journal
https://read.qxmd.com/read/38357097/plasma-amino-acids-in-major-depressive-disorder-between-pathology-to-pharmacology
#1
REVIEW
Omar Gammoh, Alaa A A Aljabali, Murtaza M Tambuwala
Addressing the formidable challenge posed by the development of effective and personalized interventions for major depressive disorder (MDD) necessitates a comprehensive comprehension of the intricate role that plasma amino acids play and their implications in MDD pathology and pharmacology. Amino acids, owing to their indispensable functions in neurotransmission, metabolism, and immune regulation, emerge as pivotal entities in this intricate disorder. Our primary objective entails unraveling the underlying mechanisms and unveiling tailored treatments through a meticulous investigation into the interplay between plasma amino acids, MDD, and pharmacological strategies...
2024: EXCLI Journal
https://read.qxmd.com/read/38357096/roles-of-the-quantification-of-serine-in-the-brain
#2
JOURNAL ARTICLE
Jia-Meng Li, Ya-Zhi Bai, Shuang-Qing Zhang
No abstract text is available yet for this article.
2024: EXCLI Journal
https://read.qxmd.com/read/38357095/azu1-a-new-promising-marker-for-infection-in-orthopedic-and-trauma-patients
#3
JOURNAL ARTICLE
Philipp Hemmann, Lisa Kloppenburg, Regina Breinbauer, Sabrina Ehnert, Gunnar Blumenstock, Marie K Reumann, Felix Erne, Johann Jazewitsch, Tobias Schwarz, Heiko Baumgartner, Tina Histing, Mika Rollmann, Andreas K Nüssler
Early and reliable detection of infection is vital for successful treatment. Serum markers such as C-reactive protein (CRP) and procalcitonin (PCT) are known to increase with a time lag. Azurocidin 1 (AZU1) has emerged as a promising marker for septic patients, but its diagnostic value in orthopedic and trauma patients remains unexplored. Between July 2020 and August 2023, all patients necessitating inpatient treatment for periprosthetic joint infection (PJI), peri-implant infection (II), soft tissue infection, chronic osteomyelitis, septic arthrodesis, bone non-union with and without infection were enrolled...
2024: EXCLI Journal
https://read.qxmd.com/read/38357094/myocardial-infarct-size-is-reduced-by-nitrite-and-nitrate-administration-a-systematic-review-and-meta-analysis-of-animal-studies
#4
REVIEW
Younes Yassaghi, Sajad Jeddi, Khosrow Kashfi, Asghar Ghasemi
Ischemic heart disease (IHD) is the leading cause of mortality worldwide and can be complicated by myocardial infarction (MI), leading to cardiac failure. Inorganic nitrite and nitrate, which release nitric oxide (NO), can protect the heart against myocardial injury. This animal systematic review and meta-analysis aims to assess whether the administration of nitrite/nitrate decreases myocardial infarct size. We systematically searched PubMed, Scopus, and Web of Science databases until October 2023; 15 eligible animal studies (35 study arms for in-vivo and 10 for in-vitro studies) published between 1989 and 2023 were included...
2024: EXCLI Journal
https://read.qxmd.com/read/38343745/unraveling-neat1-s-complex-role-in-lung-cancer-biology-a-comprehensive-review
#5
REVIEW
Md Sadique Hussain, Obaid Afzal, Gaurav Gupta, Ahsas Goyal, Waleed Hassan Almalki, Imran Kazmi, Sami I Alzarea, Abdulmalik Saleh Alfawaz Altamimi, Neelam Kukreti, Amlan Chakraborty, Sachin Kumar Singh, Kamal Dua
This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, including cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically...
2024: EXCLI Journal
https://read.qxmd.com/read/38343744/uniting-minds-and-methods-how-interprofessional-education-advances-male-infertility-research
#6
JOURNAL ARTICLE
Pallav Sengupta, Sulagna Dutta
No abstract text is available yet for this article.
2024: EXCLI Journal
https://read.qxmd.com/read/38343743/impairment-of-value-based-decision-making-in-morphine-dependent-rats-is-partly-related-to-neural-connectivity-between-the-anterior-cingulate-cortex-and-basolateral-amygdala
#7
JOURNAL ARTICLE
Zahra Fatahi, Mohammad Fatahi, Abbas Haghparast
Previous studies have established that the amygdala specifically the basolateral amygdala (BLA), has a fundamental role in decision-making. The present study aimed to investigate functional and neural synchronization between the BLA and anterior cingulate cortex (ACC) while making effort-choice decisions regarding pre-morphine dependence and morphine dependence times. A T-maze decision-making task with a differential outlay (great vs. small effort) and benefit (great vs. small reward) was done, and local field potentials from the BLA and ACC were assessed simultaneously...
2024: EXCLI Journal
https://read.qxmd.com/read/38343742/empowering-personalized-medicine-unleashing-the-potential-of-patient-derived-explants-in-clinical-practice
#8
JOURNAL ARTICLE
Oliwia Piwocka, Wiktoria M Suchorska, Katarzyna Kulcenty
In recent decades, significant progress has been made in understanding the molecular characteristics of cancer and its microenvironment, leading to the development of life-saving treatments. However, patients often experience side effects from standard therapies, highlighting the need for personalized medicine. Personalized medicine aims to customize drug therapy and preventive care based on individual patients' specific requirements. The heterogeneity within tumors and among patients necessitates personalized medicine approaches...
2024: EXCLI Journal
https://read.qxmd.com/read/38317861/phosphatidylcholine-pcl-fortified-nano-phytopharmaceuticals-for-improvement-of-therapeutic-efficacy
#9
REVIEW
Devesh U Kapoor, Mansi Gaur, Akshay Parihar, Bhupendra G Prajapati, Sudarshan Singh, Ravish J Patel
Phytopharmaceuticals, derived from plants, are increasingly recognized for their potential therapeutic benefits. However, their effectiveness is often hindered by challenges such as poor bioavailability, stability, and targeted delivery. In this study, we aimed to address these limitations by developing PCL (phosphatidylcholine) fortified nano-phytopharmaceuticals to enhance therapeutic efficacy. PCL, a biocompatible and biodegradable polymer, was employed to encapsulate the phytopharmaceuticals, thereby improving their stability and bioavailability...
2023: EXCLI Journal
https://read.qxmd.com/read/38317860/recent-studies-on-myricetin-and-its-biological-and-pharmacological-activities
#10
JOURNAL ARTICLE
Priscilla Nadalin, Jae Kwang Kim, Sang Un Park
No abstract text is available yet for this article.
2023: EXCLI Journal
https://read.qxmd.com/read/38234972/the-application-of-bioglass-to-treat-osteoarthritis
#11
JOURNAL ARTICLE
Saurav Kumar Jha, Bhupendra Kumar, Keshav Raj Paudel, Amitabha Bandyopadhyay
No abstract text is available yet for this article.
2023: EXCLI Journal
https://read.qxmd.com/read/38234971/roles-of-serine-in-neurodegenerative-diseases
#12
JOURNAL ARTICLE
Jia-Meng Li, Shuang-Qing Zhang
No abstract text is available yet for this article.
2023: EXCLI Journal
https://read.qxmd.com/read/38234970/promising-influences-of-hesperidin-and-hesperetin-against-diabetes-and-its-complications-a-systematic-review-of-molecular-cellular-and-metabolic-effects
#13
REVIEW
Amirhossein Mirzaei, Ali Mirzaei, Shakiba Najjar Khalilabad, Vahid Reza Askari, Vafa Baradaran Rahimi
Hesperidin and hesperetin, two flavonoids with potential therapeutic value, have been extensively studied in the context of diabetes management. The main objective of this research is to ascertain their potential as therapeutic options for managing diabetes and its complications. The present study utilized a systematic review methodology and comprehensively explored relevant literature from databases, including PubMed, Scopus, and Web of Science, from inception until July 2023. The review summarized the outcomes related to the molecular, cellular, and metabolic effects of hesperidin and hesperetin in diabetes and its complications...
2023: EXCLI Journal
https://read.qxmd.com/read/38234969/potential-of-melatonin-to-reverse-epigenetic-aberrations-in-oral-cancer-new-findings
#14
REVIEW
Emilio Gil-Martín, Eva Ramos, Francisco López-Muñoz, Javier Egea, Alejandro Romero
It is now an accepted principle that epigenetic alterations cause cellular dyshomeostasis and functional changes, both of which are essential for the initiation and completion of the tumor cycle. Oral carcinogenesis is no exception in this regard, as most of the tumors in the different subsites of the oral cavity arise from the cross-reaction between (epi)genetic inheritance and the huge challenge of environmental stressors. Currently, the biochemical machinery is put at the service of the tumor program, halting the cell cycle, triggering uncontrolled proliferation, driving angiogenesis and resistance to apoptosis, until the archetypes of the tumor phenotype are reached...
2023: EXCLI Journal
https://read.qxmd.com/read/38234968/embelin-a-multifaceted-anticancer-agent-with-translational-potential-in-targeting-tumor-progression-and-metastasis
#15
REVIEW
Adithya Jayaprakash Kamath, Alda Sara Chandy, Aina Ann Joseph, Jaggiah N Gorantla, Asawari Dilip Donadkar, Lekshmi R Nath, Javad Sharifi-Rad, Daniela Calina
Embelin, a natural para-benzoquinone product, is derived from plants of the Embelia genus, particularly Embelia ribes Burm.f. A staple in traditional medicinal formulations for centuries, Embelin's pharmacological actions are attributed to the hydroxyl benzoquinone present in its structure. Its therapeutic potential is bolstered by unique physical and chemical properties. Recently, Embelin, recognized as a non-peptidic, cell-permeable small inhibitor of the X-linked inhibitor of apoptosis protein (XIAP), has garnered significant attention for its anticancer activity...
2023: EXCLI Journal
https://read.qxmd.com/read/38234967/alpha-ketoglutarate-partially-alleviates-effects-of-high-fat-high-fructose-diet-in-mouse-muscle
#16
JOURNAL ARTICLE
Myroslava V Vatashchuk, Maria M Bayliak, Viktoriia V Hurza, Oleh I Demianchuk, Dmytro V Gospodaryov, Volodymyr I Lushchak
Consumption of high-calorie diets leads to excessive accumulation of storage lipids in adipose tissue. Metabolic changes occur not only in adipose tissue but in other tissues, too, such as liver, heart, muscle, and brain. This study aimed to explore the effects of high-fat high-fructose diet (HFFD) alone and in the combination with alpha-ketoglutarate (AKG), a well-known cellular metabolite, on energy metabolism in the skeletal muscle of C57BL/6J mice. Five-month-old male mice were divided into four groups - the control one fed a standard diet (10 % kcal fat), HFFD group fed a high-fat high-fructose diet (45 % kcal fat, 15 % kcal fructose), AKG group fed a standard diet with 1 % sodium AKG in drinking water, and HFFD + AKG group fed HFFD and water with 1 % sodium AKG...
2023: EXCLI Journal
https://read.qxmd.com/read/38204969/enrichment-analysis-and-chromosomal-distribution-of-gout-susceptible-loci-identified-by-genome-wide-association-studies
#17
JOURNAL ARTICLE
Mostafa Saadat
Gout is an inherited and common inflammatory arthritic disease. Many researchers will identify polymorphic loci of gout susceptibility by conducting genome-wide association studies (GWAS). In the present study, the enrichment analysis and chromosomal distribution were performed using predicted polymorphic loci associated with gout risk. The polymorphic loci associated to gout were obtained from the GWAS database. Overall, this database contains 64,806 gout patients and 2,856,174 controls. Gene ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed by using the Enrichr online server...
2023: EXCLI Journal
https://read.qxmd.com/read/38204968/interplay-between-lncrna-mirna-and-wnt-%C3%A3-catenin-signaling-in-brain-cancer-tumorigenesis
#18
REVIEW
Farzad Rahmani, Abdulridha Mohammed Al-Asady, Reyhane Hanaie, Mehrdad Zandigohar, Homeira Faridnejad, Mahya Payazdan, Pegah Safavi, Mikhail Ryzhikov, Seyed Mahdi Hassanian
Brain cancers are among the most aggressive malignancies with high mortality and morbidity worldwide. The pathogenesis of brain cancers is a very complicated process involving various genetic mutations affecting several oncogenic signaling pathways like Wnt/β-catenin axis. Uncontrolled activation of this oncogenic signaling is associated with decreased survival rate and poor prognosis in cancer patients. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) were shown to play important roles in regulating cell proliferation, differentiation, and apoptosis by regulating the expression of their target genes...
2023: EXCLI Journal
https://read.qxmd.com/read/38204967/structural-and-molecular-characterization-of-lopinavir-and-ivermectin-as-breast-cancer-resistance-protein-bcrp-abcg2-inhibitors
#19
JOURNAL ARTICLE
Julia de Paula Dutra, Gustavo Scheiffer, Thales Kronenberger, Lucas Julian Cruz Gomes, Isadora Zanzarini, Kelly Karoline Dos Santos, Arun K Tonduru, Antti Poso, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Glaucio Valdameri, Vivian Rotuno Moure
A current clinical challenge in cancer is multidrug resistance (MDR) mediated by ABC transporters. Breast cancer resistance protein (BCRP) or ABCG2 transporter is one of the most important ABC transporters implicated in MDR and the use of inhibitors is a promising approach to overcome the resistance in cancer. This study aimed to characterize the molecular mechanism of ABCG2 inhibitors identified by a repurposing drug strategy using antiviral, anti-inflammatory and antiparasitic agents. Lopinavir and ivermectin can be considered as pan-inhibitors of ABC transporters, since both compounds inhibited ABCG2, P-glycoprotein and MRP1...
2023: EXCLI Journal
https://read.qxmd.com/read/38204966/-in-vitro-screening-of-topical-formulation-excipients-for-epithelial-toxicity-in-cancerous-and-non-cancerous-cell-lines
#20
JOURNAL ARTICLE
Farzaneh Forouz, Yousuf Mohammed, Hamid S A Shobeiri Nejad, Michael S Roberts, Jeffrey E Grice
Chemical excipients used in topical formulations may be toxic to living skin cells. Here, we compared the in vitro toxicity of some common solubilizing excipients against human melanoma cells, human keratinocytes (HaCaT) and primary skin fibroblasts (FB) as examples of cancerous, immortalized and primary human skin cells, often used as experimental models representative of in vivo conditions. Two distinct endpoint assays (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and crystal violet (CV)) were used...
2023: EXCLI Journal
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