Taoping Zhang, Zhixin Chen, Lyu Xie, Ruixian Xu, Lu Chen, Ting Jia, Wengang Shi, Yongbo Wang, Yuzhu Song, Qinqin Han, Xueshan Xia, Tao Yuan, Jinyang Zhang
Japanese encephalitis virus (JEV), a member of the Flaviviridae family and a flavivirus, is known to induce acute encephalitis. Vimentin protein has been identified as a potential receptor for JEV, engaging in interactions with the viral membrane protein. The Fc fragment, an integral constituent of immunoglobulins, plays a crucial role in antigen recognition by dendritic cells (DCs) or phagocytes, leading to subsequent antigen presentation, cytotoxicity, or phagocytosis. In this study, we fused the receptor of JEV vimentin with the Fc fragment of IgG and expressed the resulting vimentin-Fc fusion protein in Escherichia coli ...
2024: Frontiers in Veterinary Science