Read by QxMD icon Read

Science Bulletin

Aleksandr Kakinen, Yunxiang Sun, Ibrahim Javed, Ava Faridi, Emily H Pilkington, Pouya Faridi, Anthony W Purcell, Ruhong Zhou, Feng Ding, Sijie Lin, Pu Chun Ke, Thomas P Davis
Although much has been learned about the fibrillization kinetics, structure and toxicity of amyloid proteins, the properties of amyloid fibrils beyond the saturation phase are often perceived as chemically and biologically inert, despite evidence suggesting otherwise. To fill this knowledge gap, we examined the physical and biological characteristics of human islet amyloid polypeptide (IAPP) fibrils that were aged up to two months. Not only did aging decrease the toxicity of IAPP fibrils, but the fibrils also sequestered fresh IAPP and suppressed their toxicity in an embryonic zebrafish model...
January 15, 2019: Science Bulletin
Julian M Stewart
No abstract text is available yet for this article.
December 15, 2018: Science Bulletin
Xiaoqin Wei, Ke Lan
The innate immune responses triggering production of type I interferons and inflammatory cytokines constitute a nonspecific innate resistance that eliminates invading pathogens including viruses. The activation of innate immune signaling through pattern recognition receptors (PRRs) is by sensing pathogen-associated molecular patterns derived from viruses. According to their distribution within cells, PRRs are classified into three types of receptors: membrane, cytoplasmic, and nuclear. Kaposi's sarcoma-associated herpesvirus (KSHV), a large DNA virus, replicates in the nucleus...
September 30, 2018: Science Bulletin
Qiwei Shen, Yeping Yang, Wenjuan Liu, Meng Wang, Yikai Shao, Bo Xu, Xiaolong Zhao, Jingjing Zhu, Rong Hua, Wanzhu Jin, Zhiyu Hu, Jae Bum Kim, Qinghua Wang, Yiming Li, Mengwei Zang, Qiyuan Yao, Zhaoyun Zhang
No abstract text is available yet for this article.
April 15, 2017: Science Bulletin
Yang Hu, Jijun Wang, Chunbo Li, Yin-Shan Wang, Zhi Yang, Xi-Nian Zuo
A brain network consisting of two key parietal nodes, the precuneus and the posterior cingulate cortex, has emerged from recent fMRI studies. Though it is anatomically adjacent to and spatially overlaps with the default mode network (DMN), its function has been associated with memory processing, and it has been referred to as the parietal memory network (PMN). Independent component analysis (ICA) is the most common data-driven method used to extract PMN and DMN simultaneously. However, the effects of data preprocessing and parameter determination in ICA on PMN-DMN segregation are completely unknown...
2016: Science Bulletin
Qipu Wang, Kuikui Jiang, Wanying Zhang, Wenying Qiu, Yijia Li, Yiqing Zheng, Chen Wang, Jimin Cao
No abstract text is available yet for this article.
2016: Science Bulletin
Qing Zhao, Xiao-Ya Chen, Cathie Martin
Scutellaria baicalensis Georgi, or Chinese skullcap, has been widely used as a medicinal plant in China for thousands of years, where the preparation from its roots is called Huang-Qin. It has been applied in the treatment of diarrhea, dysentery, hypertension, hemorrhaging, insomnia, inflammation and respiratory infections. Flavones such as baicalin, wogonoside and their aglycones baicalein wogonin are the major bioactive compounds extracted from the root of S. baicalensis. These flavones have been reported to have various pharmacological functions, including anti-cancer, hepatoprotection, antibacterial and antiviral, antioxidant, anticonvulsant and neuroprotective effects...
2016: Science Bulletin
Min Xu, Tingshuai Li, Ming Yang, Martin Andersson
The mechanical failure of solid oxide fuel cell (SOFC) components may cause cracks with consequences such as gas leakage, structure instability and reduction of cell lifetime. A comprehensive 3D model of the thermal stresses of an anode-supported planar SOFC is presented in this work. The main objective of this paper is to get an interconnect optimized design by evaluating the thermal stresses of an anode-supported SOFC for different designs, which would be a new criterion for interconnect design. The model incorporates the momentum, mass, heat, ion and electron transport, as well as steady-state mechanics...
2016: Science Bulletin
Zi-Xiang Li, Fa Wang, Hong Yao, Dung-Hai Lee
Monolayer FeSe films grown on SrTiO3 (STO) substrate show superconducting gap-opening temperatures ([Formula: see text]) which are almost an order of magnitude higher than those of the bulk FeSe and are highest among all known Fe-based superconductors. Angle-resolved photoemission spectroscopy observed "replica bands" suggesting the importance of the interaction between FeSe electrons and STO phonons. These facts rejuvenated the quest for [Formula: see text] enhancement mechanisms in iron-based, especially iron-chalcogenide, superconductors...
2016: Science Bulletin
Huimin Zhang, Christopher H Seward, Zuowei Wu, Huiyan Ye, Youjun Feng
Polymyxin acts as an ultimate line of refuge against the severe infections by multidrug-resistant Gram-negative pathogens. This conventional idea is challenged dramatically by the recent discovery of mobile colistin resistance gene (mcr-1) is prevalent in food animals and human beings worldwide. More importantly, the mcr-1 gene was found to be co-localized with other antibiotic resistance genes, raising the possibility that super-bugs with pan-drug resistance are emerging. However, little is reported on the genomes of the mcr-1-positive bacterial host reservoirs...
2016: Science Bulletin
Jiangping Hu
We elucidate a recently emergent framework in unifying the two families of high temperature (high [Formula: see text]) superconductors, cuprates and iron-based superconductors. The unification suggests that the latter is simply the counterpart of the former to realize robust extended s-wave pairing symmetries in a square lattice. The unification identifies that the key ingredients (gene) of high [Formula: see text] superconductors is a quasi two dimensional electronic environment in which the d-orbitals of cations that participate in strong in-plane couplings to the p-orbitals of anions are isolated near Fermi energy...
2016: Science Bulletin
Zhiyong Meng, Dan Yao, Lanqiang Bai, Yongguang Zheng, Ming Xue, Xiaoling Zhang, Kun Zhao, Fuyou Tian, Mingjun Wang
Based on observational analyses and on-site ground and aerial damage surveys, this work aims to reveal the weather phenomena-especially the wind situation-when Oriental Star capsized in the Yangtze River on June 1, 2015. Results demonstrate that the cruise ship capsized when it encountered strong winds at speeds of at least 31 m s-1 near the apex of a bow echo embedded in a squall line. As suggested by the fallen trees within a 2-km radius around the wreck location, such strong winds were likely caused by microburst straight-line wind and/or embedded small vortices, rather than tornadoes...
2016: Science Bulletin
Lei Yang, Changqing Yang, Chenyi Li, Qing Zhao, Ling Liu, Xin Fang, Xiao-Ya Chen
Plants synthesize and accumulate large amount of specialized (or secondary) metabolites also known as natural products, which provide a rich source for modern pharmacy. In China, plants have been used in traditional medicine for thousands of years. Recent development of molecular biology, genomics and functional genomics as well as high-throughput analytical chemical technologies has greatly promoted the research on medicinal plants. In this article, we review recent advances in the elucidation of biosynthesis of specialized metabolites in medicinal plants, including phenylpropanoids, terpenoids and alkaloids...
2016: Science Bulletin
Geoffrey J Markowitz, Gregory A Michelotti, Anna Mae Diehl, Xiao-Fan Wang
Initiation and progression of hepatocellular carcinoma (HCC) is intimately associated with a chronically diseased liver tissue. This diseased liver tissue background is a drastically different microenvironment from the healthy liver, especially with regard to immune cell prevalence and presence of mediators of immune function. To better understand the consequences of liver disease on tumor growth and the interplay with its microenvironment, we utilized two standard methods of fibrosis induction and orthotopic implantation of tumors into the inflamed and fibrotic liver to mimic the liver condition in human HCC patients...
April 1, 2015: Science Bulletin
Xiaoyang Long, Jing Ye, Di Zhao, Sheng-Jia Zhang
Current neuromodulation techniques such as optogenetics and deep-brain stimulation are transforming basic and translational neuroscience. These two neuromodulation approaches are, however, invasive since surgical implantation of an optical fiber or wire electrode is required. Here, we have invented a non-invasive magnetogenetics that combines the genetic targeting of a magnetoreceptor with remote magnetic stimulation. The non-invasive activation of neurons was achieved by neuronal expression of an exogenous magnetoreceptor, an iron-sulfur cluster assembly protein 1 (Isca1)...
2015: Science Bulletin
Andrew Paul Hutchins, Duanqing Pei
Transposable elements (TEs) are mobile genomic sequences of DNA capable of autonomous and non-autonomous duplication. TEs have been highly successful, and nearly half of the human genome now consists of various families of TEs. Originally thought to be non-functional, these elements have been co-opted by animal genomes to perform a variety of physiological functions ranging from TE-derived proteins acting directly in normal biological functions, to innovations in transcription factor logic and influence on epigenetic control of gene expression...
2015: Science Bulletin
Andrzej Balinski, Yuanlin Sun
Our perception of biodiversity in the geological past is incomplete and biased because most organisms did not have mineralized skeletons and therefore had little chance of fossilization. This especially refers to shallow-water marine environments, rarely represented by localities with exceptional preservation of fossil material (known as taphonomic windows or Konservat-Lagerstätten). Such extraordinary "windows" may markedly broaden our knowledge of biodiversity of the past. Here, we show a review of the invertebrate fossils from recently discovered locality in the Lower Ordovician Fenxiang Formation of Hubei Province in southern China revealing exceptional preservation of soft tissues...
2015: Science Bulletin
Christopher Monckton Of Brenchley, Willie W-H Soon, David R Legates, William M Briggs
Richardson et al. (Sci Bull, 2015. doi:10.1007/s11434-015-0806-z) suggest that the irreducibly simple climate model described in Monckton of Brenchley et al. (Sci Bull 60:122-135, 2015. doi:10.1007/s11434-014-0699-2) was not validated against observations, relying instead on synthetic test data based on underestimated global warming, illogical parameter choice and near-instantaneous response at odds with ocean warming and other observations. However, the simple model, informed by its authors' choice of parameters, usually hindcasts observed temperature change more closely than the general-circulation models, and finds high climate sensitivity implausible...
2015: Science Bulletin
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"