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Progress in Biomaterials

Sahebali Manafi, Fatemeh Mirjalili, Rayhaneh Reshadi
This research study concerns the evaluations of nano-biocomposite ceramics' characteristics and biocompatibility. A nanocomposite with 45S5 bioactive glass base has been synthesized by sol-gel method. The synthesized nanocomposites were characterized with the help of different techniques, using field-emission scanning electron microscope, X-ray powder diffraction, energy-dispersive X-ray spectroscopy to evaluate the crystal structure, microstructure, and the morphology of the nanocomposite. The results indicated that the synthesis of 45S5 bioactive glass-fluorapatite nanocomposites produced an average particle size of about 20-30 nm and percentages of crystallinity of about 70-90%...
April 11, 2019: Progress in Biomaterials
Marziyeh Meghdadi, Seyed-Mohammad Atyabi, Mohamad Pezeshki-Modaress, Shiva Irani, Zahra Noormohammadi, Mojgan Zandi
Poly(Ɛ-caprolactone) (PCL) is a biocompatible polymer with a high potential to be used in tissue engineering especially in tight tissues. In the current study, cold atmospheric plasma (CAP) is used as a promising method for immobilization of gelatin as a functional biomacromolecule on PCL nanofibrous substrates. The CAP surface modification leads to oxidation of chemical groups existing on the PCL surface without doing any damage to the bulk properties of biomaterials for gelatin biomacromolecule grafting...
March 27, 2019: Progress in Biomaterials
Sabrieh Asadi Shahi, Shahla Roudbar Mohammadi, Maryam Roudbary, Hamid Delavari
Candida albicans (C. albicans) belongs to the opportunistic fungal pathogens, which cause a wide spectrum of infections in immune-compromised patients. Graphene oxide (GO), a biocompatibility agent, has been reported to exhibit effective antimicrobial activity. In the present study, a graphene oxide/fluconazole (GO/Flu) compound was synthesized and characterized using Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy. The antifungal activity of GO/Flu was examined against fluconazole-resistant C...
March 11, 2019: Progress in Biomaterials
Mukti Sharma, Saurabh Yadav, Narayanan Ganesh, Man Mohan Srivastava, Shalini Srivastava
The present communication warrants the presence of significant wound healing bio-efficacy of aq. alc. extract of the seed (49.78%) of the plant Madhuca longifolia. A family of seven flavonoid fractions have been ascertained in the seed aq. alc. extract of the target plant using LCMS-8030 analysis. In vivo wound healing parameters (wound area, wound closure, epithelization period, skin breaking strength and hydroxyproline content) have been examined in Swiss albino mice models. Statistically significant (p < 0...
February 21, 2019: Progress in Biomaterials
Fabricio Marcelo Cevallos González, Erika Michele Dos Santos Araújo, Maria Regina Lorenzetti Simionato, Luciana Kfouri Siriani, Ana Del Carmen Armas Vega, Igor Studart Medeiros, Adriana Bona Matos
In vitro effect of 1% theobromine addition on the physical and chemical properties of conventional glass ionomer (GIC) cement was investigated. Conventional GIC (GIC-C) and 1% theobromine added to GIC (GIC-THEO) specimens were compared regarding the microhardness (n = 10), sorption (n = 5), solubility (n = 5), color change (n = 10), fluoride release in saliva (n = 10) and the amount of biofilm deposition (n = 20). Compared against conventional GIC, adding 1% theobromine increased microhardness (p < 0...
February 6, 2019: Progress in Biomaterials
Arefeh Basiri, Mehdi Farokhi, Mahmoud Azami, Somayeh Ebrahimi-Barough, Abdolreza Mohamadnia, Morteza Rashtbar, Elham Hasanzadeh, Narges Mahmoodi, Mohamadreza Baghaban Eslaminejad, Jafar Ai
A hybrid hydrogel was obtained from decellularized extract from Wharton's jelly (DEWJ) and silk fibroin (SF) and characterized for cartilage tissue engineering. Wharton's jelly was used due to its similarity with articular cartilage in extracellular matrix composition. Also, silk fibroin has good mechanical properties which make this construct appropriate for cartilage repair. Decellularization of Wharton's jelly was verified by DAPI staining, DNA quantification, and PCR analysis. Then, the biochemical composition of DEWJ was determined by ELISA kits for total proteins, collagens, sulfated glycosaminoglycans (sGAG), and transforming growth factor β1 (TGF-β1)...
January 31, 2019: Progress in Biomaterials
Kangkana Banerjee, V Ravishankar Rai, M Umashankar
Metal nanoparticles are widely used for the delivery and targeting of pharmaceutical, therapeutic and diagnostic agents in cancer therapy in recent years. The multifunctional nanoparticles constructed currently are supposed to show superior effects on cancer cells. This study was conducted to observe the difference between the effect of a biologically important peptide, silver (AgNPs) and gold (AuNPs) nanoparticles and their conjugates on two different cancer cells. Peptide (Boc-L-D P-L-OMe) was acquired from different sources and subjected to conjugation with biosynthesized gold and silver nanoparticles under standard conditions...
January 19, 2019: Progress in Biomaterials
Cássio M Resmim, Mariane Dalpasquale, Nilce I C Vielmo, Filipe Q Mariani, Juan C Villalba, Fauze J Anaissi, Mirian M Caetano, Marcelo M Tusi
Hydroxyapatite was obtained by bone calcinations. To study the calcination process, bovine and porcine bones were first autoclaved to remove fat and other non-bone tissues. They were then heated in an alumina pan in an oxidizing atmosphere of air, where simultaneous thermal analysis curves were recorded. To prepare the hydroxyapatites, bone samples were calcined at 850 °C and 1000 °C using a muffle furnace for 1 h. The obtained materials were powdered using mortar and pestle, and sifted in a sieve (60 mesh) without any additional purification or chemical treatment...
December 31, 2018: Progress in Biomaterials
Chinmay G Hiremath, Mahadevappa Y Kariduraganavar, Murigendra B Hiremath
Human serum albumin is the most abundant protein in plasma with the ability to bind to a variety of drug molecules. Magnetic nanoparticles are being extensively used in drug delivery due to its intrinsic magnetic properties. In this work, we have synthesized human serum albumin-coated citrate-functionalized iron oxide nanoparticles by CDI coupling. Furthermore, folic acid was decorated on human serum albumin by EDC and NHS coupling to confer targetability. Two cytotoxic drugs 5-fluorouracil (5FU) and curcumin were co-delivered...
December 18, 2018: Progress in Biomaterials
A P S Prasanna, G Devanand Venkatasubbu
Hydroxyapatite (HAP) is the main constituent of human bone and teeth. Hydroxyapatite nanoparticles are used for the treatment of various bone infections. Nanohydroxyapatite is a biocompatible material. It is used as a drug carrier for drugs and biomolecules for various diseases. Hydroxyapatite nanoparticles are made into nanocomposite with sodium alginate and polyvinyl alcohol. This nanocomposite is used for the sustained release of drugs. It is characterized by various characterization techniques like XRD, FTIR, TEM, and Raman...
November 27, 2018: Progress in Biomaterials
Nasim Rezaee, Mohammad Tafazzoli-Shadpour, Nooshin Haghighipour
Differentiation of stem cells and functionality of target cells are regulated by microenvironmental stimuli to which the cells are exposed. Chemical agents such as growth factors and physical parameters including mechanical loadings are among major stimuli. In this study, equiaxial cyclic strain with two amplitudes was applied on rat adipose-derived mesenchymal stem cells (rAMSCs) with or without 5-azacytidine. The mRNA expression of cardiac-related genes was investigated through RT-PCR (polymerase chain reaction) method...
October 26, 2018: Progress in Biomaterials
Zahra Zaredar, Fahimeh Askari, Parvin Shokrolahi
Three polyurethane formulations were prepared on the basis of siloxane; two formulations contained 1% and 3% of a hydroxyl functionalized polyhedral oligomeric silsesquioxane [POSS (ROH)2 ] nano-particles (as a co-chain extender) and one was without nano-particle. Structures of the polyurethanes were characterized by FTIR and SEM. The effect of POSS nano-particles on properties of the synthesized PUs was examined for vascular applications by tensile test, contact angle, SEM, AFM and endothelial cells viability evaluation...
October 22, 2018: Progress in Biomaterials
Hengameh Bakhtiar, Amir Mazidi S, Saeed Mohammadi Asl, M R Ellini, A Moshiri, M H Nekoofar, P M H Dummer
Infection of the dental pulp will result in inflammation and eventually tissue necrosis which is treated conventionally by pulpectomy and root canal treatment. Advances in regenerative medicine and tissue engineering along with the introduction of new sources of stem cells have led to the possibility of pulp tissue regeneration. This systematic review analyzes animal studies published since 2010 to determine the ability of stem cell therapy to regenerate the dentine-pulp complex (DPC) and the success of clinical protocols...
September 28, 2018: Progress in Biomaterials
Masoumeh Ezati, Hamide Safavipour, Behzad Houshmand, Shahab Faghihi
Many approaches have been developed to regenerate biological substitutes for repairing damaged tissues. Guided bone/tissue regeneration (GBR/GTR) that employs a barrier membrane has received much attention in recent years. Regardless of substantial efforts for treatment of damaged tissue in recent years, an effective therapeutic strategy is still a challenge for tissue engineering researchers. The aim of the current study is to fabricate a GBR membrane consisting of polycaprolactone (PCL)/gelatin/chitosan which is modified with different percentages of β-tricalcium phosphate (β-TCP) for improved biocompatibility, mechanical properties, and antibacterial activity...
September 2018: Progress in Biomaterials
Meenakshi Bhatia, Megha Saini
The aim of the present study was to improve the release rate of curcumin by microsponges prepared through quasi-emulsion solvent diffusion technique using ethylcellulose and PVA as carriers. The microsponges were characterized by FTIR, DSC, XRD and SEM studies followed by determination of total drug content and entrapment efficiency. The prepared microsponges were further filled in hard gelatin capsule shell and then loaded in carbopol gel to evaluate its potential in oral and topical drug delivery. Further, it was observed from the studies on release rate that microsponges filled in hard gelatin capsule shells (batch MS4) showed 93...
September 2018: Progress in Biomaterials
Setareh Borhani, Shadi Hassanajili, Seyed Hossein Ahmadi Tafti, Shahram Rabbani
Compared to bare-metal stents (BMSs), drug-eluting stents (DESs) have been regarded as a revolutionary change in coronary artery diseases (CADs). Releasing pharmaceutical agents from the stent surface was a promising progress in the realm of cardiovascular stents. Despite supreme advantages over BMSs, in-stent restenosis (ISR) and long-term safety of DESs are still deemed ongoing concerns over clinically application of DESs. The failure of DESs for long-term clinical use is associated with following factors including permanent polymeric coating materials, metallic stent platforms, non-optimal drug releasing condition, and factors that have recently been supposed as contributory factors such as degradation products of polymers, metal ions due to erosion and degradation of metals and their alloys utilizing in some stents as metal frameworks...
September 2018: Progress in Biomaterials
S M Fijul Kabir, Partha P Sikdar, B Haque, M A Rahman Bhuiyan, A Ali, M N Islam
Hydrogels based on cellulose comprising many organic biopolymers including cellulose, chitin, and chitosan are the hydrophilic material, which can absorb and retain a huge proportion of water in the interstitial sites of their structures. These polymers feature many amazing properties such as responsiveness to pH, time, temperature, chemical species and biological conditions besides a very high-water absorption capacity. Biopolymer hydrogels can be manipulated and crafted for numerous applications leading to a tremendous boom in research during recent times in scientific communities...
September 2018: Progress in Biomaterials
N Parvanehpour, Shahrokh Shojaei, S Khorramymehr, V Goodarzi, F Hejazi, V Faghihi Rezaei
Mechanical properties of the cells are among the most highlighted area of interests among researchers for decades. Not only many of the cells' crucial functional characteristics such as adherence to the cellular substrate, migration abilities and morphological factors are directly influenced by their mechanical properties but also changes in these traits could have importance in diagnosis and even treatments of some serious diseases. The general mechanical properties of the cells are associated with some intercellular characteristics such as arrangement and organization of the actin fibers and cytoskeleton architecture...
September 2018: Progress in Biomaterials
Mohamad Pezeshki-Modaress, Mojgan Zandi, Sarah Rajabi
The nanofibrous structure containing protein and polysaccharide has good potential in tissue engineering. The present work aims to study the role of chitosan in gelatin/chitosan nanofibrous scaffolds fabricated through electrospinning process under optimized condition. The performance of chitosan in gelatin/chitosan nanofibrous scaffolds was evaluated by mechanical tests, scanning electron microscopy (SEM), Fourier transform infrared (FTIR) and in vitro cell culture on scaffolds with different gelatin/chitosan blend ratios...
September 2018: Progress in Biomaterials
Azadehsadat Hashemi Doulabi, Hamid Mirzadeh, Mohammad Imani, Shadab Bagheri-Khoulenjani
Blending is one of the effective approaches in preparing tailored materials with a wide range of properties. Thus, chitosan-based polymers have been fabricated and used as wound dressings since they possess better properties than those of the constituent materials. The objective of this work was to evaluate the biocompatibility and biodegradability of biodegradable blend films based on polyethylene glycol-co-fumarate (PEGF) and chitosan (Ch). The blend films of Ch/PEGF were prepared by solution casting/solvent evaporation method...
June 2018: Progress in Biomaterials
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