Yueping Ren, Han Wen, Furong Bai, Binge Huang, Zhenzhen Wang, Shuwen Zhang, Yaojia Pu, Zhenmin Le, Xianhui Gong, Lei Wang, Wei Chen, Qinxiang Zheng
BACKGROUND: Abnormal blinking pattern is associated with ocular surface diseases. However, blink is difficult to analyze due to the rapid movement of eyelids. Deep learning machine (DLM) has been proposed as an optional tool for blinking analysis, but its clinical practicability still needs to be proven. Therefore, the study aims to compare the DLM-assisted Keratograph 5M (K5M) as a novel method with the currently available Lipiview in the clinic and assess whether blinking parameters can be applied in the diagnosis of dry eye disease (DED)...
February 19, 2024: Eye and Vision (London, England)
Xiangjun She, Wangjing Yao, Gongyu Huang, Zhi Liang, Jin Xie, Jiwei Tao, Sulan Wu, Jianbo Mao, Yiqi Chen, Yun Zhang, Lijun Shen
BACKGROUND: To compare the recurrence of myopic choroidal neovascularization (mCNV) based on the neovascular signal of mCNV around the perforating scleral vessel (PSV). METHODS: A consecutive series of naïve patients with mCNV accepted anti-VEGF therapy with a minimum 12-month follow-up period. The neovascular signal relationship between PSV and mCNV were classified into the presence of neovascular signal of CNV around PSV or not. The recurrence of mCNV, best-corrected visual acuity (BCVA), hyperreflective foci height, CNV area and CNV flow area were analyzed between two groups...
February 7, 2024: Eye and Vision (London, England)
Yong-Yeon Song, Hyun-Je Seong, Jung-Tae Kim, Sung-Chul Lee, Min-Woo Lee
BACKGROUND: To identify the macular neovascularization (MNV) features in exudative age-related macular degeneration (AMD) patients who exhibited residual fluid after receiving three loading doses of aflibercept. METHODS: Patients were classified into two groups: Group 1, which did not exhibit intraretinal fluid (IRF) and subretinal fluid (SRF), and Group 2, which did exhibit IRF and/or SRF. Optical coherence tomography angiography (OCTA) features were assessed and compared between the groups...
February 1, 2024: Eye and Vision (London, England)
Pooja Malaviya, Renu A Kowluru
BACKGROUND: Diabetic retinopathy is a progressive disease, and one of the key metabolic abnormalities in the pathogenesis of diabetic retinopathy, mitochondrial damage, is also influenced by the duration of hyperglycemia. Mitochondrial quality control involves a coordination of mitochondrial dynamics, biogenesis and removal of the damaged mitochondria. In diabetes, these processes are impaired, and the damaged mitochondria continue to produce free radicals. Diabetic patients also have high homocysteine and reduced levels of hydrogen sulfide, and hyperhomocysteinemia is shown to exacerbate diabetes-induced mitochondrial damage and worsen their dynamics...
January 16, 2024: Eye and Vision (London, England)
Danling Liao, Shijia Wei, Jianzhang Hu
BACKGROUND: Autophagy has recently been shown to be critical for protecting peripheral nerve regeneration. This study explored the impact of miR-542-3p on diabetic corneal nerve regeneration and epithelial healing through the regulation of autophagy. METHODS: A type 1 diabetes model was established in male mice through streptozotocin administration. Immunofluorescence staining of β-Tubulin III and sodium fluorescein staining were performed to observe corneal nerve fiber density and corneal epithelial healing, respectively...
January 3, 2024: Eye and Vision (London, England)
Phillip T Yuhas, Maddison M Fortman, Ashraf M Mahmoud, Cynthia J Roberts
BACKGROUND: Keratoconus is characterized by asymmetry in the biomechanical properties of the cornea, with focal weakness in the area of cone formation. We tested the hypothesis that centrally-measured biomechanical parameters differ between corneas with peripheral cones and corneas with central cones. METHODS: Fifty participants with keratoconus were prospectively recruited. The mean ± standard deviation age was 38 ± 13 years...
January 3, 2024: Eye and Vision (London, England)
Rui Ning, Yiran Wang, Zhenyu Xu, Ingemar Gustafsson, Jiawei Li, Giacomo Savini, Domenico Schiano-Lomoriello, Yichen Xiao, Aodong Chen, Xiaoying Wang, Xingtao Zhou, Jinhai Huang
BACKGROUND: To assess repeatability and reproducibility of corneal epithelium thickness (ET) measured by a spectral-domain optical coherence tomographer (SD-OCT)/Placido topographer (MS-39, CSO, Florence, Italy) in keratoconus (KC) population at different stages, as well as to determine the progression limits for evaluating KC progression. METHODS: A total of 149 eyes were enrolled in this study, with 29 eyes in the forme fruste keratoconus (FFKC) group, 34 eyes in the mild KC group, 40 eyes in the moderate KC group, and 46 eyes in the severe KC group...
January 2, 2024: Eye and Vision (London, England)
Pascal Aurel Gubser, Valentin Pfeiffer, Simon Hug, Xiao Shang, Joel-Benjamin Lincke, Nathanael Urs Häner, Martin S Zinkernagel, Jan Darius Unterlauft
BACKGROUND: To compare the intermediate-term efficacy of PRESERFLO (PF) MicroShunt implantation with trabeculectomy (TE) in patients with primary open-angle glaucoma, focusing on longitudinal changes of functional and structural parameters. METHODS: This retrospective comparative study included 104 eyes of 104 patients who underwent TE and 83 eyes of 83 patients that underwent PF implantation between January 2019 and December 2020, with a minimum follow-up of two years...
December 21, 2023: Eye and Vision (London, England)
Grzegorz Łabuz, Helin Güngör, Gerd U Auffarth, Timur M Yildirim, Ramin Khoramnia
BACKGROUND: Chromatic aberration of the eye results from the dispersion of polychromatic light at the interfaces of ocular media. An intraocular lens (IOL) based approach utilizing the diffractive-multifocal principle has been proposed for its correction, but the clinical evidence on the impact of reducing or increasing chromatic aberration on the visual quality of pseudophakic patients remains scarce. METHODS: In this cross-sectional study, longitudinal chromatic aberration (LCA) effects were studied monocularly in 37 patients implanted with a monofocal lens...
December 12, 2023: Eye and Vision (London, England)
Fernando Mayordomo-Cerdá, Julio Ortega-Usobiaga, Julio Baviera-Sabater, Rafael Bilbao-Calabuig, Fernando Llovet-Osuna, Vasyl Druchkiv, Rosario Cobo-Soriano
BACKGROUND: To assess whether a trifocal intraocular lens (IOL) with neutral spherical aberration (SA) provides better visual and refractive outcomes than a trifocal IOL with negative SA after hyperopic corneal laser ablation. METHODS: This is a retrospective comparative study. Patients were classified according to the IOL implanted after cataract or clear lens phacoemulsification [group 1, PhysIOL FineVision Pod-F (negative SA); group 2, Rayner RayOne Trifocal (neutral SA)]...
December 7, 2023: Eye and Vision (London, England)
Ashish Gupta, Daniel Ruminski, Alfonso Jimenez Villar, Raúl Duarte Toledo, Grzegorz Gondek, Barbara Pierscionek, Pablo Artal, Ireneusz Grulkowski
BACKGROUND: The shape and microstructure of the human crystalline lens alter with ageing, and this has an effect on the optical properties of the eye. The aim of this study was to characterise the age-related differences in the morphology and transparency of the eye lenses of healthy subjects through the optical signal discontinuity (OSD) zones in optical coherence tomography (OCT) images. We also investigated the association of those changes with the optical quality of the eye and visual function...
December 1, 2023: Eye and Vision (London, England)
Xuewei Li, Lili Zuo, Heng Zhao, Jie Hu, Tao Tang, Kai Wang, Yan Li, Mingwei Zhao
BACKGROUND: To investigate the control effect on the axial length elongation using corneal refractive therapy (CRT) with different optical zone diameters (BOZDs). We also sought to compare the difference in higher-order aberrations (HOAs), treatment zone (TZ) size and Zernike defocus coefficient with different BOZDs and seek the optimal parameter for predicting axial elongation. METHODS: This prospective cohort study included 7- to 14-year-olds fitted with orthokeratology (ortho-K) lenses of 5-mm (5-mm group) or 6-mm BOZD (6-mm group)...
November 20, 2023: Eye and Vision (London, England)
Renato Ambrósio, Marcella Q Salomão, Lorena Barros, João Batista R da Fonseca Filho, Jaime Guedes, Alexandre Neto, Aydano P Machado, Bernardo T Lopes, Nelson Sena, Louise Pellegrino Gomes Esporcatte
Different diagnostic approaches for ectatic corneal diseases (ECD) include screening, diagnosis confirmation, classification of the ECD type, severity staging, prognostic evaluation, and clinical follow-up. The comprehensive assessment must start with a directed clinical history. However, multimodal imaging tools, including Placido-disk topography, Scheimpflug three-dimensional (3D) tomography, corneal biomechanical evaluations, and layered (or segmental) tomography with epithelial thickness by optical coherence tomography (OCT), or digital very high-frequency ultrasound (dVHF-US) serve as fundamental complementary exams for measuring different characteristics of the cornea...
November 3, 2023: Eye and Vision (London, England)
Longdan Kang, Shin-Ichi Ikeda, Yajing Yang, Heonuk Jeong, Junhan Chen, Yan Zhang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara
BACKGROUND: Recent studies have indicated a strong correlation between endoplasmic reticulum (ER) stress and myopia and that eyedrops containing the ER stress inducer tunicamycin (Tm) can induce myopic changes in C57BL/6 J mice. Therefore, this study aimed to create a new myopia model using Tm eyedrops and to explore the mechanism of ER stress-mediated myopia development. METHODS: Three-week-old C57BL/6 J mice were treated with different concentrations (0, 25, 50, and 100 μg/mL) and/or number of applications (zero, one, three, and seven) of Tm eyedrops...
November 1, 2023: Eye and Vision (London, England)
Na Li, Weiping Lin, Ruixue Liang, Ziwen Sun, Bei Du, Ruihua Wei
BACKGROUND: To compare axial elongation in 8-11-year-old myopes wearing orthokeratology (OK) lenses with different back optic zone diameters (BOZD), defocus incorporated soft contact (DISC) lenses, and single-vision soft contact lenses (SCLs). METHODS: A total of 122 children (aged 8-11 years) with spherical equivalent refraction (SER) between - 1.00 D and - 4.00 D were enrolled in this prospective study and randomly assigned to four groups: 5...
October 7, 2023: Eye and Vision (London, England)
Thomas A Strong, Juan Esquivel, Qikai Wang, Paul J Ledon, Hua Wang, Gabriel Gaidosh, David Tse, Daniel Pelaez
BACKGROUND: Optic neuropathy is a major cause of irreversible blindness, yet the molecular determinants that contribute to neuronal demise have not been fully elucidated. Several studies have identified 'ephrin signaling' as one of the most dysregulated pathways in the early pathophysiology of optic neuropathy with varied etiologies. Developmentally, gradients in ephrin signaling coordinate retinotopic mapping via repulsive modulation of cytoskeletal dynamics in neuronal membranes. Little is known about the role ephrin signaling plays in the post-natal visual system and its correlation with the onset of optic neuropathy...
October 2, 2023: Eye and Vision (London, England)
Gaurav Prakash, Alex Mammen, Vishal Jhanji
BACKGROUND: To compare the rate of fractional change for multiple corneal tomographic factors in progressive keratoconus (KC). METHODS: In this retrospective case series, 40 eyes (40 patients) with progressive KC (increase in central keratometry of 1.00 D or maximum keratometry of 1.50 D on two visits at least six months apart) were included. Cases with previous history of ocular surgery, poor scans, corneal scars, severe dry eyes, post-excimer ectasia, pellucid marginal degeneration were excluded...
October 1, 2023: Eye and Vision (London, England)
Farhad Hafezi, Emilio A Torres-Netto, Leonard Kollros, Nan-Ji Lu, Nikki Hafezi, Cosimo Mazzotta, M Enes Aydemir, Mark Hillen
No abstract text is available yet for this article.
September 25, 2023: Eye and Vision (London, England)
Rachel Ka Man Chun, Hanyu Zhang, Zhengji Liu, Dennis Yan Yin Tse, Yongjin Zhou, Carly Siu Yin Lam, Chi Ho To
BACKGROUND: Myopia control interventions, such as defocus incorporated multiple segments (DIMS) spectacle lenses, have been adopted in school-aged children to reduce the prevalence of myopia and its complications. This study aimed to investigate the effect of DIMS spectacle lenses on subfoveal choroidal thickness (SfChT) over a period of two years, as the choroidal response to myopic control is a crucial factor in exploring its potential effect on predicting myopia progression. METHODS: This study involved a secondary analysis of our previous randomized clinical trial...
September 15, 2023: Eye and Vision (London, England)
Christie Hang-I Lam, Bing Zou, Henry Ho-Lung Chan, Dennis Yan-Yin Tse
BACKGROUND: Diabetic retinopathy (DR), one of the leading causes of blindness and vision impairment, is suggested to exhibit functional and structural changes in retinal neurons as the earliest manifestation, which could be used to predict the progression of related angiopathy. While neural function and survival rely on proper mitochondrial function, and a growing body of literature has supported the role of mitochondrial dysfunction in the development of DR, how diabetes affects mitochondrial function in retinal tissue remains elusive...
September 1, 2023: Eye and Vision (London, England)
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