Hasnaa Talimi, Othmane Daoui, Giovanni Bussotti, Idris Mhaidi, Anne Boland, Jean-François Deleuze, Rachida Fissoune, Meryem Lemrani, Gerald F Späth
In Morocco, cutaneous leishmaniasis (CL) caused by Leishmania ( L. ) tropica is an important health problem. Despite the high incidence of CL in the country, the genomic heterogeneity of these parasites is still incompletely understood. In this study, we sequenced the genomes of 14 Moroccan isolates of L. tropica collected from confirmed cases of CL to investigate their genomic heterogeneity. Comparative genomics analyses were conducted by applying the recently established Genome Instability Pipeline (GIP), which allowed us to conduct phylogenomic and principal components analyses (PCA), and to assess genomic variations at the levels of the karyotype, gene copy number, single nucleotide polymorphisms (SNPs) and small insertions/deletions (INDELs) variants...
April 2024: Microbial Genomics