journal
MENU ▼
Read by QxMD icon Read
search

Journal of Clinical and Translational Hepatology

journal
https://read.qxmd.com/read/30637226/2018-reviewer-acknowledgement
#1
(no author information available yet)
No abstract text is available yet for this article.
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637225/ca-125-significance-in-cirrhosis-and-correlation-with-disease-severity-and-portal-hypertension
#2
Julio Collazos
No abstract text is available yet for this article.
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637224/successful-resection-in-a-case-of-hepatocellular-carcinoma-masquerading-as-hilar-cholangiocarcinoma-a-case-report
#3
Prakriti Gupta, Shashi Dhawan, Vivek Mangla, Siddharth Mehrotra, Shailendra Lalwani, Naimish N Mehta, Samiran Nundy
Obstructive jaundice in the setting of a hilar mass raises strong suspicion of a cholangiocarcinoma, with diagnosis usually made on imaging. Jaundice, when present in patients with hepatocellular carcinoma, is mostly related to underlying liver disease (i.e. cirrhosis) and only rarely to diffuse tumor infiltration of liver parenchyma or hilar invasion. We report here the good outcome of a 67 year-old patient who presented with obstructive jaundice, underwent surgery and was given a diagnosis of hepatocellular carcinoma, which was made only at histopathological examination of resected specimen...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637223/healthy-donor-fecal-microbiota-transplantation-for-recurrent-bacterial-cholangitis-in-primary-sclerosing-cholangitis-a-single-case-report
#4
Cyriac Abby Philips, Philip Augustine, Nikhil Phadke
Recurrent acute bacterial cholangitis is a unique indication for liver transplantation in primary sclerosing cholangitis. We present the first report on utility of healthy donor fecal transplantation for management of recurrent acute bacterial cholangitis in a primary sclerosing cholangitis patient. We demonstrate the striking liver biochemistry, bile acid and bacterial community changes following intestinal microbiota transplantation associated with amelioration of recurrent cholangitis.
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637222/use-of-ribavirin-for-hepatitis-c-treatment-in-the-modern-direct-acting-antiviral-era
#5
REVIEW
Poonam Mathur, Shyamasundaran Kottilil, Eleanor Wilson
Ribavirin, once a staple of hepatitis C treatment, has significant drawbacks, including treatment-limiting side effects, the requirement for intensive laboratory monitoring, the need for frequent dose adjustments, and teratogenicity. These factors make it difficult to escalate ribavirin-based HCV treatment to most infected patients globally. Most studies have shown comparable response rates between ribavirin-inclusive and ribavirin-sparing regimens in uncomplicated patient populations. However, ribavirin is still used in the management of patients who have failed previous therapy as well as those with decompensated liver disease...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637221/therapeutic-roles-of-bile-acid-signaling-in-chronic-liver-diseases
#6
REVIEW
Yan Li, Lun-Gen Lu
Bile acids (BAs) are the major metabolic product of cholesterol, having detergent-like activities and being responsible for absorption of lipid and lipid-soluble vitamins. In addition, it has been increasingly recognized that BAs are important signaling molecules, regulating energy metabolism and immunity. Under physiological circumstances, synthesis and transport of BAs are precisely regulated to maintain bile acid homeostasis. Disruption of bile acid homeostasis results in pathological cholestasis and metabolic liver diseases...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637220/nonalcoholic-fatty-liver-disease-epidemiology-liver-transplantation-trends-and-outcomes-and-risk-of-recurrent-disease-in-the-graft
#7
REVIEW
Andy Liu, Artin Galoosian, Dharmesh Kaswala, Andrew A Li, Chiranjeevi Gadiparthi, George Cholankeril, Donghee Kim, Aijaz Ahmed
In parallel with the rising prevalence of metabolic syndrome globally, nonalcoholic fatty liver (NAFL) disease is the most common chronic liver disease in Western countries and nonalcoholic steatohepatitis (NASH) has become increasingly associated with hepatocellular carcinoma. Recent studies have identified NASH as the most rapidly growing indication for liver transplantation (LT). As a hepatic manifestation of the metabolic syndrome, NAFL disease can be histologically divided into NAFL and NASH. NAFL is considered a benign condition, with histological changes of hepatocyte steatosis but without evidence of hepatocellular injury or fibrosis...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637219/evidence-for-viral-induction-of-biliary-atresia-a-review
#8
REVIEW
Leon D Averbukh, George Y Wu
Biliary atresia (BA) is a childhood disease which manifests with abnormal narrowing, blockage or complete absence of bile ducts within the liver. Many possible etiologies have been reported for the development of BA, including congenital, perinatal and acquired conditions. Since the 1970's, there has been increasing evidence linking BA development to viral perinatal infections. The viral vectors most commonly implicated include members of the herpesviridae family (cytomegalovirus and Epstein-Barr virus) as well as those of the reoviridae family (reovirus and rotavirus)...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637218/role-of-biologics-in-the-development-of-autoimmune-hepatitis-a-review
#9
REVIEW
Leon D Averbukh, George Y Wu
Autoimmune hepatitis (AIH) is a cause of chronic, immune-mediated liver injury which without treatment may progress to end-stage liver disease. The disease state, characterized by elevations in liver enzymes, autoantibodies, and interface hepatitis on histology, has been noted to be induced by a wide range of insults. Medications, most commonly minocycline and nitrofurantoin, have long been established as potential inducers of AIH. Recently, biologics, powerful immune-modulators, have also been reported to induce AIH...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637217/acute-kidney-injury-at-admission-is-a-better-predictor-of-mortality-than-its-persistence-at-48-h-in-patients-with-acute-on-chronic-liver-failure
#10
Chitta Ranjan Khatua, Subhendu Panigrahi, Debakanta Mishra, Subhasis Pradhan, Saroj Kanta Sahu, Rakesh Kumar Barik, Prasanta Kumar Parida, Sambit Behera, Suryakanta Parida, Shivaram Prasad Singh
Background and Aims: Acute kidney injury (AKI) occurs commonly in patients with acute-on-chronic liver failure (ACLF). However, there are scant data regarding the impact of AKI on survival in ACLF. We performed a prospective study to evaluate the impact of AKI on survival in ACLF. Methods: This study was conducted in ACLF patients hospitalized in the Gastroenterology Department of Sriram Chandra Bhanja Medical College (India) between October 2016 and February 2018. Demographic, clinical and laboratory parameters were recorded, and outcomes were compared between patients with and without AKI and between patients with persistent AKI and AKI reversal at 48 h...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637216/effect-of-hepatitis-c-treatment-on-renal-function-in-liver-transplant-patients
#11
Mohamed Shoreibah, John Romano, Omar T Sims, Yuqi Guo, DeAnn Jones, Krishna Venkata, Vishnu Kommineni, Jordan Orr, Paul Fitzmorris, Omar I Massoud
Background and Aims: Hepatitis C Virus (HCV) is uniformly recurrent after liver transplant (LT) and recurrence is associated with an increased risk of mortality. Immunosuppressive medications increase the risk of chronic kidney disease, and the presence of chronic kidney disease presents a challenge for HCV treatment in LT recipients. The aim of this study was to assess changes in glomerular filtration rates (GFRs) of LT recipients receiving HCV treatment. Methods: This is a retrospective study of LT patients who received HCV treatment between 2015 and 2016 ( n = 60)...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637215/large-disparity-between-prevalence-and-treatment-rates-for-hepatitis-c-in-western-china
#12
Zhi-Wei Chen, Zhao Li, Qiao-He Wang, Xiao-Ling Wu, Hu Li, Hong Ren, Peng Hu
Background and Aims: Recently, the World Health Organization adopted the first-ever global hepatitis strategy with the dream of eliminating viral hepatitis as a public health threat by 2030. However, the epidemiology and treatment rates of hepatitis C virus (HCV) infection in Western China are still unknown. Methods: A total of 111,916 adult individuals (15-96 years) who underwent the HCV-antibody (HCV-Ab) test in the Second Affiliated Hospital of Chongqing Medical University between 2013 and 2015 were included in this study...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637214/integration-of-prealbumin-into-child-pugh-classification-improves-prognosis-predicting-accuracy-in-hcc-patients-considering-curative-surgery
#13
Xiajie Wen, Mingjie Yao, Yiwei Lu, Junhui Chen, Jiyuan Zhou, Xiangmei Chen, Yun Zhang, Weiquan Lu, Xiangjun Qian, Jingmin Zhao, Ling Zhang, Shigang Ding, Fengmin Lu
Background and Aims: The poor outcomes of hepatocellular carcinoma (HCC) patients may be due to not only malignant tumors but also limited liver function. Therefore, as stated in major guidelines, only patients with relatively normal liver function (Child-Pugh A) would be referred for curative hepatectomy. Even so, the postsurgery survival rate of patients is still extremely poor. Direct curative resection may benefit most patients. This study aimed to improve the prognosis predicting accuracy of the Child-Pugh scoring system...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637213/predictors-of-spontaneous-bacterial-peritonitis-in-patients-with-cirrhotic-ascites
#14
Khaled Metwally, Tamer Fouad, Medhat Assem, Eman Abdelsameea, Mohamed Yousery
Background and Aims: Spontaneous bacterial peritonitis (SBP) is a serious complication of liver cirrhosis and a prognostic model to predict it is needed. This study was designed to test the ability of different laboratory tests and the new scoring system by Wehmeyer and colleagues (consisting of age, C-reactive protein (CRP) and platelet count) to predict it. Methods: Three-hundred patients admitted to the National Liver Institute, University of Menoufia, Egypt (2015-2016) with liver cirrhosis and ascites were included in our study...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637212/superior-performance-of-teaching-and-transplant-hospitals-in-the-management-of-hepatic-encephalopathy-from-2007-to-2014
#15
Daniel Bodek, Pavan Patel, Sushil Ahlawat, Evan Orosz, Thayer Nasereddin, Nikolaos Pyrsopoulos
Background and Aims: Hepatic encephalopathy is a liver disease complication with significant mortality and costs. The aim of this study was to evaluate the relative performance of facilities based on their teaching status and transplant capability by correlating their connections to mortality, cost, and length of stay from 2007 to 2014. Methods: The Nationwide Inpatient Sample database was utilized to collect information on (USA) American patients admitted with a primary diagnosis of hepatic encephalopathy from 2007-2014...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637211/aliphatic-halogenated-hydrocarbons-report-and-analysis-of-liver-injury-in-60-patients
#16
Rolf Teschke
Background and Aims: Intoxications by aliphatic halogenated hydrocarbons (AHH), used as effective solvents, are rare and may cause life-threatening liver injury. Patients with acute intoxications by AHH received an innovative treatment. Methods: Analyzed were data of 60 patients intoxicated by AHH, such as dichloromethane ( n = 3), chloroform ( n = 2), carbon tetrachloride ( n = 12), 1,2-dichloroethane ( n = 18), 1,1,2-trichloroethane ( n = 2), trichloroethylene ( n = 2), tetrachloroethylene ( n = 13) or mixed AHH chemicals ( n = 8), who received a new treatment consisting of CO2 -induced hyperventilation to accelerate toxin removal via the lungs...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30637210/alpha-1-anti-trypsin-exerts-a-hepatoprotective-effect-on-immune-mediated-hepatitis-and-acetaminophen-induced-liver-injury
#17
Yehudit Shabat, Ami Ben Ya'acov, Yaron Ilan
Background and Aims: The serine proteinase inhibitor alpha-1 anti-trypsin (AAT) protects the body against protease activity. Several functions of AAT beyond those attributed to its anti-protease activity have been described, among them immunomodulatory and anti-inflammatory properties. The present study aimed to determine the efficacy of AAT for the treatment of immune-mediated liver injury using the models of concanavalin A-induced immune-mediated hepatitis and acetaminophen -induced liver damage. Methods: AAT was administered to mice subjected to concanavalin A-induced immune-mediated hepatitis or 2 h after acetaminophen-induced liver damage...
December 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30271748/incidental-collision-tumor-of-hepatocellular-carcinoma-and-neuroendocrine-carcinoma
#18
Düriye Betül Yılmaz, Zeynep Bayramoğlu, Gülşah Ünay, Erdem Ayık, Cumhur İbrahim Başsorgun, Gülsüm Özlem Elpek
The composite tumors of the liver are very rare, including the coexistence of HCC (hepatocellular carcinoma) with NEC (neuroendocrine carcinoma). The rare occurrence of these tumors necessitates more reported cases in order to fully understand their clinical characteristics, behaviors and treatments. Herein is described an incidental collision tumor of HCC-NEC, along with a review of the literature focusing on their clinicopathological findings and prognosis. The tumor presented here was found incidentally in the hepatectomy specimen of a 56-year-old man who had undergone liver transplantation for rapidly progressive liver failure because of alcoholic hepatitis and cirrhosis...
September 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30271747/role-of-srebps-in-liver-diseases-a-mini-review
#19
REVIEW
Azam Moslehi, Zeinab Hamidi-Zad
Sterol regulator element binding proteins (SREBPs) are a family of transcription factors involved in the biogenesis of cholesterol, fatty acids and triglycerides. They also regulate physiological functions of many organs, such as thyroid, brain, heart, pancreas and hormone synthesis. Beside the physiological effects, SREBPs participate in some pathological processes, diabetes, endoplasmic reticulum stress, atherosclerosis and chronic kidney disease associated with SREBP expression changes. In the liver, SREBPs are involved in the pathogenesis of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, hepatitis and hepatic cancer...
September 28, 2018: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/30271746/the-genetics-of-clinical-liver-diseases-insight-into-the-tm6sf2-e167k-variant
#20
REVIEW
Xiaoyu Zhang, Shousheng Liu, Quanjiang Dong, Yongning Xin, Shiying Xuan
The transmembrane 6 superfamily member 2 ( TM6SF2 ) gene E167K variant (rs58542926) was identified by exome-wide association study as a nonsynonymous single nucleotide polymorphism associated with nonalcoholic fatty liver disease. The TM6SF2 E167K variant features a C-to-T substitution at nucleotide 499, encoding a glutamate with lysine change at codon 167 (E167K). TM6SF2 is markedly expressed in the liver, small intestine and kidney, and has been proposed as an important risk factor for diseases associated with lipid metabolism...
September 28, 2018: Journal of Clinical and Translational Hepatology
journal
journal
52266
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"