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Journal of Clinical and Translational Hepatology

https://read.qxmd.com/read/38993515/association-of-omega-3-polyunsaturated-fatty-acids-with-sarcopenia-in-liver-cirrhosis-patients-with-hepatocellular-carcinoma
#1
JOURNAL ARTICLE
Akitoshi Sano, Jun Inoue, Eiji Kakazu, Masashi Ninomiya, Mio Tsuruoka, Kosuke Sato, Masazumi Onuki, Satoko Sawahashi, Keishi Ouchi, Atsushi Masamune
BACKGROUND AND AIMS: Sarcopenia is associated with the prognosis of patients with liver cirrhosis and hepatocellular carcinoma (HCC). Given their diverse physiological activities, we hypothesized that plasma fatty acids might influence the progression of sarcopenia. This study aimed to clarify the association between fatty acids and sarcopenia in cirrhotic patients with HCC. METHODS: In this single-center retrospective study, we registered 516 cases and analyzed 414 cases of liver cirrhosis and HCC...
July 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38993514/alcoholic-liver-disease-in-china-a-disease-influenced-by-complex-social-factors-that-should-not-be-neglected
#2
REVIEW
Xiaofeng Feng, Nafei Huang, Yuqin Wu, Fei Gao, Xiaomei Chen, Chenyi Zhang, Bing Zhang, Tao Sun
Alcoholic liver disease (ALD) encompasses liver damage caused by chronic, excessive alcohol consumption. It manifests initially as marked hepatocellular steatosis and can progress to steatohepatitis, liver fibrosis, and cirrhosis. With China's rapid economic growth, coupled with a complex social background and the influence of a deleterious wine culture, the number of patients with ALD in China has increased significantly; the disease has become a social and health problem that cannot be ignored. In this review, we briefly described the social factors affecting ALD in China and elaborated on differences between alcoholic and other liver diseases in terms of complications (e...
July 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38993513/timp-1-promotes-expression-of-mcp-1-and-macrophage-migration-by-inducing-fli-1-in-experimental-liver-fibrosis
#3
JOURNAL ARTICLE
Xiaoli Huang, Xiaofan Wang, Yanhong Wang, Shuangjun Shen, Wei Chen, Tianhui Liu, Ping Wang, Xu Fan, Lin Liu, Jidong Jia, Min Cong
BACKGROUND AND AIMS: Tissue inhibitor of metalloproteinase-1 (TIMP-1) plays a role in the excessive generation of extracellular matrix in liver fibrosis. This study aimed to explore the pathways through which TIMP-1 controls monocyte chemoattractant protein-1 (MCP-1) expression and promotes hepatic macrophage recruitment. METHODS: Liver fibrosis was triggered through carbon tetrachloride, and an adeno-associated virus containing small interfering RNA targeting TIMP-1 (siRNA-TIMP-1) was administered to both rats and mice...
July 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38993512/bacterial-infections-in-acute-on-chronic-liver-failure-epidemiology-diagnosis-pathogenesis-and-management
#4
REVIEW
Zhaoyu Xu, Xiuding Zhang, Jiyang Chen, Yu Shi, Shangwei Ji
Acute-on-chronic liver failure (ACLF) is a distinct condition characterized by the abrupt exacerbation of pre-existing chronic liver disease, often leading to multi-organ failures and significant short-term mortalities. Bacterial infection is one of the most frequent triggers for ACLF and a common complication following its onset. The impact of bacterial infections on the clinical course and outcome of ACLF underscores their critical role in the pathogenesis of systemic inflammation and organ failures. In addition, the evolving epidemiology and increasing prevalence of multidrug-resistant bacteria in cirrhosis and ACLF highlight the importance of appropriate empirical antibiotic use, as well as accurate and prompt microbiological diagnosis...
July 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38993511/hydrogen-sulfide-promotes-platelet-autophagy-via-pdgfr-%C3%AE-pi3k-akt-signaling-in-cirrhotic-thrombocytopenia
#5
JOURNAL ARTICLE
Hua-Xiang Yang, Yang-Jie Li, Yang-Lan He, Ke-Ke Jin, Ling-Na Lyu, Hui-Guo Ding
BACKGROUND AND AIMS: The role of platelet autophagy in cirrhotic thrombocytopenia (CTP) remains unclear. This study aimed to investigate the impact of platelet autophagy in CTP and elucidate the regulatory mechanism of hydrogen sulfide (H2 S) on platelet autophagy. METHODS: Platelets from 56 cirrhotic patients and 56 healthy individuals were isolated for in vitro analyses. Autophagy markers (ATG7, BECN1, LC3, and SQSTM1) were quantified using enzyme-linked immunosorbent assay, while autophagosomes were visualized through electron microscopy...
July 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38993510/real-world-effectiveness-and-tolerability-of-interferon-free-direct-acting-antiviral-for-15-849-patients-with-chronic-hepatitis-c-a-multinational-cohort-study
#6
JOURNAL ARTICLE
Fanpu Ji, Sally Tran, Eiichi Ogawa, Chung-Feng Huang, Takanori Suzuki, Yu Jun Wong, Hidenori Toyoda, Dae Won Jun, Liu Li, Haruki Uojima, Akito Nozaki, Makoto Chuma, Cheng-Hao Tseng, Yao-Chun Hsu, Masatoshi Ishigami, Takashi Honda, Masanori Atsukawa, Hiroaki Haga, Masaru Enomoto, Huy Trinh, Carmen Monica Preda, Phillip Vutien, Charles Landis, Dong Hyun Lee, Tsunamasa Watanabe, Hirokazu Takahashi, Hiroshi Abe, Akira Asai, Yuichiro Eguchi, Jie Li, Xiaozhong Wang, Jia Li, Junping Liu, Jing Liang, Carla Pui-Mei Lam, Rui Huang, Qing Ye, Hongying Pan, Jiajie Zhang, Dachuan Cai, Qi Wang, Daniel Q Huang, Grace Wong, Vincent Wai-Sun Wong, Junyi Li, Son Do, Norihiro Furusyo, Makoto Nakamuta, Hideyuki Nomura, Eiji Kajiwara, Eileen L Yoon, Sang Bong Ahn, Koichi Azuma, Kazufumi Dohmen, Jihyun An, Do Seon Song, Hyun Chin Cho, Akira Kawano, Toshimasa Koyanagi, Aritsune Ooho, Takeaki Satoh, Kazuhiro Takahashi, Ming-Lun Yeh, Pei-Chien Tsai, Satoshi Yasuda, Yunyu Zhao, Yishan Liu, Tomomi Okubo, Norio Itokawa, Mi Jung Jun, Toru Ishikawa, Koichi Takaguchi, Tomonori Senoh, Mingyuan Zhang, Changqing Zhao, Raluca Ioana Alecu, Wei Xuan Tay, Pooja Devan, Joanne Kimiko Liu, Ritsuzo Kozuka, Elena Vargas-Accarino, Ai-Thien Do, Mayumi Maeda, Wan-Long Chuang, Jee-Fu Huang, Chia-Yen Dai, Ramsey Cheung, Maria Buti, Junqi Niu, Wen Xie, Hong Ren, Seng Gee Lim, Chao Wu, Man-Fung Yuen, Jia Shang, Qiang Zhu, Yoshiyuki Ueno, Yasuhito Tanaka, Jun Hayashi, Ming-Lung Yu, Mindie H Nguyen
BACKGROUND AND AIMS: As practice patterns and hepatitis C virus (HCV) genotypes (GT) vary geographically, a global real-world study from both East and West covering all GTs can help inform practice policy toward the 2030 HCV elimination goal. This study aimed to assess the effectiveness and tolerability of DAA treatment in routine clinical practice in a multinational cohort for patients infected with all HCV GTs, focusing on GT3 and GT6. METHODS: We analyzed the sustained virological response (SVR12) of 15,849 chronic hepatitis C patients from 39 Real-World Evidence from the Asia Liver Consortium for HCV clinical sites in Asia Pacific, North America, and Europe between 07/01/2014-07/01/2021...
July 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38993509/-plcg2-mutation-in-a-patient-presenting-with-type-2-autoimmune-hepatitis
#7
JOURNAL ARTICLE
Antoine Gardin, Léa Gaigne, Aude Magérus, Frédéric Rieux-Laucat, Emmanuel Jacquemin
No abstract text is available yet for this article.
July 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38993508/exploring-the-pathogenesis-of-autoimmune-liver-diseases-from-the-heterogeneity-of-target-cells
#8
REVIEW
Zi-Xuan Qiu, Lin-Xiang Huang, Xiao-Xiao Wang, Zi-Long Wang, Xiao-He Li, Bo Feng
The incidence of autoimmune liver diseases (ALDs) and research on their pathogenesis are increasing annually. However, except for autoimmune hepatitis, which responds well to immunosuppression, primary biliary cholangitis and primary sclerosing cholangitis are insensitive to immunosuppressive therapy. Besides the known effects of the environment, genetics, and immunity on ALDs, the heterogeneity of target cells provides new insights into their pathogenesis. This review started by exploring the heterogeneity in the development, structures, and functions of hepatocytes and epithelial cells of the small and large bile ducts...
July 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38974960/bao-gan-xiao-zhi-wan-treatment-attenuates-methionine-choline-deficient-diet-induced-metabolic-dysfunction-associated-steatohepatitis-in-rats-by-modulating-the-nf-%C3%AE%C2%BAb-signal-pathway-and-autophagy
#9
JOURNAL ARTICLE
Liming Zhou, Xiaobin Zeng, Xiaofang Wei, Wanying Shen, Jie Yao, Weigang Wu, Lanlan Ge, Boping Zhou
No abstract text is available yet for this article.
June 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38974959/a-blood-hepatocellular-carcinoma-signature-recognizes-very-small-tumor-nodules-with-metastatic-traits
#10
JOURNAL ARTICLE
Kun Chen, Junxiao Wang, Liping Jiang, Fei Zhao, Ruochan Zhang, Zhiyuan Wu, Dongmei Wang, Yuchen Jiao, Hui Xie, Chunfeng Qu
BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) cases with small nodules are commonly treated with radiofrequency ablation (RFA), but the recurrence rate remains high. This study aimed to establish a blood signature for identifying HCC with metastatic traits pre-RFA. METHODS: Data from HCC patients treated between 2010 and 2017 were retrospectively collected. A blood signature for metastatic HCC was established based on blood levels of alpha-fetoprotein and des-γ-carboxy-prothrombin, cell-free DNA (cfDNA) mutations, and methylation changes in target genes in frozen-stored plasma samples that were collected before RFA performance...
June 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38974958/progress-in-the-management-of-patients-with-cholestatic-liver-disease-where-are-we-and-where-are-we-going
#11
REVIEW
Xin Luo, Lun-Gen Lu
Cholestatic liver disease is a group of diseases in which bile acid accumulates in the liver for various reasons, resulting in abnormal liver biochemical indicators and histological damage. Cholestasis can be divided into intrahepatic cholestasis and extrahepatic cholestasis, which will contribute to liver damage and progress to liver fibrosis and cirrhosis. Primary biliary cholangitis (PBC) and primary sclerosing cholangitis are the two most typical cholestatic liver diseases. Ursodeoxycholic acid is currently the first-line treatment for PBC, while obeticholic acid, budesonide and fibrates have also shown good potential in the treatment of PBC...
June 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38974957/-treat-all-strategy-for-patients-with-chronic-hepatitis-b-virus-infection-in-china-are-we-there-yet
#12
REVIEW
Mengyang Zhang, Yuanyuan Kong, Xiaoqian Xu, Yameng Sun, Jidong Jia, Hong You
Chronic hepatitis B remains the primary cause of liver-related events in China. The World Health Organization set a goal to eliminate viral hepatitis as a public health threat by 2030. However, achieving this goal appears challenging due to the current low rates of diagnosis and treatment. The "Treat-all" strategy, which proposes treating all patients with detectable hepatitis B virus (HBV) DNA or even all patients with positive HBsAg, has been suggested to simplify anti-HBV treatment. In 2022, the Chinese Society of Hepatology and the Chinese Society of Infectious Diseases updated the guidelines for the prevention and treatment of chronic hepatitis B in China, expanding antiviral indications and simplifying the treatment algorithm...
June 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38974956/association-of-mosaic-chromosomal-alterations-and-genetic-factors-with-the-risk-of-cirrhosis
#13
JOURNAL ARTICLE
Xinyuan Ge, Lu Zhang, Maojie Liu, Xiao Wang, Xin Xu, Yuqian Yan, Chan Tian, Juan Yang, Yang Ding, Chengxiao Yu, Jing Lu, Longfeng Jiang, Qiang Wang, Qun Zhang, Ci Song
BACKGROUND AND AIMS: Age-related mosaic chromosomal alterations (mCAs) detected from genotyping of blood-derived DNA are structural somatic variants that indicate clonal hematopoiesis. This study aimed to investigate whether mCAs contribute to the risk of cirrhosis and modify the effect of a polygenic risk score (PRS) on cirrhosis risk prediction. METHODS: mCA call sets of individuals with European ancestry were obtained from the UK Biobank. The PRS was constructed based on 12 susceptible single-nucleotide polymorphisms for cirrhosis...
June 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38974955/mesenchymal-stem-cells-alleviate-acute-liver-failure-through-regulating-hepatocyte-apoptosis-and-macrophage-polarization
#14
JOURNAL ARTICLE
Yachao Tao, Yonghong Wang, Menglan Wang, Hong Tang, Enqiang Chen
BACKGROUND AND AIMS: Acute liver failure (ALF) is a life-threatening clinical problem with limited treatment options. Administration of human umbilical cord mesenchymal stem cells (hUC-MSCs) may be a promising approach for ALF. This study aimed to explore the role of hUC-MSCs in the treatment of ALF and the underlying mechanisms. METHODS: A mouse model of ALF was induced by lipopolysaccharide and d-galactosamine administration. The therapeutic effects of hUC-MSCs were evaluated by assessing serum enzyme activity, histological appearance, and cell apoptosis in liver tissues...
June 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38974954/mitochondrial-grim19-loss-induces-liver-fibrosis-through-nlrp3-il33-activation-via-reactive-oxygen-species-nf-%C3%B0%C2%BAb-signaling
#15
JOURNAL ARTICLE
Xiaohui Xu, Jinmei Feng, Xin Wang, Xin Zeng, Ying Luo, Xinyu He, Meihua Yang, Tiewei Lv, Zijuan Feng, Liming Bao, Li Zhao, Daochao Huang, Yi Huang
BACKGROUND AND AIMS: Hepatic fibrosis (HF) is a critical step in the progression of hepatocellular carcinoma (HCC). Gene associated with retinoid-IFN-induced mortality 19 (GRIM19), an essential component of mitochondrial respiratory chain complex I, is frequently attenuated in various human cancers, including HCC. Here, we aimed to investigate the potential relationship and underlying mechanism between GRIM19 loss and HF pathogenesis. METHODS: GRIM19 expression was evaluated in normal liver tissues, hepatitis, hepatic cirrhosis, and HCC using human liver disease spectrum tissue microarrays...
June 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38974953/etiologies-of-splenic-venous-hypertension-a-review
#16
REVIEW
Jasmine Tidwell, Bianca Thakkar, George Y Wu
Splenic venous hypertension or left-sided portal hypertension is a rare condition caused by an obstruction of the splenic vein. Usually, it presents with upper gastrointestinal bleeding in the absence of liver disease. Etiologies can be classified based on the mechanism of development of splenic vein hypertension: compression, stenosis, inflammation, thrombosis, and surgically decreased splenic venous flow. Diagnosis is established by various imaging modalities and should be suspected in patients with gastric varices in the absence of esophageal varices, splenomegaly, or cirrhosis...
June 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38779522/the-therapeutic-effects-of-baicalein-on-the-hepatopulmonary-syndrome-in-the-rat-model-of-chronic-common-bile-duct-ligation
#17
JOURNAL ARTICLE
Ziyang Zeng, Yuhao Lei, Chunyong Yang, Xianfeng Wu, Liang Zhang, Zhiyong Yang, Lin Chen, Xiaobo Wang, Karine Belguise, Yujie Li, Bin Yi
BACKGROUND AND AIMS: Hepatopulmonary syndrome (HPS) is characterized by arterial oxygenation defects due to pulmonary vascular dilation in liver disease. To date, liver transplantation remains the only effective treatment for HPS. This study aimed to explore the preventative role of baicalein in HPS development. METHODS: Sixty male rats were randomly assigned to three groups: sham, common bile duct ligation (CBDL), and baicalein, receiving intraperitoneal injections of baicalein (40 mg·kg-1 ·d-1 , diluted in saline) for 21 days...
May 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38779521/-astragalus-polysaccharide-enhances-voriconazole-metabolism-under-inflammatory-conditions-through-the-gut-microbiota
#18
JOURNAL ARTICLE
Xiaokang Wang, Xianjing Hu, Chunxiao Ye, Jingqian Zhao, Shing Cheng Tan, Liangbin Zhou, Chenyu Zhao, Kit Hang Wu, Xixiao Yang, Jinbin Wei, Maoxun Yang
BACKGROUND AND AIMS: Voriconazole (VRC), a widely used antifungal drug, often causes hepatotoxicity, which presents a significant clinical challenge. Previous studies demonstrated that Astragalus polysaccharide (APS) can regulate VRC metabolism, thereby potentially mitigating its hepatotoxic effects. In this study, we aimed to explore the mechanism by which APS regulates VRC metabolism. METHODS: First, we assessed the association of abnormal VRC metabolism with hepatotoxicity using the Roussel Uclaf Causality Assessment Method scale...
May 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38779520/transjugular-intrahepatic-portosystemic-shunt-linked-to-increased-risk-of-hepatocellular-carcinoma-a-va-matched-cohort-study
#19
JOURNAL ARTICLE
Shalini Bansal, Tamar Taddei, Rebecca Wells, Marina Serper, Theresa Bittermann, Nadim Mahmud, David E Kaplan
No abstract text is available yet for this article.
May 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38779519/adjuvant-therapy-for-hepatocellular-carcinoma-after-curative-treatment-several-unanswered-questions
#20
REVIEW
Le Li, Zhen-Zhen Li, Li-Xin Pan, Jia-Yong Su, Shan Huang, Liang Ma, Jian-Hong Zhong
Most patients with hepatocellular carcinoma (HCC) have a poor prognosis. Hepatectomy and local ablation are the main curative treatments for HCC. Nevertheless, the recurrence rate after hepatectomy or ablation is up to 70%, which seriously affects patient prognosis. Several adjuvant therapies have been explored to reduce postoperative recurrence. However, although a variety of adjuvant therapies have been shown to reduce the recurrence rate and improve overall survival, a standard consensus of national HCC guidelines for adjuvant treatment is lacking...
May 28, 2024: Journal of Clinical and Translational Hepatology
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