journal
MENU ▼
Read by QxMD icon Read
search

EXCLI Journal

journal
https://read.qxmd.com/read/30713484/highlight-report-activating-tumor-specific-t-cells-for-breast-cancer-therapy
#1
EDITORIAL
Mikheil Gogiashvili
No abstract text is available yet for this article.
2018: EXCLI Journal
https://read.qxmd.com/read/30713483/development-of-competitive-lateral-flow-immunoassay-coupled-with-silver-enhancement-for-simple-and-sensitive-salivary-cortisol-detection
#2
Amara Apilux, Sirirat Rengpipat, Wilasinee Suwanjang, Orawon Chailapakul
Cortisol is known as a stress biomarker. The measurement of cortisol levels is an early warning indicator for health conditions and diagnosis of stress-related diseases. Herein, a lateral flow immunoassay using a gold nanoparticle label with a silver enhancement system was developed for the simple, sensitive and rapid detection of cortisol. The developed assay was based on a competitive platform of which cortisol-BSA conjugate was immobilized at the test zone to compete with an analyte. The quantitative analysis was performed using gold nanoparticles (AuNPs) as signal labeling...
2018: EXCLI Journal
https://read.qxmd.com/read/30713482/highlight-report-toxicogenomics-atlas-of-rat-hepatotoxicants
#3
EDITORIAL
Florian Seidel
No abstract text is available yet for this article.
2018: EXCLI Journal
https://read.qxmd.com/read/30713481/highlight-report-general-determinants-of-steatosis
#4
EDITORIAL
Wiebke Albrecht
No abstract text is available yet for this article.
2018: EXCLI Journal
https://read.qxmd.com/read/30713480/highlight-report-necrosis-apoptosis-conundrum-of-hepatocytes-mode-of-hepatocyte-death-after-acetaminophen-intoxication
#5
EDITORIAL
Ahmed Ghallab
No abstract text is available yet for this article.
2018: EXCLI Journal
https://read.qxmd.com/read/30713479/a-haplotype-of-the-phosphodiesterase-4d-pde4d-gene-is-associated-with-myocardial-infarction-and-with-cardiometabolic-parameters-the-gea-study
#6
José Manuel Rodríguez-Pérez, Rosalinda Posadas-Sánchez, Ruben Blachman-Braun, Gilberto Vargas-Alarcón, Carlos Posadas-Romero, Esbeidy García-Flores, Fabiola López-Bautista, Carlos Alfonso Tovilla-Zárate, Thelma Beatriz González-Castro, Verónica Marusa Borgonio-Cuadra, Nonanzit Pérez-Hernández
The phosphodiesterase family is involved in a wide spectrum of diseases, including ischemic stroke. However, few studies have analyzed the relationship between phosphodiesterase 4D (PDE4D) and myocardial infarction (MI). Therefore, the aim of this research was to evaluate the association of the PDE4D gene polymorphisms with MI, and with cardiometabolic parameters in the Mexican population. Six polymorphisms (rs2910829, rs1423246, rs966221, rs4502776, rs13172481, and rs6869495) were genotyped in 1023 MI patients and 1105 healthy controls...
2018: EXCLI Journal
https://read.qxmd.com/read/30713478/highlight-report-cell-type-selection-for-toxicity-testing
#7
EDITORIAL
H M Bolt
No abstract text is available yet for this article.
2018: EXCLI Journal
https://read.qxmd.com/read/30713477/androgen-receptor-ar-cag-trinucleotide-repeat-length-and-idiopathic-male-infertility-a-case-control-trial-and-a-meta-analysis
#8
Narges Mobasseri, Faezeh Babaei, Mohammad Karimian, Hossein Nikzad
CAG trinucleotide repeats in androgen receptor ( AR ) gene encode a polyglutamine tract in AR N-terminal transactivation domain. Studies have been conducted to evaluate the effect of CAG repeat length on male infertility, which have yielded contradictory results. This study aimed to explore the number of AR -CAG repeats in 150 fertile controls and 150 idiopathic infertile men, divided into four azoospermia, oligozoospermia, asthenozoospermia, and teratozoospermia subgroups. In addition, a meta-analysis was conducted based on previous studies to assess the association of the mentioned variation with male infertility in recent years...
2018: EXCLI Journal
https://read.qxmd.com/read/30713476/protein-arginine-methyltransferase-5-promotes-bladder-cancer-growth-through-inhibiting-nf-kb-dependent-apoptosis
#9
Guodong Hu, Xiu Wang, Yi Han, Ping Wang
Protein arginine methyltransferase 5 (PRMT5) has emerged as a key regulator of tumorigenesis. However, how PRMT5 functions in bladder cancer, the most common malignancy of the urological system, is unknown. We described here that PRMT5 is highly expressed in bladder cancer cell lines and primary human bladder cancer tissues. PRMT5 enhances the proliferation and colony formation of bladder cancer cells. PRMT5 knockdown induces bladder cancer cell apoptosis. Mechanistically, PRMT5 enhances NF-kB activation by targeting crucial anti-apoptotic genes such as BCLXL and c-IAP1 , thereby inhibiting tumor cell apoptosis and sustaining proliferation...
2018: EXCLI Journal
https://read.qxmd.com/read/30713475/highlight-report-import-of-fatty-acids-by-metastasizing-tumor-cells
#10
EDITORIAL
Tim Brecklinghaus
No abstract text is available yet for this article.
2018: EXCLI Journal
https://read.qxmd.com/read/30713474/highlight-report-protection-of-cholestatic-livers-by-shunting-of-bile-from-canaliculi-to-sinusoids
#11
EDITORIAL
Tahany Abbass, Walaa Murad, Abdel-Latif Seddek
No abstract text is available yet for this article.
2018: EXCLI Journal
https://read.qxmd.com/read/30713473/cyclosporin-a-attenuating-morphine-tolerance-through-inhibiting-no-erk-signaling-pathway-in-human-glioblastoma-cell-line-the-involvement-of-calcineurin
#12
Asma Rashki, Faiza Mumtaz, Farahnaz Jazayeri, Amir Shadboorestan, Jamileh Esmaeili, Shahram Ejtemaei Mehr, Mohammad Hossein Ghahremani, Ahmad Reza Dehpour
Cyclosporin A (CsA) is known to have an immunosuppressive action. However, it is also attracting attention due to its effects on the nervous system, such as inhibiting the development and expression of morphine-induced tolerance and dependence through unknown mechanisms. It has been shown that CsA modulates the nitric oxide (NO) synthesis and extracellular signal-regulated kinases (ERK) activation, which are potentially involved in signaling pathways in morphine-induced tolerance in cellular models. Therefore, the current study was designed to evaluate the modulatory role of CsA on the MOR tolerance, by targeting the downstream signaling pathway of NO and ERK using an in vitro model...
2018: EXCLI Journal
https://read.qxmd.com/read/30585275/a-meta-analysis-of-the-relationship-between-body-mass-index-and-risk-of-rheumatoid-arthritis
#13
Ying Zhou, Mingfang Sun
The present meta-analysis aimed to evaluate the relationship between body mass index (BMI) and rheumatoid arthritis (RA). A systematic search of the Cochrane, Pubmed, and Embase databases was conducted to identify relevant studies published before September 2017 using terms related to BMI and RA. Fixed or random-effect models were used to estimate the pooled relative risk (RR) with 95 % confidence interval (CI). Subgroup analyses by sex were performed to investigate the association between BMI and RA in male and female subgroups...
2018: EXCLI Journal
https://read.qxmd.com/read/30585274/the-inflammatory-cytokine-tnf-contributes-with-rac3-induced-malignant-transformation
#14
Mileni Soares Machado, Francisco D Rosa, María C Lira, Alejandro J Urtreger, María F Rubio, Mónica A Costas
RAC3 is a coactivator of steroid receptors and NF-κB. It is usually overexpressed in several tumors, contributes to maintain cancer stem cells and also to induce them when is overexpressed in non-tumoral cells. In this work, we investigated whether the inflammatory cytokine TNF may contribute to the transforming effects of RAC3 overexpression in the non-tumoral HEK293 cell line. The study model included the HEK293 tumoral transformed cell line constitutively overexpressing RAC3 by stable transfection and control non-tumoral cells transfected with an empty vector...
2018: EXCLI Journal
https://read.qxmd.com/read/30564086/pesticide-toxicity-a-mechanistic-approach
#15
REVIEW
Volodymyr I Lushchak, Tetiana M Matviishyn, Viktor V Husak, Janet M Storey, Kenneth B Storey
Pesticides are known for their high persistence and pervasiveness in the environment, and along with products of their biotransformation, they may remain in and interact with the environment and living organisms in multiple ways, according to their nature and chemical structure, dose and targets. In this review, the classifications of pesticides based on their nature, use, physical state, pathophysiological effects, and sources are discussed. The effects of these xenobiotics on the environment, their biotransformation in terms of bioaccumulation are highlighted with special focus on the molecular mechanisms deciphered to date...
2018: EXCLI journal
https://read.qxmd.com/read/30564085/differential-pattern-of-brain-functional-connectome-in-obsessive-compulsive-disorder-versus-healthy-controls
#16
Saeid Yazdi-Ravandi, Hassan Akhavanpour, Farshid Shamsaei, Nasrin Matinnia, Mohammad Ahmadpanah, Ali Ghaleiha, Reza Khosrowabadi
Researchers believe that recognition of functional impairment in some of brain networks such as frontal-parietal, default mode network (DMN), anterior medial prefrontal cortex (MPFC) and striatal structures could be a beneficial biomarker for diagnosis of obsessive-compulsive disorder (OCD). Although it is well recognized brain functional connectome in OCD patients shows changes, debate still remains on characteristics of the changes. In this regard, little has been done so far to statistically assess the altered pattern using whole brain electroencephalography...
2018: EXCLI Journal
https://read.qxmd.com/read/30564084/read-across-for-the-derivation-of-indoor-air-guidance-values-supported-by-pbtk-modelling
#17
Thomas Schupp
Polyurethane Flexible Foams (PUF) are versatile materials used in upholstered furniture and bed mattresses. Due to the production procedure, fresh foams emit volatile organic compounds (VOC) which may contribute to indoor air exposure. To evaluate the risk for consumers, the VOC concentration measured in chamber tests can be matched against existing benchmarks for indoor air like "Richtwerte" (RW) of the German UBA (Umweltbundesamt), "Lowest Concentration of Interest" (LCI) for construction products or derived no effect levels (DNEL) for consumer inhalation exposure...
2018: EXCLI Journal
https://read.qxmd.com/read/30564083/immunogenicity-of-a-novel-tetravalent-dengue-envelope-protein-domain-iii-based-antigen-in-mice
#18
Hossein Fahimi, Majid Sadeghizadeh, Zuhair M Hassan, Heidi Auerswald, Michael Schreiber
Dengue virus is a mosquito-borne pathogen that causes dengue diseases. All four serotypes of dengue virus are infectious for humans. Therefore, an efficacious dengue vaccine should be tetravalent to provide protection against all types of virus. The goal of this study was to design a new tetravalent recombinant protein from envelope protein of dengue viruses to induce virus-neutralizing antibodies against all four serotypes in mice. A chimeric protein was designed from domain III of envelope protein of all serotypes of dengue virus...
2018: EXCLI Journal
https://read.qxmd.com/read/30564082/study-of-correlation-between-the-nat2-phenotype-and-genotype-status-among-greenlandic-inuit
#19
Emilie Birch Kristensen, Victor Yakimov, Karen Bjorn-Mortensen, Bolette Soborg, Anders Koch, Mikael Andersson, Kasper Birch Kristensen, Sascha Wilk Michelsen, Line Skotte, Anne Ahrendt Bjerregaard, Meinolf Blaszkewicz, Klaus Golka, Jan G Hengstler, Bjarke Feenstra, Mads Melbye, Frank Geller
N -acetyltransferase 2 (NAT2) is the main enzyme metabolizing isoniazid and genotype-based treatment has been studied for years without becoming common practice. To investigate whether genotype-based isoniazid treatment is feasible in Greenland, we sequenced the coding sequence of NAT2 and determined the NAT2 enzyme-activity by caffeine test. No additional genetic variants were identified in the coding sequence of NAT2 , so that genotype status in 260 study participants could be assessed by a well-established 7-SNP panel...
2018: EXCLI Journal
https://read.qxmd.com/read/30564081/comparing-task-performance-visual-comfort-and-alertness-under-different-lighting-sources-an-experimental-study
#20
Reza Kazemi, Alireza Choobineh, Shirin Taheri, Pegah Rastipishe
The aim of this study is to compare the effects of different light sources - namely light-emitting diode (LED), compact fluorescent (FLcomp) and fluorescent with warm color temperature (FLwarm) and cool color temperature (FLcool) - on the performances, alertness, visual comfort level and preferences in a pilot study. A laboratory controlled experiment was conducted by focusing on 20 postgraduate students who volunteered to participate in a series of tests under four different light sources. "GO NO GO" task and Karolinska Sleepiness Scale (KSS) were employed to assess objective and subjective alertness, while modified OLS questionnaire was used to gauge comfort level and preferences...
2018: EXCLI Journal
journal
journal
51847
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"