Gabriel S Pena, Hector G Paez, Trevor K Johnson, Jessica L Halle, Joseph P Carzoli, Nishant P Visavadiya, Michael C Zourdos, Michael A Whitehurst, Andy V Khamoui
Aerobic training (AT) can support brain health in Alzheimer's disease (AD); however, the role of resistance training (RT) in AD is not well established. Aside from direct effects on the brain, exercise may also regulate brain function through secretion of muscle-derived myokines. Aims . This study examined the effects of AT and RT on hippocampal BDNF and IGF-1 signaling, β -amyloid expression, and myokine cathepsin B in the triple transgenic (3xTg-AD) model of AD. 3xTg-AD mice were assigned to one of the following groups: sedentary (Tg), aerobic trained (Tg+AT, 9 wks treadmill running), or resistance trained (Tg+RT, 9 wks weighted ladder climbing) ( n = 10/group)...
2020: International Journal of Chronic Diseases