journal
https://read.qxmd.com/read/38234972/the-application-of-bioglass-to-treat-osteoarthritis
#21
JOURNAL ARTICLE
Saurav Kumar Jha, Bhupendra Kumar, Keshav Raj Paudel, Amitabha Bandyopadhyay
No abstract text is available yet for this article.
2023: EXCLI Journal
https://read.qxmd.com/read/38234971/roles-of-serine-in-neurodegenerative-diseases
#22
JOURNAL ARTICLE
Jia-Meng Li, Shuang-Qing Zhang
No abstract text is available yet for this article.
2023: EXCLI Journal
https://read.qxmd.com/read/38234970/promising-influences-of-hesperidin-and-hesperetin-against-diabetes-and-its-complications-a-systematic-review-of-molecular-cellular-and-metabolic-effects
#23
REVIEW
Amirhossein Mirzaei, Ali Mirzaei, Shakiba Najjar Khalilabad, Vahid Reza Askari, Vafa Baradaran Rahimi
Hesperidin and hesperetin, two flavonoids with potential therapeutic value, have been extensively studied in the context of diabetes management. The main objective of this research is to ascertain their potential as therapeutic options for managing diabetes and its complications. The present study utilized a systematic review methodology and comprehensively explored relevant literature from databases, including PubMed, Scopus, and Web of Science, from inception until July 2023. The review summarized the outcomes related to the molecular, cellular, and metabolic effects of hesperidin and hesperetin in diabetes and its complications...
2023: EXCLI Journal
https://read.qxmd.com/read/38234969/potential-of-melatonin-to-reverse-epigenetic-aberrations-in-oral-cancer-new-findings
#24
REVIEW
Emilio Gil-Martín, Eva Ramos, Francisco López-Muñoz, Javier Egea, Alejandro Romero
It is now an accepted principle that epigenetic alterations cause cellular dyshomeostasis and functional changes, both of which are essential for the initiation and completion of the tumor cycle. Oral carcinogenesis is no exception in this regard, as most of the tumors in the different subsites of the oral cavity arise from the cross-reaction between (epi)genetic inheritance and the huge challenge of environmental stressors. Currently, the biochemical machinery is put at the service of the tumor program, halting the cell cycle, triggering uncontrolled proliferation, driving angiogenesis and resistance to apoptosis, until the archetypes of the tumor phenotype are reached...
2023: EXCLI Journal
https://read.qxmd.com/read/38234968/embelin-a-multifaceted-anticancer-agent-with-translational-potential-in-targeting-tumor-progression-and-metastasis
#25
REVIEW
Adithya Jayaprakash Kamath, Alda Sara Chandy, Aina Ann Joseph, Jaggiah N Gorantla, Asawari Dilip Donadkar, Lekshmi R Nath, Javad Sharifi-Rad, Daniela Calina
Embelin, a natural para-benzoquinone product, is derived from plants of the Embelia genus, particularly Embelia ribes Burm.f. A staple in traditional medicinal formulations for centuries, Embelin's pharmacological actions are attributed to the hydroxyl benzoquinone present in its structure. Its therapeutic potential is bolstered by unique physical and chemical properties. Recently, Embelin, recognized as a non-peptidic, cell-permeable small inhibitor of the X-linked inhibitor of apoptosis protein (XIAP), has garnered significant attention for its anticancer activity...
2023: EXCLI Journal
https://read.qxmd.com/read/38234967/alpha-ketoglutarate-partially-alleviates-effects-of-high-fat-high-fructose-diet-in-mouse-muscle
#26
JOURNAL ARTICLE
Myroslava V Vatashchuk, Maria M Bayliak, Viktoriia V Hurza, Oleh I Demianchuk, Dmytro V Gospodaryov, Volodymyr I Lushchak
Consumption of high-calorie diets leads to excessive accumulation of storage lipids in adipose tissue. Metabolic changes occur not only in adipose tissue but in other tissues, too, such as liver, heart, muscle, and brain. This study aimed to explore the effects of high-fat high-fructose diet (HFFD) alone and in the combination with alpha-ketoglutarate (AKG), a well-known cellular metabolite, on energy metabolism in the skeletal muscle of C57BL/6J mice. Five-month-old male mice were divided into four groups - the control one fed a standard diet (10 % kcal fat), HFFD group fed a high-fat high-fructose diet (45 % kcal fat, 15 % kcal fructose), AKG group fed a standard diet with 1 % sodium AKG in drinking water, and HFFD + AKG group fed HFFD and water with 1 % sodium AKG...
2023: EXCLI Journal
https://read.qxmd.com/read/38204969/enrichment-analysis-and-chromosomal-distribution-of-gout-susceptible-loci-identified-by-genome-wide-association-studies
#27
JOURNAL ARTICLE
Mostafa Saadat
Gout is an inherited and common inflammatory arthritic disease. Many researchers will identify polymorphic loci of gout susceptibility by conducting genome-wide association studies (GWAS). In the present study, the enrichment analysis and chromosomal distribution were performed using predicted polymorphic loci associated with gout risk. The polymorphic loci associated to gout were obtained from the GWAS database. Overall, this database contains 64,806 gout patients and 2,856,174 controls. Gene ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed by using the Enrichr online server...
2023: EXCLI Journal
https://read.qxmd.com/read/38204968/interplay-between-lncrna-mirna-and-wnt-%C3%A3-catenin-signaling-in-brain-cancer-tumorigenesis
#28
REVIEW
Farzad Rahmani, Abdulridha Mohammed Al-Asady, Reyhane Hanaie, Mehrdad Zandigohar, Homeira Faridnejad, Mahya Payazdan, Pegah Safavi, Mikhail Ryzhikov, Seyed Mahdi Hassanian
Brain cancers are among the most aggressive malignancies with high mortality and morbidity worldwide. The pathogenesis of brain cancers is a very complicated process involving various genetic mutations affecting several oncogenic signaling pathways like Wnt/β-catenin axis. Uncontrolled activation of this oncogenic signaling is associated with decreased survival rate and poor prognosis in cancer patients. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) were shown to play important roles in regulating cell proliferation, differentiation, and apoptosis by regulating the expression of their target genes...
2023: EXCLI Journal
https://read.qxmd.com/read/38204967/structural-and-molecular-characterization-of-lopinavir-and-ivermectin-as-breast-cancer-resistance-protein-bcrp-abcg2-inhibitors
#29
JOURNAL ARTICLE
Julia de Paula Dutra, Gustavo Scheiffer, Thales Kronenberger, Lucas Julian Cruz Gomes, Isadora Zanzarini, Kelly Karoline Dos Santos, Arun K Tonduru, Antti Poso, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Glaucio Valdameri, Vivian Rotuno Moure
A current clinical challenge in cancer is multidrug resistance (MDR) mediated by ABC transporters. Breast cancer resistance protein (BCRP) or ABCG2 transporter is one of the most important ABC transporters implicated in MDR and the use of inhibitors is a promising approach to overcome the resistance in cancer. This study aimed to characterize the molecular mechanism of ABCG2 inhibitors identified by a repurposing drug strategy using antiviral, anti-inflammatory and antiparasitic agents. Lopinavir and ivermectin can be considered as pan-inhibitors of ABC transporters, since both compounds inhibited ABCG2, P-glycoprotein and MRP1...
2023: EXCLI Journal
https://read.qxmd.com/read/38204966/-in-vitro-screening-of-topical-formulation-excipients-for-epithelial-toxicity-in-cancerous-and-non-cancerous-cell-lines
#30
JOURNAL ARTICLE
Farzaneh Forouz, Yousuf Mohammed, Hamid S A Shobeiri Nejad, Michael S Roberts, Jeffrey E Grice
Chemical excipients used in topical formulations may be toxic to living skin cells. Here, we compared the in vitro toxicity of some common solubilizing excipients against human melanoma cells, human keratinocytes (HaCaT) and primary skin fibroblasts (FB) as examples of cancerous, immortalized and primary human skin cells, often used as experimental models representative of in vivo conditions. Two distinct endpoint assays (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and crystal violet (CV)) were used...
2023: EXCLI Journal
https://read.qxmd.com/read/38204965/prevalence-and-impact-of-tobacco-use-disorder-on-in-hospital-mortality-in-patients-hospitalized-with-non-group-1-pulmonary-hypertension-a-nationwide-propensity-score-matched-analysis-2019
#31
JOURNAL ARTICLE
Rupak Desai, Zainab Gandhi, Saher Taj Shiza, Akhil Jain, Hiren Koshiya, Bibi Alli-Ramsaroop, Agatha Olawunmi Akinsete, Eko Wilson, Pranathi Rudra, Mohan Sai Sunith Vegesna, Madiha Bari, Ankit Vyas, Bisharah Rizvi, Salim Surani
Numerous studies indicated that patients with tobacco use disorder (TUD) are inversely associated with mortality in what is known as the smoker's paradox. However, limited studies have been conducted on the impact of TUD on the in-hospital mortality rates of patients with secondary pulmonary hypertension (PH, Non-Group 1 PH). Using the 2019 National Inpatient Sample, we identified PH and divided it into TUD and non-TUD to compare the comorbidities and in-hospital mortality between the two after 1:1 propensity-score matching...
2023: EXCLI Journal
https://read.qxmd.com/read/38090260/anti-inflammatory-and-anti-fibrotic-effects-of-berberine-loaded-liquid-crystalline-nanoparticles
#32
JOURNAL ARTICLE
Amlan Chakraborty, Keshav Raj Paudel, Chao Wang, Gabriele De Rubis, Dinesh Kumar Chellappan, Philip Michael Hansbro, Chrishan S Samuel, Kamal Dua
No abstract text is available yet for this article.
2023: EXCLI Journal
https://read.qxmd.com/read/38090259/is-polio-making-a-comeback-the-cost-of-vaccine-hesitancy-and-the-disparity-in-vaccine-coverage
#33
JOURNAL ARTICLE
Thalles Guilarducci Costa, Rizia Rocha Silva, João Victor Rosa de Freitas, Rodrigo Luiz Vancini, Marilia Santos Andrade, Claudio Andre Barbosa de Lira
No abstract text is available yet for this article.
2023: EXCLI Journal
https://read.qxmd.com/read/38090258/virtual-ergonomics-of-ppe-systems-a-standardization-perspective
#34
JOURNAL ARTICLE
Peter Bröde, Edith Classen, Jean Léonard, Ronald Heus, Kalev Kuklane
No abstract text is available yet for this article.
2023: EXCLI Journal
https://read.qxmd.com/read/38090257/first-case-of-lucio-s-phenomenon-in-a-lepromatous-leprosy-patient-following-covid-19-viral-vector-vaccine
#35
JOURNAL ARTICLE
Roberto Fernandes Soares-Neto, Geyse Maria Lima da Piedade, Priscila Soares Pereira, Rebeca Yasmin Ribeiro Vieira, Jerocilio Maciel de Oliveira-Júnior, Thalyta Porto Fraga, Martha Débora Lira Tenório, Pedro Dantas Oliveira, Paulo Ricardo Martins-Filho
No abstract text is available yet for this article.
2023: EXCLI Journal
https://read.qxmd.com/read/38054206/exploring-mito-nuclear-genetic-factors-in-leber-s-hereditary-optic-neuropathy-insights-from-comprehensive-profiling-of-unique-cases
#36
JOURNAL ARTICLE
Prakash Chermakani, Poigaialwar Gowri, Shanmugam Mahesh Kumar, Periasamy Sundaresan
Leber's hereditary optic neuropathy (LHON) is a mitochondrial complex I disorder and causes inexorable painless vision loss. Recent studies from India reported that a significant proportion of LHON patients lack primary mitochondrial DNA mutations, suggesting that alternative genetic factors contribute to disease development. Therefore, this study investigated the genetic profile of LHON-affected individuals in order to understand the role of mito-nuclear genetic factors in LHON. A total of thirty probands displaying symptoms consistent with LHON have undergone whole mitochondrial and whole exome sequencing...
2023: EXCLI Journal
https://read.qxmd.com/read/38054205/how-different-viruses-perturb-host-cellular-machinery-via-short-linear-motifs
#37
REVIEW
Sobia Idrees, Keshav Raj Paudel, Tayyaba Sadaf, Philip M Hansbro
The virus interacts with its hosts by developing protein-protein interactions. Most viruses employ protein interactions to imitate the host protein: A viral protein with the same amino acid sequence or structure as the host protein attaches to the host protein's binding partner and interferes with the host protein's pathways. Being opportunistic, viruses have evolved to manipulate host cellular mechanisms by mimicking short linear motifs. In this review, we shed light on the current understanding of mimicry via short linear motifs and focus on viral mimicry by genetically different viral subtypes by providing recent examples of mimicry evidence and how high-throughput methods can be a reliable source to study SLiM-mediated viral mimicry...
2023: EXCLI Journal
https://read.qxmd.com/read/38054204/proteomic-analysis-of-hepatic-effects-of-okadaic-acid-in-heparg-human-liver-cells
#38
JOURNAL ARTICLE
Leonie T D Wuerger, Greta Birkholz, Axel Oberemm, Holger Sieg, Albert Braeuning
The marine biotoxin okadaic acid (OA) is produced by dinoflagellates and enters the human food chain by accumulating in the fatty tissue of filter-feeding shellfish. Consumption of highly contaminated shellfish can lead to diarrheic shellfish poisoning. However, apart from the acute effects in the intestine, OA can also provoke toxic effects in the liver, as it is able to pass the intestinal barrier into the blood stream. However, molecular details of OA-induced hepatotoxicity are still insufficiently characterized, and especially at the proteomic level data are scarce...
2023: EXCLI Journal
https://read.qxmd.com/read/38054203/potential-and-challenges-of-high-speed-4d-body-scanning-for-mobility-analysis-of-firefighter-clothing-a-methodical-case-study
#39
JOURNAL ARTICLE
Dominik Muenks, Yordan Kyosev, Felix Kunzelmann
In this study, protective clothing for firefighters is analyzed using 4D body scanning and 3D hand scanning, with a focus on the experimental analysis of ergonomic comfort. In particular, German firefighting clothing is examined to discuss the possibilities and limitations of current scanning technologies for capturing firefighting clothing. For this purpose, various movements are recorded in the 4D scanner. In addition, a method for determining position changes of protective clothing at identified limits is presented...
2023: EXCLI Journal
https://read.qxmd.com/read/38023570/emerging-role-of-nanotechnology-in-treatment-of-non-alcoholic-fatty-liver-disease-nafld
#40
REVIEW
Atie Moghtadaie, Hamidreza Mahboobi, Somayeh Fatemizadeh, Mohammad Amjad Kamal
Non-alcoholic fatty liver disease (NAFLD) is a prevailing health challenge that requires urgent innovative interventions. This review explores the role of nanotechnology as a promising potential in the treatment of NAFLD. It delineates the limitations of the current management strategies for NAFLD and highlights the new nanotechnology-based treatments including nanoemulsions, liposomes, micelles, polymeric nanoparticles, nanogels, inorganic nanoparticles, and zinc oxide nanoparticles. Despite the optimism surrounding the nanotechnological approach, the review underscores the need to address the limitations such as technical challenges, potential toxicity, and ethical considerations that impede the practical application of nanotechnology in NAFLD management...
2023: EXCLI Journal
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