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JOURNAL ARTICLE
Ayman R Fath, Amro Aglan, Osamah Altaee, Hendre Fichardt, Hend Mansoor, Ahmed Almomani, Muhammad Hammadah, Ariel Vinas, Hemal Nayak, Hani Jneid, Marwan Saad, Islam Y Elgendy
BACKGROUND: The efficacy of direct oral anticoagulants (DOACs) in preventing ischemic and thromboembolic events may be suboptimal in atrial fibrillation (AF) patients with rheumatic mitral stenosis. However, their safety and effectiveness after mitral valve replacement (MVR) using bioprosthetic valves is unclear. OBJECTIVES: This study sought to evaluate the safety and effectiveness of DOACs vs warfarin among patients with rheumatic heart disease (RHD)-associated AF after bioprosthetic MVR...
September 19, 2024: JACC. Clinical Electrophysiology
#2
REVIEW
Godefroy Chery, Mirmilad Khoshknab, Saman Nazarian
Catheter ablation is a well-established and effective strategy for the management of ventricular tachycardia (VT). However, the identification and characterization of arrhythmogenic substrates for targeted ablation remain challenging. Electrogram abnormalities and responses to pacing during VT provide the classical and most validated methods to identify substrates. However, the 3-dimensional nature of the myocardium, nonconductive tissue, and heterogeneous strands of conductive tissue at the border zones or through the nonconductive zones can prohibit easy electrical sampling and identification of the tissue critical to VT...
September 18, 2024: JACC. Clinical Electrophysiology
#3
JOURNAL ARTICLE
Yashasvi Chugh, Praveen Ranganath, Haojie Wang, Purav Mody, George Heberton, Praveen Rao
No abstract text is available yet for this article.
September 12, 2024: JACC. Clinical Electrophysiology
#4
JOURNAL ARTICLE
Xianwei Zhang, Yixuan Wu, Charlotte E R Smith, William E Louch, Stefano Morotti, Dobromir Dobrev, Eleonora Grandi, Haibo Ni
BACKGROUND: Substantial sex-based differences have been reported in atrial fibrillation (AF), but the underlying mechanisms are poorly understood. OBJECTIVES: This study sought to gain a mechanistic understanding of Ca2+ -handling disturbances and Ca2+ -driven arrhythmogenic events in male vs female atrial cardiomyocytes and establish their responses to Ca2+ -targeted interventions. METHODS: We integrated reported sex differences and AF-associated changes (ie, expression and phosphorylation of Ca2+ -handling proteins, cardiomyocyte ultrastructural characteristics, and dimensions) into our human atrial cardiomyocyte model that couples electrophysiology with spatially detailed Ca2+ -handling processes...
September 9, 2024: JACC. Clinical Electrophysiology
#5
JOURNAL ARTICLE
Timothy M Markman, Lingyu Xu, Sohail Zahid, Darshak Patel, Francis E Marchlinski, David Callans, Saman Nazarian
BACKGROUND: Atrial conduction velocity (CV) is influenced by autonomic tone and contributes to the pathophysiology of re-entrant arrhythmias and atrial fibrillation. Cardiac sympathetic nerve activation has been reported via electrical stimulation within the vertebral vein (VV). OBJECTIVES: This study sought to characterize changes in right atrial (RA) CV associated with sympathetic stimulation from pharmacologic (isoproterenol) or direct electrical (VV stimulation) approaches...
September 6, 2024: JACC. Clinical Electrophysiology
#6
JOURNAL ARTICLE
Thomas Pilgrim, Christoph Ryffel, Pasang Phurba Sherpa, Tendi Sherpa, Ojaswee Sherchand, Oskar Galuszka, Katja E Odening, Martina Rothenbühler, Tobias Reichlin, Kunjang Sherpa
No abstract text is available yet for this article.
September 6, 2024: JACC. Clinical Electrophysiology
#7
JOURNAL ARTICLE
Akihiko Nogami, Yuki Komatsu, Yuka Oda, Ryuichi Usui, Kikuya Uno
No abstract text is available yet for this article.
September 6, 2024: JACC. Clinical Electrophysiology
#8
JOURNAL ARTICLE
Joshua Mayourian, Juul P A van Boxtel, Lynn A Sleeper, Vedang Diwanji, Alon Geva, Edward T O'Leary, John K Triedman, Sunil J Ghelani, Rachel M Wald, Anne Marie Valente, Tal Geva
BACKGROUND: Artificial intelligence-enhanced electrocardiogram (AI-ECG) analysis shows promise to predict mortality in adults with acquired cardiovascular diseases. However, its application to the growing repaired tetralogy of Fallot (rTOF) population remains unexplored. OBJECTIVES: This study aimed to develop and externally validate an AI-ECG model to predict 5-year mortality in rTOF. METHODS: A convolutional neural network was trained on electrocardiograms (ECGs) obtained at Boston Children's Hospital and tested on Boston (internal testing) and Toronto (external validation) INDICATOR (International Multicenter TOF Registry) cohorts to predict 5-year mortality...
September 4, 2024: JACC. Clinical Electrophysiology
#9
REVIEW
Louise Reilly, Mitchell Josvai, Manasa Kalluri, Corey L Anderson, Haibo Ni, Kate M Orland, Di Lang, Alexey V Glukhov, Eleonora Grandi, Lee L Eckhardt
Idiopathic ventricular fibrillation (IVF) is an unrefined diagnosis representing a heterogeneous patient group without a structural or genetic definition. IVF treatment is not mechanistic-based due to the lack of experimental patient-models. We sought to create a methodology to assess cellular arrhythmia mechanisms for IVF as a proof-of-concept study. Using IVF patient-specific induced pluripotent stem cell-derived cardiomyocytes, we integrate electrophysiological optical mapping with computational modeling to characterize the cellular phenotype...
September 3, 2024: JACC. Clinical Electrophysiology
#10
EDITORIAL
Aneesh V Tolat
No abstract text is available yet for this article.
September 2, 2024: JACC. Clinical Electrophysiology
#11
JOURNAL ARTICLE
Justin Wallet, Yoshitaka Kimura, Nico A Blom, Monique R M Jongbloed, Robin A Bertels, Mark G Hazekamp, Katja Zeppenfeld
BACKGROUND: Patients with repaired tetralogy of Fallot (rTOF) have a time-dependent increased risk of ventricular tachycardia (VT). Slow conducting anatomical isthmuses (SCAIs) are the dominant VT substrates in adults with rTOF. It is unknown if they are present at younger age. OBJECTIVES: This study aimed to characterize VT substrates in patients with rTOF <30 years of age. METHODS: Data of consecutive patients with rTOF aged <30 years who underwent electroanatomical mapping and programmed electrical stimulation between 2005 and 2022 were analyzed...
September 2, 2024: JACC. Clinical Electrophysiology
#12
JOURNAL ARTICLE
Daniel E Singer, Steven J Atlas, Alan S Go, Steven A Lubitz, David D McManus, Rowena J Dolor, Ranee Chatterjee, Michael B Rothberg, David R Rushlow, Lori A Crosson, Ronald S Aronson, Donna Mills, Michael Patlakh, Dianne Gallup, Emily C O'Brien, Renato D Lopes
BACKGROUND: The "burden" of atrial fibrillation (AF) detected by screening likely influences stroke risk, but the distribution of burden is not well described. OBJECTIVES: This study aims to determine the frequency of AF and the distribution of AF burden found when screening individuals ≥70 years of age with a 14-day electrocardiograph monitor. METHODS: This is a cohort study of the screening arm of a randomized AF screening trial among those ≥70 years of age without a prior AF diagnosis (between 2019 and 2021)...
September 1, 2024: JACC. Clinical Electrophysiology
#13
JOURNAL ARTICLE
Yumi Katsume, Kanae Hasegawa, Sarawuth Limprasert, Akiko Ueda, Arvindh N Kanagasundram, Travis D Richardson, William G Stevenson, Kyoko Soejima
BACKGROUND: Termination of ventricular tachycardia (VT) by a pacing stimulus that does not generate a QRS complex (termination without global propagation [TWGP]) can be a marker for a critical re-entry circuit isthmus. However, the electrophysiologic and anatomic features of these sites and their relation to VT substrate defined by 3-dimensional electroanatomical maps (3D-EAM) remain unknown. OBJECTIVES: This retrospective study aimed to characterize TWGP sites and their relation to VT substrate identified by 3D-EAM...
August 31, 2024: JACC. Clinical Electrophysiology
#14
JOURNAL ARTICLE
Shunmuga Sundaram Ponnusamy, Vithiya Ganesan, Sudharshana Nagalingam, Vadivelu Ramalingam, Selvaganesh Mariappan, Habibullah Moghal, Senthil Murugan, Mahesh Kumar, Riya Joseph, Pugazhendhi Vijayaraman
BACKGROUND: Left bundle branch pacing (LBBP) provides stable pacing parameters and has been suggested as an alternative for right ventricular pacing and cardiac resynchronization therapy. OBJECTIVES: The aim of the study was to assess the incidence and etiology of new-onset left ventricular dysfunction (NOLVD) following LBBP in patients with baseline normal left ventricular (LV) function and cardiomyopathy patients with normalized LV function. METHODS: Patients undergoing successful LBBP for symptomatic bradyarrhythmia or as an alternative to cardiac resynchronization therapy were included...
August 30, 2024: JACC. Clinical Electrophysiology
#15
JOURNAL ARTICLE
Cody Cichowitz, Godfrey A Kisigo, Salama P Fadhil, Grace Ruselu, Nikola Fajkis-Zajączkowska, Eva Mujuni, Megan A Willkens, Priscilla Hsue, Robert N Peck
No abstract text is available yet for this article.
August 30, 2024: JACC. Clinical Electrophysiology
#16
JOURNAL ARTICLE
Vincenzo Mirco La Fazia, Gianluca Massaro, Sanghamitra Mohanty, Carola Gianni, Domenico Giovanni Della Rocca, Prem Geeta Torlapati, Rodney Horton, Amin Al-Ahmad, Luigi Di Biase, Andrea Natale
No abstract text is available yet for this article.
August 30, 2024: JACC. Clinical Electrophysiology
#17
JOURNAL ARTICLE
Yasutoshi Shinoda, Zenith A Jameria, Naohiko Sahara, Gaurav A Upadhyay, Yu Liao, Jake Martinez, Praneeth Katrapati, Rong Bai, Michael Zawaneh, J Peter Weiss, Wilber Su, Roderick Tung
BACKGROUND: The impact of varying rates of pacemapping (PM) rates on QRS morphology and PM score matching in patients with scar-related ventricular tachycardia (VT) has not been systematically assessed. OBJECTIVES: In this study, we sought to assess the variability in PM score matching at different pacing rates. METHODS: During substrate mapping for VT ablation, PM was performed at cycle lengths (CLs) of 600 ms, 500 ms, 400 ms, 300 ms, and VT CL...
August 23, 2024: JACC. Clinical Electrophysiology
#18
JOURNAL ARTICLE
Majd A El-Harasis, Zachary T Yoneda, Katherine C Anderson, Fei Ye, Joseph A Quintana, J Roberto Martinez-Parachini, Gregory G Jackson, Bibin T Varghese, Diane M Crawford, Lili Sun, Hollie L Williams, Matthew J O'Neill, Giovanni E Davogustto, James L Laws, Brittany S Murphy, Kelsey Tomasek, Yan Ru Su, Emily McQuillen, Emma Metz, Carly Smith, Doug Stubbs, Dakota D Grauherr, Quinn S Wells, Gregory F Michaud, Pablo Saavedra, Juan Carlos Estrada, Travis D Richardson, Sharon T Shen, Arvindh N Kanagasundram, Jay A Montgomery, Harikrishna Tandri, Christopher R Ellis, George H Crossley, Prince J Kannankeril, Lynne W Stevenson, William G Stevenson, Steven A Lubitz, Patrick T Ellinor, Dan M Roden, M Benjamin Shoemaker
BACKGROUND: Patients with rare, pathogenic cardiomyopathy (CM) and arrhythmia variants can present with atrial fibrillation (AF). The efficacy of AF ablation in these patients is unknown. OBJECTIVE: This study tested the hypotheses that: 1) patients with a pathogenic variant in any CM or arrhythmia gene have increased recurrence following AF ablation; and 2) patients with a pathogenic variant associated with a specific gene group (arrhythmogenic left ventricular CM [ALVC], arrhythmogenic right ventricular CM, dilated CM, hypertrophic CM, or a channelopathy) have increased recurrence...
August 20, 2024: JACC. Clinical Electrophysiology
#19
JOURNAL ARTICLE
Paul Schurmann, Akanibo Da-Wariboko, Armen Kocharian, Adi Lador, Apoor Patel, Nilesh Mathuria, Amish S Dave, Miguel Valderrábano
BACKGROUND: Reconnection of the mitral isthmus (MI) is common after radiofrequency ablation (RFA). Vein of Marshall ethanol infusion (VOMEI) expedites MI ablation, but long-term results are unclear. OBJECTIVES: This study sought to determine anatomic substrates of failed MI ablation, with and without VOMEI. METHODS: Consecutive VOMEI procedures were included (n = 231; of which 140 were de novo ablations and 91 were prior RFA failures (rescue VOMEI)...
August 19, 2024: JACC. Clinical Electrophysiology
#20
JOURNAL ARTICLE
Tingting Zhang, Chao Gao, Jianzheng Liu, Guotao Fu, Boyu Li, Haitao Liu, Ruining Zhang, Ping Wang, Zhongping Ning, Bing Yang, Huimin Chu, Ben He, Junfeng Zhang, Ling Zhou, Yuechun Li, Yushun Zhang, Hao Hu, Yawei Xu, Jie Zeng, Jun Guo, Xi Su, Osama Soliman, Patrick W Serruys, Ling Tao
BACKGROUND: The relationship between long-term outcomes and operator experience for left atrial appendage occlusion (LAAO) is still unknown. OBJECTIVES: This study sought to explore the association between operator LAAO experience and one-year clinical outcomes. METHODS: The RECORD study (Registry to Evaluate Chinese Real-World Clinical Outcomes in Patients With AF Using the WATCHMAN Left Atrial Appendage Closure Technology; NCT03917563) was a multicenter, prospective registry that included patients with the WATCHMAN LAAO device (Boston Scientific) in China from April 1, 2019, to October 31, 2020...
August 19, 2024: JACC. Clinical Electrophysiology
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