Pizzichini, Cristiane Cinara Rocha, Michelle Gonçalves de Souza Tavares, Leila John Marques Steidle, Rosemeri Maureci da Silva, Felipe Dal Pizzol, Peter G Gibson, Emilio Pizzichini
Since 2014, the Global Initiative for Asthma (GINA) has stated that asthma control should be measured using four questions concerning diurnal and nocturnal symptoms, activity limitation, and rescue medication use. We assessed how asthma control by this definition correlates with airway inflammation and quality of life. 113 asthmatic subjects consecutively recruited from their routine clinical appointment underwent spirometry, sputum induction and answered the Standardised Asthma Quality of Life Questionnaire (AQLQ(S)) during a single visit...
February 2019: ERJ Open Research
Aneesa Vanker, Polite M Nduru, Whitney Barnett, Felix S Dube, Peter D Sly, Robert P Gie, Mark P Nicol, Heather J Zar
Indoor air pollution (IAP) or environmental tobacco smoke (ETS) exposure may influence nasopharyngeal carriage of bacterial species and development of lower respiratory tract infection (LRTI). The aim of this study was to longitudinally investigate the impact of antenatal or postnatal IAP/ETS exposure on nasopharyngeal bacteria in mothers and infants. A South African cohort study followed mother-infant pairs from birth through the first year. Nasopharyngeal swabs were taken at birth, 6 and 12 months for bacterial culture...
February 2019: ERJ Open Research
Péter Csonka, Lauri Lehtimäki
Small children with airway obstruction breathe with very low tidal volumes ( V T ) and high respiratory rates (RRs). These extreme respiratory patterns affect drug delivery unpredictably through valved holding chambers (VHCs). We compared in an in vitro study the effectiveness of two VHCs, one small (140 mL, Optichamber Diamond) and one large (350 mL, Babyhaler) without facemasks, to deliver salbutamol to filters positioned between the VHC mouthpieces and a breathing simulator. Different tidal volumes (from 30 mL to 200 mL) and RRs (25·min-1 and 50·min-1 ) were applied through a breathing simulator...
February 2019: ERJ Open Research
James H Hull, Emil S Walsted, Christopher M Orton, Parris Williams, Simon Ward, Mathew J Pavitt
Exercise-induced laryngeal obstruction (EILO) is a prevalent problem causing exertional breathlessness and wheeze. This report demonstrates the feasibility and safety of a diagnostic approach to EILO, using a portable laryngoscope during exercise.
February 2019: ERJ Open Research
Jacky W Y Au, Reginald McDonald, Sanja Stanojevic, Felix Ratjen
Spirometry does not have a short-term effect on multiple-breath washout outcomes, thus allowing greater flexibility for implementation into clinical practice
February 2019: ERJ Open Research
Rachelle Asciak, Rachel M Mercer, Robert J Hallifax, Maged Hassan, Eihab Bedawi, David McCracken, Nikolaos I Kanellakis, John M Wrightson, Ioannis Psallidas, Najib M Rahman
Prior talc pleurodesis does not result in worsened outcomes from subsequent indwelling pleural catheter use, and patients should not be dissuaded from choosing talc as a primary treatment for recurrent pleural effusion.
February 2019: ERJ Open Research
Christer Janson, Simone Accordini, Lucia Cazzoletti, Isa Cerveri, Sebastien Chanoine, Angelo Corsico, Diogenes Seraphim Ferreira, Judith Garcia-Aymerich, David Gislason, Rune Nielsen, Ane Johannessen, Rain Jogi, Andrei Malinovschi, Jesús Martinez-Moratalla Rovira, Alessandro Marcon, Isabelle Pin, Jennifer Quint, Valerie Siroux, Enrique Almar, Valeria Bellisario, Karl A Franklin, José A Gullón, Mathias Holm, Joachim Heinrich, Dennis Nowak, José Luis Sánchez-Ramos, Joost J Weyler, Deborah Jarvis
Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with the regular use of inhaled corticosteroid (ICS) treatment. Changes in the use of medication were determined in 4617 randomly selected subjects, while changes in adults with persistent asthma were analysed in 369 participants. The study compares data from three surveys in 24 centres in 11 countries...
February 2019: ERJ Open Research
Jane S Lucas, Florian Gahleitner, Adelina Amorim, Mieke Boon, Philippa Brown, Carolina Constant, Simon Cook, Suzanne Crowley, Damien M S Destouches, Ernst Eber, Huda Mussaffi, Eric Haarman, Amanda Harris, Cordula Koerner-Rettberg, Claudia E Kuehni, Philipp Latzin, Michael R Loebinger, Natalie Lorent, Bernard Maitre, Antonio Moreno-Galdó, Kim G Nielsen, Uğur Özçelik, Lue Katrine Drasbæk Philipsen, Petr Pohunek, Eva Polverino, Jessica Rademacher, Phil Robinson, Deborah Snijders, Panayiotis Yiallouros, Siobhán B Carr
Pulmonary exacerbations are a cause of significant morbidity in patients with primary ciliary dyskinesia (PCD) and are frequently used as an outcome measure in clinical research into chronic lung diseases. So far, there has been no consensus on the definition of pulmonary exacerbations in PCD. 30 multidisciplinary experts and patients developed a consensus definition for children and adults with PCD. Following a systematic review, the panel used a modified Delphi process with a combination of face-to-face meetings and e-surveys to develop a definition that can be used in research settings for children and adults with PCD...
February 2019: ERJ Open Research
Riccardo Alagna, Tinnoga Lèon Sawadogo, Adjima Combary, Souba Diandé, Daniela Maria Cirillo
Improving availability, accessibility and quality of national GeneXpert networks through ASAP-GxNet
February 2019: ERJ Open Research
Matthew Rutter, Carlos Augusto Camillo, Peter Coss, Andreja Sajnic, Aisling McGowan, Daniel Langer, Jana De Brandt, Christian Osadnik
This article provides an overview of outstanding sessions that were supported by Assembly 9 during the recent European Respiratory Society International Congress in Paris, France. Session content was mainly targeted at allied health professionals such as respiratory physiologists, respiratory physiotherapists and respiratory nurses. Recent developments and novel findings related to pulmonary function testing, respiratory muscle function assessments and treatment, and multidimensional and multidisciplinary approaches to the assessment and management of dyspnoea were the focus of these sessions and are summarised here...
February 2019: ERJ Open Research
Helen K Reddel, Maria Gerhardsson de Verdier, Alvar Agustí, Gary Anderson, Richard Beasley, Elisabeth H Bel, Christer Janson, Barry Make, Richard J Martin, Ian Pavord, David Price, Christina Keen, Asparuh Gardev, Stephen Rennard, Alecka Sveréus, Aruna T Bansal, Lance Brannman, Niklas Karlsson, Javier Nuevo, Fredrik Nyberg, Simon S Young, Jørgen Vestbo
Asthma and chronic obstructive pulmonary disease (COPD) have overlapping clinical features and share pathobiological mechanisms but are often considered distinct disorders. Prospective, observational studies across asthma, COPD and asthma-COPD overlap are limited. NOVELTY is a global, prospective observational 3-year study enrolling ∼12 000 patients ≥12 years of age from primary and specialist clinical practices in 19 countries ( identifier: NCT02760329). NOVELTY's primary objectives are to describe patient characteristics, treatment patterns and disease burden over time, and to identify phenotypes and molecular endotypes associated with differential outcomes over time in patients with a diagnosis/suspected diagnosis of asthma and/or COPD...
February 2019: ERJ Open Research
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