Mirza Alimullah, Asif Ul Haque Shuvo, Ishrat Jahan, Iffat Nowshin Ismail, S M Mufidul Islam, Mahnaj Sultana, Mahmudur Rahman Saad, Sabbir Raihan, Ferdous Khan, Md Ashraful Alam, Nusrat Subhan
Liver fibrosis, developed in almost all chronic liver injuries. Epidermal growth factor receptors (EGFR) have been thought to contribute to cirrhosis and liver fibrosis. Therefore, using a rat model of carbon tetrachloride (CCl4 )-induced liver fibrogenesis, we investigated the preventive effects of cetuximab, an inhibitor of the EGF receptor (EGFR). Ameliorative effects of cetuximab were examined in rats, brought on by biweekly doses of 50 mg/kg of carbon tetrachloride (CCl4 ). There were a total of 24 male Long Evans rats split up into four distinct groups such as control, CCl4, control+cetuximab and CCl4 +cetuximab...
July 2024: Biochemistry and Biophysics Reports