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Eye and Vision (London, England)

Wen Di Lee, Kavya Devarajan, Jacqueline Chua, Leopold Schmetterer, Jodhbir S Mehta, Marcus Ang
Optical coherence tomography angiography (OCTA) is a rapid and non-invasive technique for imaging vasculature in the eye. As OCTA can produce high-resolution cross-sectional images and allow depth-resolved analysis for accurate localization of pathology of interest, it has become a promising method for anterior segment imaging. Furthermore, OCTA offers a more patient-friendly alternative to the conventional invasive dye-based fluorescent angiography. However, conventional OCTA systems are typically designed and optimized for the posterior segment of the eye, and thus using OCTA for anterior segment imaging can present several difficulties and limitations...
2019: Eye and Vision (London, England)
Zhiping Liu, Hua Wang, Hong Jiang, Giovana Rosa Gameiro, Jianhua Wang
Background: The goal was to quantitatively analyze the bulbar conjunctival microvascular density using optical coherence tomography angiography (OCTA) and compare it to the vessel density using functional slit-lamp biomicroscopy (FSLB). Methods: Temporal bulbar conjunctiva of 20 eyes (10 healthy subjects) was imaged using both OCTA and FSLB. Image processing was performed including equalization, de-noising, thresholding, and skeletonization. The vessel density was measured by fractal analysis (box counting, Dbox) and pixel counting (%)...
2019: Eye and Vision (London, England)
Amanda D Henderson, Hong Jiang, Jianhua Wang
Background: Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of acute optic neuropathy in patients over 50 years of age, and many affected individuals are left with permanent visual deficits. Despite the frequency of NAION and its often devastating effects on vision, no effective treatment has been established. Further understanding of the acute vascular effects in NAION, using advanced ophthalmic imaging techniques like the retinal function imager, may shed light on potential treatment targets...
2019: Eye and Vision (London, England)
Kavya Devarajan, Wen Di Lee, Hon Shing Ong, Nyein C Lwin, Jacqueline Chua, Leopold Schmetterer, Jodhbir S Mehta, Marcus Ang
Background: Optical coherence tomography angiography (OCTA) is a novel non-invasive angiography technology that has recently been extensively studied for its utility in anterior segment imaging. In this study, we compared a split-spectrum amplitude decorrelation angiography (SSADA) OCTA and an optical micro-angiography (OMAG SD) OCTA system to current angiographic technique, indocyanine green angiography (ICGA), to assess corneal vascularisation in an animal model. Methods: We imaged 16 rabbits, (one eye per animal) with corneal vascularisation using SSADA OCTA (AngioVue; Optovue Inc...
2019: Eye and Vision (London, England)
Luca Buzzonetti, Gianni Petrocelli, Paola Valente, Sergio Petroni, Rosa Parrilla, Giancarlo Iarossi
Background: To evaluate refractive outcome 24 months after Deep Anterior Lamellar Keratoplasty (DALK) in pediatric patients by comparing results achieved using mechanical trephine and femtosecond laser. Methods: Twenty eyes of 20 patients affected by keratoconus were evaluated. To perform big-bubble DALK, 10 eyes (Group 1; mean age 11.2 ± 2.2 years) were subjected to the Hessburg-Barron mechanical trephine and the remaining 10 eyes (Group 2; mean age 11...
2019: Eye and Vision (London, England)
Yuqing Deng, Meng Li, Gengyuan Wang, Hong Jiang, Jianhua Wang, Jing Zhong, Saiqun Li, Jin Yuan
Background: To determine the inter-visit variability of retinal blood flow velocities (BFVs) using a retinal function imager (RFI) in healthy young subjects. Methods: Twenty eyes of 20 healthy young subjects were enrolled. RFI imaging was performed to obtain the BFVs in retinal arterioles and venules in a field measuring 7.3 × 7.3 mm2 (setting: 35 degrees) centered on the fovea, and repeated measurements were obtained on two separate days. The inter-visit variability of BFVs was assessed by the concordance correlation coefficient (CCC) and coefficient of variance (CV)...
2018: Eye and Vision (London, England)
Asaf Achiron, Idan Hecht, Chen Juza, Adiel Barak, Zvia Burgansky-Eliash
Purpose: It has been suggested that Sildenafil may have beneficial therapeutic effects in the treatment of neurodegenerative disorders. The retinal circulation is of significant interest as a marker of cerebral vascular disease since the retinal and cerebral vasculatures share many morphological and physiological properties, yet only the retinal circulation can be directly visualized. Therefore, our aim was to assess the change induced by Sildenafil on retinal blood velocity. Methods: Retinal flow velocity was measured 0...
2018: Eye and Vision (London, England)
Liang Wang, Ohemaa Kwakyi, James Nguyen, Esther Ogbuokiri, Olwen Murphy, Natalia Gonzalez Caldito, Laura Balcer, Elliot Frohman, Teresa Frohman, Peter A Calabresi, Shiv Saidha
Background: The retinal microcirculation has been studied in various diseases including multiple sclerosis (MS). However, inter-eye correlations and potential differences of the retinal blood flow velocity (BFV) remain largely unstudied but may be important in guiding eye selection as well as the design and interpretation of studies assessing or utilizing retinal BFV. The primary aim of this study was to determine inter-eye correlations in BFVs in healthy controls (HCs). Since prior studies raise the possibility of reduced BFV in MS eyes, a secondary aim was to compare retinal BFVs between MS eyes, grouped based on optic neuritis (ON) history and HC eyes...
2018: Eye and Vision (London, England)
Jorge L Alió Del Barrio, Jorge L Alió
Cellular therapy of the corneal stroma, with either ocular or extraocular stem cells, has been gaining a lot of interest over the last decade. Multiple publications from different research groups are showing its potential benefits in relation to its capacity to improve or alleviate corneal scars, improve corneal transparency in metabolic diseases by enhancing the catabolism of the accumulated molecules, generate new organized collagen within the host stroma, and its immunosuppressive and immunomodulatory properties...
2018: Eye and Vision (London, England)
António Campos, Elisa J Campos, Anália do Carmo, Francisco Caramelo, João Martins, João P Sousa, António Francisco Ambrósio, Rufino Silva
Objective: To evaluate short-term markers of outcome in diabetic macular edema (DME). Methods: Prospective interventional case series included 122 eyes of 122 patients with recently diagnosed DME. Eyes were treated with a 3-monthly loading dose of ranibizumab or aflibercept and pro re nata thereafter. Serial enhanced deep imaging SD-OCT high resolution scans were used to measure subfoveal choroidal thickness (SFCT) and central retinal thickness (CRT). Anatomic (10% CRT decrease) and functional responses (best corrected visual acuity, BCVA gain ≥5 letters) were assessed at 3 months and 6 months using univariate and multivariate analyses...
2018: Eye and Vision (London, England)
Rénuka S Birbal, Korine van Dijk, Jack S Parker, Henny Otten, Maha Belmoukadim, Lisanne Ham, Lamis Baydoun, Isabel Dapena, Gerrit R J Melles
Background: To evaluate the efficacy of manual mid-stromal dissection in stabilizing progressive keratoconus. Methods: Surgeries were performed in 16 eyes of 14 patients with progressive keratoconus. All eyes were examined before and at 1 day, 1 week, 1, 3, 6 and 12 months after surgery, and every 6 months thereafter. Pentacam (simK, Kmax and pachymetry), best corrected visual acuity (BCVA) and subjective refraction were recorded up to the latest follow-up visit (mean follow-up time 6...
2018: Eye and Vision (London, England)
Dongyi Qu, Ying Lin, Hong Jiang, Yi Shao, Yingying Shi, Shriya Airen, Giovanni Gregori, Jianhua Wang
Background: The aim was to determine retinal nerve fiber layer function and its relations to retinal microvasculature and microcirculation in patients with myopia. Method: Polarization-sensitive optical coherence tomography (PS-OCT) was used to measure phase retardation per unit depth (PR/UD, proportional to the birefringence) of the retinal nerve fiber layer (RNFL). Optical coherence tomography angiography (OCTA) was used to measure macular vessel density analyzed using fractal analysis...
2018: Eye and Vision (London, England)
Diana C Dragnea, Rénuka S Birbal, Lisanne Ham, Isabel Dapena, Silke Oellerich, Korine van Dijk, Gerrit R J Melles
Several treatment options corresponding to the grade of keratoconus have been established. These are ultra-violet corneal crosslinking and intracorneal ring segments for mild to moderate keratoconus, and penetrating keratoplasty or deep anterior lamellar keratoplasty for the more advanced cases of keratoconus. Bowman layer transplantation was developed as a procedure for patients with advanced, progressive keratoconus. The technique consists of transplanting an isolated donor Bowman layer into a mid-stromal pocket of a keratoconic cornea resulting in corneal flattening and stabilization against further ectasia...
2018: Eye and Vision (London, England)
Malvika Arya, Almyr S Sabrosa, Jay S Duker, Nadia K Waheed
Age-related macular degeneration (AMD) is a leading cause of central vision loss worldwide. The progression of dry AMD from early to intermediate stages is primarily characterized by increasing drusen formation and adverse impact on outer retinal cells. Late stage AMD consists of either geographic atrophy (GA), the non-exudative (dry) AMD subtype, or choroidal neovascularization, the exudative (wet) AMD subtype. GA is characterized by outer retinal and choroidal atrophy, specifically the photoreceptor layer, RPE, and choriocapillaris...
2018: Eye and Vision (London, England)
Patrick B Rapuano, Priya M Mathews, George J Florakis, Stephen L Trokel, Leejee H Suh
Background: Corneal collagen crosslinking (CXL) is a widely used treatment for halting the progression of keratoconus. Although initial studies of CXL were performed with a riboflavin solution containing dextran, recent protocols for CXL have indicated the use of a riboflavin solution containing isotonic hydroxypropyl methylcellulose (HPMC). This study was performed to investigate differences in visual outcomes and Scheimpflug (Pentacam) analysis in patients who have undergone epithelium-off CXL with riboflavin solution containing either 20% dextran versus 1...
2018: Eye and Vision (London, England)
Giovana Rosa Gameiro, Hong Jiang, Yi Liu, Yuqing Deng, Xiaoyan Sun, Bernardo Nascentes, Bernard Baumel, Tatjana Rundek, Jianhua Wang
Background: It remains unknow whether retinal tissue perfusion occurs in patients with Alzheimer's disease. The goal was to determine retinal tissue perfusion in patients with clinical Alzheimer's disease (CAD). Methods: Twenty-four CAD patients and 19 cognitively normal (CN) age-matched controls were recruited. A retinal function imager (RFI, Optical Imaging Ltd., Rehovot, Israel) was used to measure the retinal blood flow supplying the macular area of a diameter of 2...
2018: Eye and Vision (London, England)
Daniel Su, Sunir Garg
Background: The Retinal Function Imager (RFI) provides in vivo and noninvasive imaging of both the retinal structure and function. Review: The RFI can create capillary perfusion maps, measure blood flow velocity, and determine metabolic function including blood oximetry. It can aid clinical diagnosis as well as assess treatment response in several retinal vascular diseases including diabetic retinopathy. Blood flow velocity abnormalities have also been implicated in disease such as age-related macular degeneration and require further investigation...
2018: Eye and Vision (London, England)
Fupeng Wang, Qinqin Zhang, Anthony J Deegan, Jun Chang, Ruikang K Wang
Background: There are two forms of system implementation of optical coherence tomography angiography (OCTA) in ophthalmic imaging, i.e., spectral domain (SD-) and swept source OCTA (SS-OCTA). The purpose of this paper is to compare the SD-OCTA and SS-OCTA for elucidating structural and vascular features associated with central serous retinopathy (CSR), and to evaluate the effects of CSR on SD- and SS-OCTA's imaging capabilities. Methods: Normal subjects and CSR patients were imaged by SD- and SS-OCTA using 3 × 3 mm and 6 × 6 mm scan patterns...
2018: Eye and Vision (London, England)
Giacomo Savini, Kenneth J Hoffer
Background: This review aims to explain the reasons why intraocular lens (IOL) power calculation is challenging in eyes with previous corneal refractive surgery and what solutions are currently available to obtain more accurate results. Review: After IOL implantation in eyes with previous LASIK, PRK or RK, a refractive surprise can occur because i) the altered ratio between the anterior and posterior corneal surface makes the keratometric index invalid; ii) the corneal curvature radius is measured out of the optical zone; and iii) the effective lens position is erroneously predicted if such a prediction is based on the post-refractive surgery corneal curvature...
2018: Eye and Vision (London, England)
Megh D Patel, Fareshta Khushzad, Heather E Moss
Background: Optic nerve head measurements extracted from optical coherence tomography (OCT) show promise for monitoring clinical conditions with elevated optic nerve heads. The aim of this study is to compare reliability within and between raters and between image acquisition devices of optic nerve measurements derived from OCT scans in eyes with varying degrees of optic nerve elevation. Methods: Wide angle line scans and narrow angle radial scans through optic nerve heads were obtained using three spectral domain(SD) OCT devices on 5 subjects (6 swollen optic nerves, 4 normal optic nerves)...
2018: Eye and Vision (London, England)
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