journal
https://read.qxmd.com/read/38525737/circulating-mirnas-as-novel-clinical-biomarkers-in-temporal-lobe-epilepsy
#1
REVIEW
Lorenza Guarnieri, Nicola Amodio, Francesca Bosco, Sara Carpi, Martina Tallarico, Luca Gallelli, Vincenzo Rania, Rita Citraro, Antonio Leo, Giovambattista De Sarro
Temporal lobe epilepsy (TLE) represents the most common form of refractory focal epilepsy. The identification of innovative clinical biomarkers capable of categorizing patients with TLE, allowing for improved treatment and outcomes, still represents an unmet need. Circulating microRNAs (c-miRNAs) are short non-coding RNAs detectable in body fluids, which play crucial roles in the regulation of gene expression. Their characteristics, including extracellular stability, detectability through non-invasive methods, and responsiveness to pathological changes and/or therapeutic interventions, make them promising candidate biomarkers in various disease settings...
March 17, 2024: Non-Coding RNA
https://read.qxmd.com/read/38525736/targeting-micrornas-with-small-molecules
#2
REVIEW
Kisanet Tadesse, Raphael I Benhamou
MicroRNAs (miRs) have been implicated in numerous diseases, presenting an attractive target for the development of novel therapeutics. The various regulatory roles of miRs in cellular processes underscore the need for precise strategies. Recent advances in RNA research offer hope by enabling the identification of small molecules capable of selectively targeting specific disease-associated miRs. This understanding paves the way for developing small molecules that can modulate the activity of disease-associated miRs...
March 14, 2024: Non-Coding RNA
https://read.qxmd.com/read/38525735/mir-125-in-breast-cancer-etiopathogenesis-an-emerging-role-as-a-biomarker-in-differential-diagnosis-regenerative-medicine-and-the-challenges-of-personalized-medicine
#3
REVIEW
Roberto Piergentili, Enrico Marinelli, Gaspare Cucinella, Alessandra Lopez, Gabriele Napoletano, Giuseppe Gullo, Simona Zaami
Breast Cancer (BC) is one of the most common cancer types worldwide, and it is characterized by a complex etiopathogenesis, resulting in an equally complex classification of subtypes. MicroRNA (miRNA or miR) are small non-coding RNA molecules that have an essential role in gene expression and are significantly linked to tumor development and angiogenesis in different types of cancer. Recently, complex interactions among coding and non-coding RNA have been elucidated, further shedding light on the complexity of the roles these molecules fulfill in cancer formation...
February 21, 2024: Non-Coding RNA
https://read.qxmd.com/read/38392970/topographic-distribution-of-mirnas-mir-30a-mir-223-mir-let-7a-mir-let-7f-mir-451-and-mir-486-in-the-plasma-extracellular-vesicles
#4
JOURNAL ARTICLE
Tatiana Petrova, Olga Kalinina, Arthur Aquino, Evgeniy Grigoryev, Natallia V Dubashynskaya, Kseniya Zubkova, Anna Kostareva, Alexey Golovkin
There are many articles on the quantitative analysis of miRNAs contained in a population of EVs of different sizes under various physiological and pathological conditions. For such analysis, it is important to correctly quantify the miRNA contents of EVs. It should be considered that quantification is skewed depending on the isolation protocol, and different miRNAs are degraded by nucleases with different efficiencies. In addition, it is important to consider the contribution of miRNAs coprecipitating with the EVs population, because the amount of miRNAs in the EVs population under study is skewed without appropriate enzymatic treatment...
February 15, 2024: Non-Coding RNA
https://read.qxmd.com/read/38392969/microrna-204-regulates-angiogenesis-and-vasculogenic-mimicry-in-cd44-cd24-breast-cancer-stem-like-cells
#5
JOURNAL ARTICLE
Martha Resendiz-Hernández, Alejandra P García-Hernández, Macrina B Silva-Cázares, Rogelio Coronado-Uribe, Olga N Hernández-de la Cruz, Lourdes A Arriaga-Pizano, Jessica L Prieto-Chávez, Yarely M Salinas-Vera, Eloisa Ibarra-Sierra, Concepción Ortiz-Martínez, César López-Camarillo
Tumors have high requirements in terms of nutrients and oxygen. Angiogenesis is the classical mechanism for vessel formation. Tumoral vascularization has the function of nourishing the cancer cells to support tumor growth. Vasculogenic mimicry, a novel intratumoral microcirculation system, alludes to the ability of cancer cells to organize in three-dimensional (3D) channel-like architectures. It also supplies the tumors with nutrients and oxygen. Both mechanisms operate in a coordinated way; however, their functions in breast cancer stem-like cells and their regulation by microRNAs remain elusive...
February 9, 2024: Non-Coding RNA
https://read.qxmd.com/read/38392968/the-emerging-role-of-non-coding-rnas-ncrnas-in-plant-growth-development-and-stress-response-signaling
#6
REVIEW
Amit Yadav, Jyotirmaya Mathan, Arvind Kumar Dubey, Anuradha Singh
Plant species utilize a variety of regulatory mechanisms to ensure sustainable productivity. Within this intricate framework, numerous non-coding RNAs (ncRNAs) play a crucial regulatory role in plant biology, surpassing the essential functions of RNA molecules as messengers, ribosomal, and transfer RNAs. ncRNAs represent an emerging class of regulators, operating directly in the form of small interfering RNAs (siRNAs), microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). These ncRNAs exert control at various levels, including transcription, post-transcription, translation, and epigenetic...
February 7, 2024: Non-Coding RNA
https://read.qxmd.com/read/38392967/functional-relevance-of-extracellular-vesicle-derived-long-non-coding-and-circular-rnas-in-cancer-angiogenesis
#7
REVIEW
José A Peña-Flores, Daniela Muela-Campos, Rebeca Guzmán-Medrano, Diego Enríquez-Espinoza, Karla González-Alvarado
Extracellular vesicles (EVs) are defined as subcellular structures limited by a bilayer lipid membrane that function as important intercellular communication by transporting active biomolecules, such as proteins, amino acids, metabolites, and nucleic acids, including long non-coding RNAs (lncRNAs). These cargos can effectively be delivered to target cells and induce a highly variable response. LncRNAs are functional RNAs composed of at least 200 nucleotides that do not code for proteins. Nowadays, lncRNAs and circRNAs are known to play crucial roles in many biological processes, including a plethora of diseases including cancer...
February 6, 2024: Non-Coding RNA
https://read.qxmd.com/read/38392966/circular-rnas-noncoding-rnas-and-n6-methyladenosine-involved-in-the-development-of-mafld
#8
REVIEW
Moeka Nakashima, Naoko Suga, Yuka Ikeda, Sayuri Yoshikawa, Satoru Matsuda
Noncoding RNAs (ncRNAs), including circular RNAs (circRNAs) and N6-methyladenosine (m6A), have been shown to play a critical role in the development of various diseases including obesity and metabolic disorder-associated fatty liver disease (MAFLD). Obesity is a chronic disease caused by excessive fat accumulation in the body, which has recently become more prevalent and is the foremost risk factor for MAFLD. Causes of obesity may involve the interaction of genetic, behavioral, and social factors. m6A RNA methylation might add a novel inspiration for understanding the development of obesity and MAFLD with post-transcriptional regulation of gene expression...
February 5, 2024: Non-Coding RNA
https://read.qxmd.com/read/38392965/investigating-the-role-of-non-coding-rna-in-non-alcoholic-fatty-liver-disease
#9
REVIEW
Samar A Zailaie, Basmah B Khoja, Jumana J Siddiqui, Mohammad H Mawardi, Emily Heaphy, Amjad Aljagthmi, Consolato M Sergi
Non-coding RNAs (ncRNAs) are RNA molecules that do not code for protein but play key roles in regulating cellular processes. NcRNAs globally affect gene expression in diverse physiological and pathological contexts. Functionally important ncRNAs act in chromatin modifications, in mRNA stabilization and translation, and in regulation of various signaling pathways. Non-alcoholic fatty liver disease (NAFLD) is a set of conditions caused by the accumulation of triacylglycerol in the liver. Studies of ncRNA in NAFLD are limited but have demonstrated that ncRNAs play a critical role in the pathogenesis of NAFLD...
January 31, 2024: Non-Coding RNA
https://read.qxmd.com/read/38392964/hgsmda-mirna-disease-association-prediction-based-on-hypergcn-and-s%C3%A3-rensen-dice-loss
#10
JOURNAL ARTICLE
Zhenghua Chang, Rong Zhu, Jinxing Liu, Junliang Shang, Lingyun Dai
Biological research has demonstrated the significance of identifying miRNA-disease associations in the context of disease prevention, diagnosis, and treatment. However, the utilization of experimental approaches involving biological subjects to infer these associations is both costly and inefficient. Consequently, there is a pressing need to devise novel approaches that offer enhanced accuracy and effectiveness. Presently, the predominant methods employed for predicting disease associations rely on Graph Convolutional Network (GCN) techniques...
January 26, 2024: Non-Coding RNA
https://read.qxmd.com/read/38392963/rna-n-6-methyladenosine-affects-copper-induced-oxidative-stress-response-in-arabidopsis-thaliana
#11
JOURNAL ARTICLE
Bishwas Sharma, Ganesan Govindan, Yongfang Li, Ramanjulu Sunkar, Brian D Gregory
Recently, post-transcriptional regulation of mRNA mediated by N6 -methyladenosine (m6 A) has been found to have profound effects on transcriptome regulation during plant responses to various abiotic stresses. However, whether this RNA modification can affect an oxidative stress response in plants has not been studied. To assess the role of m6 A modifications during copper-induced oxidative stress responses, m6 A-IP-seq was performed in Arabidopsis seedlings exposed to high levels of copper sulfate. This analysis revealed large-scale shifts in this modification on the transcripts most relevant for oxidative stress...
January 19, 2024: Non-Coding RNA
https://read.qxmd.com/read/38250807/role-of-hydrogen-sulfide-in-oncological-and-non-oncological-disorders-and-its-regulation-by-non-coding-rnas-a-comprehensive-review
#12
REVIEW
Rana A Youness, Danira Ashraf Habashy, Nour Khater, Kareem Elsayed, Alyaa Dawoud, Sousanna Hakim, Heba Nafea, Carole Bourquin, Reham M Abdel-Kader, Mohamed Z Gad
Recently, myriad studies have defined the versatile abilities of gasotransmitters and their synthesizing enzymes to play a "Maestro" role in orchestrating several oncological and non-oncological circuits and, thus, nominated them as possible therapeutic targets. Although a significant amount of work has been conducted on the role of nitric oxide (NO) and carbon monoxide (CO) and their inter-relationship in the field of oncology, research about hydrogen sulfide (H2 S) remains in its infancy. Recently, non-coding RNAs (ncRNAs) have been reported to play a dominating role in the regulation of the endogenous machinery system of H2 S in several pathological contexts...
January 18, 2024: Non-Coding RNA
https://read.qxmd.com/read/38250806/srnaflow-a-tool-for-the-analysis-of-small-rna-seq-data
#13
JOURNAL ARTICLE
Pawel Zayakin
The analysis of small RNA sequencing data across a range of biofluids is a significant research area, given the diversity of RNA types that hold potential diagnostic, prognostic, and predictive value. The intricate task of segregating the complex mixture of small RNAs from both human and other species, including bacteria, fungi, and viruses, poses one of the most formidable challenges in the analysis of small RNA sequencing data, currently lacking satisfactory solutions. This study introduces sRNAflow, a user-friendly bioinformatic tool with a web interface designed for the analysis of small RNAs obtained from biological fluids...
January 17, 2024: Non-Coding RNA
https://read.qxmd.com/read/38250805/transcriptional-stress-induces-the-generation-of-dogs-in-cancer-cells
#14
JOURNAL ARTICLE
Francisco Rios, Maritere Uriostegui-Arcos, Mario Zurita
A characteristic of the cellular response to stress is the production of RNAs generated from a readthrough transcription of genes, called downstream-of-gene-(DoG)-containing transcripts. Additionally, transcription inhibitor drugs are candidates for fighting cancer. In this work, we report the results of a bioinformatic analysis showing that one of the responses to transcription inhibition is the generation of DoGs in cancer cells. Although some genes that form DoGs were shared between the two cancer lines, there did not appear to be a functional correlation between them...
January 10, 2024: Non-Coding RNA
https://read.qxmd.com/read/38250804/genetic-loss-of-mir-205-causes-increased-mammary-gland-development
#15
JOURNAL ARTICLE
Alessandra Cataldo, Douglas G Cheung, John P Hagan, Matteo Fassan, Sukhinder Sandhu-Deol, Carlo M Croce, Gianpiero Di Leva, Marilena V Iorio
MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development...
December 31, 2023: Non-Coding RNA
https://read.qxmd.com/read/38250803/long-non-coding-rnas-lncrnas-in-heart-failure-a-comprehensive-review
#16
REVIEW
Shambhavi Jha, Vasanth Kanth Thasma Loganathbabu, Kasinathan Kumaran, Gopinath Krishnasamy, Kandasamy Nagarajan Aruljothi
Heart failure (HF) is a widespread cardiovascular condition that poses significant risks to a wide spectrum of age groups and leads to terminal illness. Although our understanding of the underlying mechanisms of HF has improved, the available treatments still remain inadequate. Recently, long non-coding RNAs (lncRNAs) have emerged as crucial players in cardiac function, showing possibilities as potential targets for HF therapy. These versatile molecules interact with chromatin, proteins, RNA, and DNA, influencing gene regulation...
December 28, 2023: Non-Coding RNA
https://read.qxmd.com/read/38250802/mir-4646-5p-acts-as-a-tumor-suppressive-factor-in-triple-negative-breast-cancer-and-targets-the-cholesterol-transport-protein-gramd1b
#17
JOURNAL ARTICLE
Katharina Jonas, Felix Prinz, Manuela Ferracin, Katarina Krajina, Alexander Deutsch, Tobias Madl, Beate Rinner, Ondrej Slaby, Christiane Klec, Martin Pichler
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of gene expression, and their deregulation contributes to many aspects of cancer development and progression. Thus, miRNAs provide insight into oncogenic mechanisms and represent promising targets for new therapeutic approaches. A type of cancer that is still in urgent need of improved treatment options is triple negative breast cancer (TNBC). Therefore, we aimed to characterize a novel miRNA with a potential role in TNBC. Based on a previous study, we selected miR-4646-5p, a miRNA with a still unknown function in breast cancer...
December 26, 2023: Non-Coding RNA
https://read.qxmd.com/read/38250801/sequencing-reveals-mirnas-enriched-in-the-developing-mouse-enteric-nervous-system
#18
JOURNAL ARTICLE
Christopher Pai, Rajarshi Sengupta, Robert O Heuckeroth
The enteric nervous system (ENS) is an essential network of neurons and glia in the bowel wall. Defects in ENS development can result in Hirschsprung disease (HSCR), a life-threatening condition characterized by severe constipation, abdominal distention, bilious vomiting, and failure to thrive. A growing body of literature connects HSCR to alterations in miRNA expression, but there are limited data on the normal miRNA landscape in the developing ENS. We sequenced small RNAs (smRNA-seq) and messenger RNAs (mRNA-seq) from ENS precursor cells of mid-gestation Ednrb-EGFP mice and compared them to aggregated RNA from all other cells in the developing bowel...
December 22, 2023: Non-Coding RNA
https://read.qxmd.com/read/38133210/the-non-coding-rna-journal-club-highlights-on-recent-papers-13
#19
EDITORIAL
Patrick K T Shiu, Johanna K DiStefano, Suresh K Alahari, Francisco J Enguita, Mark W Feinberg, Nikolaos Sideris, Salih Bayraktar, Leandro Castellano, Diana Luna Buitrago, Andrea Caporali, Alessandro Mannucci, Ajay Goel
We are delighted to share with you our thirteenth Journal Club and highlight some of the most interesting papers published recently [...].
December 14, 2023: Non-Coding RNA
https://read.qxmd.com/read/38133209/regulation-of-macrophage-polarization-in-allergy-by-noncoding-rnas
#20
REVIEW
Osamu Ishibashi, Stefan A Muljo, Zohirul Islam
Allergy is a type 2 immune reaction triggered by antigens known as allergens, including food and environmental substances such as peanuts, plant pollen, fungal spores, and the feces and debris of mites and insects. Macrophages are myeloid immune cells with phagocytic abilities that process exogenous and endogenous antigens. Upon activation, they can produce effector molecules such as cytokines as well as anti-inflammatory molecules. The dysregulation of macrophage function can lead to excessive type 1 inflammation as well as type 2 inflammation, which includes allergic reactions...
December 11, 2023: Non-Coding RNA
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