journal
https://read.qxmd.com/read/36900148/clinical-characteristics-and-current-status-of-treatment-for-recurrent-bladder-cancer-after-surgeries-on-upper-tract-urothelial-carcinoma
#1
REVIEW
Xinfeng Hu, Yufan Xue, Guodong Zhu
Upper tract urothelial carcinoma (UTUC) is a relatively rare, but highly malignant, disease with an estimated annual incidence of 2 cases per 100,000 people. The main surgical treatment modalities for UTUC are radical nephroureterectomy (RNU) with bladder cuff resection. After surgery, intravesical recurrence (IVR) can occur in up to 47% of patients, and 75% of them present with non-muscle invasive bladder cancer (NMIBC). However, there are few studies focused on the diagnosis and treatment of postoperatively recurrent bladder cancer for patients with previous UTUC history (UTUC-BC), and many of the influencing factors are still controversial...
March 6, 2023: Diagnostics
https://read.qxmd.com/read/36900147/comparison-of-ultra-magnifying-endocytoscopic-and-hematoxylin-eosin-stained-images-of-lung-specimens
#2
JOURNAL ARTICLE
Misato Kobayashi, Noriaki Kurimoto, Ryosuke Tanino, Yohei Shiratsuki, Takae Okuno, Mika Nakao, Takamasa Hotta, Yukari Tsubata, Makoto Nagasaki, Takashi Nishisaka, Takeshi Isobe
Endocytoscopy enables real-time observation of lesions at ultra-magnification. In the gastrointestinal and respiratory fields, endocytoscopic images are similar to hematoxylin-eosin-stained images. This study aimed to compare the nuclear features of pulmonary lesions in endocytoscopic and hematoxylin-eosin-stained images. We performed an endocytoscopy to observe resected specimens of normal lung tissue and lesions. Nuclear features were extracted using ImageJ. We analyzed five nuclear features: nuclear number per area, mean nucleus area, median circularity, coefficient of variation of roundness, and median Voronoi area...
March 6, 2023: Diagnostics
https://read.qxmd.com/read/36900146/high-frequency-ultrasound-in-diagnosis-and-treatment-of-non-melanoma-skin-cancer-in-the-head-and-neck-region
#3
JOURNAL ARTICLE
Tiberiu Tamas, Cristian Dinu, Lavinia Manuela Lenghel, Emil Boțan, Adela Tamas, Sebastian Stoia, Daniel Corneliu Leucuta, Simion Bran, Florin Onisor, Grigore Băciuț, Gabriel Armencea, Mihaela Băciuț
Non-melanoma skin cancer is one of the most frequently diagnosed cancers in the human body and unfortunately the incidence continues to increase. NMSC is represented by the basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs), which are the most prevalent forms, and basosquamous cell carcinomas (BSC) together with Merkel cell carcinoma (MCC), which are rare types but with a very aggressive pattern and poor prognosis. The pathological diagnosis is hard to assess without a biopsy, even by the dermoscopy...
March 6, 2023: Diagnostics
https://read.qxmd.com/read/36900145/diabetic-retinopathy-and-diabetic-macular-edema-detection-using-ensemble-based-convolutional-neural-networks
#4
JOURNAL ARTICLE
Swaminathan Sundaram, Meganathan Selvamani, Sekar Kidambi Raju, Seethalakshmi Ramaswamy, Saiful Islam, Jae-Hyuk Cha, Nouf Abdullah Almujally, Ahmed Elaraby
Diabetic retinopathy (DR) and diabetic macular edema (DME) are forms of eye illness caused by diabetes that affects the blood vessels in the eyes, with the ground occupied by lesions of varied extent determining the disease burden. This is among the most common cause of visual impairment in the working population. Various factors have been discovered to play an important role in a person's growth of this condition. Among the essential elements at the top of the list are anxiety and long-term diabetes. If not detected early, this illness might result in permanent eyesight loss...
March 6, 2023: Diagnostics
https://read.qxmd.com/read/36900144/rise-of-the-bq-1-1-37-sars-cov-2-sublineage-italy
#5
JOURNAL ARTICLE
Daniele Focosi, Pietro Giorgio Spezia, Anna-Lisa Capria, Federico Gueli, Scott McConnell, Federica Novazzi, Mauro Pistello
BQ.1.1 has dominated the Europe and Americas COVID-19 wave across the 2022-2023 winter, and further viral evolution is expected to escape the consolidating immune responses. We report here the emergence of the BQ.1.1.37 variant in Italy, peaking in January 2022 before suffering competition by XBB.1.*. We attempted to correlate the potential fitness of BQ.1.1.37 with a unique two-amino acid insertion within the Spike protein.
March 6, 2023: Diagnostics
https://read.qxmd.com/read/36900143/the-prevalence-and-risk-factors-of-chronic-heart-failure-in-the-mongolian-population
#6
JOURNAL ARTICLE
Pagmadulam Sukhbaatar, Batzorig Bayartsogt, Ganchimeg Ulziisaikhan, Bolortuul Byambatsogt, Chingerel Khorloo, Burmaa Badrakh, Sumiya Tserendavaa, Naranchimeg Sodovsuren, Mungunchimeg Dagva, Mungun-Ulzii Khurelbaatar, Sodchimeg Tsedensodnom, Bat-Erdene Nyamsuren, Rinchyenkhand Myagmardorj, Tsolmon Unurjargal
BACKGROUND: The prevalence of heart failure in the Mongolian population is unknown. Thus, in this study, we aimed to define the prevalence of heart failure in the Mongolian population and to identify significant risk factors for heart failure among Mongolian adults. METHODS: This population-based study included individuals 20 years and older from seven provinces as well as six districts of the capital city of Mongolia. The prevalence of heart failure was based on the European Society of Cardiology diagnostic criteria...
March 6, 2023: Diagnostics
https://read.qxmd.com/read/36900142/association-of-body-mass-index-bmi-with-lip-morphology-characteristics-a-cross-sectional-study-based-on-chinese-population
#7
JOURNAL ARTICLE
Yiyin Chen, Hongmei Yang, Zhijin Zheng, Xiaoqi Zhang, Xinyu Yan, Hu Long, Wenli Lai
BACKGROUND: Lip morphology is essential in diagnosis and treatment of orthodontics and orthognathic surgery to ensure facial aesthetics. Body mass index (BMI) has proved to have influence on facial soft tissue thickness, but its relationship with lip morphology is unclear. This study aimed to evaluate the association between BMI and lip morphology characteristics (LMCs) and thus provide information for personalized treatment. METHODS: A cross-sectional study consisted of 1185 patients from 1 January 2010 to 31 December 2020 was conducted...
March 6, 2023: Diagnostics
https://read.qxmd.com/read/36900141/association-of-vitamin-d-deficiency-and-insufficiency-with-pathology-in-hospitalized-patients
#8
JOURNAL ARTICLE
Sandica Bucurica, Ioana Prodan, Mihaela Pavalean, Corina Taubner, Ana Bucurica, Calin Socol, Roxana Calin, Florentina Ionita-Radu, Mariana Jinga
Vitamin D deficiency is one of the most common medical conditions, with approximately one billion people having low vitamin D levels. Vitamin D is associated with a pleiotropic effect (immunomodulatory, anti-inflammatory and antiviral), which can be essential for a better immune response. The aim of this research was to evaluate the prevalence of vitamin D deficiency/insufficiency in hospitalized patients focusing on demographic parameters as well as assessing the possibility of its associations with different comorbidities...
March 6, 2023: Diagnostics
https://read.qxmd.com/read/36900140/super-resolution-of-dental-panoramic-radiographs-using-deep-learning-a-pilot-study
#9
JOURNAL ARTICLE
Hossein Mohammad-Rahimi, Shankeeth Vinayahalingam, Erfan Mahmoudinia, Parisa Soltani, Stefaan J Bergé, Joachim Krois, Falk Schwendicke
Using super-resolution (SR) algorithms, an image with a low resolution can be converted into a high-quality image. Our objective was to compare deep learning-based SR models to a conventional approach for improving the resolution of dental panoramic radiographs. A total of 888 dental panoramic radiographs were obtained. Our study involved five state-of-the-art deep learning-based SR approaches, including SR convolutional neural networks (SRCNN), SR generative adversarial network (SRGAN), U-Net, Swin for image restoration (SwinIr), and local texture estimator (LTE)...
March 6, 2023: Diagnostics
https://read.qxmd.com/read/36900139/ultrasonic-diagnosis-of-intestinal-obstruction-in-neonates-original-article
#10
JOURNAL ARTICLE
Binbin Guo, Lin Pang, Chang Liu, Xiaoya Chen, Qiang Qiao, Cong Zhang
BACKGROUND: Intestinal obstruction in neonates is a common problem that requires prompt diagnosis and treatment, and ultrasound could be a potential tool for it. The purpose of this study was to investigate the accuracy of ultrasonography in diagnosing and identifying the cause of intestinal obstruction in neonates, the corresponding ultrasonic manifestations, as well as to utilize the diagnostic method. METHODS: We conducted a retrospective study of all neonatal intestinal obstruction in our institute between 2009 and 2022...
March 6, 2023: Diagnostics
https://read.qxmd.com/read/36900138/differentiation-of-spontaneous-bacterial-peritonitis-from-secondary-peritonitis-in-patients-with-liver-cirrhosis-retrospective-multicentre-study
#11
JOURNAL ARTICLE
Silvia Würstle, Alexander Hapfelmeier, Siranush Karapetyan, Fabian Studen, Andriana Isaakidou, Tillman Schneider, Roland M Schmid, Stefan von Delius, Felix Gundling, Rainer Burgkart, Andreas Obermeier, Ulrich Mayr, Marc Ringelhan, Sebastian Rasch, Tobias Lahmer, Fabian Geisler, Paul E Turner, Benjamin K Chan, Christoph D Spinner, Jochen Schneider
Ascitic fluid infection is a serious complication of liver cirrhosis. The distinction between the more common spontaneous bacterial peritonitis (SBP) and the less common secondary peritonitis in patients with liver cirrhosis is crucial due to the varying treatment approaches. This retrospective multicentre study was conducted in three German hospitals and analysed 532 SBP episodes and 37 secondary peritonitis episodes. Overall, >30 clinical, microbiological, and laboratory parameters were evaluated to identify key differentiation criteria...
March 6, 2023: Diagnostics
https://read.qxmd.com/read/36900137/assessment-of-the-carotid-bodies-in-magnetic-resonance-a-head-to-head-comparison-with-computed-tomography
#12
JOURNAL ARTICLE
Lukasz Budynko, Tomasz K Nowicki, Mariusz F Kaszubowski, Dominik Swieton, Maciej Piskunowicz
OBJECTIVES: To evaluate carotid body visibility in contrast-enhanced magnetic resonance (MR) studies and to compare the results to contrast-enhanced computed tomography (CT). METHODS: Two observers separately evaluated MR and CT examinations of 58 patients. MR scans were acquired with contrast-enhanced isometric T1-weighted water-only Dixon sequence. CT examinations were performed 90 s after contrast agent administration. Carotid bodies' dimensions were noted and their volumes calculated...
March 5, 2023: Diagnostics
https://read.qxmd.com/read/36900136/more-than-just-skin-deep-a-review-of-imaging-s-role-in-guiding-car-t-cell-therapy-for-advanced-melanoma
#13
REVIEW
Conor M Prendergast, Kathleen M Capaccione, Egesta Lopci, Jeeban P Das, Alexander N Shoushtari, Randy Yeh, Daniel Amin, Laurent Dercle, Dorine De Jong
Advanced melanoma is one of the deadliest cancers, owing to its invasiveness and its propensity to develop resistance to therapy. Surgery remains the first-line treatment for early-stage tumors but is often not an option for advanced-stage melanoma. Chemotherapy carries a poor prognosis, and despite advances in targeted therapy, the cancer can develop resistance. CAR T-cell therapy has demonstrated great success against hematological cancers, and clinical trials are deploying it against advanced melanoma. Though melanoma remains a challenging disease to treat, radiology will play an increasing role in monitoring both the CAR T-cells and response to therapy...
March 5, 2023: Diagnostics
https://read.qxmd.com/read/36900135/secondary-breast-malignancy-from-renal-cell-carcinoma-challenges-in-diagnosis-and-treatment-case-report
#14
Marko Spasic, Dusan Zaric, Minja Mitrovic, Sanja Milojevic, Nikola Nedovic, Marija Sekulic, Bojan Stojanovic, Dejan Vulovic, Bojan Milosevic, Filip Milutinovic, Neda Milosavljevic
Renal cell carcinoma represents about 2% of all malignant tumours in adults. Metastases of the primary tumour in the breast make up to about 0.5-2% of the cases. Renal cell carcinoma metastases in the breast are extremely rare and have been sporadically recorded in the literature. In this paper, we present the case of a patient with breast metastasis of renal cell carcinoma 11 years after primary treatment. Case presentation: An 82-year-old female who had right nephrectomy due to renal cancer in 2010 felt a lump in her right breast in August 2021, whereby a clinical examination revealed a tumour at the junction of the upper quadrants of her right breast, about 2 cm, movable toward the base, vaguely limited, and with a rough surface...
March 5, 2023: Diagnostics
https://read.qxmd.com/read/36900134/advanced-imaging-for-robotic-bronchoscopy-a-review
#15
REVIEW
Nakul Ravikumar, Elliot Ho, Ajay Wagh, Septimiu Murgu
Recent advances in navigational platforms have led bronchoscopists to make major strides in diagnostic interventions for pulmonary parenchymal lesions. Over the last decade, multiple platforms including electromagnetic navigation and robotic bronchoscopy have allowed bronchoscopists to safely navigate farther into the lung parenchyma with increased stability and accuracy. Limitations persist, even with these newer technologies, in achieving a similar or higher diagnostic yield when compared to the transthoracic computed tomography (CT) guided needle approach...
March 5, 2023: Diagnostics
https://read.qxmd.com/read/36900133/impact-of-breathing-phase-liver-segment-and-prandial-state-on-ultrasound-shear-wave-speed-shear-wave-dispersion-and-attenuation-imaging-of-the-liver-in-healthy-volunteers
#16
JOURNAL ARTICLE
Catherine Paverd, Sivert Kupfer, Iara Nascimento Kirchner, Sherin Nambiar, Alexander Martin, Naiara Korta Martiartu, Thomas Frauenfelder, Marga B Rominger, Lisa Ruby
OBJECTIVES: Measurement location and patient state can impact noninvasive liver assessment and change clinical staging in ultrasound examinations. Research into differences exists for Shear Wave Speed (SWS) and Attenuation Imaging (ATI), but not for Shear Wave Dispersion (SWD). The aim of this study is to assess the effect of breathing phase, liver lobe, and prandial state on SWS, SWD, and ATI ultrasound measurements. METHODS: Two experienced examiners performed SWS, SWD, and ATI measurements in 20 healthy volunteers using a Canon Aplio i800 system...
March 5, 2023: Diagnostics
https://read.qxmd.com/read/36900132/outpatient-hysteroscopic-polypectomy-a-retrospective-study-comparing-rigid-and-semirigid-office-hysteroscopes
#17
JOURNAL ARTICLE
Benito Chiofalo, Mauro Calandra, Valentina Bruno, Vincenzo Tarantino, Giovanni Esposito, Enrico Vizza, Giacomo Corrado, Giovanni Scambia, Ursula Catena
Endometrial polyps are one of the most common pathological conditions in gynecology. Hysteroscopy is the gold standard for the diagnosis and treatment of endometrial polyps. The purpose of this multicenter, retrospective study was to compare patients' pain perception during an operative hysteroscopic endometrial polypectomy in an outpatient setting with two different hysteroscopes (rigid and semirigid) and to identify some clinical and intraoperative characteristics that are related to worsening pain during the procedure...
March 5, 2023: Diagnostics
https://read.qxmd.com/read/36900131/mechanisms-of-resistance-to-cdk4-6-inhibitors-and-predictive-biomarkers-of-response-in-hr-her2-metastatic-breast-cancer-a-review-of-the-literature
#18
REVIEW
Ioana-Miruna Stanciu, Andreea Ioana Parosanu, Cristina Orlov-Slavu, Ion Cristian Iaciu, Ana Maria Popa, Cristina Mihaela Olaru, Cristina Florina Pirlog, Radu Constantin Vrabie, Cornelia Nitipir
The latest and newest discoveries for advanced and metastatic hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancer are the three cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) in association with endocrine therapy (ET). However, even if this treatment revolutionized the world and continued to be the first-line treatment choice for these patients, it also has its limitations, caused by de novo or acquired drug resistance which leads to inevitable progression after some time...
March 5, 2023: Diagnostics
https://read.qxmd.com/read/36900130/a-high-efficiency-consultation-improves-urological-diagnosis-in-patients-with-complex-luts-a-pilot-study
#19
JOURNAL ARTICLE
Alexandru Ciudin, Bernat Padulles, Pasqualino Manasia, Josep Alcoberro, Sanae Ounia, Maria Lopez, Natalia Allue, Joan Maria Ferrer, Jaume Duran, Antonio Aguilar
(1) Background: The diagnosis of moderate-severe lower urinary tract symptoms (LUTS) is not easy due to the complexity of the micturition act. Sequential diagnostic tests can be time consuming due to waiting lists. Thus, we developed a diagnostic model combining all the tests in a single one-stop consultation. (2) Methods: In a prospective pilot study in patients with complex LUTS, they received all diagnostic tests (ultrasound, uroflowmetry, cystoscopy, pressure-flow study) in a single consultation and by the same doctor...
March 4, 2023: Diagnostics
https://read.qxmd.com/read/36900129/differentiating-fordyce-spots-from-their-common-simulators-using-ultraviolet-induced-fluorescence-dermatoscopy-retrospective-study
#20
JOURNAL ARTICLE
Paweł Pietkiewicz, Cristian Navarrete-Dechent, Mohamad Goldust, Katarzyna Korecka, Verce Todorovska, Enzo Errichetti
Fordyce spots (FS) are heterotopic sebaceous glands affecting mostly oral and genital mucosa, commonly misdiagnosed with sexually transmitted infections. In a single-center retrospective study, we aimed to assess the ultraviolet-induced fluorescencedermatoscopy (UVFD) clues of Fordyce spots and their common clinical simulants: molluscum contagiosum, penile pearly papules, human papillomavirus warts, genital lichen planus, and genital porokeratosis. Analyzed documentation included patients' medical records (1 September-30 October 2022) and photodocumentation, which included clinical images as well as polarized, non-polarized, and UVFD images...
March 4, 2023: Diagnostics
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