journal
https://read.qxmd.com/read/38074212/severe-hyponatraemia-peripartum-associated-with-omeprazole-therapy
#1
Adam Morton
Hyponatraemia is the most commonly encountered electrolyte abnormality in pregnancy and may be associated with adverse maternal and neonatal outcomes. Rapid onset, severe hyponatraemia has been reported with proton-pump inhibitor therapy in non-pregnant individuals. Gastro-oesophageal reflux is very common during pregnancy, and proton-pump inhibitors are available without a prescription in many countries. A case of severe maternal hyponatraemia in the setting of recent omeprazole therapy is presented. Health professionals should be aware of this complication given the availability of proton-pump inhibitors without prescription and high rates of gestational gastro-oesophageal reflux...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074211/a-curious-case-of-covid-toes-in-pregnancy
#2
Harold Wilson-Morkeh, Iona Thorne
The novel coronavirus of 2019 (COVID-19) can affect multiple organ systems with a wide spectrum of illness severity. Its effect on the respiratory tract is well-documented and has resulted in considerable excess mortality worldwide. However, observed cutaneous manifestations of COVID-19 are rising, ranging from short-lived viral exanthems to vesicular eruptions and urticaria. An unusual subgroup of these manifestations - pseudo-chilblains, also referred to as pernio-like lesions or 'COVID toes' - describes the acral areas of erythema and oedema that can affect young individuals following COVID-19...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074210/pregnancy-in-women-with-cystic-fibrosis-and-diabetes-an-audit-of-outcomes-at-two-tertiary-obstetric-hospitals-in-australia-in-the-pre-cystic-fibrosis-transmembrane-conductance-regulator-modulator-era
#3
JOURNAL ARTICLE
Sarah J Davidson, Megan France, Leonie K Callaway, Karin Lust, Daniel Chambers, Peter Hopkins, Scott C Bell, Lucy Burr, Rebecca Keating, Helen L Barrett
BACKGROUND: Pregnancy in women with cystic fibrosis (CF) is becoming more common. Long-term metabolic issues such as diabetes are also becoming more common and have potentially important impacts on pregnancy outcomes. This study aimed to assess the impact of diabetes on pregnancy outcomes for women with CF. METHODS: We undertook a retrospective chart audit of pregnancies to women with CF at the two tertiary obstetric hospitals in Southeast Queensland associated with CF and transplant management clinics between 2006 and 2016...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074209/pregnancy-childbirth-and-neonatal-outcomes-of-women-with-rare-inherited-coagulation-disorders
#4
JOURNAL ARTICLE
Lucy Jane McCann, Erin Scullion, Lauren Doy, Etienne Ciantar
BACKGROUND: We aimed to describe the characteristics and the pregnancy outcomes of women with rare inherited coagulation factor disorders managed at a tertiary obstetric-haematology unit in the United Kingdom. METHODS: A retrospective service evaluation was conducted using routinely collected medical records. Descriptive analyses were applied to investigate pregnancy, childbirth and neonatal management and outcomes. RESULTS: Overall, 20 patients with rare inherited coagulation disorders were included who birthed 30 live infants from 29 pregnancies...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074208/a-systematic-review-of-posterior-reversible-encephalopathy-syndrome-in-pregnant-women-with-severe-preeclampsia-and-eclampsia
#5
JOURNAL ARTICLE
Dalal A Tawati, Wee-Shian Chan
BACKGROUND: The association of posterior reversible encephalopathy syndrome (PRES) and severe preeclampsia/eclampsia has been established but the frequency is uncertain. OBJECTIVES: To determine the frequency of PRES in severe preeclampsia or eclampsia. METHODS: We searched published articles in PubMed, Cochrane library, Embase, and CINAHL from 1990 to 2020. We included articles that reported on six or more cases of PRES with eclampsia or severe preeclampsia who underwent neuroimaging during pregnancy or up to 6 weeks postpartum...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074207/how-other-countries-can-improve-canada-s-maternal-mortality-statistics
#6
REVIEW
Kayvan Aflaki, Joel G Ray
Maternal mortality is the death of a woman while pregnant or within 42 days of the end of pregnancy. Late maternal deaths are from 42 to 365 days thereafter. Maternal mortality is an important surrogate indicator of a woman's overall health, social and economic status, and the provision of antenatal and emergency obstetric care at regional and national levels. Canada does not have a national system to report on maternal mortality; rather, maternal death investigations fall under the legal purview of coroners and medical examiners within each individual province or territory...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074206/a-case-of-acute-onset-paraplegia-due-to-spinal-tuberculosis-in-term-pregnancy
#7
JOURNAL ARTICLE
Aishwarya Yadav, Anuradha Singh, Kiran Aggarwal
Acute paraplegia in pregnancy is uncommon but can result from pathology including Guillain-Barre syndrome, acute transverse myelitis, and spinal tuberculosis, also known as Pott's disease of the spine. India has a high incidence of tuberculosis (2.8 million cases annually) therefore spinal tuberculosis is a particularly important disease to consider during pregnancy. Management of spinal tuberculosis in pregnancy poses a challenge especially at term gestation as immobilization of the spine and maintaining supination is difficult, particularly at delivery...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074205/cardiac-tamponade-during-pregnancy-due-to-primary-lung-cancer-a-case-report
#8
Tomomichi Ito, Norikazu Watanabe, Mariko Watanabe, Urara Idei, Keiko Yamanouchi, Masamichi Sato, Masafumi Watanabe, Satoru Nagase
We report a rare case of cardiac tamponade caused by lung cancer in a pregnant woman. A 32-year-old multiparous pregnant woman was admitted to the hospital at 15 weeks of gestation with a persistent cough and dyspnea. Transthoracic echocardiography revealed a pericardial effusion with evidence of tamponade physiology. Computed tomography (CT) revealed a massive pericardial effusion and a left lung tumor. Pericardial tamponade was successfully treated using pericardiocentesis. She was diagnosed with lung adenocarcinoma stage IVB based on bronchoscopic lung biopsy, which showed adenocarcinoma and CT, which showed brain metastasis...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074204/editorial-meetings-education-and-collaboration
#9
EDITORIAL
Stephen E Lapinsky, Jessica Gehlert, Charlotte J Frise
No abstract text is available yet for this article.
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074203/dialysis-and-a-plant-based-diet-to-achieve-physiologic-urea-levels-for-fetal-benefit-normal-pregnancy-outcome-despite-chronic-kidney-disease-and-hypertension
#10
Emma Seed, Elise Gilbertson
Chronic kidney disease significantly increases the risk of adverse maternal and perinatal outcomes. A growing body of evidence suggests that intensive dialysis, achieving physiologic pre-dialysis blood urea, is associated with decreased morbidity. We report a case of a successful pregnancy outcome in a 32-year-old nulliparous woman with stage 4 chronic kidney disease who underwent haemodialysis from 11 to 31 weeks' gestation for fetal benefit and concurrently trialled a plant-based diet. We hypothesise that her dietary changes assisted with urea reduction, enabling her to become dialysis independent...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074202/acute-leg-pain-and-weakness-in-pregnancy-a-new-diagnosis-of-myotonic-dystrophy
#11
JOURNAL ARTICLE
Vanessa C Heron, Ashmitha Thomas, Bonnia Liu, Amy A Crosthwaite, Hannah Skrzypek, Catriona A McLean, Kathy Paizis
We present a unique case of a 44-year-old woman who presented at 29 weeks' gestation with proximal limb pain and elevated creatine kinase. This occurred in the background of premature cataracts, atrial fibrillation and abnormal liver function. Clinical, pathological and neurodiagnostic findings supported a diagnosis of myotonic dystrophy, confirmed by genetic testing which revealed dystrophia myotonica protein kinase gene expansion. Muscle biopsy found both recent necrotising and chronic myopathic processes...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074201/outcomes-of-pregnant-women-hospitalized-with-unrepaired-congenital-heart-disease-insights-from-a-multidisciplinary-center-in-vietnam
#12
JOURNAL ARTICLE
Thanh-Huong Truong, Ngoc-Thanh Kim, Dinh-Phuc Nguyen, Mai-Ngoc Thi Nguyen, Doan-Loi Do, Thanh-Tung Le, Hong-An Le
BACKGROUND: In developing countries, fewer women have access to multidisciplinary congenital heart disease and reproductive programs staffed by experts. We report pregnancy outcomes of a multidisciplinary healthcare strategy utilizing an in-hospital teamwork approach in Vietnam. METHODS: This retrospective cohort study included pregnant women with unrepaired congenital heart disease managed at a referral cardiovascular center. RESULTS: Undiagnosed congenital heart disease before pregnancy, a lack of pre-pregnancy cardiology counseling, and modified World Health Organization class III/IV were common...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074200/haematinic-deficiency-in-pregnancy-another-hellp-mimic
#13
JOURNAL ARTICLE
Lauren J Green, Christina Yl Aye, Rayan Mohamed-Ahmed, Balvinder Sagoo, Lucy Mant, Charlotte J Frise
Haematinic deficiency is not uncommon in pregnancy. Folate deficiency is more common than B12 deficiency because of the increased uptake of folate in pregnancy, and the fact that B12 stores take much longer to deplete. Described here are five cases of anaemia in pregnancy secondary to severe haematinic deficiency with subsequent management and pregnancy outcomes. In the majority of cases, the women were proteinuric, but systemically well and normotensive. Thrombotic thrombocytopenic purpura and HELLP were both considered, but the identification of very abnormal folate levels of less than 3 μg/L in all and low B12 deficiency in the majority made haematinic deficiency the most likely diagnosis...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/38074199/cutaneous-hypersensitivity-reaction-to-low-molecular-weight-heparins-in-pregnancy-cross-reactivity-and-prednisolone-treatment-a-case-report
#14
JOURNAL ARTICLE
Susana Saraiva, Matilde Martins, Sara Sereno, Patrícia Ferreira, Augusta Pinto, Cátia Rasteiro
In pregnant women, low molecular weight heparin is recommended as the preferred agent for venous thromboembolism prophylaxis and treatment. Despite their widespread application, heparin-induced skin lesions are probably under-reported and under-estimated. We present a case report of a primigravida treated with low molecular weight heparin for deep vein thrombosis, who developed a delayed-type hypersensitivity reaction to enoxaparin, tinzaparin and dalteparin. As the patient was pregnant, treatment options were restricted...
December 2023: Obstetric Medicine
https://read.qxmd.com/read/37720005/gordon-s-syndrome-in-pregnancy
#15
REVIEW
Adam Morton
Gordon's syndrome, also known as pseudohypoaldosteronism type II and familial hyperkalaemic hypertension, is a rare inherited condition characterised by familial hyperkalaemia, normal anion gap hyperchloraemic metabolic acidosis, low renin with normal glomerular filtration rate and hypertension. The outcome of 11 pregnancies in 3 women with Gordon's syndrome is presented and combined with 13 pregnancies in 7 women previously described. Pregnancy in women with Gordon's syndrome appears to be associated with a significant risk of adverse pregnancy outcomes, particularly where there is maternal hypertension preconception...
September 2023: Obstetric Medicine
https://read.qxmd.com/read/37720004/impact-of-the-covid-19-pandemic-on-perinatal-mental-health-screening-illness-and-pregnancy-outcomes-a-cohort-study
#16
JOURNAL ARTICLE
Andre C Q Lo, Michelle Kemp, Nikolett Kabacs
BACKGROUND: The aim was to explore the impact of the COVID-19 pandemic on perinatal mental health screening, illness and related pregnancy complications/outcomes. METHODS: A single-centre retrospective cohort study in mothers giving birth before versus during the pandemic. Primary outcomes were the comparative prevalence/incidence of peripartum psychiatric diagnoses. Secondary outcomes were the pandemic's effect on psychiatric screening accuracy, and on other pregnancy outcomes linked to mental health...
September 2023: Obstetric Medicine
https://read.qxmd.com/read/37720003/-obstetric-medicine-impact-factors-and-publishing
#17
EDITORIAL
Stephen E Lapinsky, Charlotte J Frise
No abstract text is available yet for this article.
September 2023: Obstetric Medicine
https://read.qxmd.com/read/37720002/postpartum-complications-following-neuraxial-anaesthesia-for-obstetric-physicians
#18
REVIEW
Heather Lawrence, Adam Morton
Neuraxial analgesia and anaesthesia are widely accepted and well-tolerated modes of delivery analgesia, being employed in up to 76% of vaginal deliveries and 94% of caesarean deliveries in the United States.1 A cause of considerable concern for postpartum women, their family and caring health professionals is the occurrence of unexplained postpartum complications, not only for management in the index pregnancy, but the uncertain risk of recurrence in future pregnancies. Complications of neuraxial blocks may impact significantly on the ability of mothers to care for and bond with their newborn...
September 2023: Obstetric Medicine
https://read.qxmd.com/read/37720001/crigler-najjar-type-ii-in-pregnancy-a-case-report
#19
Katherine Creeper, Dorothy Graham
Crigler-Najjar is a rare, autosomal recessive disorder that results in mutations causing a complete absence (type I) or deficiency (type II) of the hepatic uridine diphospho-glucuronosyl transferase (UDPGT) enzyme. Both forms, however, result in unconjugated hyperbilirubinaemia which can lead to kernicterus and potentially death. Phenobarbitone can be used as an enzyme inducer in Type II to facilitate a reduction in total serum bilirubin. We report two consecutive pregnancies in a 29-year-old woman with Crigler-Najjar Type II syndrome...
September 2023: Obstetric Medicine
https://read.qxmd.com/read/37720000/maternal-health-and-pregnancy-outcomes-in-autosomal-dominant-tubulointerstitial-kidney-disease
#20
JOURNAL ARTICLE
Anthony J Bleyer, Kendrah O Kidd, Adrienne H Williams, Emily Johnson, Victoria Robins, Lauren Martin, Abbigail Taylor, Alice Kim, Isai Bowline, Dervla M Connaughton, Carl D Langefeld, Martina Zivna, Stanislav Kmoch
INTRODUCTION: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized cause of chronic kidney disease. ADTKD pregnancy outcomes have not previously been described. METHODS: A cross-sectional survey was sent to women from ADTKD families. RESULTS: Information was obtained from 85 afffected women (164 term pregnancies) and 23 controls (50 pregnancies). Only 16.5% of genetically affected women knew they had ADTKD during pregnancy...
September 2023: Obstetric Medicine
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