journal
https://read.qxmd.com/read/37753364/pushing-the-frontiers-in-the-fight-against-antimicrobial-resistance-the-potential-of-fecal-and-maggot-therapies
#1
REVIEW
Bashar Haruna Gulumbe, Abdulrakib Abdulrahim
The escalating crisis of antimicrobial resistance (AMR) warrants innovative therapeutic strategies. Fecal microbiota transplantation (FMT) and maggot debridement therapy (MDT) represent paradigm-shifting approaches, leveraging biological systems to mitigate AMR. FMT restores a healthy gut microbiome, providing a biotherapeutic counter to pathogenic bacteria, thereby reducing reliance on traditional antibiotics. Conversely, MDT, a form of bio-debridement, utilizes the antimicrobial secretions of maggots to cleanse wounds and eliminate resistant bacteria...
December 2023: Future Science OA
https://read.qxmd.com/read/37753363/iatrogenic-orbital-hematoma-an-exceptional-complication-of-upper-gastrointestinal-endoscopy
#2
Myriam Ayari, Sameh Riahi, Imen Abdelaali, Taieb Jomni, Mohamed Hedi Douggui
Iatrogenic orbital hematoma is a rare event, most often manifested by a painful exophthalmos that could compromise the patient's visual prognosis. We report the case of a 51-year-old female patient with a history of non-ischemic dilated cardiomyopathy and high blood pressure, who developed a painful exophthalmos following an upper gastrointestinal sedation-free endoscopy. The diagnosis of an intra-orbital hematoma was made by computed tomographic scan and a conservative attitude was adopted after a thorough ophthalmological examination...
December 2023: Future Science OA
https://read.qxmd.com/read/37753362/a-primary-hepatic-lymphoma-in-a-patient-with-crohn-s-disease-receiving-thiopurine-and-anti-tnf-therapy-a-case-report
#3
Salma Merhaben, Shema Ayadi, Monia Tangour, Nadia Boujelbene, Rayfa Ghariani, Leila Mouelhi, Fathi Merhaben
Primary hepatic lymphoma is a rare variant of non-Hodgkin's lymphoma with an incidence of 0.016% of all non-Hodgkin lymphomas. The most common histologic subtype is large diffuse B-cell lymphoma. Pathogenesis is not clearly established and undergoing immunosuppressive therapy has been proposed as a risk factor for primary hepatic lymphoma. We report an intriguing case study, featuring a 23-year-old male patient with Crohn's Disease who had been receiving a combination therapy of thiopurine and anti-TNF for 6 years and was diagnosed with primary hepatic diffuse large B-cell lymphoma...
December 2023: Future Science OA
https://read.qxmd.com/read/37753361/%C3%AE-1-adrenergic-receptor-polymorphisms-a-possible-genetic-predictor-of-bisoprolol-response-in-acute-coronary-syndrome
#4
JOURNAL ARTICLE
Mohamed S Fayed, Mohamed Ayman Saleh, Nagwa A Sabri, Amal A Elkholy
AIM: To investigate the association between beta1-adrenergic receptor ( ADRB1 ) polymorphisms and response to bisoprolol treatment in beta-blocker naive patients with acute coronary syndrome (ACS). PATIENTS & METHODS: Seventy-seven patients received bisoprolol for four weeks. Blood pressure and heart rate were measured at baseline and during treatment. TaqMan allelic discrimination method was utilized for ADRB1 Ser49Gly and Arg389Gly genotyping. RESULTS: Arg389Arg carriers showed greater reductions in systolic and diastolic blood pressure (-8...
December 2023: Future Science OA
https://read.qxmd.com/read/37753360/a-microfluidic-organ-on-a-chip-into-the-next-decade-of-bone-tissue-engineering-applied-in-dentistry
#5
REVIEW
Muhammad Hidayat Syahruddin, Rahmi Anggraeni, Ika Dewi Ana
A comprehensive understanding of the complex physiological and pathological processes associated with alveolar bones, their responses to different therapeutics strategies, and cell interactions with biomaterial becomes necessary in precisely treating patients with severe progressive periodontitis, as a bone-related issue in dentistry. However, existing monolayer cell culture or pre-clinical models have been unable to mimic the complex physiological, pathological and regeneration processes in the bone microenvironment in response to different therapeutic strategies...
December 2023: Future Science OA
https://read.qxmd.com/read/37753359/societal-influence-and-psychological-distress-among-indonesian-adults-in-java-on-the-early-omicron-wave-of-covid-19
#6
JOURNAL ARTICLE
Annette d'Arqom, Muh Akram, Nafesa Shafira Azzahranisa, Mhd Zamal Nasution, Endang Retno Surjaningrum, Junaidah Yusof
AIM: Changes during the COVID-19 pandemic might create pressure on different people, thus this study aimed to measure respondents' psychological distress during the early phase of the Omicron wave in Java Island. METHODS: A web-based survey on societal influence and COVID-19-related psychological distress was distributed through social media in November-December 2021, and received 396 responses. RESULTS: This study showed that almost 50% of respondents faced psychological distress during the early phase of the Omicron variant, especially concerning hypervigilance and avoidance...
December 2023: Future Science OA
https://read.qxmd.com/read/37753358/molecular-mechanisms-of-colistin-and-multidrug-resistance-in-bacteria-among-patients-with-hospital-acquired-infections
#7
JOURNAL ARTICLE
Surbhi Khurana, Amit Katiyar, Mamta Puraswani, Divya Sharma, Kamini Walia, Rajesh Malhotra, Purva Mathur
AIM: The increasing burden of resistance in Gram-negative bacteria (GNB) is becoming a major issue for hospital-acquired infections. Therefore, understanding the molecular mechanisms is important. METHODOLOGY: Resistance genes of phenotypically colistin-resistant GNB (n = 60) were determined using whole genome sequencing. Antimicrobial susceptibility patterns were detected by Vitek®2 & broth microdilution. RESULTS: Of these phenotypically colistin-resistant isolates, 78% were also genetically resistant to colistin...
December 2023: Future Science OA
https://read.qxmd.com/read/37753357/prognostic-performance-of-pretreatment-systemic-immune-inflammation-index-in-women-with-epithelial-ovarian-cancer
#8
JOURNAL ARTICLE
Kehinde S Okunade, Sarah O John-Olabode, Adaiah P Soibi-Harry, Austin C Okoro, Adebola A Adejimi, Iyabo Y Ademuyiwa, Benedetto Osunwusi, Hameed Adelabu, Omolola Salako
PURPOSE: This study investigated the prognostic performance of the systemic immune-inflammation index (SII) in patients with epithelial ovarian cancer (EOC) in Lagos, Nigeria. METHODS: We performed a secondary analysis of the data of 91 women who had treatment for EOC between 2009 and 2018. The associations between pretreatment SII and survivals were tested. RESULTS: Pretreatment SII more than 610.2 was a significant independent predictor of reduced progression-free survival (HR = 2...
December 2023: Future Science OA
https://read.qxmd.com/read/37753356/alexithymia-impairs-quality-of-life-in-irritable-bowel-syndrome
#9
JOURNAL ARTICLE
Mona Boudabbous, Ala Ben Issa, Ines Feki, Héla Gdoura, Lassad Chtourou, Manel Moalla, Rim Sallemi, Leila Mnif, Ali Amouri, Jaweher Masmoudi, Nabil Tahri
AIM: Our objectives were to compare the frequency of alexithymia and the alteration of quality of life in irritable bowel syndrome (IBS) and to determine the factors associated with alexithymia and quality of life deterioration. METHOD: This is a comparative study which collected 80 IBS patients and 80 controls. RESULTS: Quality of life was impaired in 75% of patients vs 37.5% (p < 0.0001). The prevalence of alexithymia was 50% in patients vs 1...
December 2023: Future Science OA
https://read.qxmd.com/read/37753355/efficacy-and-safety-of-mavacamten-in-treatment-of-hypertrophic-cardiomyopathy-a-systematic-review-and-meta-analysis
#10
JOURNAL ARTICLE
Areeba Memon, Muhammad Omar Larik, Zoha Khan, Maryam Urooj, Areeka Irfan, Beena Kumari, Mehak Faisal, Rida Siddiqui, Moniba Tehrim, Ishaque Hameed
AIM: This meta-analysis was performed to assess the efficacy and safety of mavacamten in patients with hypertrophic cardiomyopathy. METHODS & MATERIALS: A search was conducted using PubMed, Cochrane, and Scopus up to August 2022 for randomized studies reporting our pre-specified outcomes. RESULTS: It was observed that mavacamten significantly improved New York Heart Association class (p < 0.009), Clinical Summary Score of the Kansas City Cardiomyopathy Questionnaire (p = 0...
December 2023: Future Science OA
https://read.qxmd.com/read/37752923/epidemiology-of-bone-tumors-in-lebanon-a-retrospective-study-from-2000-to-2022-at-a-tertiary-center
#11
JOURNAL ARTICLE
Mohammad Daher, Ziad Zalaquett, Elio Mekhael, Marven Aoun, Ralph Chalhoub, Majd Abdo, Marc Aoude, Sami Abi Farraj, Ali Ghoul, Jean Tarchichi, Joe Rassi, Amer Sebaaly, Viviane Trak-Smayra, Carole Kesrouani, Hampig-Raphaël Kourie, Ismat Ghanem
AIM: Bone tumors are rare and have an uneven geographic distribution. METHODS: 730 patients diagnosed with bone tumors were included in this retrospective analysis. RESULTS: With a 64% rate of malignancy, the most common tumors were metastasis (40%) mostly in the axial skeleton, Osteosarcoma (9%) mostly in the femur, Osteochondroma (8%) mostly in the femur, giant cell tumors (7%) mostly in the knee, and Ewing's sarcoma (6%) mostly in the axial skeleton...
October 2023: Future Science OA
https://read.qxmd.com/read/37752922/the-impact-of-cellular-environment-on-in-vitro-drug-screening
#12
REVIEW
Aiman Moldasheva, Laura Bakyt, Denis Bulanin, Mohamad Aljofan
There are various reasons for drug failure in the developmental stage including toxicity, adverse effects and inefficacy. This is likely due to the differences in drug behavior between a simple and controlled cell culture system to that of a more complex whole organism environment. While the use of human phenotypical cells relevant to the condition may provide more accurate screening results, they are susceptible to producing false positives as cells are continuously influenced by constant chemical and physical interaction with the surrounding microenvironment...
October 2023: Future Science OA
https://read.qxmd.com/read/37752921/vaccination-strategies-the-power-of-the-unmatched-double-hits
#13
JOURNAL ARTICLE
Talal S Al-Qaisi, Berjas Abumsimir
No abstract text is available yet for this article.
October 2023: Future Science OA
https://read.qxmd.com/read/37752920/a-rare-cause-of-spontaneous-hemoperitoneum-intra-abdominal-vein-rupture
#14
Moufida Mahmoudi, Ghada Gharbi, Amal Khsiba, Amine Jallouli, Asma Ben Mohamed, Manel Yakoubi, Mouna Medhioub, Lamine Hamzaoui, Khaled Bouzaidi, Mohamed Mousadek Azouz
AIM: Ruptures of the intra-abdominal vein causing a spontaneous hemoperitoneum in cirrhotic patients is a rare condition. However, diagnosis must be considered early in cirrhotic patients with hematic ascites as a delayed diagnosis with hemodynamic instability is associated with a poor prognosis. CASE REPORT: We present the case of a 54-year-old cirrhotic patient who presented a spontaneous hemoperitoneum due to the rupture of the intra-abdominal vein that was diagnosed during exploratory laparoscopy...
October 2023: Future Science OA
https://read.qxmd.com/read/37752919/investigation-of-microbial-coinfection-in-453-septic-covid-19-patients-admitted-to-hospital-a-retrospective-study
#15
JOURNAL ARTICLE
Armin Khavandegar, Zeinab Siami, Sogand Goudarzi, Aziz Rasooli, Yeganeh Ettehad
AIM: We evaluated the rate of COVID-19 microbial coinfection in an Iranian population. METHODS: In this single-center, retrospective observational study, we evaluated 453 septic COVID-19 patients for possible coinfection in an Iranian hospital. RESULTS: Overall, 211 (46.57%) cases died due to COVID-19 complications. Positive respiratory secretion and blood cultures were reported in 99 (21.9%) and 19 (4.2%) cases. Klebsiella species were the most commonly isolated microorganisms in respiratory (n = 50, 50...
October 2023: Future Science OA
https://read.qxmd.com/read/37752918/screening-for-renal-impairment-in-viral-hepatopathy-b-it-is-time-to-begin
#16
JOURNAL ARTICLE
Mona Boudabbous, Fatma Bouzid, Ikram Agrebi, Héla Gdoura, Lassad Chtourou, Manel Moalla, Leila Mnif, Ali Amouri, Khaoula Kammoun, N Tahri
AIM: The aim of this study was to assess the value of routine screening for renal damage in cases of B viral infection, by looking for proteinuria and elevated creatinemia. MATERIALS & METHODS: We investigate the frequency and associated factors of renal impairment in patients with viral B hepatopathy. RESULTS: Pathological albuminuria was confirmed in 44.73%. The chronic kidney disease with slightly decreased filtration rate was found in 21...
October 2023: Future Science OA
https://read.qxmd.com/read/37752917/migrasomes-and-tetraspanins-in-hepatocellular-carcinoma-current-status-and-future-prospects
#17
REVIEW
Zhongqi Zhang, Tianmiao Zhang, Rongcheng Zhang, Zhengbao Zhang, Shengkui Tan
In recent years, many studies have attempted to clarify the formation, structure and biological function of migrasomes, which are defined as specialized organelles formed by the tips and intersections of Retraction Fibrils during cell migration. It has confirmed that migrasomes were involved in various critical biological processes and diseases, and has became a new research hotspot. In this paper, we reviewed the formation and biological functions of migrasomes, explored the relationship between migrasomes, tetraspanins and hepatocellular carcinoma and discussed the potential applications of migrasomes in hepatocellular carcinoma...
October 2023: Future Science OA
https://read.qxmd.com/read/37752916/reduced-pde4d7-in-prostate-cancer-correlates-with-genomic-downregulation-within-the-upstream-pde4d-coding-region
#18
JOURNAL ARTICLE
Chloe Gulliver, George S Baillie, Ralf Hoffmann
AIM: PDE4D7 expression is significantly associated with prostate cancer (PCa) progression, representing an attractive prognostic biomarker. We sought to determine whether other genes in the PDE4D coding region were associated. PATIENTS & METHODS: RNA from biopsy punch samples of resected tumor tissue was analyzed via RNA sequencing. RT-qPCR was used to determine PDE4D7 score. RESULTS: Numerous genomic sequences within the PDE4D coding region on Chr5q12 revealed similar mRNA expression profiles to PDE4D7 ...
October 2023: Future Science OA
https://read.qxmd.com/read/37752915/data-sets-of-human-and-mouse-protein-kinase-inhibitors-with-curated-activity-data-including-covalent-inhibitors
#19
JOURNAL ARTICLE
Elena Xerxa, Jürgen Bajorath
AIM: Generation of high-quality data sets of protein kinase inhibitors (PKIs). METHODOLOGY: Publicly available PKIs with reliable activity data were curated. PKIs with very weak activity were classified as inactive. Analogue series and PKIs containing reactive groups (warheads) enabling covalent inhibition were systematically identified. EXEMPLARY RESULTS & DATA: A total of 155,579 human and 3057 mouse PKIs were obtained. Human PKIs were active 440 kinases and included 13,949 covalent PKIs...
October 2023: Future Science OA
https://read.qxmd.com/read/37752914/the-prevalence-risk-factors-and-lifestyle-patterns-of-jordanian-females-with-premenstrual-syndrome-a-cross-sectional-study
#20
JOURNAL ARTICLE
Mera A Ababneh, Malak Alkhalil, Abeer Rababa'h
AIM: The study aims to assess factors associated with premenstrual syndrome (PMS) and the frequency of using painkillers to relieve premenstrual pain. METHODS: This is a cross-sectional study of 1580 premenopausal women. An online self-administered questionnaire consists of sociodemographics, and the diagnostic criteria using the Arabic Premenstrual Syndrome Scale (A-PMS). RESULTS: The prevalence of PMS among Jordanian females was 94%. Moreover, a significant correlation was found between several factors, including BMI, family history of PMS, smoking, and herbal tea consumption and the psychological, physical and behavioral symptoms of PMS...
October 2023: Future Science OA
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