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Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

Jingjing Guo, Jianzhong Fan, Lili Lin, Jiajie Zeng, Hao Liu, Chuan-Kui Wang, Zujin Zhao, Ben Zhong Tang
Organic materials with aggregation-induced delayed fluorescence (AIDF) have exhibited impressive merits for improving electroluminescence efficiency and decreasing efficiency roll-off of nondoped organic light-emitting diodes (OLEDs). However, the lack of comprehensive insights into the underlying mechanism may impede further development and application of AIDF materials. Herein, AIDF materials consisting of benzoyl serving as an electron acceptor, and phenoxazine and fluorene derivatives as electron donors are reported...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Xiyuan Mao, Ruoyu Cheng, Hongbo Zhang, Jinhong Bae, Liying Cheng, Lu Zhang, Lianfu Deng, Wenguo Cui, Yuguang Zhang, Hélder A Santos, Xiaoming Sun
The fabrication of highly biocompatible hydrogels with multiple unique healing abilities for the whole healing process, for example, multifunctional hydrogels with injectable, degradation, antibacterial, antihypoxic, and wound healing-promoting properties that match the dynamic healing process of skin flap regeneration, is currently a research challenge. Here, a multifunctional and dynamic coordinative polyethylene glycol (PEG) hydrogel with mangiferin liposomes (MF-Lip@PEG) is developed for clinical applications through Ag-S coordination of four-arm-PEG-SH and Ag+ ...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Fei-Xiang Ma, Cheng-Yan Xu, Fucong Lyu, Bo Song, Shu-Chao Sun, Yang Yang Li, Jian Lu, Liang Zhen
Developing noble-metal-free based electrocatalysts with high activity, good stability, and low cost is critical for large-scale hydrogen production via water splitting. In this work, hollow FeP nanoparticles densely encapsulated in carbon nanosheet frameworks (donated as hollow FeP/C nanosheets), in situ converted from Fe-glycolate precursor nanosheets through carbonization and subsequent phosphorization, are designed and synthesized as an advanced electrocatalyst for the hydrogen evolution reaction. FeP hollow nanoparticles are transformed from intermediate Fe3 O4 nanoparticles through the nanoscale Kirkendall effect...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Anouk R Killaars, Joseph C Grim, Cierra J Walker, Ella A Hushka, Tobin E Brown, Kristi S Anseth
Bone marrow derived human mesenchymal stem cells (hMSCs) are a promising cell source for regenerative therapies; however, ex vivo expansion is often required to achieve clinically useful cells numbers. Recent results reveal that when MSCs are cultured in stiff microenvironments, their regenerative capacity can be altered in a manner that is dependent on time (e.g., a mechanical dosing analogous to a chemical one). It is hypothesized that epigenomic modifications are involved in storing these mechanical cues, regulating gene expression, and ultimately leading to a mechanical memory...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Hongliang Li, Menglin Wang, Laihao Luo, Jie Zeng
Single-atom catalysts provide an ideal platform to bridge the gap between homogenous and heterogeneous catalysts. Here, the recent progress in this field is reported from the perspectives of static regulation and dynamic evolution. The syntheses and characterizations of single-atom catalysts are briefly discussed as a prerequisite for catalytic investigation. From the perspective of static regulation, the metal-support interaction is illustrated in how the supports alter the electronic properties of single atoms and how the single atoms activate the inert atoms in supports...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Armando Hernandez-Garcia, Zaida Álvarez, Dina Simkin, Ashwin Madhan, Eloise Pariset, Faifan Tantakitti, Oscar de J Vargas-Dorantes, Sungsoo S Lee, Evangelos Kiskinis, Samuel I Stupp
Small interfering ribonucleic acid (siRNA)-based gene knockdown is an effective tool for gene screening and therapeutics. However, the use of nonviral methods has remained an enormous challenge in neural cells. A strategy is reported to design artificial noncationic modular peptides with amplified affinity for siRNA via supramolecular assembly that shows efficient protein knockdown in neural cells. By solid phase synthesis, a sequence that binds specifically double-stranded ribonucleic acid (dsRNA) with a self-assembling peptide for particle formation is integrated...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Seo Woo Song, Su Deok Kim, Dong Yoon Oh, Yongju Lee, Amos Chungwon Lee, Yunjin Jeong, Hyung Jong Bae, Daewon Lee, Sumin Lee, Jiyun Kim, Sunghoon Kwon
Large-scale screening of sequential drug combinations, wherein the dynamic rewiring of intracellular pathways leads to promising therapeutic effects and improvements in quality of life, is essential for personalized medicine to ensure realistic cost and time requirements and less sample consumption. However, the large-scale screening requires expensive and complicated liquid handling systems for automation and therefore lowers the accessibility to clinicians or biologists, limiting the full potential of sequential drug combinations in clinical applications and academic investigations...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Seunguk Song, Se-Yang Kim, Jinsung Kwak, Yongsu Jo, Jung Hwa Kim, Jong Hwa Lee, Jae-Ung Lee, Jong Uk Kim, Hyung Duk Yun, Yeoseon Sim, Jaewon Wang, Do Hee Lee, Shi-Hyun Seok, Tae-Il Kim, Hyeonsik Cheong, Zonghoon Lee, Soon-Yong Kwon
As the elements of integrated circuits are downsized to the nanoscale, the current Cu-based interconnects are facing limitations due to increased resistivity and decreased current-carrying capacity because of scaling. Here, the bottom-up synthesis of single-crystalline WTe2 nanobelts and low- and high-field electrical characterization of nanoscale interconnect test structures in various ambient conditions are reported. Unlike exfoliated flakes obtained by the top-down approach, the bottom-up growth mode of WTe2 nanobelts allows systemic characterization of the electrical properties of WTe2 single crystals as a function of channel dimensions...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Wenchong Zou, Mingqiang Lai, Yue Zhang, Lei Zheng, Zhe Xing, Ting Li, Zhipeng Zou, Qiancheng Song, Xiaoyang Zhao, Laixin Xia, Jian Yang, Anling Liu, Han Zhang, Zhong-Kai Cui, Yu Jiang, Xiaochun Bai
Exosomes are small membrane-bound vesicles released into extracellular spaces by many types of cells. These nanovesicles carry proteins, mRNA, and miRNA, and are involved in cell waste management and intercellular communication. In the present study, it is shown that exosome release, which leads to net loss of cellular membrane and protein content, is negatively regulated by mechanistic target of rapamycin complex 1 (mTORC1). It is found that in cells and animal models exosome release is inhibited by sustained activation of mTORC1, leading to intracellular accumulation of CD63-positive exosome precursors...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
SeungBeum Suh, Ami Jo, Mahama A Traore, Ying Zhan, Sheryl L Coutermarsh-Ott, Veronica M Ringel-Scaia, Irving C Allen, Richey M Davis, Bahareh Behkam
Cancer drug delivery remains a formidable challenge due to systemic toxicity and inadequate extravascular transport of nanotherapeutics to cells distal from blood vessels. It is hypothesized that, in absence of an external driving force, the Salmonella enterica serovar Typhimurium could be exploited for autonomous targeted delivery of nanotherapeutics to currently unreachable sites. To test the hypothesis, a nanoscale bacteria-enabled autonomous drug delivery system (NanoBEADS) is developed in which the functional capabilities of the tumor-targeting S ...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Binghua Zou, Yuanyuan Chen, Yihan Liu, Ruijie Xie, Qinjie Du, Tao Zhang, Yu Shen, Bing Zheng, Sheng Li, Jiansheng Wu, Weina Zhang, Wei Huang, Xin Huang, Fengwei Huo
Electronic skin (e-skin), an important part toward the realization of artificial intelligence, has been developing through comprehending, mimicking, and eventually outperforming skin in some aspects. Most of the e-skin substrates are flexible polymers, such as polydimethylsiloxane (PDMS). Although PDMS was found to be biocompatible, it is not suitable for long-time wearing due to its air impermeability. This study reports a simple and designable leather based e-skin by merging the natural sophisticated structure and wearing comfort of leather with the multifunctional properties of nanomaterials...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Oliver Nagel, Manuel Frey, Matthias Gerhardt, Carsten Beta
Cell-driven microtransport is one of the most prominent applications in the emerging field of biohybrid systems. While bacterial cells have been successfully employed to drive the swimming motion of micrometer-sized cargo particles, the transport capacities of motile adherent cells remain largely unexplored. Here, it is demonstrated that motile amoeboid cells can act as efficient and versatile trucks to transport microcargo. When incubated together with microparticles, cells of the social amoeba Dictyostelium discoideum readily pick up and move the cargo particles...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Angel Tan, Linda Hong, Joanne D Du, Ben J Boyd
Self-assembly of lipid-based liquid crystalline (LLC) nanoparticles is a formulation art arising from the hydrophilic-lipophilic qualities and the geometric packing of amphiphilic lipid molecules in an aqueous environment. The diversity of commercialized amphiphilic lipids and an increased understanding of the physicochemical factors dictating their membrane curvature has enabled versatile architectural design and engineering of LLC nanoparticles. While these exotic nanostructured materials are hypothesized to form the next generation of smart therapeutics for a broad field of biomedical applications, biological knowledge particularly on the systemic biocompatibility or cytotoxicity of LLC materials remains unclear...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Xiao Zhang, Jiangfeng Du, Zhao Guo, Jie Yu, Qin Gao, Wenyan Yin, Shuang Zhu, Zhanjun Gu, Yuliang Zhao
Mild photothermal therapy (PTT), as a new anticancer therapeutic strategy, faces big challenges of limited therapeutic accuracy and side-effects due to uneven heat distribution. Here, near infrared triggered nitric oxide (NO) release nanocomposites based on bismuth sulfide (Bi2 S3 ) nanoparticles and bis- N -nitroso compounds (BNN) are constructed for NO-enhanced mild photothermal therapy. Upon 808 nm irradiation, the high photothermal conversion efficiency and on-demand NO release are realized simultaneously...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Seoung-Bum Son, Lei Cao, Taeho Yoon, Arthur Cresce, Simon E Hafner, Jun Liu, Markus Groner, Kang Xu, Chunmei Ban
Silicon (Si) has been well recognized as a promising candidate to replace graphite because of its earth abundance and high-capacity storage, but its large volume changes upon lithiation/delithiation and the consequential material fracturing, loss of electrical contact, and over-consumption of the electrolyte prevent its full application. As a countermeasure for rapid capacity decay, a composite electrode of graphite and Si has been adopted by accommodating Si nanoparticles in a graphite matrix. Such an approach, which involves two materials that interact electrochemically with lithium in the electrode, necessitates an analytical methodology to determine the individual electrochemical behavior of each active material...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Xiying Li, Jia Ming Zhang, Xin Yi, Zhongyi Huang, Pengyu Lv, Huiling Duan
3D printing with a high degree of spatial and compositional precision could open new avenues to the design and fabrication of functional composites. By combining the direct ink writing and microfluidics, a multimaterial 3D printing system for fabricating textured composites with liquid inclusions of programmable spatial distribution and compositions is reported here. Phase diagrams for the rational selection of desired printing parameters are determined through a combination of simple theoretical analysis and experimental studies...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Ahmed Mourtada Elseman, Walid Sharmoukh, Sajid Sajid, Peng Cui, Jun Ji, Shangyi Dou, Dong Wei, Hao Huang, Wenkang Xi, Lihua Chu, Yingfeng Li, Bing Jiang, Meicheng Li
[This corrects the article DOI: 10.1002/advs.201800568.].
January 23, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Jianwei Yu, Peng Chen, Chang Woo Koh, Hang Wang, Kun Yang, Xin Zhou, Bin Liu, Qiaogan Liao, Jianhua Chen, Huiliang Sun, Han Young Woo, Shiming Zhang, Xugang Guo
Highly efficient nonfullerene polymer solar cells (PSCs) are developed based on two new phthalimide-based polymers phthalimide-difluorobenzothiadiazole (PhI-ffBT) and fluorinated phthalimide-ffBT (ffPhI-ffBT). Compared to all high-performance polymers reported, which are exclusively based on benzo[1,2- b :4,5- b ']dithiophene (BDT), both PhI-ffBT and ffPhI-ffBT are BDT-free and feature a D-A1 -D-A2 type backbone. Incorporating a second acceptor unit difluorobenzothiadiazole leads to polymers with low-lying highest occupied molecular orbital levels (≈-5...
January 23, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Long Zhang, Lianwei Wu, Kai Wang, Bo Zou
2D Ruddlesden-Popper halide perovskites, which incorporate hydrophobic organic interlayers to considerably improve environmental stability and optical properties diversity, have attracted substantial research attention for optoelectronic applications. The burgeoning broad emission arising from exciton self-trapping of 2D perovskites shows a strong dependence on a deformable structure. Here, the pressure-induced broadband emission of layered (001) Pb-Br perovskite with a large Stokes shift in the visible region is observed by finely improving lattice distortion to increase exciton-phonon coupling under hydrostatic pressure...
January 23, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Xiao-Ting Xu, Lun Pan, Xiangwen Zhang, Li Wang, Ji-Jun Zou
Photo-electrochemical (PEC) water splitting, as an essential and indispensable research branch of solar energy applications, has achieved increasing attention in the past decades. Between the two photoelectrodes, the photoanodes for PEC water oxidation are mostly studied for the facile selection of n-type semiconductors. Initially, the efficiency of the PEC process is rather limited, which mainly results from the existing drawbacks of photoanodes such as instability and serious charge-carrier recombination...
January 23, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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