journal
https://read.qxmd.com/read/37761387/molecular-characterization-of-patients-with-cryptorchidism-preliminary-search-for-an-expression-profile-related-to-that-of-testicular-germ-cell-tumors
#1
JOURNAL ARTICLE
Fabiola García-Andrade, Rosa María Vigueras-Villaseñor, Margarita Dolores Chávez-Saldaña, Julio César Rojas-Castañeda, Ivan Uriel Bahena-Ocampo, Elena Aréchaga-Ocampo, Mauricio Flores-Fortis, José Díaz-Chávez, Luis Alonso Herrera, Daniel Adrian Landero-Huerta
Cryptorchidism (CO) is a risk factor for the development of testicular germ-cell tumors (TGCT). This is supported by reports showing the persistence of gonocytes in CO patients. These cells are proposed to be related to the development of germ-cell neoplasia in situ (GCNIS), which is considered the precursor stage/lesion of TGCT. Therefore, it is proposed that some patients with CO could express some molecular markers related to TGCT. In this study, we analyzed testicular tissue samples from CO, TGCT, and controls...
September 21, 2023: Diagnostics
https://read.qxmd.com/read/37761386/a-functional-assay-for-the-determination-of-heparin-induced-thrombocytopenia-via-flow-cytometry
#2
JOURNAL ARTICLE
Ingrid Skornova, Tomas Simurda, Lucia Stanciakova, Viliam Lauko, Pavol Holly, Matej Samos, Tomas Bolek, Martin Schnierer, Miroslava Drotarova, Kristina Maria Belakova, Juraj Sokol, Jan Stasko, Marian Mokan, Jaroslav Gumulec, Leona Chrastinova
Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of heparin therapy (both unfractionated heparin and low-molecular-weight heparin). In our study, we examined a group of 122 patients with suspected HIT. The samples of all patients were analyzed in the first step using an immunoassay (ID-PaGIA Heparin/PF4, Hemos1L-Acustar HIT IgG, ZYMUTEST HIA Monostrip IgG) to detect the presence of antibodies against heparin-PF4 complexes (platelet factor 4). When the immunoassay was positive, the sample was subsequently analyzed for HIT with a functional flow cytometry assay, the HITAlert kit, the purpose of which was to demonstrate the ability of the antibodies present to activate platelets...
September 21, 2023: Diagnostics
https://read.qxmd.com/read/37761385/the-utility-and-safety-of-a-continuous-glucose-monitoring-system-cgms-in-asphyxiated-neonates-during-therapeutic-hypothermia
#3
JOURNAL ARTICLE
Lucia Giordano, Alessandro Perri, Eloisa Tiberi, Annamaria Sbordone, Maria Letizia Patti, Vito D'Andrea, Giovanni Vento
BACKGROUND: The present study was designed to assess the feasibility and reliability of a Continuous Glucose Monitoring System (CGMS) in a population of asphyxiated neonates during therapeutic hypothermia. METHODS: This non-randomized feasibility study was conducted in the Neonatal Intensive Care Unit (NICU) facilities of Fondazione Policlinico A. Gemelli IRCSS. Infants matching the criteria for hypothermic treatment were included in this study and were connected to the CGMS (Medtronic, Northridge, CA, USA) within the first 12 h of life...
September 21, 2023: Diagnostics
https://read.qxmd.com/read/37761384/factors-influencing-visual-acuity-in-patients-with-active-subfoveal-circumscribed-polypoidal-choroidal-vasculopathy-and-changes-in-imaging-parameters
#4
JOURNAL ARTICLE
Fan Xia, Peiyu Xing, Hao Zhang, Tongtong Niu, Qi Wang, Rui Hua
We performed a retrospective, observational study of 51 eyes in 51 treatment-naïve patients with polypoidal choroidal vasculopathy (PCV), whose lesion ranged within the 6 × 6 mm scope of optical coherence tomography angiography (OCTA). The patients were divided into an ill-defined group and a well-defined group based on the pattern of branching vascular network (BVN) on OCTA. BVN morphology was not related to baseline best-corrected visual acuity (BCVA). However, the BCVA in the ill-defined BVN group (-0...
September 21, 2023: Diagnostics
https://read.qxmd.com/read/37761383/machine-learning-algorithm-predicts-mortality-risk-in-intensive-care-unit-for-patients-with-traumatic-brain-injury
#5
JOURNAL ARTICLE
Kuan-Chi Tu, Eric Nyam Tee Tau, Nai-Ching Chen, Ming-Chuan Chang, Tzu-Chieh Yu, Che-Chuan Wang, Chung-Feng Liu, Ching-Lung Kuo
BACKGROUND: Numerous mortality prediction tools are currently available to assist patients with moderate to severe traumatic brain injury (TBI). However, an algorithm that utilizes various machine learning methods and employs diverse combinations of features to identify the most suitable predicting outcomes of brain injury patients in the intensive care unit (ICU) has not yet been well-established. METHOD: Between January 2016 and December 2021, we retrospectively collected data from the electronic medical records of Chi Mei Medical Center, comprising 2260 TBI patients admitted to the ICU...
September 21, 2023: Diagnostics
https://read.qxmd.com/read/37761382/dielectric-characterization-of-breast-biopsied-tissues-as-pre-pathological-aid-in-early-cancer-detection-a-blinded-feasibility-study
#6
JOURNAL ARTICLE
Eliana Canicattì, Daniel Álvarez Sánchez-Bayuela, Cristina Romero Castellano, Paul Martín Aguilar Angulo, Rubén Giovanetti González, Lina Marcela Cruz Hernández, Juan Ruiz Martín, Gianluigi Tiberi, Agostino Monorchio
Dielectric characterization has significant potential in several medical applications, providing valuable insights into the electromagnetic properties of biological tissues for disease diagnosis, treatment planning, and monitoring of therapeutic interventions. This work presents the use of a custom-designed electromagnetic characterization system, based on an open-ended coaxial probe, for discriminating between benign and malignant breast tissues in a clinical setting. The probe's development involved a well-balanced compromise between physical feasibility and its combined use with a reconstruction algorithm known as the virtual transmission line model (VTLM)...
September 21, 2023: Diagnostics
https://read.qxmd.com/read/37761381/volume-assisted-estimation-of-remnant-liver-function-based-on-gd-eob-dtpa-enhanced-mr-relaxometry-a-prospective-observational-trial
#7
JOURNAL ARTICLE
Niklas Verloh, Carolina Rio Bartulos, Kirsten Utpatel, Frank Brennfleck, Andrea Goetz, Andreas Schicho, Claudia Fellner, Dominik Nickel, Florian Zeman, Johannes F Steinmann, Wibke Uller, Christian Stroszczynski, Hans-Jürgen Schlitt, Phillip Wiggermann, Michael Haimerl
In the context of liver surgery, predicting postoperative liver dysfunction is essential. This study explored the potential of preoperative liver function assessment by MRI for predicting postoperative liver dysfunction and compared these results with the established indocyanine green (ICG) clearance test. This prospective study included patients undergoing liver resection with preoperative MRI planning. Liver function was quantified using T1 relaxometry and correlated with established liver function scores...
September 21, 2023: Diagnostics
https://read.qxmd.com/read/37761380/machine-learning-ct-based-automatic-nodal-segmentation-and-pet-semi-quantification-of-intraoperative-68-ga-psma-11-pet-ct-images-in-high-risk-prostate-cancer-a-pilot-study
#8
JOURNAL ARTICLE
Guido Rovera, Serena Grimaldi, Marco Oderda, Monica Finessi, Valentina Giannini, Roberto Passera, Paolo Gontero, Désirée Deandreis
High-resolution intraoperative PET/CT specimen imaging, coupled with prostate-specific membrane antigen (PSMA) molecular targeting, holds great potential for the rapid ex vivo identification of disease localizations in high-risk prostate cancer patients undergoing surgery. However, the accurate analysis of radiotracer uptake would require time-consuming manual volumetric segmentation of 3D images. The aim of this study was to test the feasibility of using machine learning to perform automatic nodal segmentation of intraoperative 68 Ga-PSMA-11 PET/CT specimen images...
September 21, 2023: Diagnostics
https://read.qxmd.com/read/37761379/a-rare-axillary-lymph-node-metastasis-on-18-f-fdg-pet-ct-for-staging-in-a-patient-with-common-bile-duct-cancer
#9
JOURNAL ARTICLE
Yeongjoo Lee, Hye Sung Won, Kyung Jin Seo, Sae Jung Na
Distant metastasis of cholangiocarcinoma is most commonly diagnosed in the liver; however, it can also be found in the lungs, distant lymph nodes, bones, and brain. Distant lymph node metastasis outside the abdominal region without concurrent abdominal metastasis is exceedingly rare in extrahepatic cholangiocarcinoma. Herein, we present interesting 18 F-FDG PET/CT images of a 49-year-old male patient with common bile duct cancer. In this case, the patient, who was scheduled for surgery, unexpectedly showed axillary lymph node metastasis on a preoperative 18 F-FDG PET scan, which was subsequently confirmed via histological examination...
September 21, 2023: Diagnostics
https://read.qxmd.com/read/37761378/one-stage-detection-without-segmentation-for-multi-type-coronary-lesions-in-angiography-images-using-deep-learning
#10
JOURNAL ARTICLE
Hui Wu, Jing Zhao, Jiehui Li, Yan Zeng, Weiwei Wu, Zhuhuang Zhou, Shuicai Wu, Liang Xu, Min Song, Qibin Yu, Ziwei Song, Lin Chen
It is rare to use the one-stage model without segmentation for the automatic detection of coronary lesions. This study sequentially enrolled 200 patients with significant stenoses and occlusions of the right coronary and categorized their angiography images into two angle views: The CRA (cranial) view of 98 patients with 2453 images and the LAO (left anterior oblique) view of 176 patients with 3338 images. Randomization was performed at the patient level to the training set and test set using a 7:3 ratio. YOLOv5 was adopted as the key model for direct detection...
September 21, 2023: Diagnostics
https://read.qxmd.com/read/37761377/extraction-free-detection-of-sars-cov-2-viral-rna-using-lumiradx-s-rna-star-complete-assay-from-clinical-nasal-swabs-stored-in-a-novel-collection-and-transport-medium
#11
JOURNAL ARTICLE
Luke T Daum, John D Rodriguez, Susan R Ward, James P Chambers
Background: The rapid detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is vital for patient care. The LumiraDx™ SARS-CoV-2 RNA Star Complete (RSC) is an Emergency Use Authorization -recognized molecular test using nasal/nasopharyngeal swabs immersed in a viral/universal transport medium (VTM/UTM). However, there is a critical need for an alternative medium for point-of-care testing (POCT). This study aimed to investigate Xtract-Free (XF), a novel collection medium for transport and direct (extraction-free) use with nucleic acid tests...
September 21, 2023: Diagnostics
https://read.qxmd.com/read/37761376/a-new-classification-of-the-morphology-of-complete-ponticulus-posticus-on-cone-beam-computed-tomography
#12
JOURNAL ARTICLE
Raphael Olszewski, Julien Issa, Guillaume-Anthony Odri
UNLABELLED: The objectives of this retrospective study were to measure the prevalence of complete ponticulus posticus (CPP), to propose a new classification based on two different shapes of CPP, to compare these shapes with age and gender, and to test two different methods of measurements of the diameters of CPP on cone beam computed tomography (CBCT). MATERIAL AND METHODS: We used 2012 CBCT scans from Planmeca Promax 3D Mid and Romexis 5.1 software tools to measure the height and width of the CPP, and we measured the surface of the CPP using an ellipse tool...
September 21, 2023: Diagnostics
https://read.qxmd.com/read/37761375/palpation-and-ultrasonography-reveal-an-ignored-function-of-the-inferior-belly-of-omohyoid-a-case-series-and-a-proof-of-concept-study
#13
JOURNAL ARTICLE
Juan J Canoso, José Alvarez Nemegyei, Esperanza Naredo, Jorge Murillo González, José Ramón Mérida Velasco, Cristina Hernández Díaz, Otto Olivas Vergara, José Guillermo Alvarez Acosta, José Eduardo Navarro Zarza, Robert A Kalish
BACKGROUND: Palpation, a traditional haptic ability, is used daily by practitioners of all medical and surgical specialties to assess patients. In the current study, one of the authors, in a routine clinical setting, was able to deduce the dynamic features of the putative inferior belly of omohyoid. This led to a proof-of-concept study that yielded results consistent with the clinical findings. METHODS: The first part of the study involved a survey of 300 rheumatic disease patients in whom the greater supraclavicular fossa was explored by palpation...
September 20, 2023: Diagnostics
https://read.qxmd.com/read/37761374/indeterminate-thyroid-nodules-from-cytology-to-molecular-testing
#14
REVIEW
Paola Vignali, Elisabetta Macerola, Anello Marcello Poma, Rebecca Sparavelli, Fulvio Basolo
Thyroid cancer is the most common malignancy of the endocrine system. Fine-needle aspiration (FNA) biopsy of thyroid nodules has become the gold standard procedure, in terms of cost and efficacy, for guiding clinicians towards appropriate patients' management. One challenge for cytopathologists is to accurately classify cytological specimens as benign or malignant based on cytomorphological features. In fact, with a frequency ranging from 10% to 30%, nodules are diagnosed as indeterminate. In recent years, the mutational landscape of thyroid tumors has been extensively described, and two molecular profiles have been identified: RAS -like ( NRAS , HRAS, and KRAS mutations; EIF1AX mutations; BRAF K601E mutation; and PPARG and THADA fusions) and BRAF V600E -like (including BRAF V600E mutation and RET and BRAF fusions)...
September 20, 2023: Diagnostics
https://read.qxmd.com/read/37761373/a-review-of-recent-advances-in-brain-tumor-diagnosis-based-on-ai-based-classification
#15
REVIEW
Reham Kaifi
Uncontrolled and fast cell proliferation is the cause of brain tumors. Early cancer detection is vitally important to save many lives. Brain tumors can be divided into several categories depending on the kind, place of origin, pace of development, and stage of progression; as a result, tumor classification is crucial for targeted therapy. Brain tumor segmentation aims to delineate accurately the areas of brain tumors. A specialist with a thorough understanding of brain illnesses is needed to manually identify the proper type of brain tumor...
September 20, 2023: Diagnostics
https://read.qxmd.com/read/37761372/observation-of-anatomical-structures-in-the-human-larynx-using-micro-computed-tomography-with-lugol-s-solution-enhancement
#16
JOURNAL ARTICLE
Kyu-Ho Yi, Siyun Lee, Ji-Hyun Lee, Hyung-Jin Lee
Histological and naked-eye dissections are frequently used to investigate human anatomy. However, limitations of conventional methods include tissue damage and difficulty in observing structures, rendering findings limited. Micro-computed tomography (micro-CT) allows for a three-dimensional observation with whole-mount staining for contrast enhancement. A precise anatomical understanding of the larynx is essential for both the medical and surgical fields; however, the larynx is difficult to dissect because of its minuscule and complex structures...
September 20, 2023: Diagnostics
https://read.qxmd.com/read/37761371/comparison-of-18-f-fdg-pet-ct-and-68-ga-fapi-in-spindle-cell-rhabdomyosarcoma
#17
JOURNAL ARTICLE
Zhihui Shen, Ruimin Wang
We report a rare case of spindle cell rhabdomyosarcoma. Sarcomas generally exhibit an abnormal increased FDG uptake on 18 F-FDG PET/CT imaging, while spindle cell rhabdosarcomas exhibits a significantly increased lesion uptake on 68 Ga FAPI PET/CT imaging compared to 18 F-FDG. This case suggests that 68 Ga-FAPI PET/CT has potential value in evaluating spindle cell rhabdomyosarcoma.
September 20, 2023: Diagnostics
https://read.qxmd.com/read/37761370/eye-lens-radiation-dose-to-nurses-during-cardiac-interventional-radiology-an-initial-study
#18
JOURNAL ARTICLE
Ayumi Yamada, Yoshihiro Haga, Masahiro Sota, Mitsuya Abe, Yuji Kaga, Yohei Inaba, Masatoshi Suzuki, Norio Tada, Masayuki Zuguchi, Koichi Chida
Although interventional radiology (IVR) is preferred over surgical procedures because it is less invasive, it results in increased radiation exposure due to long fluoroscopy times and the need for frequent imaging. Nurses engaged in cardiac IVR receive the highest lens radiation doses among medical workers, after physicians. Hence, it is important to measure the lens exposure of IVR nurses accurately. Very few studies have evaluated IVR nurse lens doses using direct dosimeters. This study was conducted using direct eye dosimeters to determine the occupational eye dose of nurses engaged in cardiac IVR, and to identify simple and accurate methods to evaluate the lens dose received by nurses...
September 20, 2023: Diagnostics
https://read.qxmd.com/read/37761369/the-correlation-between-transperineal-shear-wave-elastography-and-transabdominal-ultrasound-when-assessing-pelvic-floor-function-in-nulliparous-women
#19
JOURNAL ARTICLE
Yerim Do, Youngeun Lim, Soohyun Lee, Haneul Lee
Pelvic floor muscles (PFMs) play a crucial role in maintaining pelvic organ support and continence. However, pelvic floor dysfunction (PFD), often resulting from insufficient PFM control, poses a substantial global health challenge for women. This study aims to explore the relationship between levator ani muscle elasticity when assessed through transperineal shear-wave elastography (SWE) and bladder base displacement, quantified using transabdominal ultrasonography (TAUS), as a means to comprehensively evaluate PFM function...
September 20, 2023: Diagnostics
https://read.qxmd.com/read/37761368/simple-point-of-care-nucleic-acid-amplification-test-for-rapid-sars-cov-2-infection-diagnosis
#20
JOURNAL ARTICLE
Hyunseul Jee, Minkyeong Choi, In Su Park, Junmin Lee, Woong Sik Jang, Chae Seung Lim
After three years of the SARS-CoV-2 pandemic, the demand for developing field-deployable point-of-care (PoC) molecular diagnostic tests has increased. Although RT-qPCR is the molecular diagnostic gold standard and is accurate, it is not readily applied to point-of-care testing (POCT). Meanwhile, rapid diagnostic kits have the disadvantage of low sensitivity. Recently, rapid isothermal nucleic acid amplification technology has emerged as an alternative for rapid diagnosis. Here, we developed a rapid SARS-CoV-2 reverse transcription loop-mediated isothermal amplification (RT-LAMP)-lateral flow assay (LFA) kit...
September 20, 2023: Diagnostics
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